再次全肺灌洗治療肺泡蛋白沉積癥一例_Chinese Journal of Respiratory and Critical Care Medicine

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朱際平 , 鄭玲 , 于力克

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Keywords：

全肺灌洗; 肺泡蛋白沉積癥

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肺泡蛋白沉積癥（PAP）是一種罕見的呼吸系統疾病，主要是由于肺泡腔中大量的嗜酸性富含脂質和蛋白質的物質沉積[1]，可分為先天性、繼發性和獲得性三類。目前PAP最有效的治療是全肺灌洗[2]。多數文獻報道的是對初次診斷的PAP患者的全肺灌洗治療。2005年我們收治了1例PAP患者，經全肺灌洗治療10個月后復診，根據其影像學表現再次進行全肺灌洗治療，現報告如下。

Citation： 朱際平,鄭玲,于力克. 再次全肺灌洗治療肺泡蛋白沉積癥一例. Chinese Journal of Respiratory and Critical Care Medicine, 2007, 6(1): 68-69. doi: Copy

1.	Trapnell BC, Whitsett JA, Nakata K. Pulmonary alveolar proteinosis. N Engl J Med,2003，349:2527-2539.
2.	Beccaria M, Luisetti M, Rodi G,et al. Long-term durable benefit after whole lung lavage in pulmonary alveolar proteinosis.Eur Respir J,2004，23: 526-531.
3.	Ramirez J, Schultz RB, Dutton RE. Pulmonary alveolar proteinosis: a new technique and rationale for treatment. Arch Intern Med,1963，112:419-431.
4.	Goldstein LS, Kavuru MS, Curtis-McCarthy P, et al. Pulmonary alveolar proteinosis: clinical features and outcomes. Chest, 1998，114: 1357-1362.
5.	Richard A.Morris Manual of Clinical problems in pulmonary medicine 5th ed .天津：天津科技翻譯出版公司,2003.524.
6.	蔡后榮，崔蘇陽，金陵，等.體外循環膜氧合支持下全肺灌洗治療肺泡蛋白沉積癥一例并文獻復習.中華結核和呼吸雜志，2005，28：242-244.
7.	Simpson RI, Ramsay MA, Millard MW, et al. Management of pulmonary alveolar proteinosis by repeated bronchoalveolar lavage. Proc (Bayl Univ Med Cent),2000，13:119-120.
8.	Seymour JF, Presneill JJ.Pulmonary alveolar proteinosis:progress in the first 44 years. Am J Respir Crit Care Med, 2002，166:215-235.

1. Trapnell BC, Whitsett JA, Nakata K. Pulmonary alveolar proteinosis. N Engl J Med,2003，349:2527-2539.
2. Beccaria M, Luisetti M, Rodi G,et al. Long-term durable benefit after whole lung lavage in pulmonary alveolar proteinosis.Eur Respir J,2004，23: 526-531.
3. Ramirez J, Schultz RB, Dutton RE. Pulmonary alveolar proteinosis: a new technique and rationale for treatment. Arch Intern Med,1963，112:419-431.
4. Goldstein LS, Kavuru MS, Curtis-McCarthy P, et al. Pulmonary alveolar proteinosis: clinical features and outcomes. Chest, 1998，114: 1357-1362.
5. Richard A.Morris Manual of Clinical problems in pulmonary medicine 5th ed .天津：天津科技翻譯出版公司,2003.524.
6. 蔡后榮，崔蘇陽，金陵，等.體外循環膜氧合支持下全肺灌洗治療肺泡蛋白沉積癥一例并文獻復習.中華結核和呼吸雜志，2005，28：242-244.
7. Simpson RI, Ramsay MA, Millard MW, et al. Management of pulmonary alveolar proteinosis by repeated bronchoalveolar lavage. Proc (Bayl Univ Med Cent),2000，13:119-120.
8. Seymour JF, Presneill JJ.Pulmonary alveolar proteinosis:progress in the first 44 years. Am J Respir Crit Care Med, 2002，166:215-235.

Chinese Journal of Respiratory and Critical Care Medicine

再次全肺灌洗治療肺泡蛋白沉積癥一例

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