The application of macrolides in the treatment of asthma_Chinese Journal of Respiratory and Critical Care Medicine

Authors：

YAO Rong , LIANG Zongan

Department of Respiratory Medicine, West China Hospital, Sichuan University. Chengdu, Sichuan ,610041, China;

Corresponding?author：

Keywords：

大環內酯; 抗生素; 治療; 哮喘

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抗生素在哮喘當中的應用一直備受爭議。近年的研究主要集中于大環內酯類抗生素(Macrolides)的非抗菌效應，已有研究發現l4元環和l5元環的大環內酯類抗生素具有類激素樣抗炎活性[1]。作為新一代大環內酯類衍生物的泰利霉素(Telithromycin)由于其獨特的抗細菌耐藥性，一問世便受到廣泛關注，而近期公布的TELICAST試驗(The Telithromycin，Chlamydophila，and Asthma Trial)中關于其在哮喘急性加重療效方面的結果更是令人振奮。該試驗發現，對已確診的哮喘急性加重期患者，在指南推薦的常規治療基礎上加用為期10 d的泰利霉素口服(800 mg／d)，可使哮喘癥狀評分明顯下降，肺功能指標改善，但其發揮療效的機制尚不十分清楚[2]。

Citation： YAO Rong,LIANG Zongan. The application of macrolides in the treatment of asthma. Chinese Journal of Respiratory and Critical Care Medicine, 2007, 6(5): 326-328. doi: Copy

1.	Avila PC，Boushey HA.Macrolides，asthma，inflammation，and infection.Ann Allergy Asthma Immunol，2000，84：565-568.
2.	Johnston SL，Blasi F，Black PN，et al.The effect of telithromycin in acute exacerbations of asthma.N Engl J Med，2006，354：1589-1600.
3.	顧覺奮，周海斌.新一代大環內酯類抗生素—酮內酯類簡介.抗感染藥學，2006，3：49-53.
4.	王登旭，王二兵，彭向前.泰利霉素的藥理作用及臨床應用.中國藥物與臨床，2005，5：524-525.
5.	Balfour JA，Figgitt DP.Telithromycin.Drugs，2001，61：815-829.
6.	Felmingham D.Microbiological profile of telithromycin，the first ketolides antimicrobial.Clin Microbiol Infect，2001，7（Suppl 3）：2-10.
7.	Lieberman D，Lieberman D，Printz S，et al.Atypical pathogen infection in adults with acute exacerbation of bronchial asthma.Am J Respir Crit Care Med，2003，167：406-410.
8.	Blasi F.Atypical pathogens and respiratory tract infections.Eur Respir J，2004，24：171-181.
9.	Little FF.Treating acute asthma with antibiotics--not quite yet.N Engl J Med，2006，354：1632-1634.
10.	Bousquet J，Jeffery PK，Busse WW，et al Asthma.From bronchoconstriction to airways inflammation and remodeling.Am J Respir Crit Care Med，2000，161，1720-1745.
11.	Garey KW，Alwani A，Danziger LH，et al.Tissue reparative effects of macrolide antibiotics in chronic inflammatory sinopulmonary diseases.Chest，2003，123：261-265.
12.	Ogawa N，Sugawara Y，Fujiwara Y，et al.Roxithromycin promotes lymphocyte apoptosis in Dermatophagoides-sensitive asthma patients.Eur J Pharmacol，2003，474：273-281.
13.	Wales D，Woodhead M.The anti-inflammatory effects of macrolides.Thorax，1999，54：58-62.
14.	Kohyama T，Takizawa H，Kawasaki S，et al.Fourteen-member macrolides inhibit interleukin-8 release by human eosinophils from atopic donors.Antimicrob Agents Chemother，1999，43：907-911.
15.	沈慧，沈策.大環內酯類藥物對免疫調節作用的研究進展.國外醫學呼吸系統分冊，2005，25：818-821.
16.	Tagaya E，Tamaoki J，Kondo M，et al.Effect of a short course of clarithromycin therapy on sputum production in patients with chronic airway hypersecretion.Chest，2002，122：213-218.
17.	Niven AS，Argyros G.Alternate treatment in asthma.Chest，2003，123：1254-1265.
18.	Manchee GR，Eddershaw PJ，Ranshaw LE，et al.The aliphatic oxidation of salmeterol to alpha-hydroxysalmeterol in human liver microsomes is catalyzed by CYP3A.Drug Metab Dispos，1996，24：555-559.
19.	Nosaka H，Nadai M，Kato M，et al.Effect of a newly developed ketolide antibiotic，telithromycin，on metabolism of theophylline and expression of cytochrome P450 in rats.Life Sci，2006，79：50-56.
20.	Peeters TL.Erythromycin and other macrolides as prokinetic agents.Gastroenterology，1993，105：1886-1899.
21.	Caramori G，Papi A.Telithromycin in acute exacerbations of asthma.N Engl J Med，2006，355：96-98.

1. Avila PC，Boushey HA.Macrolides，asthma，inflammation，and infection.Ann Allergy Asthma Immunol，2000，84：565-568.
2. Johnston SL，Blasi F，Black PN，et al.The effect of telithromycin in acute exacerbations of asthma.N Engl J Med，2006，354：1589-1600.
3. 顧覺奮，周海斌.新一代大環內酯類抗生素—酮內酯類簡介.抗感染藥學，2006，3：49-53.
4. 王登旭，王二兵，彭向前.泰利霉素的藥理作用及臨床應用.中國藥物與臨床，2005，5：524-525.
5. Balfour JA，Figgitt DP.Telithromycin.Drugs，2001，61：815-829.
6. Felmingham D.Microbiological profile of telithromycin，the first ketolides antimicrobial.Clin Microbiol Infect，2001，7（Suppl 3）：2-10.
7. Lieberman D，Lieberman D，Printz S，et al.Atypical pathogen infection in adults with acute exacerbation of bronchial asthma.Am J Respir Crit Care Med，2003，167：406-410.
8. Blasi F.Atypical pathogens and respiratory tract infections.Eur Respir J，2004，24：171-181.
9. Little FF.Treating acute asthma with antibiotics--not quite yet.N Engl J Med，2006，354：1632-1634.
10. Bousquet J，Jeffery PK，Busse WW，et al Asthma.From bronchoconstriction to airways inflammation and remodeling.Am J Respir Crit Care Med，2000，161，1720-1745.
11. Garey KW，Alwani A，Danziger LH，et al.Tissue reparative effects of macrolide antibiotics in chronic inflammatory sinopulmonary diseases.Chest，2003，123：261-265.
12. Ogawa N，Sugawara Y，Fujiwara Y，et al.Roxithromycin promotes lymphocyte apoptosis in Dermatophagoides-sensitive asthma patients.Eur J Pharmacol，2003，474：273-281.
13. Wales D，Woodhead M.The anti-inflammatory effects of macrolides.Thorax，1999，54：58-62.
14. Kohyama T，Takizawa H，Kawasaki S，et al.Fourteen-member macrolides inhibit interleukin-8 release by human eosinophils from atopic donors.Antimicrob Agents Chemother，1999，43：907-911.
15. 沈慧，沈策.大環內酯類藥物對免疫調節作用的研究進展.國外醫學呼吸系統分冊，2005，25：818-821.
16. Tagaya E，Tamaoki J，Kondo M，et al.Effect of a short course of clarithromycin therapy on sputum production in patients with chronic airway hypersecretion.Chest，2002，122：213-218.
17. Niven AS，Argyros G.Alternate treatment in asthma.Chest，2003，123：1254-1265.
18. Manchee GR，Eddershaw PJ，Ranshaw LE，et al.The aliphatic oxidation of salmeterol to alpha-hydroxysalmeterol in human liver microsomes is catalyzed by CYP3A.Drug Metab Dispos，1996，24：555-559.
19. Nosaka H，Nadai M，Kato M，et al.Effect of a newly developed ketolide antibiotic，telithromycin，on metabolism of theophylline and expression of cytochrome P450 in rats.Life Sci，2006，79：50-56.
20. Peeters TL.Erythromycin and other macrolides as prokinetic agents.Gastroenterology，1993，105：1886-1899.
21. Caramori G，Papi A.Telithromycin in acute exacerbations of asthma.N Engl J Med，2006，355：96-98.

Chinese Journal of Respiratory and Critical Care Medicine

The application of macrolides in the treatment of asthma

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