Clinical Features of Adult Still’s Disease_West China Medical Journal

Authors：

LI Xianyong , XIA Gang , SU Zunwei

Department of Infection, the Second People’s Hospital, Neijiang, Sichuan 641000, P.R. China;

Corresponding?author：

Keywords：

Still病; 成人; 血清鐵蛋白

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方法回顧分析從2007年1月-2009年12月收治的12例成人Still病患者的臨床資料，觀察其臨床特點。結果 12例患者體溫均≥39.0℃，有一過性皮疹、關節疼痛，周圍血常規白細胞總數、中性粒細胞增高（白細胞≥15.0×109/L、中性粒細胞≥80%），血沉、C-反應蛋白、血清鐵蛋白增高，骨髓涂片為增生性骨髓像，其次有咽痛，肝、脾、淋巴結腫大等臨床表現。糖皮質激素是治療的主要措施。結論成人Still病臨床表現復雜多樣，實驗室檢查缺乏特異性，血清鐵蛋白檢測值的明顯增高有助于診斷。患者經糖皮質激素治療后預后效好。
【Abstract】 Objective To observe the clinical characteristics of adult onset Still’s disease and enhance the awareness of the disease. Methods The clinical data of 12 patients with Still’s disease from January 2007 to December 2009 were retrospective analyzed. The clinical characteristics of the disease were observed. Results Twelve patients had high fever (body temperature≥39.0℃), evanescent eruption, arthralgia, increase of leucocyte and neutrophilic granulocyte (leucocyte≥15.0×109/L, neutrophilic granulocyte≥80%), blood sedimentation, and C-reactive protein, increase of serum ferritin, bone marrow smear being hyperplasticmyelogram, as well as the tumefaction of angina, liver, spleen, and lymphaden. Glucocorticoid was the main measure of the treatment. Conclusions Clinical presentation of adult Still’s disease is various with involvement of many systems with lack of specificity of the lab inspection. Obvious increase of detected value of serum ferritin attributes greatly to the diagnosis. The prognosis of the patients who have undergone glucocorticoid treatment is very good.

Citation： LI Xianyong,XIA Gang,SU Zunwei. Clinical Features of Adult Still’s Disease. West China Medical Journal, 2010, 25(10): 1805-1807. doi: Copy

1.	陳景珠, 林果. 實用內科學[M]. 13版. 上海: 人民衛生出版社, 2009: 2720-2723.
2.	劉建忠, 王小磊, 譚舉鵬, 等. 成人Still病診治研究進展[J]. 中國臨床實用醫學, 2008, 12(2): 108-110.
3.	陳潔, 李發菊, 陳梅, 等. 成人Still病回顧性分析[J]. 瀘州醫學院學報, 2009, 32(2): 152-155.
4.	李建東, 于忠和. 成人Still病32例臨床分析[J]. 臨床肺科雜志, 2009, 14(5): 571-572.
5.	陶仲為. 成人Still病診治討論[J]. 中國實用內科雜志, 2009, 29(12): 1093-1095.
6.	潘正論, 郟雁飛, 吳倩, 等. 成人Still病的輔助檢查[J]. 山東醫學, 2008, 48(20): 111.
7.	Arlet JB, Le Thi Huong DB, Pouchot J, et al. Current Concepts on the physiopathology of adult onset Still’s disease[J]. Revmed Interne, 2005, 26(7): 549-556.
8.	Fitzgerald AA, Leclercq SA, Yan A, et al. Rapid responses to anakinrain patientswith refactory adult-onset Still’s disease[J]. Arthritis Rheum, 2005, 52(6): 1794-1803.
9.	Pelkinen P, Swanljung K, Siimes MA. Ferritinemia as an indicator of systemic disease activity in children with systemic juvenile rheumatoid arthritis[J]. Acta paediatr scand, 1986, 75(1): 64.
10.	王偉卓, 臧國慶. 成人Still病26例臨床分析[J]. 世界感染雜志, 2008, 8(3): 205-207.
11.	Fautrel B. Ferritin levels in adult Still’s disease: any sugar[J]. Joint Bone Spine, 2002, 69(4): 355.
12.	胡欽鳳, 顧美華. 血清鐵蛋白在成人Still病診療中的臨床價值[J]. 蘇州大學學報(醫學版), 2008, 28(1): 119-120.
13.	龔益, 殷少軍, 顏正茂, 等. 成人Still病臨床分析[J]. 同濟大學學報(醫學版), 2009, 30(1): 135-138.
14.	馬麗, 鉗志晶. 成人Still病與急性重度肝損害[J]. 中華風濕病學雜志, 2007, 11(8): 489-491.

1. 陳景珠, 林果. 實用內科學[M]. 13版. 上海: 人民衛生出版社, 2009: 2720-2723.
2. 劉建忠, 王小磊, 譚舉鵬, 等. 成人Still病診治研究進展[J]. 中國臨床實用醫學, 2008, 12(2): 108-110.
3. 陳潔, 李發菊, 陳梅, 等. 成人Still病回顧性分析[J]. 瀘州醫學院學報, 2009, 32(2): 152-155.
4. 李建東, 于忠和. 成人Still病32例臨床分析[J]. 臨床肺科雜志, 2009, 14(5): 571-572.
5. 陶仲為. 成人Still病診治討論[J]. 中國實用內科雜志, 2009, 29(12): 1093-1095.
6. 潘正論, 郟雁飛, 吳倩, 等. 成人Still病的輔助檢查[J]. 山東醫學, 2008, 48(20): 111.
7. Arlet JB, Le Thi Huong DB, Pouchot J, et al. Current Concepts on the physiopathology of adult onset Still’s disease[J]. Revmed Interne, 2005, 26(7): 549-556.
8. Fitzgerald AA, Leclercq SA, Yan A, et al. Rapid responses to anakinrain patientswith refactory adult-onset Still’s disease[J]. Arthritis Rheum, 2005, 52(6): 1794-1803.
9. Pelkinen P, Swanljung K, Siimes MA. Ferritinemia as an indicator of systemic disease activity in children with systemic juvenile rheumatoid arthritis[J]. Acta paediatr scand, 1986, 75(1): 64.
10. 王偉卓, 臧國慶. 成人Still病26例臨床分析[J]. 世界感染雜志, 2008, 8(3): 205-207.
11. Fautrel B. Ferritin levels in adult Still’s disease: any sugar[J]. Joint Bone Spine, 2002, 69(4): 355.
12. 胡欽鳳, 顧美華. 血清鐵蛋白在成人Still病診療中的臨床價值[J]. 蘇州大學學報(醫學版), 2008, 28(1): 119-120.
13. 龔益, 殷少軍, 顏正茂, 等. 成人Still病臨床分析[J]. 同濟大學學報(醫學版), 2009, 30(1): 135-138.
14. 馬麗, 鉗志晶. 成人Still病與急性重度肝損害[J]. 中華風濕病學雜志, 2007, 11(8): 489-491.

West China Medical Journal

Clinical Features of Adult Still’s Disease

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