KAI1 Gene Expressions in Human Lung Cancer Cell Lines with Different Metastatic Potential_West China Medical Journal

Authors：

ZHAO Ying , JI Yuling

West China Hospital，Sichuan University，Chengdu 610041，China;

Corresponding?author：

Keywords：

KAI1基因; 人肺癌細胞株; 腫瘤轉移

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目的:探討人肺癌細胞轉移潛能與KAI1基因表達的關系。方法:應用real-time RTPCR技術檢測不同轉移潛能的人肺癌細胞株和正常人成纖維細胞株MRC-5中KAI1基因mRNA的表達水平及差異。結果:人肺癌細胞株中KAI1基因mRNA表達水平均顯著低于正常肺成纖維細胞株MRC-5；不同轉移潛能人大細胞肺癌細胞株中KAI1基因mRNA表達水平有明顯差異。結論:KAI1基因表達降低與人肺癌細胞的轉移潛能高低有關！

Citation： ZHAO Ying,JI Yuling. KAI1 Gene Expressions in Human Lung Cancer Cell Lines with Different Metastatic Potential. West China Medical Journal, 2009, 24(1): 58-60. doi: Copy

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5.	Guo XZ，Friess H，Graber Hu，et al.KAII expression is upregulated in early cancer and decreased in the presence of metastases[J].Cancer Res，1996，56（21）:4876-4880..
6.	Lijovic M，Somers G，Frauman AG.KAI1/CD82 protein expression in primary prostate cancer and in BPH associated with cancer[J].Cancer Detect Prev，2002，26（1）:69-77..
7.	Shinohara T，Nishimura N，Hanibuchi M，et al.Transduction of KAI1/CD82 cDNA promotes hematogenous spread of human lungcancer cells in natural killer celldepleted SCID mice[J].Int J Cancer，2001，94（1）:16-23..

1. Dong JT，Lamb PW，RinkerSchaeffer CW，et al.KAI1，a metastasis suppressor gene for prostate cancer on human chromosome 11 p112[J].Science，1995，268（5212）:884886..
2. Adachi M，Taki T，Leki Y，et al.Correlation of KAIⅠ/CD82 gene expression with good prognosis in patients with nonsmall cell lung cancer[J].Cancer Res，1996，56（8）:17511755..
3. Higashiyama M，Kodama K，Yokouchi H，et al.KAIⅠ expression in nonmsall cell lung carcinoma is a novel favorable prognostic factorAn immunohistochernical analysis[J].Cancer，1998，83（3）:466-474..
4. Adachi M，Taki T，Konish T，et al.Novel staging protocol for nonsmall cell lung cancers according to MRP1/CD9 and KAI1 Ⅰ/CD82 gene expression[J].J Clin Oncol，1998，16（4）:1397-1406..
5. Guo XZ，Friess H，Graber Hu，et al.KAII expression is upregulated in early cancer and decreased in the presence of metastases[J].Cancer Res，1996，56（21）:4876-4880..
6. Lijovic M，Somers G，Frauman AG.KAI1/CD82 protein expression in primary prostate cancer and in BPH associated with cancer[J].Cancer Detect Prev，2002，26（1）:69-77..
7. Shinohara T，Nishimura N，Hanibuchi M，et al.Transduction of KAI1/CD82 cDNA promotes hematogenous spread of human lungcancer cells in natural killer celldepleted SCID mice[J].Int J Cancer，2001，94（1）:16-23..

West China Medical Journal

KAI1 Gene Expressions in Human Lung Cancer Cell Lines with Different Metastatic Potential

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