Obstructive Sleep Apnea Sysndrome and Hypertension_Chinese Journal of Respiratory and Critical Care Medicine

Authors：

WANG Wei

Institute of Respiratory Disease，the First Affiliated Hospital，China Medical University，Shengyang，Liaoning 110001，P.R.China;

Corresponding?author：

Keywords：

阻塞性睡眠呼吸暫停綜合征; 高血壓

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阻塞性睡眠呼吸暫停綜合征( obstructive sleep apnea syndrome, OSAS) 是一種常見的睡眠呼吸障礙性疾病, 在成人發生率為2% ～4% , 由于睡眠中反復發生上氣道部分或完
全阻塞而表現為夜間間斷低氧和高碳酸血癥、反復覺醒、睡眠結構紊亂, 臨床上常引起心、腦、腎等多器官損害。越來越多的證據表明, OSAS并發高血壓、冠心病、肺動脈高壓、心力衰竭、中風的危險性增高, 是心腦血管疾病的獨立危險因素。未經治療的重度OSAS 患者5 年病死率高達11% ～13% , 而心腦血管并發癥是主要死因。如果及時給予有效治療, 在一定程度上可以預防并發癥的發生, 甚至逆轉心腦血管并發癥的轉歸。

Citation： WANG Wei. Obstructive Sleep Apnea Sysndrome and Hypertension. Chinese Journal of Respiratory and Critical Care Medicine, 2010, 9(1): 1-2. doi: Copy

1.	Somers VK,White DP, Amin R, et al. Sleep apnea and cardiovascular disease: an American Heart Association/American College of Cardiology Foundation Scientific Statement from the American Heart Association Council for High Blood Pressure Research Professional Education Committee, Council on Clinical Cardiology, StrokeCouncil, and Council on Cardiovascular Nursing. J Am Coll Cardiol,2008, 52: 686-717.
2.	Peppard PE, Young T, Palta M, et al. Prospective study of the association between sleep-disordered breathing and hypertension. N Engl J Med, 2000, 342: 1378-1384.
3.	Lavie P, Herer P, Hoffstein V. Obstructive sleep apnea syndrome as a risk factor for hypertension: population study. Br Med J, 2000 , 320 :479- 482.
4.	中華醫學會呼吸病學分會睡眠呼吸疾病學組. 睡眠呼吸暫停人群高血壓患病率的多中心研究. 中華結核和呼吸雜志, 2007, 30:894-897.
5.	宋秀萍, 張軍英. 睡眠呼吸暫停綜合征合并高血壓的臨床特點觀察. 臨床和實驗醫學雜志, 2008, 12, 72-73.
6.	Das AM, Khayat R. Hypertension in obstructive sleep apnea: risk and therapy. Expert Rev Cardiovasc Ther, 2009, 7: 619-626.

1. Somers VK,White DP, Amin R, et al. Sleep apnea and cardiovascular disease: an American Heart Association/American College of Cardiology Foundation Scientific Statement from the American Heart Association Council for High Blood Pressure Research Professional Education Committee, Council on Clinical Cardiology, StrokeCouncil, and Council on Cardiovascular Nursing. J Am Coll Cardiol,2008, 52: 686-717.
2. Peppard PE, Young T, Palta M, et al. Prospective study of the association between sleep-disordered breathing and hypertension. N Engl J Med, 2000, 342: 1378-1384.
3. Lavie P, Herer P, Hoffstein V. Obstructive sleep apnea syndrome as a risk factor for hypertension: population study. Br Med J, 2000 , 320 :479- 482.
4. 中華醫學會呼吸病學分會睡眠呼吸疾病學組. 睡眠呼吸暫停人群高血壓患病率的多中心研究. 中華結核和呼吸雜志, 2007, 30:894-897.
5. 宋秀萍, 張軍英. 睡眠呼吸暫停綜合征合并高血壓的臨床特點觀察. 臨床和實驗醫學雜志, 2008, 12, 72-73.
6. Das AM, Khayat R. Hypertension in obstructive sleep apnea: risk and therapy. Expert Rev Cardiovasc Ther, 2009, 7: 619-626.

Chinese Journal of Respiratory and Critical Care Medicine

Obstructive Sleep Apnea Sysndrome and Hypertension

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