Effects of Isoflurane on Learning and Memory in Aged Rats_West China Medical Journal

Authors：

CHEN Li ¹ ,  WANG Xiao ¹ , YANG Jing ¹ , ZHANG Huiwei ²

1. Department of Anesthesiology, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, P. R. China; 2. Department of Anesthesiology, the First People’s Hospital of Leshan City, Leshan, Sichuan 614000, P. R. China;

Corresponding?author：

WANG Xiao, Email: chenli0763@163.com

Keywords：

異氟醚; Y迷宮實驗; 學習記憶能力; 大鼠

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目的　探討異氟醚吸入麻醉對（SD）老年大鼠學習和記憶的影響。方法　 36只SD健康雄性大鼠隨機分為異氟醚麻醉組和對照組，每組各18只。麻醉組給予2%異氟醚和40%氧氣誘導及維持麻醉3 h，對照組單純吸入含40%氧氣的空氧混合氣體3 h。麻醉組或對照組干預結束24 h后開始為期1周的盲法測試學習記憶能力。結果　麻醉組大鼠與對照組大鼠相比，Y-迷宮測試成績錯誤反應次數差異無統計學意義（P＞0.05）；除第7天麻醉組大鼠起步電壓高于對照組（P＜0.05）外，其余時間兩組大鼠起步電壓差異均無統計學意義（P＞0.05）；除第3天麻醉組大鼠跑步電壓高于對照組（P＜0.05）外，其余時間兩組大鼠跑步電壓差異均無統計學意義（P＞0.05）。結論　2%單純異氟醚吸入麻醉不改變老年大鼠麻醉后學習和記憶能力。

Citation： CHEN Li,WANG Xiao,YANG Jing,ZHANG Huiwei. Effects of Isoflurane on Learning and Memory in Aged Rats. West China Medical Journal, 2012, 27(3): 372-374. doi: Copy

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11.	馮昌棟, 戴體俊. 異氟醚全麻機制的研究進展[J]. 國外醫學·麻醉學與復蘇分冊, 2002, 23(6): 327-329.
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1. 　王躍春. Y型電迷宮在大鼠學習記憶功能測試中的合理運用[J]. 中國行為醫學科學, 2005, 14(1): 69-70.
2. 　王躍春. 大鼠Y型迷宮測試法的篩選與優化[J]. 中國行為醫學科學, 2005, 14(1): 50-52.
3. 　Butterfield NN, Graf P, Ries C, et al. The effect of repeated isoflurane anesthesia on spatial and psychomotor performance in young and aged mice[J]. Anesth Analg, 2004, 98(5): 1305-1311.
4. 　Culley DJ, Baxter M, Yukhananov R, et al. The memory effects of general anesthesia persist for weeks in young and aged rats[J]. Anesth Analg, 2003, 96(4): 1004-1009.
5. 　徐靜, 萬燕杰, 曾因明. 脾切除術對大鼠空間學習記憶能力的影響[J]. 中華麻醉學雜志, 2006, 26(2): 144-146.
6. 　袁力勇, 戴體俊, 王霞民, 等. 咪達唑侖與鹽酸戊乙奎醚對小鼠學習記憶獲得和鞏固及再現的影響[J]. 醫藥導報, 2008, 27(1): 7-10.
7. 　Cibelli M, Fidalgo, AR, Terrando N, et al. Role of interleukin-1beta in postoperative cognitive dysfunction[J]. Ann Neurol, 2010, 68(3): 360-368.
8. 　Cao XZ, Ma H, Wang JK, et al. Postoperative cognitive deficits and neuroinflammation in the hippocampus triggered by surgical trauma are exacerbated in aged rats[J]. Prog Neuropsychopharmacol Biol Psychiatry, 2010, 34(8): 1426-1432.
9. 　Perucho J, Rubio I, Casarejos MJ, et al. Anesthesia with isoflurane increases amyloid pathology in mice models of Alzheimer’s disease[J]. J Alzheimers Dis, 2010, 19(4): 1245-1257.
10. 　Wang Y, Sands LP, Vaurio L, et al. The effects of postoperative pain and its man agement on postoperative cognitive dysfunction[J]. Am J Geriatr Psychiatry, 2007, 15(1): 50-59.
11. 　馮昌棟, 戴體俊. 異氟醚全麻機制的研究進展[J]. 國外醫學·麻醉學與復蘇分冊, 2002, 23(6): 327-329.
12. 　肖春紅, 郭安梅, 郭素香. 異氟醚對認知功能的影響機制[J]. 現代生物醫學進展, 2010, 10(17): 3382-3383.

West China Medical Journal

Effects of Isoflurane on Learning and Memory in Aged Rats

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