Clinical Efficacy of Pueraria for Acute Cerebral Infarction_Chinese Journal of Evidence-Based Medicine

Authors：

TAN Yan ¹ ,  LIU Ming ² , Wu Bo ²

1. Department of Neurology, Guangzhou Brain Hospitol, Guangzhou 510370 ,China 2. Department of Neurology, West China Hospital, Sichuan University, Chengdu 610041, China;

Corresponding?author：

LIU Ming, Email: wyplm@mail.sc.cninfo.net

Keywords：

Pueraria; Acute cerebral infarction; Systematic reviewe

Video：

Export PDF Favorites Scan Get Citation

Abstract Full text Figures/Tables Video References Cited by

Objective 　To assess the efficacy and safety of pueraria for acute cerebral infarction.
Methods 　We searched MEDLINE, EMBASE, CBM, and the Chinese Stroke Clinical Trials Database. The search was conducted in Feb., 2006. Data were extracted and assessed by two reviewers independently. Revman 4.2 software was used for statistical analysis.
Results 　Nineteen potentially eligible trials were identified, of which 14 (1 141 patients) were included. Only one trial reported the death or disability rate at the end of 6-month follow-up (the difference between the two groups was not significant). Meta-analysis of 11 trials invovling the improvement of neurological deficit indicated that pueraria was significantly more effective than the control group [OR 3.04, 95%CI 2.11, 4.39].
Conclusions 　Pueraria might improve the short-term neurological deficit of patients with acute cerebral infarction. But the methodological quality of all the included trials is poor, reliable conclusions can not be drawn from the present data. More high-quality randomized controlled trials are required.

Citation： TAN Yan,LIU Ming,Wu Bo. Clinical Efficacy of Pueraria for Acute Cerebral Infarction. Chinese Journal of Evidence-Based Medicine, 2006, 06(7): 494-499. doi: Copy

1.	劉鳴, 張世洪. 臨床試驗中的意向處理分析. 英國醫學雜志 (中文版), 2001; 4(4): 223-224.
2.	吳祖舜, 高俊鳳, 陳玉山, 等. 普潤 (葛根素) 葡萄糖注射液聯合低分子肝素 (海普甯) 治療急性腦梗死的療效觀察－附30例報告. 腦與神經疾病雜志, 2004; 12(1): 53～54,58.
3.	巢建新, 葉明. 葛根素治療急性缺血性腦卒中的臨床研究. 廣東藥學, 2004; 14(3): 38～39.
4.	宋春江, 李秋茹, 鐘曉閔, 等. 葛根素治療腦梗死40例療效觀察. 四川醫學, 2005; 26(3): 306 ～307.
5.	石云, 馬湖蕊. 葛根素治療急性腦梗塞32例療效觀察. 云南中醫中藥雜志, 2005; 26(3): 7-8.
6.	榮培紅, 林海, 查鵬洲. 葛根素聯合降纖酶治療急性腦梗塞48例. 陜西中醫, 2004; 25(2): 123～124.
7.	王吉, 管仁蓮. 葛根素與腦活素聯合治療急性腦梗塞的效果. 實用醫藥雜志, 2002; 19(7): 502.
8.	趙路清. 葛根素治療急性腦梗死的臨床觀察. 實用臨床醫藥雜志, 2004; 8(2): 76.
9.	吳新艷. 葛根素加川芎嗪治療急性腦梗死臨床療效觀察. 臨床急診雜志, 2003; 4(6): 26～27.
10.	龍明智, 王軍, 諶蓉, 等. 中西醫結合治療急性缺血性腦梗塞的臨床分析. 現代康復, 2000; 4(5): 682~683.
11.	李賢昌, 黃靜波, 孫彥俊. 葛根素治療腦梗死64例臨床觀察. 浙江中西醫結合雜志, 2003; 13(9): 560.
12.	劉明龍. 葛根素氯化鈉注射液輔助治療急性腦梗死療效觀察. 現代中西醫結合雜志, 2005; 14(7): 872~873。.
13.	鄧娟, 周華東, 陳曼娥. 葛根素注射液對急性腦梗塞患者微循環保護機制的臨床研究. 微循環學雜志, 2001; 11(1): 14~15.
14.	曹大力, 許宏偉, 胡景云, 等. 葛根素注射液治療腦梗死的臨床療效. 湖南醫學, 1999; 16(3): 191.
15.	張儉華. 葛根素治療急性缺血性腦梗塞32例療效觀察. 浙江中西醫結合雜志, 2002; 12(12): 731~732.
16.	賀卒英. 普樂林治療老年人腦梗塞臨床觀察. 現代康復, 1998; 2(1): 44~45.
17.	應衛嬋. 葛根素注射液治療腦梗塞療效觀察. 浙江中西醫結合雜志, 2002; 12(11): 690。.
18.	王碧云, 張梅麗, 譚燕, 等. 葛根素注射液對缺血性腦卒中患者的臨床觀察及其對血漿ET及HCY、OX-LDL的影響. 海南醫學, 2005; 16(5): 9~10.
19.	馬付堅. 葛根素對急性腦梗死纖溶及內皮功能治療作用研究. 醫學文選, 2001; 20(6): 794~795.
20.	扈友莊, 楊彬, 劉東彪. 葛根素對急性腦梗死患者血清SICAM-1, TNF-α水平的影響. 中國醫師雜志, 2005; 7(8): 1135~1136.
21.	吳波, 劉鳴. 腦卒中臨床試驗療效判定指標現狀及趨勢. 中華神經科雜志, 2002; 35(3): 177~179.
22.	International stroke trial collaborative group. The international stroke trial (IST): a randomized trial of aspirin, subcutaneous heparin, both, or neither among 19 345 patients with acute ischaemic stroke. Lancet, 1997; 349(9065): 1569-1581.
23.	Tissue plasminogen activator for acute ischemic stroke. The National Institute of Neurological Disorders and Stroke rt-PA Stroke Study Group. N Engl J Med, 1995; 333(24): 1581-1587.
24.	Stroke--1989. Recommendations on stroke prevention, diagnosis, and therapy. Report of the WHO Task Force on Stroke and other Cerebrovascular Disorders. Stroke, 1989; 20(10): 1407-1431.
25.	Mahoney FI, Barthel DW. Functional evaluation: the Barthel index. Md State Med J, 1965; 14: 61- 65.
26.	Sulter G, Steen C, De Keyser J. Use of the Barthel index and modified Rankin scale in acute stroke scale in acute stroke trials. Stroke, 1999;30(8): 1538-1541.
27.	Liu M, Zhang SH. Intention to treat analysis in clinical trials. BMJ (Chinese edition), 2001; 4(4): 223-224.
28.	Wu ZS, Gao JF, Chen YS, et al. Observation of effect of pueraria injection and low molecular heparin on acute cerebral infarction. Journal of Brain and Neurology Disease, 2004; 12(1): 53-54, 58.
29.	Chao JX, Ye M. Clinical study of pueraria for acute ischemic stroke. Pharmacy of Guangdong, 2004; 14(3): 38-39.
30.	Song CJ, Li QR, Zhong XM, et al. Observation of effect of pueraria on cerebral infarction. Sichuan Medical Journal, 2005; 26(3): 306-307.
31.	. Shi Y, Ma HR. Observation of effect of pueraria on acute cerebral infarction. Yunnan Journal of Traditional Chinese Medicine and Materia Medica, 2005; 26(3): 7-8.
32.	Rong PH, Lin H, Cha PZ. 48 cases of pueraria and defibrase for acute cerebral infarction. Shaanxi Journal of Traditional Chinese Medicine, 2004; 25(2): 123-124.
33.	Wang J, Guang RL. Effect of pueraria and cerebrolysis on acute cerebral infarction. Practical Journal of Medicine and Pharmacy, 2002; 19(7): 502.
34.	Zhao LQ. Clinical observation on pueraria for acute ischemic stroke. Journal of Clinical Medicine in Practice, 2004; 8(2): 76.
35.	Wu XY. Observation on effect of pueraria and chuanxiongzine on acute cerebral infarction. Journal of Clinical Emergency, 2003; 4(6): 26 -27.
36.	Long MZ, Wang J, Shen R, et al. Observation on effect of gegen injection in treating patients of acute ischemic stroke. Modern Rehabilitation, 2000; 4(5): 682-683.
37.	Li CX, Huang JB, Shun YB. Clinical observation on pueraria injection for cerebral infarction. Zhejiang Journal of Integrated Traditional Chinese and Western Medicine, 2003; 13(9): 560.
38.	Liu ML. Observation on effect of pueraria injection on acute cerebral infarction. Modern Journal of Integrated Traditional Chinese and Western Medicine, 2005; 14(7): 72-873.
39.	Deng J, Zhou HD, Chen ME. Mechanism of Puerarin Induced Microcirculation Protection in Acute Cerebral Infarction. Chinese Journal of Microcirculation, 2001; 11(1): 14-15.
40.	Cao DL, Xu HW, Hu JY, et al. Observation of effect of pueraria injection on cerebral infarction. Hunan Medical Journal, 1999; 16(3): 191.
41.	Zhang JH. Observation of Therapeutic Efficacy in Treating Acute Cerebral Ischemia with Kankonein. Zhejiang Journal of Integrated Traditional Chinese and Western Medicine, 2002; 12(12): 731-732.
42.	He ZY. Clinical observation of pueraria injection on cerebral infarction in the elder. Modern Rehabilitation, 1998; 2(1): 44- 45.
43.	Ying WC. Observation of effect of pueraria injection on cerebral infarction. Zhejiang Journal of Integrated Traditional Chinese and Western Medicine, 2002; 12(11): 690.
44.	Wang BY, Zhang ML, Tan Y, et al. Effects of puerarin injection treatment of cerebral ischemic stroke and its influence on plasma ET、HCY and OX-LDL. Hainan Medical Journal, 2005; 16(5): 9-10.
45.	Ma FJ. Effects of puerarin in treatment of acute cerebral infarction and its influence on fibrolysis system and endothelium function. Anthology of Medicine, 2001; 20(6): 794-795.
46.	Hu YZ, Yang B, Liu DB. Influence on plasma SICAM-1, TNF of puerarin for acute cerebral infarction. Journal of Chinese Physician, 2005; 7(8): 1135-1136.
47.	Wu B, Liu M. Trends of outcome measurement in stroke trials. Chinese Journal of Neurology, 2002; 35(3): 177-179.

1. 劉鳴, 張世洪. 臨床試驗中的意向處理分析. 英國醫學雜志 (中文版), 2001; 4(4): 223-224.
2. 吳祖舜, 高俊鳳, 陳玉山, 等. 普潤 (葛根素) 葡萄糖注射液聯合低分子肝素 (海普甯) 治療急性腦梗死的療效觀察－附30例報告. 腦與神經疾病雜志, 2004; 12(1): 53～54,58.
3. 巢建新, 葉明. 葛根素治療急性缺血性腦卒中的臨床研究. 廣東藥學, 2004; 14(3): 38～39.
4. 宋春江, 李秋茹, 鐘曉閔, 等. 葛根素治療腦梗死40例療效觀察. 四川醫學, 2005; 26(3): 306 ～307.
5. 石云, 馬湖蕊. 葛根素治療急性腦梗塞32例療效觀察. 云南中醫中藥雜志, 2005; 26(3): 7-8.
6. 榮培紅, 林海, 查鵬洲. 葛根素聯合降纖酶治療急性腦梗塞48例. 陜西中醫, 2004; 25(2): 123～124.
7. 王吉, 管仁蓮. 葛根素與腦活素聯合治療急性腦梗塞的效果. 實用醫藥雜志, 2002; 19(7): 502.
8. 趙路清. 葛根素治療急性腦梗死的臨床觀察. 實用臨床醫藥雜志, 2004; 8(2): 76.
9. 吳新艷. 葛根素加川芎嗪治療急性腦梗死臨床療效觀察. 臨床急診雜志, 2003; 4(6): 26～27.
10. 龍明智, 王軍, 諶蓉, 等. 中西醫結合治療急性缺血性腦梗塞的臨床分析. 現代康復, 2000; 4(5): 682~683.
11. 李賢昌, 黃靜波, 孫彥俊. 葛根素治療腦梗死64例臨床觀察. 浙江中西醫結合雜志, 2003; 13(9): 560.
12. 劉明龍. 葛根素氯化鈉注射液輔助治療急性腦梗死療效觀察. 現代中西醫結合雜志, 2005; 14(7): 872~873。.
13. 鄧娟, 周華東, 陳曼娥. 葛根素注射液對急性腦梗塞患者微循環保護機制的臨床研究. 微循環學雜志, 2001; 11(1): 14~15.
14. 曹大力, 許宏偉, 胡景云, 等. 葛根素注射液治療腦梗死的臨床療效. 湖南醫學, 1999; 16(3): 191.
15. 張儉華. 葛根素治療急性缺血性腦梗塞32例療效觀察. 浙江中西醫結合雜志, 2002; 12(12): 731~732.
16. 賀卒英. 普樂林治療老年人腦梗塞臨床觀察. 現代康復, 1998; 2(1): 44~45.
17. 應衛嬋. 葛根素注射液治療腦梗塞療效觀察. 浙江中西醫結合雜志, 2002; 12(11): 690。.
18. 王碧云, 張梅麗, 譚燕, 等. 葛根素注射液對缺血性腦卒中患者的臨床觀察及其對血漿ET及HCY、OX-LDL的影響. 海南醫學, 2005; 16(5): 9~10.
19. 馬付堅. 葛根素對急性腦梗死纖溶及內皮功能治療作用研究. 醫學文選, 2001; 20(6): 794~795.
20. 扈友莊, 楊彬, 劉東彪. 葛根素對急性腦梗死患者血清SICAM-1, TNF-α水平的影響. 中國醫師雜志, 2005; 7(8): 1135~1136.
21. 吳波, 劉鳴. 腦卒中臨床試驗療效判定指標現狀及趨勢. 中華神經科雜志, 2002; 35(3): 177~179.
22. International stroke trial collaborative group. The international stroke trial (IST): a randomized trial of aspirin, subcutaneous heparin, both, or neither among 19 345 patients with acute ischaemic stroke. Lancet, 1997; 349(9065): 1569-1581.
23. Tissue plasminogen activator for acute ischemic stroke. The National Institute of Neurological Disorders and Stroke rt-PA Stroke Study Group. N Engl J Med, 1995; 333(24): 1581-1587.
24. Stroke--1989. Recommendations on stroke prevention, diagnosis, and therapy. Report of the WHO Task Force on Stroke and other Cerebrovascular Disorders. Stroke, 1989; 20(10): 1407-1431.
25. Mahoney FI, Barthel DW. Functional evaluation: the Barthel index. Md State Med J, 1965; 14: 61- 65.
26. Sulter G, Steen C, De Keyser J. Use of the Barthel index and modified Rankin scale in acute stroke scale in acute stroke trials. Stroke, 1999;30(8): 1538-1541.
27. Liu M, Zhang SH. Intention to treat analysis in clinical trials. BMJ (Chinese edition), 2001; 4(4): 223-224.
28. Wu ZS, Gao JF, Chen YS, et al. Observation of effect of pueraria injection and low molecular heparin on acute cerebral infarction. Journal of Brain and Neurology Disease, 2004; 12(1): 53-54, 58.
29. Chao JX, Ye M. Clinical study of pueraria for acute ischemic stroke. Pharmacy of Guangdong, 2004; 14(3): 38-39.
30. Song CJ, Li QR, Zhong XM, et al. Observation of effect of pueraria on cerebral infarction. Sichuan Medical Journal, 2005; 26(3): 306-307.
31. . Shi Y, Ma HR. Observation of effect of pueraria on acute cerebral infarction. Yunnan Journal of Traditional Chinese Medicine and Materia Medica, 2005; 26(3): 7-8.
32. Rong PH, Lin H, Cha PZ. 48 cases of pueraria and defibrase for acute cerebral infarction. Shaanxi Journal of Traditional Chinese Medicine, 2004; 25(2): 123-124.
33. Wang J, Guang RL. Effect of pueraria and cerebrolysis on acute cerebral infarction. Practical Journal of Medicine and Pharmacy, 2002; 19(7): 502.
34. Zhao LQ. Clinical observation on pueraria for acute ischemic stroke. Journal of Clinical Medicine in Practice, 2004; 8(2): 76.
35. Wu XY. Observation on effect of pueraria and chuanxiongzine on acute cerebral infarction. Journal of Clinical Emergency, 2003; 4(6): 26 -27.
36. Long MZ, Wang J, Shen R, et al. Observation on effect of gegen injection in treating patients of acute ischemic stroke. Modern Rehabilitation, 2000; 4(5): 682-683.
37. Li CX, Huang JB, Shun YB. Clinical observation on pueraria injection for cerebral infarction. Zhejiang Journal of Integrated Traditional Chinese and Western Medicine, 2003; 13(9): 560.
38. Liu ML. Observation on effect of pueraria injection on acute cerebral infarction. Modern Journal of Integrated Traditional Chinese and Western Medicine, 2005; 14(7): 72-873.
39. Deng J, Zhou HD, Chen ME. Mechanism of Puerarin Induced Microcirculation Protection in Acute Cerebral Infarction. Chinese Journal of Microcirculation, 2001; 11(1): 14-15.
40. Cao DL, Xu HW, Hu JY, et al. Observation of effect of pueraria injection on cerebral infarction. Hunan Medical Journal, 1999; 16(3): 191.
41. Zhang JH. Observation of Therapeutic Efficacy in Treating Acute Cerebral Ischemia with Kankonein. Zhejiang Journal of Integrated Traditional Chinese and Western Medicine, 2002; 12(12): 731-732.
42. He ZY. Clinical observation of pueraria injection on cerebral infarction in the elder. Modern Rehabilitation, 1998; 2(1): 44- 45.
43. Ying WC. Observation of effect of pueraria injection on cerebral infarction. Zhejiang Journal of Integrated Traditional Chinese and Western Medicine, 2002; 12(11): 690.
44. Wang BY, Zhang ML, Tan Y, et al. Effects of puerarin injection treatment of cerebral ischemic stroke and its influence on plasma ET、HCY and OX-LDL. Hainan Medical Journal, 2005; 16(5): 9-10.
45. Ma FJ. Effects of puerarin in treatment of acute cerebral infarction and its influence on fibrolysis system and endothelium function. Anthology of Medicine, 2001; 20(6): 794-795.
46. Hu YZ, Yang B, Liu DB. Influence on plasma SICAM-1, TNF of puerarin for acute cerebral infarction. Journal of Chinese Physician, 2005; 7(8): 1135-1136.
47. Wu B, Liu M. Trends of outcome measurement in stroke trials. Chinese Journal of Neurology, 2002; 35(3): 177-179.

Chinese Journal of Evidence-Based Medicine

Clinical Efficacy of Pueraria for Acute Cerebral Infarction

Abstract Full text Figures/Tables Video References Cited by

Format

Content