The Clinical Analysis of 48 Cases of Psoriasis with Proteinuria_West China Medical Journal

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銀屑病; 蛋白尿; 病理

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目的：探討銀屑病合并蛋白尿患者的臨床特點。方法：回顧性分析1996年1月～2005年8月收治的銀屑病合并蛋白尿者臨床資料，并與銀屑病非蛋白尿者的臨床特點比較。結果：銀屑病合并不明原因蛋白尿48例，皮膚受累面積與蛋白尿程度無相關關系（P＞0.05），但銀屑病合并蛋白尿組的銀屑病病程更短,腎臟病理熒光表現為IgA沉積為主。蛋白尿組皮膚受累面積與非蛋白尿組皮膚受累面積比較，無統計學意義（P＞0.05），蛋白尿組和非蛋白尿組的病程也無統計學差異（P＞0.05）。結論：銀屑病合并不明原因蛋白尿值得重視，有必要對其發病機制、臨床特點、病理特征進行深入的研究。

Citation： ZHONG Hui,MA Aijing,JIANG Xian. The Clinical Analysis of 48 Cases of Psoriasis with Proteinuria. West China Medical Journal, 2008, 23(1): 117-118. doi: Copy

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2.	Madeddu P，Ena P,Glorioso N,et al.High prevalence of microproteinuria,an early index of renal impairment,in patients withdiffuse psoriasis[J].Nephron，1988,48(3):222-225．.
3.	Alenius GM,Stegmayr BG,Dahlqvist SR.Renalabnormalities in a population of patients with psoriatic arthritis[J].Scand JRheumatol，2001,30(5):271-4．.
4.	Szepietowski JC,Bielicka E,Wasik F,et al.Microalbuminuria as a subclinical marker of renal in subjects with psoriasis vulgaris[J].J Eur Acad Dermatol Venereol，2000,14(6):513-514．.
5.	Yamamoto M,Yorioka T,et al.A Case of IgA nephropathy associated with psoriasis vulgaris[J].Nippon Jinzo Gakkai Shi，1994,36(6):779-783．.
6.	Tejinder S,Marjorie F,John J，et al.IgA nephropathy in psoriasis[J].Am J Nephrol，1998,18:425-429．.
7.	陳惠萍，王文榮，等．銀屑病所致的腎損害[J].腎臟病與透析移植雜志，2003,12(4):393-396．.
8.	Yamaji H，Shikata K,Wada J,et al.A case of membranous nephropathy associated with psoriasis vulgaris[J].Acta Derm Venereol，1996,76(6):492．.
9.	Kida H,Asamoto T,Abe T,et al.Psoriasis vulgaris associated with mesangiocapillary glomerulonephritis[J].Clin Nephrol，1985,23(50）：255-257．.
10.	Saxena S,Verma K,Bhuyan UN,et al.Amyloidosis complicating psoriatic arthropathy[J].J Assoc Physicians India，1992,40(9):609-610．.
11.	Hall RP,Peck GL,Lawley TJ.Circulating IgA immune complexes in patients with psoriasis[J].J Invest Dermatol，1983,80(6):465-468．.
12.	楊劍輝，井艷華，張紀蕓.銀屑病患者腎臟損害的臨床與病理觀察[J].中華皮膚科雜志，2002，35（2）:155．.
13.	于厚南,梅長林，廖萬清.銀屑病并發慢性腎功能衰竭8例報道[J].腎臟病與透析腎移植雜志，1997,6(3)：242-243．.

1. [１]Omdal R，Husby G．Renal affection in patients with ankylosing sponylitis and psoriatic arthritis[J]．Clin Rheumatol，1987,6(1):74-79．.
2. Madeddu P，Ena P,Glorioso N,et al.High prevalence of microproteinuria,an early index of renal impairment,in patients withdiffuse psoriasis[J].Nephron，1988,48(3):222-225．.
3. Alenius GM,Stegmayr BG,Dahlqvist SR.Renalabnormalities in a population of patients with psoriatic arthritis[J].Scand JRheumatol，2001,30(5):271-4．.
4. Szepietowski JC,Bielicka E,Wasik F,et al.Microalbuminuria as a subclinical marker of renal in subjects with psoriasis vulgaris[J].J Eur Acad Dermatol Venereol，2000,14(6):513-514．.
5. Yamamoto M,Yorioka T,et al.A Case of IgA nephropathy associated with psoriasis vulgaris[J].Nippon Jinzo Gakkai Shi，1994,36(6):779-783．.
6. Tejinder S,Marjorie F,John J，et al.IgA nephropathy in psoriasis[J].Am J Nephrol，1998,18:425-429．.
7. 陳惠萍，王文榮，等．銀屑病所致的腎損害[J].腎臟病與透析移植雜志，2003,12(4):393-396．.
8. Yamaji H，Shikata K,Wada J,et al.A case of membranous nephropathy associated with psoriasis vulgaris[J].Acta Derm Venereol，1996,76(6):492．.
9. Kida H,Asamoto T,Abe T,et al.Psoriasis vulgaris associated with mesangiocapillary glomerulonephritis[J].Clin Nephrol，1985,23(50）：255-257．.
10. Saxena S,Verma K,Bhuyan UN,et al.Amyloidosis complicating psoriatic arthropathy[J].J Assoc Physicians India，1992,40(9):609-610．.
11. Hall RP,Peck GL,Lawley TJ.Circulating IgA immune complexes in patients with psoriasis[J].J Invest Dermatol，1983,80(6):465-468．.
12. 楊劍輝，井艷華，張紀蕓.銀屑病患者腎臟損害的臨床與病理觀察[J].中華皮膚科雜志，2002，35（2）:155．.
13. 于厚南,梅長林，廖萬清.銀屑病并發慢性腎功能衰竭8例報道[J].腎臟病與透析腎移植雜志，1997,6(3)：242-243．.

West China Medical Journal

The Clinical Analysis of 48 Cases of Psoriasis with Proteinuria

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