【Abstract】Objective The effects of tumor infiltrating lymphocytes (TIL) on cellular immunologic function of patients with breast cancer were studied. Methods Twenty five patients with breast cancer were treated by the TIL that were isolated from tissue of tumor. T cell subgroups and natural killer cell (NK cell) activity of peripheral blood, the levels of serum soluble interleukin-2 receptor (sIL-2R) were assayed before and after treatment. Results CD3, CD4, CD4/CD8 and NK cell activity were ascended obviously, and CD8, sIL-2R were descended obviously after the treatment of TIL. Conclusion TIL can enhance the cellular immunologic function of patients with breast cancer.
Citation：
LI Cheng,LU Junmin,GUAN Xin,et al.. EFFECTS OF TUMOR INFILTRATING LYMPHOCYTES ON CELLULAR IMMUNOLOGIC FUNCTION OF PATIENTS WITH BREAST CANCER. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 2001, 8(5): 329-330. doi:
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顧琴龍，林言箴，尹浩然等. TIL細胞治療對惡性腫瘤患者免疫功能的影響 〔Ｊ〕. 中國腫瘤臨床， 1996； 23（3）∶184.
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- 1. Rosenberg SA, Spiess P, Diane S, et al. A new approach to theadoptive immunotherapy of cancer with tumorinfiltrating lymphocytes 〔Ｊ〕. Science, 1986; 233(4770)∶1318.
- 2. Whiteside TL, Miescher S, Mac Donald HR. Separation lymphocytes from tumor cells in human solid tumors. A comparison between velocity sedimentation and discontinuous density gradients 〔Ｊ〕. J Immunol Methods, 1986; 90(2)∶221.
- 3. 趙長春，王庭桂，楊春生主編. 臨床免疫檢驗學 〔M〕. 天津： 天津科學技術出版社，1990∶ 351～364.
- 4. 劉劍勇，李挺，楊南武等. 肝癌疫苗激活的腫瘤浸潤性淋巴細胞對血清sIL2R水平的影響及意義 〔Ｊ〕. 廣西醫學， 1999； 21（5）∶835.
- 5. 陳建思，陳漢華，劉劍侖等. 乳腺癌患者手術前后血清可溶性白細胞介素2受體水平的變化 〔Ｊ〕. 中國普外基礎與臨床雜志， 1999； 6（5）∶284.
- 6. 房家智，宋連生，葉紅軍等. 胃癌術后患者腫瘤浸潤性淋巴細胞治療的臨床觀察 〔Ｊ〕. 中國腫瘤臨床， 1997； 24（11）∶869.
- 7. 顧琴龍，林言箴，尹浩然等. TIL細胞治療對惡性腫瘤患者免疫功能的影響 〔Ｊ〕. 中國腫瘤臨床， 1996； 23（3）∶184.
