Clinical Analysis of 96 Patients with Hemorrhagic Transformation after Cerebral Infarction_West China Medical Journal

Authors：

QING Shaohua , GU Chengwu , HE Hui.

Deparement of Neurology，Suining Central Hospital，Suining Sichuan 629000，China;

Corresponding?author：

Keywords：

腦梗死; 出血轉化; 臨床分析

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目的：探討腦梗死出血轉化(HT)的病因，發生率，臨床表現和影像學特點及預后。方法：對我院2002年1月至2008年7月96例腦梗死出血轉化患者進行回顧性分析。結果：糖尿病、高血壓、心房纖顫、血脂異常、大面積腦梗死是HT的主要病因，其發生率為20.3%，第一周為62.5%，第二周為31.2%，兩周后為6.3%，其臨床表現為頭痛、嘔吐、肢體無力加重、意識障礙加深，CT或MRI表現為非血腫型與血腫型，死亡率為16.7%。結論：對神經癥狀及體征加重的患者，尤其是大面積腦死患者，應及早查復查CT或MRI，有利于HT的早期診治。

Citation： QING Shaohua,GU Chengwu,HE Hui.. Clinical Analysis of 96 Patients with Hemorrhagic Transformation after Cerebral Infarction. West China Medical Journal, 2009, 24(2): 269-270. doi: Copy

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1. Bayramoglu M，Karatas M，Leblebici B，et al.Hemorrhagic transformation in stroke patients[J].Am J Phys Med Rehabil，2003，82(1)：48-52..
2. Silva Y，Leira R，Tejada J，et al.Molecular signatures of vascular injury are associated with early growth of intracerebral hemorrhage[J].Stroke.2005，36(1)：86-91..
3. Tong DC，Adami A，Moseley ME，et al.Relationship between apparent diffusion coefficient and subsequent hemorrhagic transformation following acute ischemic stroke[J].Stroke，2000，31(10)：2378-2384..
4. Kerenyi L，Kardos L，Szasz J，et al.Factors influencing hemorrhagic transformation in ischemic stroke：a clinicopathological comparison[J].Eur J Neurol，2006，13(11)：1251-1255..
5. 段遼江，齊中華，李勝.出血性腦梗死52例臨床分析[J].大連醫科大學學報，2007，29(2)：151-152..
6. Castellanos M，Sobrino T，Millan M，et al.Serum cellular fibronectin and matrix metalloproteinase9 as screening biomarkers for the prediction of parenchymal hematoma after thrombolytic therapy in acute ischemic stroke：a multicenter confirmatory study[J].Stroke.2007，38(6)：1855-1859..
7. Montaner J，Molina CA，Monasterio J，et al.Matrix metalloproteinase9 pretreatment level predicts intracranial hemorrhagic complications after thrombolysis in human stroke[J].Circulation，2003，107(4)：598-603.

West China Medical Journal

Clinical Analysis of 96 Patients with Hemorrhagic Transformation after Cerebral Infarction

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