The Relationship between Microalbuminuria and Atherosclerosis in Aged Patients with Essential Hypertension_West China Medical Journal

Authors：

1.Department of Geriatric,West China Hospital,Sichuan University,Chengdu 610041,China;2.The 452 nd Hospital of PLA,Chengdu 610000,China;

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Keywords：

原發性高血壓; 微量白蛋白尿; 頸動脈內中膜厚度; 動脈粥樣硬化

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目的:探討老年原發性高血壓(EH)患者早期腎損害指標微量白蛋白尿(MAU)和動脈粥樣硬化的早期征象頸動脈內中膜厚度(C-IMT)之間的關系。方法:99名老年EH患者按尿白蛋白/肌酐比值(ACR)分為異常ACR組和正常ACR組,對兩組的C-IMT、斑塊發生率、ACR水平及血中尿素氮(Bun)、肌酐(Cr)、總膽固醇(TC)、甘油三酯(TG)、血糖(Glu)、體重指數(BMI)等進行分析和比較。結果:異常ACR組的年齡、尿酸、ACR、C-IMT、24小時平均收縮壓,平均動脈壓及脈壓均高于正常ACR組(P lt;0.05);且C-IMT與ACR水平呈正相關(P lt;0.05)。結論:微量白蛋白尿和頸動脈IMT密切相關,提示微量白蛋白尿不僅和老年高血壓腎臟病變有關,也是亞臨床期動脈粥樣硬化的早期標志.

Citation： ZHANG Yan,ZHANG Junqi,ZHONG Liang. The Relationship between Microalbuminuria and Atherosclerosis in Aged Patients with Essential Hypertension. West China Medical Journal, 2009, 24(3): 657-660. doi: Copy

1.	謝秀梅,李志凌,李兢,等.老年原發性高血壓微量白蛋白尿與血管內皮功能及頸總動脈粥樣硬化[J].高血壓雜志,2006,14(2):94-96..
2.	BARGHOUTI N,ELKELES R,NICOLAIDES A,et al.The ultrasonic evaluation of the carotid intimamedia thickness and its relation to risk factors of atherosclerosis in normal and diabetic population[J].Int Angiol,1997,16(1):50-54..
3.	《中國高血壓防治指南》修訂委員會/高血壓的危險分層.中國高血壓防治指南2005年修訂版[s].北京:人民衛生出版社,2006:15..
4.	SALONNEN JI,SALONEN R.Ultrasound Bmode imaging in observational studies of atherosclerotic progression[J].Circulation,1993,87(3 Suppl):1156-1157..
5.	DEVEREUX RB,LUTAS EM,CASALE PN,et al.Standardization of Mmode echocardiography left ventricular anatomic measurements[J].J Am Coll Cardiol,1984,4(6):1222-1230..
6.	BIGAZZI R,BIANCHI S,CAMPESE VM,et al.Prevalence of microalbuminuria in a large population of patients with mild to moderate essential hypertension[J].Nephron,1992,61:94-97..
7.	JAY PG,GEORGE LB.Microalbuminuria:marker of vascular dysfunction,risk factor for cardiovascular disease [J].Vascular Med,2002,7:35-43..
8.	KLAUSEN K,BORCHJOHNSEN K,FELDTRASMUSSEN B,et al.Very low levels of microalbuminuria are associated with increased riskof coronary heart disease and death independently of renal function,hypertension,and diabetes[J].Circulation,2004,110(1):32-35..
9.	KRISTIAN W,HANS I,MICHAEL H,et al.Albuminuria and cardiovascular risk in hypertensive patients with left ventricular hypertrophy:the LIFE study[J].Kidney Int Suppl,2004,66(92):S56S58.
10.	張曉梅,胡肇衡,梁紅,等.微量白蛋白尿不同測定方法的比較[J].Chinese Journal of Medicinal Guide,2007,9:186-188..
11.	LANGE LA,BOWDEN DW,LANGEFELD CD,et al.Heritability of carotid artery intimamedial thickness in type 2 diabetes [J].Stroke,2002,33(7):1876-1881..
12.	JORGENSEN L,JENSSEN T,JOHNSEN SH,et al.Albuminuria as risk factor for initiation and progression of carotid atherosclerosis in nondiabetic persons:the Tromso Study [J].Eur Heart J,2007,28(3):363-369..
13.	GERSTEIN HC,MANN JF,POGUE J,et al.Prevalence and determinants of microalbuminuria in high risk diabetic and no diabetic patients in heart outcomes prevention evaluation study[J].The HOPE Study Investigators.Diabetes Care,2000,23(supple 2):B35-39..
14.	VIBERTI G,WHEELDON NM,MARVAL STUDY INVESTIGATORS.Microalbumihuria reduction with Vallarta in patients with type 2 diabetes mellitus:a blood pressureindependent effect[J].Circulation,2002,106(6):643-645..
15.	鄧先金,曾學豐,繆世海,等.苯那普利與依貝沙坦聯合用藥對高血壓患者尿蛋白、血肌酐清除率,血肌酐的影響[J].高血壓雜志,2004,12:400-403..
16.	SEGURA J,RUILOPE LM,RODICIO JL.Microalbuminuria[J].Clin Exp Hypertens,2004,26:701-707..

1. 謝秀梅,李志凌,李兢,等.老年原發性高血壓微量白蛋白尿與血管內皮功能及頸總動脈粥樣硬化[J].高血壓雜志,2006,14(2):94-96..
2. BARGHOUTI N,ELKELES R,NICOLAIDES A,et al.The ultrasonic evaluation of the carotid intimamedia thickness and its relation to risk factors of atherosclerosis in normal and diabetic population[J].Int Angiol,1997,16(1):50-54..
3. 《中國高血壓防治指南》修訂委員會/高血壓的危險分層.中國高血壓防治指南2005年修訂版[s].北京:人民衛生出版社,2006:15..
4. SALONNEN JI,SALONEN R.Ultrasound Bmode imaging in observational studies of atherosclerotic progression[J].Circulation,1993,87(3 Suppl):1156-1157..
5. DEVEREUX RB,LUTAS EM,CASALE PN,et al.Standardization of Mmode echocardiography left ventricular anatomic measurements[J].J Am Coll Cardiol,1984,4(6):1222-1230..
6. BIGAZZI R,BIANCHI S,CAMPESE VM,et al.Prevalence of microalbuminuria in a large population of patients with mild to moderate essential hypertension[J].Nephron,1992,61:94-97..
7. JAY PG,GEORGE LB.Microalbuminuria:marker of vascular dysfunction,risk factor for cardiovascular disease [J].Vascular Med,2002,7:35-43..
8. KLAUSEN K,BORCHJOHNSEN K,FELDTRASMUSSEN B,et al.Very low levels of microalbuminuria are associated with increased riskof coronary heart disease and death independently of renal function,hypertension,and diabetes[J].Circulation,2004,110(1):32-35..
9. KRISTIAN W,HANS I,MICHAEL H,et al.Albuminuria and cardiovascular risk in hypertensive patients with left ventricular hypertrophy:the LIFE study[J].Kidney Int Suppl,2004,66(92):S56S58.
10. 張曉梅,胡肇衡,梁紅,等.微量白蛋白尿不同測定方法的比較[J].Chinese Journal of Medicinal Guide,2007,9:186-188..
11. LANGE LA,BOWDEN DW,LANGEFELD CD,et al.Heritability of carotid artery intimamedial thickness in type 2 diabetes [J].Stroke,2002,33(7):1876-1881..
12. JORGENSEN L,JENSSEN T,JOHNSEN SH,et al.Albuminuria as risk factor for initiation and progression of carotid atherosclerosis in nondiabetic persons:the Tromso Study [J].Eur Heart J,2007,28(3):363-369..
13. GERSTEIN HC,MANN JF,POGUE J,et al.Prevalence and determinants of microalbuminuria in high risk diabetic and no diabetic patients in heart outcomes prevention evaluation study[J].The HOPE Study Investigators.Diabetes Care,2000,23(supple 2):B35-39..
14. VIBERTI G,WHEELDON NM,MARVAL STUDY INVESTIGATORS.Microalbumihuria reduction with Vallarta in patients with type 2 diabetes mellitus:a blood pressureindependent effect[J].Circulation,2002,106(6):643-645..
15. 鄧先金,曾學豐,繆世海,等.苯那普利與依貝沙坦聯合用藥對高血壓患者尿蛋白、血肌酐清除率,血肌酐的影響[J].高血壓雜志,2004,12:400-403..
16. SEGURA J,RUILOPE LM,RODICIO JL.Microalbuminuria[J].Clin Exp Hypertens,2004,26:701-707..

West China Medical Journal

The Relationship between Microalbuminuria and Atherosclerosis in Aged Patients with Essential Hypertension

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