YE SiWei , Xu Xun.
  • the Department of Ophthalmology,The First People’s Hospital,Shanghai Jiaotong University,Shanghai 200080,China;
眼局部給藥方式; 藥代動力學; 安全ocular drug delivery system; pharmacokinetic; safety
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摘要:眼部的局部給藥方式影響著藥物作用的強度,速率及持續時間和不良反應。視網膜,脈絡膜,玻璃體及視神經的疾病則對眼后節的局部給藥治療提出了挑戰,以局部給藥的方式通過解剖學的膜屏障及淚液排泄,并達到在特定部位起治療作用的藥物濃度是其中的重要課題。全身給藥則難以在眼組織積蓄足夠的藥物濃度,且易引起全身性的不良反應。眼表局部應用滴眼劑在淚液循環及角膜,結膜的屏障作用下易發生流失,而有創的給藥方式包括玻璃體內注射,結膜下注射等變得越來越普遍的同時,除對病人造成疼痛不適外,甚至也可導致多種嚴重于疾病本身的并發癥。本文綜述了近幾年來隨著各種眼科疾病分子機制的研究和解明,眼部局部給藥方式及新劑型的藥代動力學及安全性的研究進展。
Abstract: The ocular drug delivery system affects the drug’s efficacy,rate of speed,velocity and adverse reaction.How to deliver the drug with therapeutic local concentrations to the posterior segment remains a challenge. Many invasive methods such as intravitreal injection,subconjunctival injection are generally used,noninvasive method like eye drop can not pass through the barrier of the eye although it is convenient.The recent progress in safty and pharmacokinetic of ocular drug delivery system is reviewed in this article.

Citation： YE SiWei,Xu Xun.. Recent progress in saefty and pharmacokinetic of ocular drug delivery system. West China Medical Journal, 2009, 24(12): 3262-3268. doi: Copy

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