ObjectiveTo observe the effect of 5Fluorouracil(5FU) on the exocrine pancreas. MethodsThe effects of 5FU were investigated in 8 patients who had undergone pancreatoduodenectomy. The pancreatic juice was temporarily diverted to the exterior via a pancreatic duct catheter.Ten days after operation,the patients were injected intravenously with 5FU 500 mg/d for three days. The samples of pancreatic juice were taken for measurement of amylase,pH, HCO3-, Na+, K+, Cl-, Ca2+ and Mg2+.ResultsThe amylase, pH, HCO3-, Na+, K+, Cl-, Ca2+ and Mg2+ did not alteredsignificantly before and after 5FU injection.Conclusion5FU has no shortterm effect on exocrine pancreas. Therefore, improvement of acute pancreatitis cannot be achieved through inhibiting pancreatic enzymes synthesis.
Citation：
JIANG Lisheng,YAO Yougui,PENG Qifang.. Effect of 5Fluorouracil on the Exocrine Pancreas. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 2003, 10(3): 266-267. doi:
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Copyright ? the editorial department of CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY of West China Medical Publisher. All rights reserved
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陳曉理，黃興蘭，吳浩，等. 5FU對急性胰腺炎炎癥相關細胞因子的調節作用 [Ｊ].中華外科雜志，2001; 39(4)∶271.
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陳曉理，黃興蘭，吳浩，等. 常用免疫抑制劑對急性胰腺炎免疫異常的調節作用 [Ｊ].中國普外基礎與臨床雜志，2002; 9(6)∶384.
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- 1. Johnson RM, Barone RM, Newson BL,et al. Treatment of experimental acute pancreatitis with 5Fluorouracil (5FU) [J]. Am J Surg, 1973; 125(2)∶211.
- 2. Bielecki K, Wiedmann M, Meyer F,et al. Effect of 5Fluorouracil on secretion and synthesis of pancreatic digestive enzymes: studies in isolated pancreatic acini and perfused pancreas derived from normal rats and from rats with acute necrotizing pancreatitis [Ｊ]. Pancreas, 1994; 9(4)∶518.
- 3. Steinberg WM, Schlesselman SE. Treatment of acute pancreatitis. Comparison of animal and human studies [Ｊ]. Gastroenterology, 1987; 93(6)∶1420.
- 4. Niederau C, Niederau M, Luthen R,et al. Pancreatic exocrine secretion in acute experimental pancreatitis [Ｊ]. Gastroenterology, 1990; 99(4)∶1120.
- 5. 陳曉理，黃興蘭，吳浩，等. 5FU對急性胰腺炎炎癥相關細胞因子的調節作用 [Ｊ].中華外科雜志，2001; 39(4)∶271.
- 6. 陳曉理，黃興蘭，吳浩，等. 常用免疫抑制劑對急性胰腺炎免疫異常的調節作用 [Ｊ].中國普外基礎與臨床雜志，2002; 9(6)∶384.
