CELLULAR THERAPY OF STRESS URINARY INCONTINENCE_Chinese Journal of Reparative and Reconstructive Surgery

Authors：

YUAN Haichao , LIU Liangren , WEI Qiang , HAN Ping.

Department of Urology, West China Hospital, Sichuan University, Chengdu Sichuan, 610041, P.R.China.;

Corresponding?author：

Keywords：

Stress urinary incontinence; Cellular therapy; Stem cells

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【Abstract】 Objective To review the progress and cl inical appl ication of cellular therapy for stress urinary
incontinence (SUI). Methods The l iterature about cellular therapy of SUI was extensively reviewed. Results Because
of having no or poor regeneration capacity, the cl inical application of chondrocytes and myoblasts were l imited. Based on the rapid progress in stem cell biology, an increasing number of animal experiments and cl inical trials about cellular therapy of SUI have been reported with encouraging results. All these show that cellular therapy has great potential in cl inical application. Stem cells are considered as ideal seeded-cells for treatment of SUI. Conclusion Cellular therapy, especially stem cells, provides a novel approach for treatment of SUI, but the mechanism needs further study.

Citation： YUAN Haichao,LIU Liangren,WEI Qiang,HAN Ping.. CELLULAR THERAPY OF STRESS URINARY INCONTINENCE. Chinese Journal of Reparative and Reconstructive Surgery, 2012, 26(2): 182-185. doi: Copy

1.	Peggy N, Brubaker L. Urinary incontinence in women. Lancet, 2006, 367(9504): 57-67.
2.	Hampel C, Wienhold D, Benken N, et al. Prevalence and natural history of female incontinence. Eur Urol, 1997, 32 Suppl 2: 3-12.
3.	Bump RC, Norton PA. Epidemiology and natural history of pelvic fioor dysfunction. Obstet Gynecol Clin North Am, 1998, 25(4): 723-746.
4.	Strasser H, Berjukow S, Marksteiner R, et al. Stem cell therapy for urinary stress incontinence. Exp Gerontol, 2004, 39(9): 1259-1265．.
5.	韓平, 解慧琪, 羅靜聰, 等. 細胞治療臨床應用新進展. 中國修復重建外科雜志, 2008, 22(2): 221-227.
6.	Bhatia NN, Ho MH. Stem cell therapy for urinary incontinence and pelvic floor disorders: a novel approach. Curr Opin Obstet Gynecol, 2004, 16(5): 397-398．.
7.	Corcos J, Loutochin O, Campeau L, et al. Bone marrow mesenchymal stromal cell therapy for External urethral sphincter restoration in a rat model of stress urinary incontinence. Neurourol Urodyn, 2011, 30(3): 447-455.
8.	Kim SO, Na HS, Kwon D, et al. Bone-marrow-derived Mese nc hymal stem cell transplantation enhances closing pressure and leak point pressure in a female urinary incontinence rat model. Urol Int, 2011, 86(1): 110-116.
9.	Kinebuchi Y, Aizawa N, Imamura T, et al. Autologous bone-marrow-derived mesenchymal stem cell transplantation into injured rat urethral sphincter. Int J Urol, 2010, 17(4): 359-368.
10.	Imamura T, Ishizuka O, Kinebuchi Y, et al. Implantation of autologous bone-marrow-derived cells Reconstructs functional urethral sphincters in rabbits. Tissue Eng Part a, 2011, 17(7-8): 1069-1081.
11.	Strasser H, Marksteiner R, Margreiter E, et al. Transurethral ultrasound guided injection of clonally cultured autologous myoblasts and fibroblasts: experimental results. J Urol, 2003, 169: 39.
12.	Lee JY, Cannon TW, Pruchnic R, et al. The effects of periurethral muscle-derived stem cell injection on leak point pressure in a rat model of stress urinary incontinence. Int Urogynecol J Pelvic Floor Dysfunct, 2003, 14(1): 31-37.
13.	Gimble JM. Adipose tissue-derived therapeutics. Expert Opin Biol Ther, 2003, 3(5): 705-713.
14.	Wu G, Zheng X, Jiang Z, et al. Induced differentiation of adipose-derived stromal cells into myoblasts. J Huazhong Univ Sci Technol, 2010, 30(3): 285-290.
15.	Forraz N, Mcguckin CP. The umbilical cord: a rich and ethical stem cell source to advance regenerative medicine. Cell Prolif, 2011, 44(Suppl 1): 60-69.
16.	Chermansky CJ, Tarin T, Kwon DD, et al. Intraurethral muscle-derived cell injections increase leak point pressure in a rat model of intrinsic sphincter deficiency. Urology, 2004, 63(4): 780-785.
17.	Lim JJ, Jang JB, Kim JY, et al. Human umbilical cord blood mononuclear cell transplantation in rats with intrinsic sphin cter deficiency. J Korean Med Sci, 2010, 25(5): 663-670.
18.	Carr LK, Steele D, Steele S, et al. 1-year follow-up of autologous muscle-derived stem cell injection pilot study to treat stress urinary incontinence. Int Urogynecol J Pelvic Floor Dysfunct, 2008, 19(6): 881-883.
19.	Lee CN, Jang JB, Kim JY, et al. Human cord blood stem cell therapy for treatment of stress urinary incontinence. J Korean Med Sci, 2010, 25(6): 813-816.
20.	Atala A, Cima LG, Kim W, et al. Injectable alginate seeded with chondrocytes as a potential treatment for vesicoureteral reflux. J Urol, 1993, 150(2 Pt 2): 745-747．.
21.	Atala A, Kim W, Paige KT, et al. Endoscopic treatment of vesicoureteral reflux with a chondrocyte-alginate suspension. J Urol, 1994, 152(2 Pt 2): 641-643.
22.	Bent AE, Tutrone RT, McLennan MT, et al. Treatment of intrinsic sphincter deficiency using autologous ear chond rocytes as a bulking agent. Neurourol Urodyn, 2001, 20(2): 157-165.
23.	Vandenburgh H, Del TM, Shansky J, et al. Tissue-engineered skeletal muscle organoids for reversible gene therapy. Hum Gene Ther, 1996, 7(17): 2195-2200.
24.	Chancellor MB, Yokoyama T, Tirney S, et al. Preliminary results of myoblast injection into the urethra and bladder wall: a possible method for the treatment of stress urinary incontin ence and impaired detrusor contractility. Neurourol Urodyn, 2000, 19(3): 279-287.
25.	Wakitani S, Saito T, Caplan AI. Myogenic cells derived from rat bone marrow mesenchymal stem cells exposed to 5-azacytidine. Muscle Nerve, 1995, 18(12): 1417-1426.
26.	Strasser H, Berjukow S, Marksteiner R, et al. Stem cell therapy for urinary stress incontinence. Exp Gerontol, 2004, 39(9): 1259-1265.
27.	Fu Q, Song XF, G, Liao GL, et al. Myoblasts differentiated from adipose-derived stem cells to treat stress urinary incontinence. Urology, 2010, 75(2): 718-723.
28.	Lee OK, Kuo TK, Chen WM, et al. Isolation of multipotent mesenchymal stem cells from umbilical cord blood. Blood, 2004, 103(5): 1669-1675.
29.	Sarugaser R, Lickorish D, Baksh D, et al. Human umbilical cord perivascular(hucpv)cells: a source of mesenchymal progenitors. Stem Cells, 2005, 23(2): 220-229.
30.	Kaviani A, Perry TE, Dzakovic A, et al. The amniotic fluid as a source of cells for fetal tissue engineering. J Pediatr Surg, 2001, 36(11): 1662-1665.
31.	Bilic G, Zeisberger SM, Mallik AS, et al. Comparative characterization of cultured human term amnion epithelial and mesenchymal stromal cells for application in cell therapy. Cell Transplant, 2008, 17(8): 955-968.
32.	Portmann-Lanz PC, Andreina S, Huber A, et al. Placental mesenchymal stem cells as potential autologous graft for pre-and perinatal neuroregeneration. Am J Obstet Gynecol, 2006, 194(3): 664-673.

1. Peggy N, Brubaker L. Urinary incontinence in women. Lancet, 2006, 367(9504): 57-67.
2. Hampel C, Wienhold D, Benken N, et al. Prevalence and natural history of female incontinence. Eur Urol, 1997, 32 Suppl 2: 3-12.
3. Bump RC, Norton PA. Epidemiology and natural history of pelvic fioor dysfunction. Obstet Gynecol Clin North Am, 1998, 25(4): 723-746.
4. Strasser H, Berjukow S, Marksteiner R, et al. Stem cell therapy for urinary stress incontinence. Exp Gerontol, 2004, 39(9): 1259-1265．.
5. 韓平, 解慧琪, 羅靜聰, 等. 細胞治療臨床應用新進展. 中國修復重建外科雜志, 2008, 22(2): 221-227.
6. Bhatia NN, Ho MH. Stem cell therapy for urinary incontinence and pelvic floor disorders: a novel approach. Curr Opin Obstet Gynecol, 2004, 16(5): 397-398．.
7. Corcos J, Loutochin O, Campeau L, et al. Bone marrow mesenchymal stromal cell therapy for External urethral sphincter restoration in a rat model of stress urinary incontinence. Neurourol Urodyn, 2011, 30(3): 447-455.
8. Kim SO, Na HS, Kwon D, et al. Bone-marrow-derived Mese nc hymal stem cell transplantation enhances closing pressure and leak point pressure in a female urinary incontinence rat model. Urol Int, 2011, 86(1): 110-116.
9. Kinebuchi Y, Aizawa N, Imamura T, et al. Autologous bone-marrow-derived mesenchymal stem cell transplantation into injured rat urethral sphincter. Int J Urol, 2010, 17(4): 359-368.
10. Imamura T, Ishizuka O, Kinebuchi Y, et al. Implantation of autologous bone-marrow-derived cells Reconstructs functional urethral sphincters in rabbits. Tissue Eng Part a, 2011, 17(7-8): 1069-1081.
11. Strasser H, Marksteiner R, Margreiter E, et al. Transurethral ultrasound guided injection of clonally cultured autologous myoblasts and fibroblasts: experimental results. J Urol, 2003, 169: 39.
12. Lee JY, Cannon TW, Pruchnic R, et al. The effects of periurethral muscle-derived stem cell injection on leak point pressure in a rat model of stress urinary incontinence. Int Urogynecol J Pelvic Floor Dysfunct, 2003, 14(1): 31-37.
13. Gimble JM. Adipose tissue-derived therapeutics. Expert Opin Biol Ther, 2003, 3(5): 705-713.
14. Wu G, Zheng X, Jiang Z, et al. Induced differentiation of adipose-derived stromal cells into myoblasts. J Huazhong Univ Sci Technol, 2010, 30(3): 285-290.
15. Forraz N, Mcguckin CP. The umbilical cord: a rich and ethical stem cell source to advance regenerative medicine. Cell Prolif, 2011, 44(Suppl 1): 60-69.
16. Chermansky CJ, Tarin T, Kwon DD, et al. Intraurethral muscle-derived cell injections increase leak point pressure in a rat model of intrinsic sphincter deficiency. Urology, 2004, 63(4): 780-785.
17. Lim JJ, Jang JB, Kim JY, et al. Human umbilical cord blood mononuclear cell transplantation in rats with intrinsic sphin cter deficiency. J Korean Med Sci, 2010, 25(5): 663-670.
18. Carr LK, Steele D, Steele S, et al. 1-year follow-up of autologous muscle-derived stem cell injection pilot study to treat stress urinary incontinence. Int Urogynecol J Pelvic Floor Dysfunct, 2008, 19(6): 881-883.
19. Lee CN, Jang JB, Kim JY, et al. Human cord blood stem cell therapy for treatment of stress urinary incontinence. J Korean Med Sci, 2010, 25(6): 813-816.
20. Atala A, Cima LG, Kim W, et al. Injectable alginate seeded with chondrocytes as a potential treatment for vesicoureteral reflux. J Urol, 1993, 150(2 Pt 2): 745-747．.
21. Atala A, Kim W, Paige KT, et al. Endoscopic treatment of vesicoureteral reflux with a chondrocyte-alginate suspension. J Urol, 1994, 152(2 Pt 2): 641-643.
22. Bent AE, Tutrone RT, McLennan MT, et al. Treatment of intrinsic sphincter deficiency using autologous ear chond rocytes as a bulking agent. Neurourol Urodyn, 2001, 20(2): 157-165.
23. Vandenburgh H, Del TM, Shansky J, et al. Tissue-engineered skeletal muscle organoids for reversible gene therapy. Hum Gene Ther, 1996, 7(17): 2195-2200.
24. Chancellor MB, Yokoyama T, Tirney S, et al. Preliminary results of myoblast injection into the urethra and bladder wall: a possible method for the treatment of stress urinary incontin ence and impaired detrusor contractility. Neurourol Urodyn, 2000, 19(3): 279-287.
25. Wakitani S, Saito T, Caplan AI. Myogenic cells derived from rat bone marrow mesenchymal stem cells exposed to 5-azacytidine. Muscle Nerve, 1995, 18(12): 1417-1426.
26. Strasser H, Berjukow S, Marksteiner R, et al. Stem cell therapy for urinary stress incontinence. Exp Gerontol, 2004, 39(9): 1259-1265.
27. Fu Q, Song XF, G, Liao GL, et al. Myoblasts differentiated from adipose-derived stem cells to treat stress urinary incontinence. Urology, 2010, 75(2): 718-723.
28. Lee OK, Kuo TK, Chen WM, et al. Isolation of multipotent mesenchymal stem cells from umbilical cord blood. Blood, 2004, 103(5): 1669-1675.
29. Sarugaser R, Lickorish D, Baksh D, et al. Human umbilical cord perivascular(hucpv)cells: a source of mesenchymal progenitors. Stem Cells, 2005, 23(2): 220-229.
30. Kaviani A, Perry TE, Dzakovic A, et al. The amniotic fluid as a source of cells for fetal tissue engineering. J Pediatr Surg, 2001, 36(11): 1662-1665.
31. Bilic G, Zeisberger SM, Mallik AS, et al. Comparative characterization of cultured human term amnion epithelial and mesenchymal stromal cells for application in cell therapy. Cell Transplant, 2008, 17(8): 955-968.
32. Portmann-Lanz PC, Andreina S, Huber A, et al. Placental mesenchymal stem cells as potential autologous graft for pre-and perinatal neuroregeneration. Am J Obstet Gynecol, 2006, 194(3): 664-673.

Chinese Journal of Reparative and Reconstructive Surgery

CELLULAR THERAPY OF STRESS URINARY INCONTINENCE

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