Association of TGF-β1 Gene Polymorphism with IgA Nephropathy_West China Medical Journal

Authors：

1Division of Nephrology,2Division of Rheumatology,West China Hospital,Sichuan University,Chengdu 610041,China;

Corresponding?author：

Keywords：

IgA腎病; TGF-β1; 基因多態性

Video：

Export PDF Favorites Scan Get Citation

Abstract Full text Figures/Tables Video References Cited by

目的：對TGF-β1的G-800A，C-509T，T869C和G915C多態性位點與IgA腎病及其臨床表現之間的相關性進行了分析。方法：納入119例經腎活檢證實為IgA腎病的患者和116例健康正常成人作為對照組。采用多聚酶鏈式反應-限制片段長度多態性分析和多聚酶鏈式反應-擴增受阻突變體系方法測定TGF-β1的G-800A，C-509T，T869C和G915C多態性位點的基因型，分析其與IgA腎病發病以及臨床表現的相關性。結果：研究對象中G-800A和G+915C這兩個位點沒有多態性。IgAN患者C-509T位點的等位基因型分布與正常對照具有顯著性差異（Ｐ＜0.05），且IgAN患者TT純合子的頻率顯著高于對照組（33% vs 20%,Ｐ=0.02）。C869T位點等位基因的分布無顯著性差異。C-509T和C869T位點等位基因分布和患者臨床表現無明顯的相關性。結論：TGF-β1基因C-509T位點的T等位基因攜帶可能與IgA腎病的發病易感性具有相關性。

Citation： QIN Wei,ZHANG Yingjuan,TAN Chunyu,et al.. Association of TGF-β1 Gene Polymorphism with IgA Nephropathy. West China Medical Journal, 2008, 23(1): 61-63. doi: Copy

1.	Barratt,J.and J.Feehally.IgA nephropathy[J].J Am Soc Nephrol,2005,16(7):2088-97.
2.	秦偉,李學旺,秦巖,等.傳遞不平衡檢測IL-1β基因多態性和IgA腎病的相關性[J].華西醫學,2007,22(2):305-307.
3.	Fan J,M,Y Y Ng,P A Hill,et al.Transforming growth factor-beta regulates tubular epithelial-myofibroblast transdifferentiation in vitro[J].Kidney Int,1999,56(4):1455-67.
4.	沈蓮莉,鄧躍毅.轉化生長因子-β1與IgA腎病[J].中國中西醫結合腎病雜志,2006,7(3):180-181.
5.	K/DOQI clinical practice guidelines for chronic kidney disease:evaluation,classification,and stratification[J].Am J Kidney Dis,2002,39(2 Suppl 1):S1-266.
6.	Perrey C,S J Turner,V Pravica,et al.ARMS-PCR methodologies to determine IL-10,TNF-alpha,TNF-beta and TGF-beta 1 gene polymorphisms [J].Transpl Immunol,1999,7(2):p.127-8.
7.	王文新,張青霞,劉宏偉,等.TGF-β1在IgA腎病患者腎組織中的表達[J].基礎醫學與臨床,2002,22(1):43-44.
8.	Grainger D J,K Heathcote,M Chiano,et al.Genetic control of the circulating concentration of transforming growth factor type beta1[J].Hum Mol Genet,1999,8(1)93-7.
9.	Yokota M,S.Ichihara,T L Lin,et al.Association of a T29--＞C polymorphism of the transforming growth factor-beta1 gene with genetic susceptibility to myocardial infarction in Japanese[J].Circulation,2000,101(24):2783-7.
10.	Lim C S,Y S Kim,D W Chae,et al.Association of C-509T and T869C polymorphisms of transforming growth factor-beta1 gene with susceptibility to and progression of IgA nephropathy[J].Clin Nephrol,2005,63(2):61-7.
11.	薛超,李幼姬,李彩霞,等.基于家庭的TGF-β1-509C/T多態性和IgA腎病相關性研究 [J].中國病理生理雜志,2005,21(3):422-426.
12.	Sato F,I Narita,S Goto,et al.Transforming growth factor-beta1 gene polymorphism modifies the histological and clinical manifestations in Japanese patients with IgA nephropathy[J].Tissue Antigens,2004,64(1):35-42.

1. Barratt,J.and J.Feehally.IgA nephropathy[J].J Am Soc Nephrol,2005,16(7):2088-97.
2. 秦偉,李學旺,秦巖,等.傳遞不平衡檢測IL-1β基因多態性和IgA腎病的相關性[J].華西醫學,2007,22(2):305-307.
3. Fan J,M,Y Y Ng,P A Hill,et al.Transforming growth factor-beta regulates tubular epithelial-myofibroblast transdifferentiation in vitro[J].Kidney Int,1999,56(4):1455-67.
4. 沈蓮莉,鄧躍毅.轉化生長因子-β1與IgA腎病[J].中國中西醫結合腎病雜志,2006,7(3):180-181.
5. K/DOQI clinical practice guidelines for chronic kidney disease:evaluation,classification,and stratification[J].Am J Kidney Dis,2002,39(2 Suppl 1):S1-266.
6. Perrey C,S J Turner,V Pravica,et al.ARMS-PCR methodologies to determine IL-10,TNF-alpha,TNF-beta and TGF-beta 1 gene polymorphisms [J].Transpl Immunol,1999,7(2):p.127-8.
7. 王文新,張青霞,劉宏偉,等.TGF-β1在IgA腎病患者腎組織中的表達[J].基礎醫學與臨床,2002,22(1):43-44.
8. Grainger D J,K Heathcote,M Chiano,et al.Genetic control of the circulating concentration of transforming growth factor type beta1[J].Hum Mol Genet,1999,8(1)93-7.
9. Yokota M,S.Ichihara,T L Lin,et al.Association of a T29--＞C polymorphism of the transforming growth factor-beta1 gene with genetic susceptibility to myocardial infarction in Japanese[J].Circulation,2000,101(24):2783-7.
10. Lim C S,Y S Kim,D W Chae,et al.Association of C-509T and T869C polymorphisms of transforming growth factor-beta1 gene with susceptibility to and progression of IgA nephropathy[J].Clin Nephrol,2005,63(2):61-7.
11. 薛超,李幼姬,李彩霞,等.基于家庭的TGF-β1-509C/T多態性和IgA腎病相關性研究 [J].中國病理生理雜志,2005,21(3):422-426.
12. Sato F,I Narita,S Goto,et al.Transforming growth factor-beta1 gene polymorphism modifies the histological and clinical manifestations in Japanese patients with IgA nephropathy[J].Tissue Antigens,2004,64(1):35-42.

West China Medical Journal

Association of TGF-β1 Gene Polymorphism with IgA Nephropathy

Abstract Full text Figures/Tables Video References Cited by

Format

Content