LIU Zhigang
  • Blood Tumor Medicine Department, People’s Hospital of Dazhu, Sichuan 635100, P.R.China;
白血病; 髓樣; 慢性; 聯合抗腫瘤療法
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【摘要】 目的  探討高三尖杉酯堿（HHT）聯合三氧化二砷（As2O3）、羥基脲治療高白細胞慢性粒細胞白血病（CML）的療效和毒副作用。 方法  對2004年11月-2009年12月行高三尖杉酯堿聯合As2O3、羥基脲治療高白細胞CML患者21例的療效和不良反應進行分析。 結果  經高三尖杉酯堿聯合As2O3、羥基脲治療后3～6個療程，21例CML患者中完全緩解15例，占71%；部分緩解2例，占10%；總有效率81%；未緩解4例，占19%。不良反應僅表現乏力、納差、惡心、脫發。 結論  HHT聯合As2O3、羥基脲是治療高白細胞CML一種有效率高，臨床容易開展，安全性好的方法。
【Abstract】 Objective  To investigate the effects and side effects of homoharringtonine combined with arsenic trioxide or hydroxycarbamide on hyperleukocytic chronic myelocytic leukemia (CML). Methods  The therapeutic effects and adverse effects of homoharringtonine combined with arsenic trioxide or hydroxycarbamide administered in 21 cases with CML from November 2004 to December 2009. Results  In 21 patients with CML, the CR rate was 71% (15/21) and PR rate was 10% (2/21). The total respondence rate was 81% and the side effects were slight. The side effect only shows short of strength, appetite decrease, naupathia, hair loss and no heart side effect. Conclusion  Homoharringtonine combined with arsenic trioxide or hydroxycabamide has a high effect rate on CML with good safety.

Citation： LIU Zhigang. Curative Effect of Homoharringtonine United Program on Patients with Chronic Myelocytic Leukemia. West China Medical Journal, 2010, 25(8): 1421-1422. doi: Copy

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