Analysis on Clinical Characteristics of Infectious Mononucleosis in Children_West China Medical Journal

Authors：

XU Yuxia , LIAO Xianhua , YI Zhigang , LIU Zengrong

Department of Pediatrics, The Affiliated Hospital of North Sichuan Medical College, Nanchong, Sichuan 637000, P.R.China;

Corresponding?author：

Keywords：

傳染性單核細胞增多癥; 臨床特點; 更昔洛韋

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【摘要】目的探討兒童傳染性單核細胞增多癥（IM）的臨床特點。方法回顧性分析2005年8月-2009年8月收治的151例IM患兒的癥狀、體征、實驗室檢查及治療效果。結果 IM臨床表現以發熱、咽峽炎、肝脾和淋巴結腫大最常見，鼻塞、眼瞼浮腫也是重要體征。外周血出現異型淋巴細胞及EBV-IgM抗體檢測可幫助確診。更昔洛韋治療IM效果確切。結論應重視IM臨床特點，有助于早期診斷并提高確診率，應用更昔洛韋治療值得推廣。
【Abstract】 Objective To investigate the clinical features of infectious mononucleosis (IM) in children. Methods A total of 151 children with infectious mononucleosis admitted from August 2005 to August 2009 were reviewed. The symptoms, signs, laboratory tests, and treatment of infectious mononucleosis were analyzed. Results Fever, angina, hepatomegaly, splenomegaly, and swollen lymph nodes were the most common clinical manifestations of IM. Nasal congestion and eyelid edema were also two important signs. Atypical lymphocytes in peripheral blood and EBV antibody (VCA-IgM) could help confirm the diagnosis. The antiviral treatment with ganciclovir was effective for infectious mononucleosis. Conclusion Clinical features of infectious mononucleosis are helpful to the diagnosis. Treatment with ganciclovir should be promoted.

Citation： XU Yuxia,LIAO Xianhua,YI Zhigang,LIU Zengrong. Analysis on Clinical Characteristics of Infectious Mononucleosis in Children. West China Medical Journal, 2010, 25(7): 1270-1272. doi: Copy

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12.	李奇志, 朱朝敏. 更昔洛韋治療小兒傳染性單核細胞增多癥的臨床療效觀察[J]. 中國實用兒科雜志, 2006, 21(1): 74.
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1. 胡亞美, 江載芳. 實用兒科學[M]. 北京: 人民衛生出版社, 2002: 821.
2. 朱易平, 高舉, 杜惠容, 等. 196例傳染性單核細胞增多癥的并發癥和實驗室檢查[J]. 實用臨床兒科雜志, 2003, 18(11): 902.
3. Kanegane H, Kanegane C, Yachie A, et al. Infectious mononucleosis as a disease of early childhood in Japan caused by primary Epstein-Barr virus infection[J]. Acta Paediatr Jpn, 1997, 39(2): 166-171.
4. 劉增榮, 王嵩忠, 魏鈺書, 等. 兒童傳染性單核細胞增多癥57例臨床及實驗室分析[J]. 川北醫學院學報, 2006, 21(2): 139-141.
5. 樸金花, 孫景輝, 楊思睿, 等. 兒童傳染性單核細胞增多癥臨床特點與發病年齡的關系(附142例分析)[J]. 中國小兒血液, 2005, 10(2): 71-74.
6. 王曉莉, 于潔, 徐西華. 傳染性單核細胞增多癥及其相關疾病臨床特點分析[J]. 中國實用兒科雜志, 2006, 21(9): 696-698.
7. 張愛民, 賀湘玲. 182例小兒傳染性單核細胞增多癥的血液學表現[J]. 中國小兒血液, 2005, 10(1): 12-13.
8. 方在軍, 毛平惠, 朱朝敏. 兒童傳染性單核細胞增多癥的肝臟損害特點[J]. 中國當代兒科雜志, 2003, 5(2): 153.
9. Chan CW, Chiang AK, Chan KH, et al. Epstein-Barr virus-associated infectious mononucleos Chinese children[J]. Pediatr Infect Dis J, 2003, 22(11): 974.
10. 趙曉慶, 張寶璽, 吳曉莉. 慢性活動性EB病毒感染轉為惡性淋巴瘤1例[J]. 中國實用兒科雜志, 2008, 23(2): 105.
11. 郭霞, 李強, 周晨燕, 等. 兒童傳染性單核細胞增多癥并發EB病毒相關性噬血綜合征臨床危險因素分析[J]. 中華兒科雜志, 2008, 48(1): 72.
12. 李奇志, 朱朝敏. 更昔洛韋治療小兒傳染性單核細胞增多癥的臨床療效觀察[J]. 中國實用兒科雜志, 2006, 21(1): 74.
13. 鄧佳, 鄢力, 羅葦. 傳染性單核細胞增多癥的抗病毒治療分析[J]. 現代預防醫學, 2005, 32(2): 148.

West China Medical Journal

Analysis on Clinical Characteristics of Infectious Mononucleosis in Children

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