The Effect of Simvastatin in Patient with Chronic Renal Insufficiency MOU Hong,CHEN Tong,HE Long_West China Medical Journal

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羥甲戊二酰輔酶A還原酶抑制劑; 辛伐他汀; 慢性腎功能不全

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目的：研究羥甲戊二酰輔酶A還原酶抑制劑辛伐他汀治療慢性腎功能不全的臨床療效。方法：選擇慢性腎功能衰竭患者共40例，隨機分成兩組，在原有基礎治療上治療組20例患者予以辛伐他汀治療，對照組20例單純以基礎治療，在24周時監測TC、TG、24 h尿蛋白、Scr、BUN、C-反應蛋白的值。結果：與治療前相比，兩組TC、TG、24 h尿蛋白、Scr、BUN、C-反應蛋白均明顯下降，與對照組相比，治療組血脂有顯著下降（P＜0.01）而且24h尿蛋白、Scr、BUN、C-反應蛋白均明顯下降(P＜0.05)。結論：辛伐他汀能降低蛋白尿，延緩慢性腎功能不全的進展

Citation： MOU Hong,CHEN Tong,HE Long. The Effect of Simvastatin in Patient with Chronic Renal Insufficiency MOU Hong,CHEN Tong,HE Long. West China Medical Journal, 2008, 23(1): 130-130. doi: Copy

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1. [１]Nakamura T，Ushiyama C，Hirokawa K，et a1．Effect of cerivastatin on proteinuria and urinary podocytes in patients with chronic glomlo nephritis[J].Nephrol Dial Transplant，2002,17(5)：798－802．.
2. 李航，李學旺，段琳，等，洛伐他汀對系膜細胞核因子-kB活性及炎性細胞因子表達的影響[Ｊ]．中華腎臟病雜志，2001，17（4）；242-245．.
3. 陳楠，李婭，王偉銘，等，辛伐他汀對大鼠腎間質成纖維細胞的影響[Ｊ]．腎臟病與透析腎移植雜志，2000，9（5）：411-415．.
4. Danesh FR,Sadeghi M M,Amro N,et a1.3 Hydroxy-3-methyl-glutaryl CoA reductase inhibitors prevent high glucose-induced proliferation of mesangial cells via modulation of Rho GTPase／p21 signaling pathway:Implications for diabetic nephropathy[J].Proc Natl Acad Sci,2002,11,99:8301-8305..
5. Yokota N，O Donnell M，DanM s F，ct a1．Protective effect of HMG～CoA reductase inhibitor on experimental renal ischemia－reperfusion injury[J]．Am J Nephrol，2003，23：13－17．.
6. Fehr T，Kahlert C，Fierz W，et a1．Statin induced immunomodulatory effects on human T cells in vivo[J]．Atherosclerosis，2004，175:83－90．.

West China Medical Journal

The Effect of Simvastatin in Patient with Chronic Renal Insufficiency MOU Hong,CHEN Tong,HE Long

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