支氣管哮喘的藥物治療和相關不良反應_Chinese Journal of Respiratory and Critical Care Medicine

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陶雪飛 , 朱蕾

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Keywords：

支氣管哮喘; 藥物治療; 不良反應

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支氣管哮喘( 簡稱哮喘) 是氣道的非特異性炎癥性疾病。近年來, 通過規范化治療, 大部分患者可獲得良好的治療效果, 重癥哮喘的發生率降低, 需要急診或住院的患者減少[1] 。同時哮喘作為一種不能根治的慢性病, 規范化治療也意味著需要較長的療程, 隨之可能帶來一定的不良反應, 但這些不良反應又較少受到重視。

Citation： 陶雪飛,朱蕾. 支氣管哮喘的藥物治療和相關不良反應. Chinese Journal of Respiratory and Critical Care Medicine, 2010, 9(6): 654-656. doi: Copy

1.	Anandan C, Nurmatov U, Van Schayck OC, et al. Is the prevalence of asthma declining? Systematic review of epidemiological studies.Allergy, 2010 , 65: 152-67 .
2.	Gibson PG, Powell H, Gibson PG. Initial corticosteroid therapy for asthma. Curr Opin Pulm Med, 2006, 12: 48-53 .
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4.	Sasaki A, Ouchi K, Makata H, et al. The effect of inhaled corticosteroids on Chlamydophila pneumoniae and Mycoplasma pneumoniae infection in children with bronchial asthma. J Infect Chemother, 2009, 15: 99 -103.
5.	Mullaoglu S, Turktas H, Kokturk N, et al. Esophageal candidiasis and Candida colonization in asthma patients on inhaled steroids.Allergy Asthma Proc, 2007, 28: 544-549 .
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7.	Christensson C, Thoren A, Lindberg B, et al. Safety of inhaled budesonide: clinical manifestations of systemic corticosteroid-related adverse effects. Drug Saf, 2008 , 31: 965-988.
8.	Gluck PA, Gluck JC. A review of pregnancy outcomes after exposure to orally inhaled or intranasal budesonide. Curr Med Res Opin,2005, 21: 1075-1084 .
9.	Fal AM, Kopec A. Status of leukotrienes in the pathophysiology of asthma. Necessity for antileukotrienes treatment. Pneumomol Alergol Pol, 2010, 78: 68 -73 .
10.	Polosa R. Critical appraisal of antileukotriene use in asthma management. Curr Opin Pulm Med, 2007, 13: 24-30 .
11.	Currie GP, McLaughlin K. The expanding role of leukotriene receptor antagonists in chronic asthma. Ann Allergy Asthma Immunol, 2006, 97: 731 -741.
12.	Droszcz W. Antileukotrienes in asthma-critical view. Pneumomol Alergol Pol, 2010 , 78 : 60-67.
13.	Guilpain P, Pagnoux C, Lhote F, et al. Antileukotrienes and Churg-Strauss syndrome. Preese Med, 2007, 36: 890-894 .
14.	Wouden JC, Uijen JH, Bernsen RM, et al. Inhaled sodium cromoglycate for asthma in children. Cochrane Database Sysr Rev,2008, 8: CD002173.
15.	Guevara JP, Duchame FM, Keren R, et al. Inhaled corticosteroids versus sodium cromoglycate in children and adults with asthma.Cochrane Database Sysr Rev, 2006, 19: CD003558.
16.	Sridhar AV, McKean M. Nedocromil sodium for chronic asthma in children. Cochrane Database Syst Rev, 2006 , 19: CD004108.
17.	Ortega VE, Peter SP. Beta-2 adrenergic agonists: focus on safety and benefits versus risks. Curr Opin Pharmacol, 2010, 6: 246 -253.
18.	Michael J, Walters E, Walters J, et al. Adverse effects of betaagonists:are they clinically relevant? Am J Respir Med, 2003, 2 :287 -297.
19.	Gupta P, Mahony MS. Potential adverse effects of bronchodilators in the treatment of airways obstruction in older people:recommendations for prescribing. Drugs Aging, 2008, 25: 415-443 .
20.	賴克方. 支氣管哮喘非特異性免疫治療. 實用醫院臨床雜志,2007, 4: 19-21.
21.	Pipe A, Botturi K, Pinot D, et al. Allergen-specific immunotherapy in allergic rhinitis and asthma. Mechanisms and proof of efficacy.Respir Med, 2009 , 103: 800-812.
22.	Niederberger V. Allergen-specific immunotherapy. Immunol Lett,2009, 122: 131-133.
23.	Passalacqua G, Durham SR; Global Allergy and Asthma European Network. Allergic rhinitis and its impact on asthma update: allergen immunotherapy. J Allergy Clin Immunol, 2007, 119: 881 -891.

1. Anandan C, Nurmatov U, Van Schayck OC, et al. Is the prevalence of asthma declining? Systematic review of epidemiological studies.Allergy, 2010 , 65: 152-67 .
2. Gibson PG, Powell H, Gibson PG. Initial corticosteroid therapy for asthma. Curr Opin Pulm Med, 2006, 12: 48-53 .
3. Kaiser H. Cortison therapy today. Wien Klin Wochenschr, 2003 ,115: 6 -21 .
4. Sasaki A, Ouchi K, Makata H, et al. The effect of inhaled corticosteroids on Chlamydophila pneumoniae and Mycoplasma pneumoniae infection in children with bronchial asthma. J Infect Chemother, 2009, 15: 99 -103.
5. Mullaoglu S, Turktas H, Kokturk N, et al. Esophageal candidiasis and Candida colonization in asthma patients on inhaled steroids.Allergy Asthma Proc, 2007, 28: 544-549 .
6. Sekine A, Hagiwara E, Ogura T, et al. A case of pulmonary Mycobacterium avium infection presenting multiple nodules with substantial difference in 18F-fluorodeoxyglucose uptake. Nihon Kokyuki Gakkai Zasshi, 2009, 47: 575-580 .
7. Christensson C, Thoren A, Lindberg B, et al. Safety of inhaled budesonide: clinical manifestations of systemic corticosteroid-related adverse effects. Drug Saf, 2008 , 31: 965-988.
8. Gluck PA, Gluck JC. A review of pregnancy outcomes after exposure to orally inhaled or intranasal budesonide. Curr Med Res Opin,2005, 21: 1075-1084 .
9. Fal AM, Kopec A. Status of leukotrienes in the pathophysiology of asthma. Necessity for antileukotrienes treatment. Pneumomol Alergol Pol, 2010, 78: 68 -73 .
10. Polosa R. Critical appraisal of antileukotriene use in asthma management. Curr Opin Pulm Med, 2007, 13: 24-30 .
11. Currie GP, McLaughlin K. The expanding role of leukotriene receptor antagonists in chronic asthma. Ann Allergy Asthma Immunol, 2006, 97: 731 -741.
12. Droszcz W. Antileukotrienes in asthma-critical view. Pneumomol Alergol Pol, 2010 , 78 : 60-67.
13. Guilpain P, Pagnoux C, Lhote F, et al. Antileukotrienes and Churg-Strauss syndrome. Preese Med, 2007, 36: 890-894 .
14. Wouden JC, Uijen JH, Bernsen RM, et al. Inhaled sodium cromoglycate for asthma in children. Cochrane Database Sysr Rev,2008, 8: CD002173.
15. Guevara JP, Duchame FM, Keren R, et al. Inhaled corticosteroids versus sodium cromoglycate in children and adults with asthma.Cochrane Database Sysr Rev, 2006, 19: CD003558.
16. Sridhar AV, McKean M. Nedocromil sodium for chronic asthma in children. Cochrane Database Syst Rev, 2006 , 19: CD004108.
17. Ortega VE, Peter SP. Beta-2 adrenergic agonists: focus on safety and benefits versus risks. Curr Opin Pharmacol, 2010, 6: 246 -253.
18. Michael J, Walters E, Walters J, et al. Adverse effects of betaagonists:are they clinically relevant? Am J Respir Med, 2003, 2 :287 -297.
19. Gupta P, Mahony MS. Potential adverse effects of bronchodilators in the treatment of airways obstruction in older people:recommendations for prescribing. Drugs Aging, 2008, 25: 415-443 .
20. 賴克方. 支氣管哮喘非特異性免疫治療. 實用醫院臨床雜志,2007, 4: 19-21.
21. Pipe A, Botturi K, Pinot D, et al. Allergen-specific immunotherapy in allergic rhinitis and asthma. Mechanisms and proof of efficacy.Respir Med, 2009 , 103: 800-812.
22. Niederberger V. Allergen-specific immunotherapy. Immunol Lett,2009, 122: 131-133.
23. Passalacqua G, Durham SR; Global Allergy and Asthma European Network. Allergic rhinitis and its impact on asthma update: allergen immunotherapy. J Allergy Clin Immunol, 2007, 119: 881 -891.

Chinese Journal of Respiratory and Critical Care Medicine

支氣管哮喘的藥物治療和相關不良反應

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