曲美他嗪治療缺血性擴張型心肌病療效觀察_West China Medical Journal

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任靜 , 馮勝紅

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曲美他嗪; 擴張型心肌病

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【摘要】　目的　總結曲美他嗪在缺血性擴張型心肌病患者心功能改善方面的作用。　方法　 2007年1月-2009年12月隨機將61例患者分為二組，觀察組給予常規藥物治療加用曲美他嗪，對照組給予常規治療，通過心功能及左心室射血分數兩個方面來評估治療效果。　結果　觀察組較對照組顯著增加左室射血分數，并能改善患者心功能分級。　結論　缺血性擴張型心肌病患者可以很好地耐受較長期的曲美他嗪治療，同時心功能也得到改善。

Citation： 任靜,馮勝紅. 曲美他嗪治療缺血性擴張型心肌病療效觀察. West China Medical Journal, 2010, 25(11): 2060-2061. doi: Copy

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1. 　Di Napoli P, Taccardi AA, Bardotti A. Long term cardio-protective action of trimetazidine and potential effect on the inflammatory process in patients with ischemic dilated cardiomyopathy[J]. Heart, 2005, 92(2): 161-165.
2. 　賈三慶, 董曉冬, 胡大一, 等. 曲美他嗪心肌細胞保護作用的臨床研究[J]. 中華心血管病雜志, 2003, 31(增刊): 201-208.
3. 　Belardinelli R, Purcaro A. Effects of trimetazidine on the contractile response of chronically dysfunctional myocardium to low-dose dobutamine in ischmic cardiomyopathy[J]. Eur Heart J, 2001, 22(23): 2164-2170.
4. 　謝瑞芹, 都軍, 郝玉明, 等. 曲美他嗪治療冠心病心力衰竭療效觀察[J]. 中華心血管病雜志, 2004, 32(1): 77.
5. 　胡大一, 趙秀麗. 曲美他嗪對穩定性勞力型心絞痛的療效觀察[J]. 中華心血管病雜志, 2000, 29(15): 18-20.
6. 　Guarnieri C, Muscari C. Effict of trimetazidine on mitochondrial function and oxidative damage during reperfusion of ischmic hypertrophied myocardium[J]. Pharmacology, 1993, 46: 324-331.
7. 　Belardinelli R, Purcaro A. Effects of trimetazidine on the contractile response of chronically dysfunctional myocardium to low-dose dobutamine in ischmic cardiomyopathy[J]. Eur Heart J, 2001, 22: 2164-2170.
8. 　Lu C, Dabrowski P, Fracasso G, et al. Effects of trimetazidine on ischmic left ventricular dysfunction in patients with coronary disease: a doubleblind. Placebo-controlled, crossover study[J]. Am J Cardiol, 1998, 82: 898-901.

West China Medical Journal

曲美他嗪治療缺血性擴張型心肌病療效觀察

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