- 1. Department pharmacy, Third Hospital Peking University, Bejing 100083, China2. Department pharmacy, First Hospital Lanzhou University, Lanzhou 730000, China3. Department of obstetrics, First Hospital Lanzhou University, Lanzhou 730000, China4. Department of surgery, First Hospital Lanzhou University, Lanzhou 730000, China;
Objective To assess the effectiveness and safety of salbutamol in the treatment of preterm labor.
Methods We searched MEDLINE (1966-Jan. 2007), EMBASE (1966-Jan. 2007), Cochrane Central Register of Controlled Trials (Issue 4, 2006), CBMdisc (1978-Jan. 2007) and CNKI (1979-Jan. 2007). Randomized controlled trials (RCTs) or quasi-randomized controlled trials (quasi-RCT) involving salbutamol for preterm labor were collected. The quality of the retrieved trials was assessed using the Jadad Scale. Meta-analyses were conducted with The Cochrane Collaboration’s RevMan 4.2 software.
Results A total of 19 RCTs and quasi-RCTs were included, of which 16 were published in Chinese and 3 in English. The quality of the 16 Chinese studies was low, scored less than 3 by the Jadad Scale. None of the 16 RCTs mentioned the method of randomization, allocation concealment, double-blinding or the long-term effect. The quality of the 3 English studies was high. Compared with basic treatment, salbutamol was more effective in prolonging pregnancy over 48 hours (RR=6.30, 95%CI 3.23 to 14.32), and preventing neonatal asphyxia (RR=0.44, 95%CI 0.33 to 0.59), but the incidence of adverse events in pregnant women was higher in the salbutamol group (RR=4.57, 95%CI 1.34 to 15.54). Salbutamol was as effective as magnesium sulfate in prolonging pregnancy over 48 hours (OR=1.60, 95%CI 0.92 to 2.76), but more effective in preventing neonatal asphyxia (OR=0.29, 95%CI 0.14 to 0.61). Salbutamol was similar to atosiban in terms of prolonging pregnancy over 48 hours (OR=1.18, 95%CI 0.42 to 3.37) and preventing neonatal asphyxia (OR=1.13, 95%CI 0.30 to 4.31).
Conclusion Salbutamol is effective in prolonging pregnancy over 48 hours and preventing neonatal asphyxia, but may cause more adverse events in pregnant women. Salbutamol has similar effects to other commonly-used drugs in regard to prolonging pregnancy over 48 hours, but is better than magnesium sulfate in decreasing the incidence of neonatal asphyxia. Salbutamol may lead to more adverse events compared with atosiban, but fewer adverse events than magnesium sulfate.
Citation： MIN Guangning,LIU Fang,ZHAI Shuodi,ZHU Jinsong,ZHANG Hong,WANG Ting. Salbutamol in Preventing Preterm Labour: A Systematic Review. Chinese Journal of Evidence-Based Medicine, 2007, 07(8): 591-600. doi: Copy
Copyright ? the editorial department of Chinese Journal of Evidence-Based Medicine of West China Medical Publisher. All rights reserved
| 1. | Jiang XH. Clinical observation of alternative use of magnesium sulfate and sulfuric acid to cure the prematurity. Journal of Huaihai Medicine, 2004, 22(6): 452-453. |
| 2. | Chen SX, Yang PH, Lv SY. Clinical observation of magnesium sulfate coadunation albuterol sulfate treatment threatened premature labor. Chinese Journal of Clinical Obstetric and Gynecology, 2005, 6(6): 456-457. |
| 3. | Xia ML. Clinical observation of magnesium sulfate coadunation albuterol sulfate treatment threatened premature labor. Contemporary Medicine , 2006, (10): 88-89. |
| 4. | Chen DL. Clinical observation of albuterol sulfate treatment premature labor of 35 cases. Journal of Guiyang Medical College, 1996, 21(2): 144-145. |
| 5. | Li DM, Zhou XD. Observations on treatment of premature labor with salbutamol sulphate - an analysis of 45 cases. Journal of Shanxi Medical College for Continuing Educatlon, 1997, 7(2): 11-13. |
| 6. | Ying XY. Salbutamol treatment premature labor. Academic Journal of Kaifeng Medical College, 1998, 17(1): 11-13. |
| 7. | Teng JF. Effect analysis of albuterol sulfate treatment premature labor. Qingdao Medical Journal , 1998, 30(12): 42. |
| 8. | Xiao QG. Clinical observation of albuterol sulfate treatment premature labor of 66 cases. Maternal and Child Health Care of China, 2003, 18(6): 374. |
| 9. | Wang JF. Clinical observation of albuterol sulfate treatment premature labor of 74 cases. Central Plains Medical Journal, 2004, 31(15): 49-50. |
| 10. | Gao XF. Clinical observation of albuterol sulfate treatment premature labor of 54 cases. Proceeding of Clinical Medicine, 2006, 15(8): 629-630. |
| 11. | Xing LY. Clinical observation of albuterol sulfate treatment premature labor of 48 cases. Shanxi Medical Journal, 1999, 28(6): 373. |
| 12. | Li Y, Ma YH. Application of salbutamol treatment threatened premature labor. Henan Medical Information, 2001, 9(8): 64. |
| 13. | Yu DF. Study of magnesium sulfate, salbutamol treatment premature labor of 48 cases. Acta Academidae Medicinae Suzhou, 1995, 15(2): 346. |
| 14. | Jin YJ. Clinical observation of albuterol sulfate treatment premature labor of 108 cases. Modern Medicine & Health, 2006, 22(11): 1693-1694. |
| 15. | Liu WQ, Yu LX, Zhu P. Clinical observation of nifedipine treatment premature labor.Qingdao Medical Journal, 1996, 28(9): 12-13. |
| 16. | Zhao RX, Liu YY, Li LJ. Efficacy of nifedipine in management of premature labor. Clinical Misdiagnosis & Mistherapy, 2006, 19(3): 6-7. |
| 17. | Xiang J. Clinical observation of nifedipine treatment premature labor . Medical Journal of Communications, 2003, 17(6) : 704-705. |
| 18. | Wang ZX. Report of albuterol sulfate treatment premature labor of 54 cases. Chinese Journal of Rural Medicine and Pharmacy, 1997, 4(7): 17. |
| 19. | Liu DY. Treatment premature labor—An analysis of 146 cases. Anthology of Medicine, 2005, 24 (4): 548-549. |
| 20. | Chen JZ, Cao ZX, Wu WX. Inhibitor of uterine contraction treatment threatened premature labor of 146 cases. Chongqing Medical Journal, 1990, 19(3): 19-20. |
| 21. | Am J Obstet Gynecol, 2004, 191(3): 683-690. |
| 22. | Guyer B, Strobino DM, Ventura SJ, et al. Annual summary in vital statistics: 1995. Pediatrics 1996; 98: 1007-1019. Bibliographic Links Library Holdings. |
| 23. | Jadad AR, Moore RA, Carroll D, et al. Assessing the quality of reports of randomized clinical trials: is blinding necessary? Control Clin Trials, 1996 , 17(1): 1-12. |
| 24. | 江雪華. 硫酸鎂、硫酸舒喘靈交替使用治療早產臨床觀察. 淮海醫藥, 2004, 22(6): 452~453. |
| 25. | 陳淑霞, 楊培紅, 呂素英. 硫酸鎂聯合硫酸舒喘靈治療先兆早產臨床觀察. 中國婦產科臨床雜志, 2005, 6(6): 456~457. |
| 26. | 夏麗美. 硫酸鎂聯合硫酸舒喘靈治療先兆早產臨床觀察. 當代醫學, 2006, (10): 88~89. |
| 27. | 陳達麗. 硫酸舒喘靈治療早產35例療效觀察. 貴陽醫學院學報, 1996, 21(2): 144~145. |
| 28. | 李冬梅, 周銜弟. 硫酸舒喘靈治療早產45例臨床觀察. 山西職工醫學院學報, 1997, 7(2): 11~13. |
| 29. | 尹學英. 硫酸舒喘靈在早產治療中的應用. 河南大學學報(醫學科學版), 1998, 17(1): 11~13. |
| 30. | 滕金鳳. 硫酸舒喘靈治療早產效果分析. 青島醫藥衛生, 1998, 30(12): 42. |
| 31. | 肖秋桂. 硫酸舒喘靈治療早產66例療效觀察. 中國婦幼保健, 2003, 18(6): 374. |
| 32. | 王進鳳. 硫酸舒喘靈治療早產74例臨床報告. 中原醫刊, 2004, 31(15): 49~50. |
| 33. | 高曉芳. 硫酸舒喘靈治療早產54例療效觀察. 臨床醫藥實踐雜志, 2006, 15(8): 629~630. |
| 34. | 邢蘭瑛. 硫酸舒喘靈治療早產48例療效觀察. 陜西醫學雜志, 1999, 28(6): 373. |
| 35. | 李巖, 馬玉紅. 硫酸舒喘靈在先兆早產中的應用. 河南醫藥信息, 2001, 9(8): 64. |
| 36. | 于德鳳. 硫酸鎂、舒喘靈治療早產142例報告. 蘇州醫學院學報, 1995, 15(2): 346. |
| 37. | 金玉杰. 硫酸舒喘靈治療108例早產的臨床觀察. 現代醫藥衛生, 2006, 22(11): 1693~1694. |
| 38. | 劉維琴, 于麗霞, 朱萍. 硝苯吡啶治療早產的效果觀察. 青島醫藥衛生, 1996, 28(9): 12~13. |
| 39. | 趙榮銜, 劉元昀, 李麗君. 硝苯地平治療早產的療效觀察. 臨床誤診誤治, 2006, 19(3): 6~7. |
| 40. | 向京. 硝苯吡啶治療早產的臨床觀察. 交通醫學, 2003, 17(6): 704~705. |
| 41. | 王澤香. 硫酸舒喘靈治療早產54例報告. 中國鄉村醫藥, 1997, 4(7): 17. |
| 42. | 劉冬艷. 146例早產婦治療分析. 醫學文選, 2005, 24(4): 548~549. |
| 43. | 梁淑花. 硫酸舒喘靈治療45例先兆早產療效觀察. 航空航天醫藥, 2004, (1): 37.Liang SH. Effect of albuterol sulfate treatment premature labor of 45 Cases. Aerospace Medicine, 2004, (1): 37. |
| 44. | 陳建宗, 曹珍修, 吳味辛. 先兆早產宮縮抑制劑治療63例分析. 重慶醫藥, 1990, 19(3): 19~20. |
| 45. | Jannet D, Abankwa A, Guyard B, et al. Nicardipine versus salbutamol in the treatment of premature labor. A prospective randomized study. Eur J Obstet Gynecol Reprod Biol, 1997, 73(1): 11-16. |
| 46. | French/Australian Atosiban Investigators Group. Treatment of preterm labor with the oxytocin antagonist atosiban: a double-blind, randomized, controlled comparison with salbutamol. Eur J Obstet Gynecol Reprod Biol, 2001, 98(2): 177-185. |
| 47. | Bisits A, Madsen G, Knox M, et al. The Randomized Nitric Oxide Tocolysis Trial (RNOTT) for the treatment of preterm labor. |
| 48. | Anotayanonth S, Subhedar NV, Garner P, et al. Betamimetics for inhibiting preterm labour. Cochrane Database Syst Rev, 2004, (4): CD004352. |
- 1. Jiang XH. Clinical observation of alternative use of magnesium sulfate and sulfuric acid to cure the prematurity. Journal of Huaihai Medicine, 2004, 22(6): 452-453.
- 2. Chen SX, Yang PH, Lv SY. Clinical observation of magnesium sulfate coadunation albuterol sulfate treatment threatened premature labor. Chinese Journal of Clinical Obstetric and Gynecology, 2005, 6(6): 456-457.
- 3. Xia ML. Clinical observation of magnesium sulfate coadunation albuterol sulfate treatment threatened premature labor. Contemporary Medicine , 2006, (10): 88-89.
- 4. Chen DL. Clinical observation of albuterol sulfate treatment premature labor of 35 cases. Journal of Guiyang Medical College, 1996, 21(2): 144-145.
- 5. Li DM, Zhou XD. Observations on treatment of premature labor with salbutamol sulphate - an analysis of 45 cases. Journal of Shanxi Medical College for Continuing Educatlon, 1997, 7(2): 11-13.
- 6. Ying XY. Salbutamol treatment premature labor. Academic Journal of Kaifeng Medical College, 1998, 17(1): 11-13.
- 7. Teng JF. Effect analysis of albuterol sulfate treatment premature labor. Qingdao Medical Journal , 1998, 30(12): 42.
- 8. Xiao QG. Clinical observation of albuterol sulfate treatment premature labor of 66 cases. Maternal and Child Health Care of China, 2003, 18(6): 374.
- 9. Wang JF. Clinical observation of albuterol sulfate treatment premature labor of 74 cases. Central Plains Medical Journal, 2004, 31(15): 49-50.
- 10. Gao XF. Clinical observation of albuterol sulfate treatment premature labor of 54 cases. Proceeding of Clinical Medicine, 2006, 15(8): 629-630.
- 11. Xing LY. Clinical observation of albuterol sulfate treatment premature labor of 48 cases. Shanxi Medical Journal, 1999, 28(6): 373.
- 12. Li Y, Ma YH. Application of salbutamol treatment threatened premature labor. Henan Medical Information, 2001, 9(8): 64.
- 13. Yu DF. Study of magnesium sulfate, salbutamol treatment premature labor of 48 cases. Acta Academidae Medicinae Suzhou, 1995, 15(2): 346.
- 14. Jin YJ. Clinical observation of albuterol sulfate treatment premature labor of 108 cases. Modern Medicine & Health, 2006, 22(11): 1693-1694.
- 15. Liu WQ, Yu LX, Zhu P. Clinical observation of nifedipine treatment premature labor.Qingdao Medical Journal, 1996, 28(9): 12-13.
- 16. Zhao RX, Liu YY, Li LJ. Efficacy of nifedipine in management of premature labor. Clinical Misdiagnosis & Mistherapy, 2006, 19(3): 6-7.
- 17. Xiang J. Clinical observation of nifedipine treatment premature labor . Medical Journal of Communications, 2003, 17(6) : 704-705.
- 18. Wang ZX. Report of albuterol sulfate treatment premature labor of 54 cases. Chinese Journal of Rural Medicine and Pharmacy, 1997, 4(7): 17.
- 19. Liu DY. Treatment premature labor—An analysis of 146 cases. Anthology of Medicine, 2005, 24 (4): 548-549.
- 20. Chen JZ, Cao ZX, Wu WX. Inhibitor of uterine contraction treatment threatened premature labor of 146 cases. Chongqing Medical Journal, 1990, 19(3): 19-20.
- 21. Am J Obstet Gynecol, 2004, 191(3): 683-690.
- 22. Guyer B, Strobino DM, Ventura SJ, et al. Annual summary in vital statistics: 1995. Pediatrics 1996; 98: 1007-1019. Bibliographic Links Library Holdings.
- 23. Jadad AR, Moore RA, Carroll D, et al. Assessing the quality of reports of randomized clinical trials: is blinding necessary? Control Clin Trials, 1996 , 17(1): 1-12.
- 24. 江雪華. 硫酸鎂、硫酸舒喘靈交替使用治療早產臨床觀察. 淮海醫藥, 2004, 22(6): 452~453.
- 25. 陳淑霞, 楊培紅, 呂素英. 硫酸鎂聯合硫酸舒喘靈治療先兆早產臨床觀察. 中國婦產科臨床雜志, 2005, 6(6): 456~457.
- 26. 夏麗美. 硫酸鎂聯合硫酸舒喘靈治療先兆早產臨床觀察. 當代醫學, 2006, (10): 88~89.
- 27. 陳達麗. 硫酸舒喘靈治療早產35例療效觀察. 貴陽醫學院學報, 1996, 21(2): 144~145.
- 28. 李冬梅, 周銜弟. 硫酸舒喘靈治療早產45例臨床觀察. 山西職工醫學院學報, 1997, 7(2): 11~13.
- 29. 尹學英. 硫酸舒喘靈在早產治療中的應用. 河南大學學報(醫學科學版), 1998, 17(1): 11~13.
- 30. 滕金鳳. 硫酸舒喘靈治療早產效果分析. 青島醫藥衛生, 1998, 30(12): 42.
- 31. 肖秋桂. 硫酸舒喘靈治療早產66例療效觀察. 中國婦幼保健, 2003, 18(6): 374.
- 32. 王進鳳. 硫酸舒喘靈治療早產74例臨床報告. 中原醫刊, 2004, 31(15): 49~50.
- 33. 高曉芳. 硫酸舒喘靈治療早產54例療效觀察. 臨床醫藥實踐雜志, 2006, 15(8): 629~630.
- 34. 邢蘭瑛. 硫酸舒喘靈治療早產48例療效觀察. 陜西醫學雜志, 1999, 28(6): 373.
- 35. 李巖, 馬玉紅. 硫酸舒喘靈在先兆早產中的應用. 河南醫藥信息, 2001, 9(8): 64.
- 36. 于德鳳. 硫酸鎂、舒喘靈治療早產142例報告. 蘇州醫學院學報, 1995, 15(2): 346.
- 37. 金玉杰. 硫酸舒喘靈治療108例早產的臨床觀察. 現代醫藥衛生, 2006, 22(11): 1693~1694.
- 38. 劉維琴, 于麗霞, 朱萍. 硝苯吡啶治療早產的效果觀察. 青島醫藥衛生, 1996, 28(9): 12~13.
- 39. 趙榮銜, 劉元昀, 李麗君. 硝苯地平治療早產的療效觀察. 臨床誤診誤治, 2006, 19(3): 6~7.
- 40. 向京. 硝苯吡啶治療早產的臨床觀察. 交通醫學, 2003, 17(6): 704~705.
- 41. 王澤香. 硫酸舒喘靈治療早產54例報告. 中國鄉村醫藥, 1997, 4(7): 17.
- 42. 劉冬艷. 146例早產婦治療分析. 醫學文選, 2005, 24(4): 548~549.
- 43. 梁淑花. 硫酸舒喘靈治療45例先兆早產療效觀察. 航空航天醫藥, 2004, (1): 37.Liang SH. Effect of albuterol sulfate treatment premature labor of 45 Cases. Aerospace Medicine, 2004, (1): 37.
- 44. 陳建宗, 曹珍修, 吳味辛. 先兆早產宮縮抑制劑治療63例分析. 重慶醫藥, 1990, 19(3): 19~20.
- 45. Jannet D, Abankwa A, Guyard B, et al. Nicardipine versus salbutamol in the treatment of premature labor. A prospective randomized study. Eur J Obstet Gynecol Reprod Biol, 1997, 73(1): 11-16.
- 46. French/Australian Atosiban Investigators Group. Treatment of preterm labor with the oxytocin antagonist atosiban: a double-blind, randomized, controlled comparison with salbutamol. Eur J Obstet Gynecol Reprod Biol, 2001, 98(2): 177-185.
- 47. Bisits A, Madsen G, Knox M, et al. The Randomized Nitric Oxide Tocolysis Trial (RNOTT) for the treatment of preterm labor.
- 48. Anotayanonth S, Subhedar NV, Garner P, et al. Betamimetics for inhibiting preterm labour. Cochrane Database Syst Rev, 2004, (4): CD004352.