Effects of Total Glucosides of Paeony on the Level of Interleukin-22 in the Serum of Patients with Psoriasis Vulgaris_West China Medical Journal

Authors：

ZHANG YUhong ,  GUO Zaipei , JIAO Xiaoyan , LI Mengmeng , CHEN Tao

Department of Dermatovenereology, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, P. R. China;

Corresponding?author：

GUO Zaipei, Email: zhangyuhongqq@163.com

Keywords：

白芍總苷; 尋常型銀屑病; 白細胞介素-22; 角質形成細胞

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目的　通過對白芍總苷治療前后尋常型銀屑病患者血清中白介素（IL）-22水平的研究，探討其治療尋常型銀屑病的作用機制。方法　2009年10月－2010年8月采用雙抗體夾心酶聯免疫吸附法，檢測30例尋常型銀屑病患者，經白芍總苷治療前后及健康對照組20例外周血清中IL-22濃度的變化，分析其在治療前、后與銀屑病皮損面積和嚴重程度指數（PASI）評分的相關性。結果　尋常型銀屑病患者血清IL-22濃度[（90.50 ± 51.80）pg/mL]較對照組[（40.10 ± 17.20）pg/mL]升高，白芍總苷治療后血清中IL-22水平[（48.70 ± 23.90）pg/mL]較治療前降低（P＜0.05），并與對照組差異無統計學意義（P＞0.05）；治療前、后患者血清IL-22水平與PASI評分呈正相關。結論　白芍總苷可能通過調節IL-22發揮治療尋常型銀屑病的作用。

Citation： ZHANG YUhong,GUO Zaipei,JIAO Xiaoyan,LI Mengmeng,CHEN Tao. Effects of Total Glucosides of Paeony on the Level of Interleukin-22 in the Serum of Patients with Psoriasis Vulgaris. West China Medical Journal, 2012, 27(4): 542-544. doi: Copy

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12.	李傳應, 王春, 魏偉. 白芍總苷對小鼠慢性皮炎-濕疹的治療作用及其部分機制[J]. 中國藥理學通報, 2008, 24(10): 1366-1369.
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1. 　熊承成, 劉厚君. IL-22在銀屑病發病機制中的作用[J].國際皮膚性病學雜志, 2011, 37(1): 29-32.
2. 　趙辨. 臨床皮膚病學[M]. 3版. 南京: 江蘇科學出版社, 2001: 765.
3. 　張長宋, 趙天恩, 陳樹民. 銀屑病病情嚴重程度評判指標的研究現狀[J]. 國際皮膚性病學雜志, 2002, 28(2): 82-84.
4. 　Ghoreschi K, Weigert C, Röcken M. Immunopathogenesis and role of T cells in psoriasis[J]. Clin Dermatol, 2007, 25(6): 574-580.
5. 　Res PC, Piskin G, de Boer OJ, et al. Overrepresentation of IL-17A and IL-22 producing CD8 T cells in lesional skin suggests their involvement in the pathogenesis of psoriasis[J]. PLoS One, 2010, 5(11): e14108.
6. 　Dumoutier L, Louahed J, Renauld JC. Characterication of IL-10-related Tcell-derived inducible factor (IL-TIF), a novel cytokine structurally related to IL-10 and inducible by IL-9[J]. J Immunol, 2000, 164(4): 1814-1819.
7. 　Duhen T, Geiger R, Jarrossay D, et al. Production of interleukin 22 but not interleukin 17 by a subset of human skin-homing memory T cells[J]. Nat Immunol, 2009, 10(8): 857-863.
8. 　Nograles KE, Zaba LC, Guttman-Yassky E, et al. Th17 cytokines interleukin(IL)-17 and IL-22 modulate distinct in?ammatory and keratinocyte-response pathways[J]. Br J Dermatol, 2008, 159(5): 1092-1102.
9. 　Boniface K, Guignouard E, Pedretti N, et al. A role for T cell-derived interleukin 22 in psoriatic skin in?ammation[J]. Clin Exp Immunol, 2007, 150(3): 407-415.
10. 　關小紅, 王寧麗. 白芍總苷對尋常性斑塊狀銀屑病外周血T細胞亞群的影響[J]. 河南中醫, 2010, 30(5): 455-456.
11. 　張宇虹, 郭在培, 焦曉燕, 等. 白芍總苷治療尋常型銀屑病的臨床觀察[J]. 臨床皮膚科雜志, 2011, 40(7): 433-435.
12. 　李傳應, 王春, 魏偉. 白芍總苷對小鼠慢性皮炎-濕疹的治療作用及其部分機制[J]. 中國藥理學通報, 2008, 24(10): 1366-1369.
13. 　王佐, 吳正祥, 楊九華, 等. 白芍總甙對大鼠實驗性結腸炎Th17細胞相關因子的作用[J]. 世界華人消化雜志, 2010, 18(1): 84-88.

West China Medical Journal

Effects of Total Glucosides of Paeony on the Level of Interleukin-22 in the Serum of Patients with Psoriasis Vulgaris

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