【Abstract】Objective To assess the value of 99Tcm-tetrofosmin imaging in discriminating malignant mass from benign breast mass.Methods From June 2000 to January 2002, 104 patients with breast mass detected by clinical examination were included. After 740 MBq 99Tcm-tetrofosmin was injected intravenously in the contralateral arm to the breast lesion, the front and the lateral images were collected in 5 min, 10 min and 20 min respectively. 99Tcm-tetrofosmin imaging localized in breast was defined as the positive sign of affinitive tumor. All patients underwent operation within one week. Using histological assessment as a golden standard, the sensitivity, specificity, positive and negative predictive value for 99Tcm-tetrofosmin SPECT of the breast were calculated respectively. Results The sensitivity of 99Tcm-tetrofosmin imaging for discriminating between malignant mass and benign mass in palpable breast lesions was 87%, specificity 84%, positive and negative predictive value were 85% and 86% respectively. Conclusion The results suggested that 99Tcm-tetrofosmin imaging is a valuable tool for distinguishing between malignant mass and benign mass in palpable breast lesions.
Citation：
ZHOU Leilei,SONG Wenzhong,CHEN Mingxi,LIU Jinping,HUANG Jin,XIE Hongjun,WANG Xiaodong,LUO Jing.. A Clinical Study about 99Tcm-Tetrofosmin Imaging in Detection of Suspicious Palpable Breast Lesions. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 2005, 12(6): 609-611. doi:
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1 Kerlikowske K, Grady D, Barclay J, et al. Effect of age, breast density, and family history on the sensitivity of first screening mammography
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- 1. 1 Kerlikowske K, Grady D, Barclay J, et al. Effect of age, breast density, and family history on the sensitivity of first screening mammography
[Ｊ]. JAMA, 1996; 276(1)332 中華人民共和國衛生部醫政司. 核醫學診斷與治療規范 [S]. 第1版.北京: 中國科學技術出版社, 1997241~2423 Taillefer R. The role of 99Tcmsestamibi and other conventional radiopharmaceuticals in breast cancer diagnosis [Ｊ]. Semin Nucl Med, 1999; 29(1)164 章斌.99mTetetrofosmin 在乳腺癌及其轉移灶顯像中的應用[Ｊ]. 國外醫學放射醫學核醫學分冊, 2001; 25(1)125 de Jong M, Bernard BF, Breeman WA, et al. Comparison of uptake of 99mTcMIBI, 99mTctetrofosmin and 99mTcQ12 into human breast cancer cell lines [Ｊ]. Eur J Nucl Med, 1996; 23(10)13616 唐謹. 核素乳腺顯像的現狀和今后工作的思考 [Ｊ]. 中華核醫學雜志，1997; 17(1)697 Mansi L, Rambaldi PF, Cuccurullo V, et al. Diagnostic and prognostic role of 99mTctetrofosmin in breast cancer [Ｊ]. Q J Nucl Med, 1997; 41(3)2398 Mansi L, Rambaldi PF, Procaccini E, et al. Scintimammography with technetium99m tetrofosmin in the diagnosis of breast cancer and lymph node metastases [Ｊ]. Eur J Nucl Med, 1996; 23(8)9329 宋文忠,周蕾蕾,陳明曦，等. 99mTetetrofosmin 顯像對乳腺癌及腋窩淋巴結轉移診斷價值評價 [Ｊ]. 中國醫學影像技術, 2003； 19(11)153110 Obwegeser R, Berghammer P, MuellauerErtl S, et al. 99mTctetrofosmin scintigraphy for the evaluation of suspicious palpable and nonpalpable breast lesions [Ｊ]. Breast Cancer Res Treat, 2000; 62(3)253.
