The Correlation of Plasma 5-hytroxytryptamine andHypertension Associated with Obstructive Sleep Apnea Syndrome_West China Medical Journal

Authors：

ZHANG Yanling , LEI Fei , YANG Zhonghua

1Department of Geriatric,West China Hospital,Sichuan University,Chengdu 610041，China;

Corresponding?author：

Keywords：

5-羥色胺; 高血壓; 阻塞性睡眠呼吸暫停綜合征

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目的：探討高血壓合并阻塞性睡眠呼吸暫停綜合征（OSAS）患者血漿5-羥色胺（5-HT）水平的變化。方法：應用放射免疫法測定45例高血壓合并阻塞性睡眠呼吸暫停綜合征患者血清5-HT濃度。結果：高血壓合并阻塞性睡眠呼吸暫停綜合癥患者與單純高血壓不合并OSAS的患者相比，血壓控制較差，而血漿5-HT水平明顯增高（P＜0.05），輕、中、重度阻塞性睡眠呼吸暫停綜合征患者血漿5-HT水平之間相比較有差異（P＜0.05）。結論：5-HT水平可能與血壓控制和阻塞性睡眠呼吸暫停綜合征的發病有關。

Citation： ZHANG Yanling,LEI Fei,YANG Zhonghua. The Correlation of Plasma 5-hytroxytryptamine andHypertension Associated with Obstructive Sleep Apnea Syndrome. West China Medical Journal, 2008, 23(1): 43-44. doi: Copy

1.	李明嫻，王瑩，華樹成，等.長春市20歲以上人群阻塞性睡眠呼吸暫停低通氣綜合征流行病學現況調查[J].中華結核和呼吸雜志，2005，28（12）：833-835.
2.	Foley D,Ancoli-Iarael S,Britz P,Walsh J.Sleep disturbances and chronic diseases in older adults:Results of the 2003 National Sleep Foundation Sleep in America Survey[J].J Psychosom Res,2004,56:497-502.
3.	李明嫻，王瑩，雷虹，等.阻塞性睡眠呼吸暫停綜合征與高血壓的相關性分析[J].中華老年心腦血管病雜志，2005，7（5）：295-297.
4.	Bokinsky G,Miller M,Ault K,et al.Spontaneous platelet activation and aggregation during obstructive sleep apnea and its response to therapy with nasal continuous positive airway pressure[J].Chest,1995,108:625-630.
5.	Carley DW,Radulovacki M.Mirtazapine,a mixed profile serotonin agonist/antagonist,suppresses sleep apnea in rhe rat[J].Am J Respir Crit Care,1999,160:1824-1829.
6.	Kraiczi,H,Hedner,J,Dahlof,P et al.Effect of serotonin uptake inhibition on breathing during sleep and daytime symptoms in obstructive sleep apnea[J].Sleep,1999,22:61.
7.	Berry,RB,Yamaura,EM,Gill,K,Reist,C.Acute effects of paroxetine on genioglossus activity in obstructive sleep apnea[J].Sleep,1999,22:1087.

1. 李明嫻，王瑩，華樹成，等.長春市20歲以上人群阻塞性睡眠呼吸暫停低通氣綜合征流行病學現況調查[J].中華結核和呼吸雜志，2005，28（12）：833-835.
2. Foley D,Ancoli-Iarael S,Britz P,Walsh J.Sleep disturbances and chronic diseases in older adults:Results of the 2003 National Sleep Foundation Sleep in America Survey[J].J Psychosom Res,2004,56:497-502.
3. 李明嫻，王瑩，雷虹，等.阻塞性睡眠呼吸暫停綜合征與高血壓的相關性分析[J].中華老年心腦血管病雜志，2005，7（5）：295-297.
4. Bokinsky G,Miller M,Ault K,et al.Spontaneous platelet activation and aggregation during obstructive sleep apnea and its response to therapy with nasal continuous positive airway pressure[J].Chest,1995,108:625-630.
5. Carley DW,Radulovacki M.Mirtazapine,a mixed profile serotonin agonist/antagonist,suppresses sleep apnea in rhe rat[J].Am J Respir Crit Care,1999,160:1824-1829.
6. Kraiczi,H,Hedner,J,Dahlof,P et al.Effect of serotonin uptake inhibition on breathing during sleep and daytime symptoms in obstructive sleep apnea[J].Sleep,1999,22:61.
7. Berry,RB,Yamaura,EM,Gill,K,Reist,C.Acute effects of paroxetine on genioglossus activity in obstructive sleep apnea[J].Sleep,1999,22:1087.

West China Medical Journal

The Correlation of Plasma 5-hytroxytryptamine andHypertension Associated with Obstructive Sleep Apnea Syndrome

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