• Cancer Center, the Second Clinical Medical School Affiliated to North Sichuan Medical College, Nanchong Central Hospital, Nanchong, Sichuan 637000, P.R.China;
LI Guangming, Email: helang729@163.com
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目的  觀察消化道腫瘤患者服用甲羥孕酮(medroxyprogesterone acetate, MPA)對化療后骨髓抑制的影響。 方法  2008年11月-2009年8月,將接受化療的消化道腫瘤患者共100例隨機分為治療組(MPA加化療組,54例)及對照組(單純化療組,46例),2周期化療后評價骨髓抑制狀況和生活質量變化。 結果  治療組和對照組化療后白細胞、血紅蛋白和血小板Ⅰ~Ⅱ度骨髓抑制發生率沒有差異(P gt;0.05),但治療組Ⅲ~Ⅳ度骨髓抑制發生率低于對照組,KPS評分改善率高于對照組(P lt;0.05)。未見明顯不良反應。 結論  MPA可有效減輕化療后骨髓抑制。

Citation: HE Lang,LI Guangming,WEN Shimin,REN Dacheng,GUO Cuihua,BIE Jun,HU Xin,PAN Rongqiang. Clinical Observation of Medroxyprogesterone Acetate to Palliate Myelosuppression after Chemotherapy. West China Medical Journal, 2010, 25(5): 865-867. doi: Copy

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