To search for the relationship between immune state and tumor metastases, CD3,CD4,CD8 and CD44 contents in 13 speciments of fine needle aspiration (FNA) from thyroid cancer patients were detected by the flowcytometry (FCM) and comparison between thyroid cancer and benign tumor was made. The result showed :in thyroid cancer group, CD＋3，CD＋4 cells and the ratio of CD＋4/CD＋8 reduced significantly (Ｐ＜0.01),and CD＋8 cell increased significantly (Ｐ＜0.01), in metastases group,this change was much significantly. CD44 expressed significantly higher in cancer group than that of the benign thyroid neoplasms, and the change was related to the tumor metastases. The results indicate that CD44 can be as a marker of tumor and indicator of metastases. The disturbance of immune system results in active expression of CD44 by tumor cells, so, lead to metastases. It is helpful to the diagnosis of thyroid cancer, assessment of metastases and management in surgery.
Citation：
Zhao Jun,Liu Shaolan,Shan Licheng,et al.. DETECTATION OF CD3,CD4,CD8 AND CD44 CONTENT OF FINE NEEDLE ASPIRATION SPECIMENTS IN THYROID CANCER PATIENTS. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 1998, 5(5): 265-266. doi:
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Copyright ? the editorial department of CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY of West China Medical Publisher. All rights reserved
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- 1. 曲大偉，趙武，譚毓銓等.純系小鼠阻塞性黃疸模型T淋巴細胞亞群及其功能變化.中華實驗外科雜志，1994； 11(1)∶3.
- 2. 王文閣譯.CD3抗體激活的殺傷細胞及其抗腫瘤作用.國外醫學免疫學分冊，1991； 14(5)∶257.
- 3. Picker LJ, Nakache M, Butcher EC, et al. Expression and modulation of CD44 variant isoforms in humans. J Cell Biol, 1989; 109(3)∶927.
- 4. Gunthert U, Hofmann M, Rudy W, et al. A new variant of glycoprotein CD44 confers metastatic potential to rat carcinoma cells. Cell, 1991; 65(1)∶13.
- 5. Heider KH, Hofmann M, Horst E, et al. A human homologue of the rat metastasisassociated variant of CD44 is expressed in colorectal carcinomas and adenomatous polyps. J Cell Biol, 1993; 120(2)∶227.
- 6. Herrlich P, Margot Z, Steeven T, et al. CD44 splice variants: metastases meet lymphocytes. Immuno Today, 1993; 14(8)∶395.
