Some Issues on Mechanical Ventilation in Surving Sepsis Campaign Guideline 2008_Chinese Journal of Respiratory and Critical Care Medicine

Authors：

LI Yimin , HE Guoqing

The State Key Lab. of Respiratory Disease，Guangzhou Institute of Respiratory Disease，The First Affiliated Hospital，Guangzhou Medical College. Guangzhou, Guangdong, 510120，China;

Corresponding?author：

Keywords：

sepsis; Mechanical ventilation

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Sepsis 已經成為危重癥醫學中較為常見的一種綜合征，它定義為因病原體感染而引起的全身性炎癥反應綜合征。嚴重Sepsis患者預后不佳，治療上也較為困難，特別是合并Septic Shock和多器官功能不全綜合征（MODS）的患者，死亡率仍然較高，因此近年來在臨床及研究上均已引起明顯的重視。為了能促進Sepsis的研究及治療，國際上多個醫學專科分會聯合發起“拯救Sepsis運動（Surviving Sepsis Campaign, SSC）”，并于2004年首次發表了相應的指南，即Surviving Sepsis Campaign Guideline for Management of Severe Sepsis and Septic Shock。今年初SSC再次發表了新版的指南，主要是結合近年的研究成果而在原版的基礎上進行適當的補充和更新，以指導臨床上嚴重Sepsis的搶救及治療。

Citation： LI Yimin,HE Guoqing. Some Issues on Mechanical Ventilation in Surving Sepsis Campaign Guideline 2008. Chinese Journal of Respiratory and Critical Care Medicine, 2009, 09(2): 101-103. doi: Copy

1.	、 The Acute Respiratory Distress Syndrome Network: Ventilation with lower tidal volumes as compared with traditional tidal volumes for acute lung injury and the acute respiratory distress syndrome. N Engl J Med.
2.	、 Ferguson ND, Frutos-Vivar F, Esteban A, et al. Airway pressures, tidal volumes, and mortality in patients with acute respiratory distress syndrome. Crit Care Med.
3.	、 Villar J, Kacmarek RM, Perez-Mendez L, et al. A high positive end-expiratory pressure, low tidal volume ventilatory strategy improves outcome in persistent acute respiratory distress syndrome: A randomized, controlled trial. Crit Care Med.
4.	、 van den Berg PC, Jansen JR, Pinsky MR. Effect of positive pressure on venous return in volume-loaded cardiac surgical patients. J Appl Physiol.
5.	、 George DL, Falk PS, Wunderink RG, et al. Epidemiology of ventilator acquired pneumonia based on protected bronchoscopic sampling. Am J Respir Crit Care Med.
6.	; 158:1839-1847Safdar N, Said A, Lucey MR. The role of selective digestive decontamination for reducing infection in patients undergoing liver transplantation: a systematic review and meta-analysis. Liver Transpl.
7.	; 342: 1301-1308.
8.	; 92: 1223-1231.
9.	; 10817-827.
10.	; 33: 21-30.
11.	; 34: 1311-1318.

1. 、 The Acute Respiratory Distress Syndrome Network: Ventilation with lower tidal volumes as compared with traditional tidal volumes for acute lung injury and the acute respiratory distress syndrome. N Engl J Med.
2. 、 Ferguson ND, Frutos-Vivar F, Esteban A, et al. Airway pressures, tidal volumes, and mortality in patients with acute respiratory distress syndrome. Crit Care Med.
3. 、 Villar J, Kacmarek RM, Perez-Mendez L, et al. A high positive end-expiratory pressure, low tidal volume ventilatory strategy improves outcome in persistent acute respiratory distress syndrome: A randomized, controlled trial. Crit Care Med.
4. 、 van den Berg PC, Jansen JR, Pinsky MR. Effect of positive pressure on venous return in volume-loaded cardiac surgical patients. J Appl Physiol.
5. 、 George DL, Falk PS, Wunderink RG, et al. Epidemiology of ventilator acquired pneumonia based on protected bronchoscopic sampling. Am J Respir Crit Care Med.
6. ; 158:1839-1847Safdar N, Said A, Lucey MR. The role of selective digestive decontamination for reducing infection in patients undergoing liver transplantation: a systematic review and meta-analysis. Liver Transpl.
7. ; 342: 1301-1308.
8. ; 92: 1223-1231.
9. ; 10817-827.
10. ; 33: 21-30.
11. ; 34: 1311-1318.

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Some Issues on Mechanical Ventilation in Surving Sepsis Campaign Guideline 2008

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