The Observation on Efficacy of Moxifloxacin in Treating Primary Peritonitis in Patients with Cirrhosis_West China Medical Journal

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Department of Infectious Disease,General Hospital of Chengdu Military Command,Chengdu 610083,China;

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Keywords：

莫西沙星; 原發性腹膜炎; 肝硬化

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目的:觀察莫西沙星治療肝硬化并發原發性腹膜炎的療效。方法:98例病例隨機分成治療組(51例)和對照組(47例),治療組使用莫西沙星注射液400mg,靜滴,1次 /天;對照組使用頭孢哌酮/舒巴坦鈉2g+左氧氟沙星注射液0.2g,靜滴,2次/次,療程7~10天。結果:治療組總有效率為90.2%,明顯高于對照組72.3%(P lt;0.05),并且能較快緩解患者感染的癥狀和體征,不良反應發生率僅為3.9%。結論:莫西沙星是治療肝硬化并發原發性腹膜炎安全有效的藥物

Citation： LI Xiaoan,CHEN Xianlan,HU Jian,et al. The Observation on Efficacy of Moxifloxacin in Treating Primary Peritonitis in Patients with Cirrhosis. West China Medical Journal, 2009, 24(3): 641-643. doi: Copy

1.	黎敏,李才,鄧興臣.肝硬化腹水合并自發性腹膜炎的臨床分析和預后[J].中國社區醫師,2006,8(143):66-67..
2.	FIGUEIREDO FA,COELHO HS,SOARES JA.Spontaneous bacterial peritonitis in hepatic cirrhosis:prevalence,predictive factors and prognosis[J].Rev Assoc Med Bras,1999,45(2):128-136..
3.	張錦前,楊玉英,吳亮,等.肝硬化合并自發性細菌性腹膜炎臨床診斷標準及其病原分析[J].中國醫師進修雜志,2006,29(4):47-49..
4.	胡傳芳.湖北地區腹水病人中常見細菌的分布及耐藥性分析[J].湖北中醫學院學報,2007,9(2):55-56..
5.	朱欣榮,潘云影.頭孢噻肟鈉聯合左氧氟沙星治療肝硬化并自發細菌性腹膜炎療效觀察[J].現代醫藥衛生,2008,24(17):2579-2580..
6.	陸穎,李宏力.莫西沙星注射液治療急性細菌感染臨床研究[J].中國現代醫藥雜志,2008,10(3):58-60..
7.	TORRES A,MUIR JF,CORRIS P,et al.Effectiveness of oral moxi?oxacin in standard ?rstline therapy in communityacquired pneumonia[J].Eur Respir J,2003,21(1):135-143..
8.	WILSON R,KUBIN R,BALLIN I,et al.Five day moxifloxacin therapy compared with 7 day clarithromycin therapy for the treatment of acute exacerbations of chronic bronchitis[J].Journal of Antimicrobial Chemotherapy,1999,44(4):501-513..
9.	STASS H,RINK A.D,DELESEN H,et al.Pharmacokinetics and peritoneal penetration of moxifloxacin in peritonitis[J].Journal of Antimicrobial Chemotherapy,2006,58(3):693-696..
10.	中華醫學會傳染病與寄生蟲病學會分會、肝病學分會.病毒性肝炎防治方案[J].中華傳染病雜志,2001,19(1):56-62..
11.	王守義.肝硬化自發性細菌性腹膜炎的診斷和治療[J].臨床肝膽病雜志,2006,22(1):19-21..
12.	任小華,張郁馨,李暉.頭孢三嗪和環丙沙星治療慢性重型肝炎并發原發性腹膜炎療效比較[J].四川醫學,1999,20(1):24-25..
13.	謝維釗.左氧氟沙星治療肝硬化腹水并發原發性腹膜炎的療效觀察[J].廣東醫學院學報,2001,19(5):365-366..
14.	張斌.肝硬化合并自發性細菌性腹膜炎發病機制研究進展[J].國外醫學·生理、病理科學與臨床分冊,2003,23(1):103-105..
15.	Llovet JM,Bartolí R,Planas R,et al.Bacterial translocation in cirrhotic rats.Its role in the development of spontaneous bacterial peritonitis[J].Gut,1994,35(11):1648-1652..
16.	張慧琳,呂曉菊,王其南,等.舒巴坦 頭孢哌酮與頭孢噻肟隨機對照多中心臨床研究[J].中國抗生素雜志,2001,26(4):274--280..
17.	肖永紅,王進,趙彩云,等.2006-2007年Mohnarin細菌耐藥監測[J].中華醫院感染學雜志,2008,18(8):1051-1056..
18.	龍鑫,陳虹年,周清.頭孢哌酮/舒巴坦治療自發性細菌性腹膜炎療效觀察[J].現代醫藥衛生,2006,22(5):664..
19.	李慶興,潘發憤,王邦松,等.第三代頭孢菌素對4666株醫院致病菌的耐藥情況分析[J].中國微生態學雜志,2000,12(2):93-94..
20.	王進,李家泰,李耘.氟喹諾酮類抗菌藥物對2554株細菌的抗菌活性分析[J].中國抗感染化療雜志,2004,4(1):14-17..
21.	MALANGONI MA,SONG J,HERRINGTON J,et al.Randomized controlled trial of moxifloxacin compared with piperacillintazobactam and amoxicillinclavulanate for the treatment of complicated intraabdominal infections[J].Ann Surg,2006,244(2):204-211..
22.	章怡彬,劉明亮,郭慧元.新喹諾酮的結構特征及其對革蘭陽性菌的構效關系[J].國外醫藥抗生素分冊,2008,29(1):12-19..

1. 黎敏,李才,鄧興臣.肝硬化腹水合并自發性腹膜炎的臨床分析和預后[J].中國社區醫師,2006,8(143):66-67..
2. FIGUEIREDO FA,COELHO HS,SOARES JA.Spontaneous bacterial peritonitis in hepatic cirrhosis:prevalence,predictive factors and prognosis[J].Rev Assoc Med Bras,1999,45(2):128-136..
3. 張錦前,楊玉英,吳亮,等.肝硬化合并自發性細菌性腹膜炎臨床診斷標準及其病原分析[J].中國醫師進修雜志,2006,29(4):47-49..
4. 胡傳芳.湖北地區腹水病人中常見細菌的分布及耐藥性分析[J].湖北中醫學院學報,2007,9(2):55-56..
5. 朱欣榮,潘云影.頭孢噻肟鈉聯合左氧氟沙星治療肝硬化并自發細菌性腹膜炎療效觀察[J].現代醫藥衛生,2008,24(17):2579-2580..
6. 陸穎,李宏力.莫西沙星注射液治療急性細菌感染臨床研究[J].中國現代醫藥雜志,2008,10(3):58-60..
7. TORRES A,MUIR JF,CORRIS P,et al.Effectiveness of oral moxi?oxacin in standard ?rstline therapy in communityacquired pneumonia[J].Eur Respir J,2003,21(1):135-143..
8. WILSON R,KUBIN R,BALLIN I,et al.Five day moxifloxacin therapy compared with 7 day clarithromycin therapy for the treatment of acute exacerbations of chronic bronchitis[J].Journal of Antimicrobial Chemotherapy,1999,44(4):501-513..
9. STASS H,RINK A.D,DELESEN H,et al.Pharmacokinetics and peritoneal penetration of moxifloxacin in peritonitis[J].Journal of Antimicrobial Chemotherapy,2006,58(3):693-696..
10. 中華醫學會傳染病與寄生蟲病學會分會、肝病學分會.病毒性肝炎防治方案[J].中華傳染病雜志,2001,19(1):56-62..
11. 王守義.肝硬化自發性細菌性腹膜炎的診斷和治療[J].臨床肝膽病雜志,2006,22(1):19-21..
12. 任小華,張郁馨,李暉.頭孢三嗪和環丙沙星治療慢性重型肝炎并發原發性腹膜炎療效比較[J].四川醫學,1999,20(1):24-25..
13. 謝維釗.左氧氟沙星治療肝硬化腹水并發原發性腹膜炎的療效觀察[J].廣東醫學院學報,2001,19(5):365-366..
14. 張斌.肝硬化合并自發性細菌性腹膜炎發病機制研究進展[J].國外醫學·生理、病理科學與臨床分冊,2003,23(1):103-105..
15. Llovet JM,Bartolí R,Planas R,et al.Bacterial translocation in cirrhotic rats.Its role in the development of spontaneous bacterial peritonitis[J].Gut,1994,35(11):1648-1652..
16. 張慧琳,呂曉菊,王其南,等.舒巴坦 頭孢哌酮與頭孢噻肟隨機對照多中心臨床研究[J].中國抗生素雜志,2001,26(4):274--280..
17. 肖永紅,王進,趙彩云,等.2006-2007年Mohnarin細菌耐藥監測[J].中華醫院感染學雜志,2008,18(8):1051-1056..
18. 龍鑫,陳虹年,周清.頭孢哌酮/舒巴坦治療自發性細菌性腹膜炎療效觀察[J].現代醫藥衛生,2006,22(5):664..
19. 李慶興,潘發憤,王邦松,等.第三代頭孢菌素對4666株醫院致病菌的耐藥情況分析[J].中國微生態學雜志,2000,12(2):93-94..
20. 王進,李家泰,李耘.氟喹諾酮類抗菌藥物對2554株細菌的抗菌活性分析[J].中國抗感染化療雜志,2004,4(1):14-17..
21. MALANGONI MA,SONG J,HERRINGTON J,et al.Randomized controlled trial of moxifloxacin compared with piperacillintazobactam and amoxicillinclavulanate for the treatment of complicated intraabdominal infections[J].Ann Surg,2006,244(2):204-211..
22. 章怡彬,劉明亮,郭慧元.新喹諾酮的結構特征及其對革蘭陽性菌的構效關系[J].國外醫藥抗生素分冊,2008,29(1):12-19..

West China Medical Journal

The Observation on Efficacy of Moxifloxacin in Treating Primary Peritonitis in Patients with Cirrhosis

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