RESEARCH PROGRESS OF EXTRACELLULAR MATRIX MATERIAL FOR TISSUE ENGINEERING_Chinese Journal of Reparative and Reconstructive Surgery

Authors：

YUAN Haichao , PU Chunxiao , WEI Qiang , HAN Ping.

Department of Urology, West China Hospital, Sichuan University, Chengdu Sichuan, 610041, P.R.China. Corresponding author: HAN Ping, E-mail: hanping@scu.edu.cn;

Corresponding?author：

Keywords：

Tissue engineering; Scaffold material; Extracellular matrix

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Objective To review the current research status and clinical application progress of extracellular matrix (ECM) material in tissue engineering. Methods The literature about the latest progress in the preparation, biocompatibility, mechanical property, degradability, and clinical application of ECM material was extensively reviewed. Results The improvement of the ECM preparation method and thorough understanding of the immunological properties have laid the foundation for the repair and reconstruction of the tissue. Moreover, a series of animal studies also confirm that the feasibility and effectiveness of the ECM such as small intestinal submucosa, bladder ECM grift, and acellular dermis which have been applied to the repair and reconstruction of the urethra, bladder, arteries, and skin tissue. It shows a wide prospect of clinical application in the future. Conclusion ECM material is a good bio-derived scaffold, which is expected to become an important source of alternative materials for the repair and reconstruction of the tissue.

Citation： YUAN Haichao,PU Chunxiao,WEI Qiang,HAN Ping.. RESEARCH PROGRESS OF EXTRACELLULAR MATRIX MATERIAL FOR TISSUE ENGINEERING. Chinese Journal of Reparative and Reconstructive Surgery, 2012, 26(10): 1251-1254. doi: Copy

1.	Huebsh N, Moony DJ. Inspiration and application in the evolution of biomaterials. Nature, 2009, 462(7272): 426-432.
2.	羅靜聰, 楊志明, 李秀群, 等. 小腸黏膜下層細胞相容性的研究. 生物醫學工程學雜志, 2004, 21(5): 800-804.
3.	韓平, 宋超, 魏強, 等. 組織工程膀胱細胞外基質生物相容性的實驗研究. 四川大學學報: 醫學版, 2007, 38(6): 1009-1012.
4.	孔清泉, 高博, 幸嶸, 等. 以小腸黏膜下層為支架體外構建組織工程軟骨的實驗研究. 生物醫學工程學雜志, 2011, 28(3): 521-525.
5.	Zhu WD, Xu YM, Feng C, et al. Different bladder defects reconstructed with bladder acellular matrix grafts in a rabbit model. Urologe A, 2011, 50(11): 1420-1425.
6.	Gilbert TW, Sellaro TL, Badylak SF. Decellularization of tissues and organs. Biomaterials, 2006, 27(19): 3675-3683.
7.	羅靜聰, 楊志明. 小腸黏膜下層的制備及其特性的研究進展. 中國修復重建外科雜志, 2003, 17(5): 425-428.
8.	Luo JC, Chen W, Chen XH, et al. A multi-step method for preparation of porcine small intestinal submucosa (SIS). Biomaterials, 2011, 32(3): 706-713.
9.	Raghavan D, Kropp BP, Lin HK, et al. Physical characteristics of small intestinal submucosa scaffolds are location-dependent. J Biomed Mater Res A, 2005, 73(1): 90-96.
10.	Basile P, Dadali T, Jacobson J, et al. Freeze-dried tendon allografts as tissue-engineering scaffolds for Gdf5 gene delivery. Mol Ther, 2008, 16(3): 466-473.
11.	Giannini S, Buda R, Caprio F, et al. Effects of freezing on the biomechanical and structural properties of human posterior tibial tendons. Int Orthop, 2008, 32(2): 145-151.
12.	Ott HC, Matthiesen TS, Goh SK, et al. Perfusion-decellularized matrix: using nature, s platform to engineer a bioartificial heart. Nat Med, 2008, 14(2): 213-221.
13.	羅靜聰, 李秀群, 楊志明, 等. 脫細胞羊膜的制備及其生物相容性研究. 中國修復重建外科雜志, 2004, 18(2): 108-111.
14.	Brown B, Lindberg K, Reing J, et al. The basement membrane component of biologic scaffolds derived from extracellular matrix. Tissue Eng, 2006, 12(3): 519-526.
15.	Hodde JP, Record RD, Liang HA, et al. Vascular endothelial growth factor in porcine- derived extracellular matrix. Endothelium, 2001, 8(1): 11-24.
16.	Joo KJ, Kim BS, Han JH, et al. Porcine vesical acellular matrix graft of tunica albuginea for penile reconstruction. Asian J Androl, 2006, 8(5): 543-548.
17.	Chun SY, Lim GJ, Kwon TG, et al. Identification and characterization of bioactive factors in bladder submucosa matrix. Biomaterials, 2007, 28(29): 4251-4256.
18.	Dahms SE, Piechota HJ, Dahiya R, et al. Composition and biomechanical properties of the bladder acellular matrix graft: comparative analysis in rat, pig and human. Br J Urol, 1998, 82(3): 411-419.
19.	Freytes DO, Badylak SF, Webster TJ, et al. Biaxial strength of multilaminated extracellular matrix scaffolds. Biomaterials, 2004, 25(2): 2353-2361.
20.	Badylak S, Kokini K, Tullius B, et al. Strength over time of a resorbable bioscaffold for body wall repair in a dog model. J Surg Res, 2001, 99(2): 282-287.
21.	Gilbert TW, Stewart-Akers AM, Simmons-Byrd A, et al. Degradation and remodeling of small intestinal submucosa in canine Achilles tendon repair. J Bone Joint Surg (Am), 2007, 89(3): 621-630.
22.	Valentin JE, Stewart-Akers AM, Gilbert TW, et al. Macrophage participation in the degradation and remodeling of extracellular matrix scaffolds. Tissue Eng Part A, 2009, 15(7): 1687-1694.
23.	Deeken CR, Eliason BJ, Pichert MD, et al. Differentiation of biologic scaffold materials through physicomechanical, thermal, and enzymatic degradation techniques. Ann Surg, 2012, 255(3): 595-604.
24.	Ferguson RE Jr, Pu LL. Repair of the abdominal donor-site fascial defect with small intestinal submucosa (Surgisis) after TRAM flap breast reconstruction. Ann Plast Surg, 2007, 58(1): 95-98.
25.	Ansaloni L, Catena F, Gagliardi S, et al. Hernia repair with porcine small-intestinal submucosa. Hernia, 2007, 11(4): 321-326.
26.	Ho KL, Witte MN, Bird ET. 8-ply small intestinal submucosa tension-free sling: spectrum of postoperative inflammation. J Urol, 2004, 171(1): 268-271.
27.	Petter-Puchner AH, Fortelny RH, Mittermayr R, et al. Adverse effects of porcine small intestine submucosa implants in experimental ventral hernia repair. Surg Endosc, 2006, 20(6): 942-946.
28.	McPherson TB, Liang H, Record RD, et al. Galalpha(1, 3)Gal epitope in porcine small intestinal submucosa. Tissue Eng, 2000, 6(3): 233-239.
29.	Galili U, Clark MR, Shohet SB, et al. Evolutionary relationship between the natural anti-Gal antibody and the Gal alpha 1-3Gal epitope in primates. Proc Natl Acad Sci U S A, 1987, 84(5): 1369-1373.
30.	Galili U, Shohet SB, Kobrin E, et al. Man, apes, and Old World monkeys differ from other mammals in the expression of alpha-galactosyl epitopes on nucleated cells. J Biol Chem, 1988, 263(33): 17755-17762.
31.	Galili U, Rachmilewitz EA, Peleg A, et al. A unique natural human IgG antibody with anti-alpha-galactosyl specificity. J Exp Med, 1984, 160(5): 1519-1531.
32.	Daly KA, Stewart-Akers AM, Hara H, et al. Effect of the alphaGal epitope on the response to small intestinal submucosa extracellular matrix in a nonhuman primate model. Tissue Eng Part A, 2009, 15(12): 3877-3888.
33.	Allman AJ, McPherson TB, Badylak SF, et al. Xenogeneic extracellular matrix grafts elicit a TH2-restricted immune response. Transplantation, 2001, 71(11): 1631-1640.
34.	黃翔, 羅靜聰, 廖勇, 等. 小腸黏膜下層修復尿道的實驗研究. 中國修復重建外科雜志, 2006, 20(3): 206-209.
35.	Kropp BP, Ludlow JK, Spicer D, et al. Rabbit urethral regeneration using small intestinal submucosa onlay grafts. Urology, 1998, 52(1): 138-142.
36.	Badylak SF, Lantz GC, Coffey A, et al. Small intestinal submucosa as a large diameter vascular graft in the dog. J Surg Res, 1989, 47(1): 74-80.
37.	Padalino MA, Castellani C, Dedja A, et al. Extracellular matrix graft for vascular reconstructive surgery: evidence of autologous regeneration of the neoaorta in a murine model. Eur J Cardiothorac Surg, 2012. [Epub ahead of print].
38.	Ko R, Kazacos EA, Snyder S, et al. Tensile strength comparison of small intestinal submucosa body wall repair. J Surg Res, 2006, 135(1): 9-17.
39.	Knoll LD. Use of small intestinal submucosa graft for the surgical management of Peyronie’s disease. J Urol, 2007, 178(6): 2474-2478.
40.	Malcaeney HL, Bonar F, Murrell GA. Early inflammatory reaction after rotator cuff repair with a porcine small intestine submucosal implant: a report of 4 cases. Am J Sports Med, 2005, 33(6): 907-911.
41.	Callcut RA, Schurr MJ, Sloan M, et al. Clinical experience with Alloderm: a one-staged composite dermal/epidermal replacement utilizing processed cadaver dermis and thin autografts. Burns, 2006, 32(5): 583-588.
42.	Chen F, Yoo JJ, Atala A. Acellular collagen matrix as a possible “off the shelf” biomaterial for urethral repair. Urology, 1999, 54(3): 407-410.
43.	el-Kassaby A, AbouShwared T, Atala A. Randomized comparative study between buccal mucosal and acellular bladder matrix grafts in complex anterior urethral strictures. J Urol, 2008, 179(4): 1432-1436.
44.	Limpert JN, Desai AR, Kumpf AL, et al. Repair of abdominal wall defects with bovine pericardium. Am J Surg, 2009, 198(5): e60-655.
45.	鞠曉軍, 潘鋒, 柏樹令, 等. 人脫細胞羊膜復合脂肪源性干細胞修復大鼠全層皮膚缺損的實驗研究. 中國修復重建外科雜志, 2010, 24(2): 143-149.
46.	胡云飛, 楊嗣星, 王玲瓏, 等. 尿道細胞外基質在兔尿道重建中的應用. 中華整形外科雜志, 2009, 25(1): 54-57.

1. Huebsh N, Moony DJ. Inspiration and application in the evolution of biomaterials. Nature, 2009, 462(7272): 426-432.
2. 羅靜聰, 楊志明, 李秀群, 等. 小腸黏膜下層細胞相容性的研究. 生物醫學工程學雜志, 2004, 21(5): 800-804.
3. 韓平, 宋超, 魏強, 等. 組織工程膀胱細胞外基質生物相容性的實驗研究. 四川大學學報: 醫學版, 2007, 38(6): 1009-1012.
4. 孔清泉, 高博, 幸嶸, 等. 以小腸黏膜下層為支架體外構建組織工程軟骨的實驗研究. 生物醫學工程學雜志, 2011, 28(3): 521-525.
5. Zhu WD, Xu YM, Feng C, et al. Different bladder defects reconstructed with bladder acellular matrix grafts in a rabbit model. Urologe A, 2011, 50(11): 1420-1425.
6. Gilbert TW, Sellaro TL, Badylak SF. Decellularization of tissues and organs. Biomaterials, 2006, 27(19): 3675-3683.
7. 羅靜聰, 楊志明. 小腸黏膜下層的制備及其特性的研究進展. 中國修復重建外科雜志, 2003, 17(5): 425-428.
8. Luo JC, Chen W, Chen XH, et al. A multi-step method for preparation of porcine small intestinal submucosa (SIS). Biomaterials, 2011, 32(3): 706-713.
9. Raghavan D, Kropp BP, Lin HK, et al. Physical characteristics of small intestinal submucosa scaffolds are location-dependent. J Biomed Mater Res A, 2005, 73(1): 90-96.
10. Basile P, Dadali T, Jacobson J, et al. Freeze-dried tendon allografts as tissue-engineering scaffolds for Gdf5 gene delivery. Mol Ther, 2008, 16(3): 466-473.
11. Giannini S, Buda R, Caprio F, et al. Effects of freezing on the biomechanical and structural properties of human posterior tibial tendons. Int Orthop, 2008, 32(2): 145-151.
12. Ott HC, Matthiesen TS, Goh SK, et al. Perfusion-decellularized matrix: using nature, s platform to engineer a bioartificial heart. Nat Med, 2008, 14(2): 213-221.
13. 羅靜聰, 李秀群, 楊志明, 等. 脫細胞羊膜的制備及其生物相容性研究. 中國修復重建外科雜志, 2004, 18(2): 108-111.
14. Brown B, Lindberg K, Reing J, et al. The basement membrane component of biologic scaffolds derived from extracellular matrix. Tissue Eng, 2006, 12(3): 519-526.
15. Hodde JP, Record RD, Liang HA, et al. Vascular endothelial growth factor in porcine- derived extracellular matrix. Endothelium, 2001, 8(1): 11-24.
16. Joo KJ, Kim BS, Han JH, et al. Porcine vesical acellular matrix graft of tunica albuginea for penile reconstruction. Asian J Androl, 2006, 8(5): 543-548.
17. Chun SY, Lim GJ, Kwon TG, et al. Identification and characterization of bioactive factors in bladder submucosa matrix. Biomaterials, 2007, 28(29): 4251-4256.
18. Dahms SE, Piechota HJ, Dahiya R, et al. Composition and biomechanical properties of the bladder acellular matrix graft: comparative analysis in rat, pig and human. Br J Urol, 1998, 82(3): 411-419.
19. Freytes DO, Badylak SF, Webster TJ, et al. Biaxial strength of multilaminated extracellular matrix scaffolds. Biomaterials, 2004, 25(2): 2353-2361.
20. Badylak S, Kokini K, Tullius B, et al. Strength over time of a resorbable bioscaffold for body wall repair in a dog model. J Surg Res, 2001, 99(2): 282-287.
21. Gilbert TW, Stewart-Akers AM, Simmons-Byrd A, et al. Degradation and remodeling of small intestinal submucosa in canine Achilles tendon repair. J Bone Joint Surg (Am), 2007, 89(3): 621-630.
22. Valentin JE, Stewart-Akers AM, Gilbert TW, et al. Macrophage participation in the degradation and remodeling of extracellular matrix scaffolds. Tissue Eng Part A, 2009, 15(7): 1687-1694.
23. Deeken CR, Eliason BJ, Pichert MD, et al. Differentiation of biologic scaffold materials through physicomechanical, thermal, and enzymatic degradation techniques. Ann Surg, 2012, 255(3): 595-604.
24. Ferguson RE Jr, Pu LL. Repair of the abdominal donor-site fascial defect with small intestinal submucosa (Surgisis) after TRAM flap breast reconstruction. Ann Plast Surg, 2007, 58(1): 95-98.
25. Ansaloni L, Catena F, Gagliardi S, et al. Hernia repair with porcine small-intestinal submucosa. Hernia, 2007, 11(4): 321-326.
26. Ho KL, Witte MN, Bird ET. 8-ply small intestinal submucosa tension-free sling: spectrum of postoperative inflammation. J Urol, 2004, 171(1): 268-271.
27. Petter-Puchner AH, Fortelny RH, Mittermayr R, et al. Adverse effects of porcine small intestine submucosa implants in experimental ventral hernia repair. Surg Endosc, 2006, 20(6): 942-946.
28. McPherson TB, Liang H, Record RD, et al. Galalpha(1, 3)Gal epitope in porcine small intestinal submucosa. Tissue Eng, 2000, 6(3): 233-239.
29. Galili U, Clark MR, Shohet SB, et al. Evolutionary relationship between the natural anti-Gal antibody and the Gal alpha 1-3Gal epitope in primates. Proc Natl Acad Sci U S A, 1987, 84(5): 1369-1373.
30. Galili U, Shohet SB, Kobrin E, et al. Man, apes, and Old World monkeys differ from other mammals in the expression of alpha-galactosyl epitopes on nucleated cells. J Biol Chem, 1988, 263(33): 17755-17762.
31. Galili U, Rachmilewitz EA, Peleg A, et al. A unique natural human IgG antibody with anti-alpha-galactosyl specificity. J Exp Med, 1984, 160(5): 1519-1531.
32. Daly KA, Stewart-Akers AM, Hara H, et al. Effect of the alphaGal epitope on the response to small intestinal submucosa extracellular matrix in a nonhuman primate model. Tissue Eng Part A, 2009, 15(12): 3877-3888.
33. Allman AJ, McPherson TB, Badylak SF, et al. Xenogeneic extracellular matrix grafts elicit a TH2-restricted immune response. Transplantation, 2001, 71(11): 1631-1640.
34. 黃翔, 羅靜聰, 廖勇, 等. 小腸黏膜下層修復尿道的實驗研究. 中國修復重建外科雜志, 2006, 20(3): 206-209.
35. Kropp BP, Ludlow JK, Spicer D, et al. Rabbit urethral regeneration using small intestinal submucosa onlay grafts. Urology, 1998, 52(1): 138-142.
36. Badylak SF, Lantz GC, Coffey A, et al. Small intestinal submucosa as a large diameter vascular graft in the dog. J Surg Res, 1989, 47(1): 74-80.
37. Padalino MA, Castellani C, Dedja A, et al. Extracellular matrix graft for vascular reconstructive surgery: evidence of autologous regeneration of the neoaorta in a murine model. Eur J Cardiothorac Surg, 2012. [Epub ahead of print].
38. Ko R, Kazacos EA, Snyder S, et al. Tensile strength comparison of small intestinal submucosa body wall repair. J Surg Res, 2006, 135(1): 9-17.
39. Knoll LD. Use of small intestinal submucosa graft for the surgical management of Peyronie’s disease. J Urol, 2007, 178(6): 2474-2478.
40. Malcaeney HL, Bonar F, Murrell GA. Early inflammatory reaction after rotator cuff repair with a porcine small intestine submucosal implant: a report of 4 cases. Am J Sports Med, 2005, 33(6): 907-911.
41. Callcut RA, Schurr MJ, Sloan M, et al. Clinical experience with Alloderm: a one-staged composite dermal/epidermal replacement utilizing processed cadaver dermis and thin autografts. Burns, 2006, 32(5): 583-588.
42. Chen F, Yoo JJ, Atala A. Acellular collagen matrix as a possible “off the shelf” biomaterial for urethral repair. Urology, 1999, 54(3): 407-410.
43. el-Kassaby A, AbouShwared T, Atala A. Randomized comparative study between buccal mucosal and acellular bladder matrix grafts in complex anterior urethral strictures. J Urol, 2008, 179(4): 1432-1436.
44. Limpert JN, Desai AR, Kumpf AL, et al. Repair of abdominal wall defects with bovine pericardium. Am J Surg, 2009, 198(5): e60-655.
45. 鞠曉軍, 潘鋒, 柏樹令, 等. 人脫細胞羊膜復合脂肪源性干細胞修復大鼠全層皮膚缺損的實驗研究. 中國修復重建外科雜志, 2010, 24(2): 143-149.
46. 胡云飛, 楊嗣星, 王玲瓏, 等. 尿道細胞外基質在兔尿道重建中的應用. 中華整形外科雜志, 2009, 25(1): 54-57.

Chinese Journal of Reparative and Reconstructive Surgery

RESEARCH PROGRESS OF EXTRACELLULAR MATRIX MATERIAL FOR TISSUE ENGINEERING

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