Clinical study on the effect of hormone shock on children with epilepsy and sleep status epilepticus_Journal of Epilepsy

Authors：

CHEN Lilan ,  WANG Jianbiao , SUN Mingxia

Department of Neurology of Wuxi Children's Hospital, Wuxi 214000, China;

Corresponding?author：

WANG Jianbiao, Email: wjb00883@sina.com

Keywords：

Hormone pulse; Epileptic electrical status; Children

DOI：

10.7507/2096-0247.20210081

Video：

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Objective To investigate the effect of high-dose hormone pulse therapy on children with epilepsy and sleep status epilepticus.Methods 60 children were randomly divided into control group (30 cases) and study group (30 cases) according to the admission sequence. The control group was treated with antiepileptic drugs (according to clinical electroencephalogram or syndrome), and the study group was treated with methylprednisolone sodium succinate [20 mg/(kg·d) × 3 days, once a month, for 6 months]. During the period, antiepileptic drugs were taken normally. After 6 months, the curative effect, abnormal EEG and side effects were compared.Results After 6 months of treatment, the clinical conditions of the two groups were significantly improved (effective rate: control group: 19/30 vs. study group: 26/30), and the clinical efficacy (26/30) and EEG improvement (26/30) of the study group were better than those of the control group (P<0.05), weight gain can be improved by diet control and reasonable exercise.Conclusion Hormone pulse therapy for children with epilepsy and sleep status epilepticus in the control of clinical seizures and improve the effect of abnormal EEG, recommended.

Citation： CHEN Lilan, WANG Jianbiao, SUN Mingxia. Clinical study on the effect of hormone shock on children with epilepsy and sleep status epilepticus. Journal of Epilepsy, 2021, 7(6): 497-499. doi: 10.7507/2096-0247.20210081 Copy

1.	張赟, 鄭輯英, 李光來, 等. 癲癇發病機制研究的進展與腦損傷機制. 中華臨床醫師雜志(電子版), 2016, 10(8): 116-119.
2.	鄭芳, 王華. 兒童睡眠中癲癇性電持續狀態的分子遺傳學研究進展. 國際科學雜志, 2021, 48(3): 182-185.
3.	Yilmaz S, Serdaroglu G, Akcay A, et al. Clinical characteristics and outcome of children with electrical status epilepticus during slow wave sleep. Journal of Pediatric Neurosciences, 2014, 9(2): 105-109.
4.	Nissenkorn A, Pappo A, Feldmann Y, et al. Influence of epileptic activity during sleep on cognitive performance in benign childhood epilepsy with centrotemporal spikes. Eur J Paediatr Neurol, 2017, 21(6): 858-863.
5.	Veggiotti P, Peramc, Teutonico F, et al. Therapy of encepha1opathy with status epilepticus during sleep (ESES /CSWS syndrome): an update. Epileptic Disord, 2012, 14(1): 1-11.
6.	Anne T, Berg Samuel F, Berkovic Martin J, et al. 發作和癲癇分類框架術語及概念的修訂: 國際抗癲癇聯盟分類和術語委員會報告, 2005-2009. 中華神經科雜志, 2011, 44(3): 23-28.
7.	De?erliyurt A, Yalnizo?lu D, Bakar EE, et al. Electrical status epilepticus during sleep: A study of 22 patients. Brain and Development, 2015, 37(2): 250-264.
8.	楊志仙, 錢萍. 睡眠中癲癇性電持續狀態的研究進展. 中華實用兒科臨床雜志, 2017, 32(012): 881-886.
9.	Sanchez FI, Peters JM, Akhondiasl A, et al. Reduced thalamic volume in patients with electrical status epilepticus in sleep. Epilepsy research, 2017, 130(12): 74-80.
10.	Gencpinaar P, Dunadr NO, Tekgul H. Electricalstatus epilepticusin sleep (ESES)/ continuous spikes and waves during slow sleep (CSWS) syndrome in children: An electroclinical evaluation according to the EEG patterns. Epilepsy & Behavior, 2016, 61(15): 107-111.
11.	陳靜, 楊志仙, 劉曉燕, 等. 甲潑尼龍沖擊治療對兒童睡眠中癲癇性電持續狀態的療效. 中華兒科雜志, 2014, 52(9): 678-682.
12.	Kramer U, Sagi L, Goldberg-Stern H. Clinical spectrum and medical treatment of children with electrical status epilepticus in sleep (ESES). Epilepsia, 2009, 50(6): 17-24.

1. 張赟, 鄭輯英, 李光來, 等. 癲癇發病機制研究的進展與腦損傷機制. 中華臨床醫師雜志(電子版), 2016, 10(8): 116-119.
2. 鄭芳, 王華. 兒童睡眠中癲癇性電持續狀態的分子遺傳學研究進展. 國際科學雜志, 2021, 48(3): 182-185.
3. Yilmaz S, Serdaroglu G, Akcay A, et al. Clinical characteristics and outcome of children with electrical status epilepticus during slow wave sleep. Journal of Pediatric Neurosciences, 2014, 9(2): 105-109.
4. Nissenkorn A, Pappo A, Feldmann Y, et al. Influence of epileptic activity during sleep on cognitive performance in benign childhood epilepsy with centrotemporal spikes. Eur J Paediatr Neurol, 2017, 21(6): 858-863.
5. Veggiotti P, Peramc, Teutonico F, et al. Therapy of encepha1opathy with status epilepticus during sleep (ESES /CSWS syndrome): an update. Epileptic Disord, 2012, 14(1): 1-11.
6. Anne T, Berg Samuel F, Berkovic Martin J, et al. 發作和癲癇分類框架術語及概念的修訂: 國際抗癲癇聯盟分類和術語委員會報告, 2005-2009. 中華神經科雜志, 2011, 44(3): 23-28.
7. De?erliyurt A, Yalnizo?lu D, Bakar EE, et al. Electrical status epilepticus during sleep: A study of 22 patients. Brain and Development, 2015, 37(2): 250-264.
8. 楊志仙, 錢萍. 睡眠中癲癇性電持續狀態的研究進展. 中華實用兒科臨床雜志, 2017, 32(012): 881-886.
9. Sanchez FI, Peters JM, Akhondiasl A, et al. Reduced thalamic volume in patients with electrical status epilepticus in sleep. Epilepsy research, 2017, 130(12): 74-80.
10. Gencpinaar P, Dunadr NO, Tekgul H. Electricalstatus epilepticusin sleep (ESES)/ continuous spikes and waves during slow sleep (CSWS) syndrome in children: An electroclinical evaluation according to the EEG patterns. Epilepsy & Behavior, 2016, 61(15): 107-111.
11. 陳靜, 楊志仙, 劉曉燕, 等. 甲潑尼龍沖擊治療對兒童睡眠中癲癇性電持續狀態的療效. 中華兒科雜志, 2014, 52(9): 678-682.
12. Kramer U, Sagi L, Goldberg-Stern H. Clinical spectrum and medical treatment of children with electrical status epilepticus in sleep (ESES). Epilepsia, 2009, 50(6): 17-24.

Journal of Epilepsy

Clinical study on the effect of hormone shock on children with epilepsy and sleep status epilepticus

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