A preliminary investigation of adenoid hypertrophy in children with epilepsy_Journal of Epilepsy

Authors：

JIANG Yumei ¹ , LING Zhijuan ¹ , SU Ying ¹ , YE Jinghua ² , PAN Hongguang ¹ , LI Lan ¹ , YE Yuanzhen ² , HU Zhanqi ² , CAO Dezhi ² ,  LIAO Jianxiang ²

1. Department of Otolaryngology, Shenzhen Children’s Hospital, Shenzhen 518038, China;
2. Epilepsy Center, Shenzhen Children’s Hospital, Shenzhen 518038, China;

Corresponding?author：

LIAO Jianxiang, Email: liaojianxiang@vip.sina.com

Keywords：

Epilepsy; Comorbidity; Adenoid hypertrophy; Clinical characteristics; Etiology; Nursing; Children

DOI：

10.7507/2096-0247.20210064

Video：

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Adenoid hypertrophy in children with epilepsy is rarely reported. This paper analyzes the clinical characteristics and incidence of adenoid hypertrophy in children with epilepsy.Methods The clinical data in children with epilepsy from December 2014 to April 2020 in Shenzhen Children's hospital were analyzed retrospectively.Results There were 449 cases diagnosed with adenoid hypertrophy (2.74%) in 16387 children with epilepsy. Among 449 cases of adenoid hypertrophy, 276 males (61.47%) and 173 females (38.53%). The age distribution was: 28 days to 1 year old, 8 cases (2%); 1-3 years old, 78 cases (17%); 3-6 years old 167 cases (37%); 6-12 years old, 153 cases (34%); 12-18 years old, 43 cases (10%). In 40 patients the IgG antibody were positive for EB capsid antigen in 25 (62.5%). In 56 cases of EB virus DNA were detected by fluorescence quantitative PCR, 25 (44.64%) positive, and 21/44 cases (47.72%) were positive by general nucleic acid detection of enteroviruses. The neutrophil reduction rate in peripheral blood was 42.19% in 673 tests, lymphocyteincreased in 292 (43.38%), platelet count increased in 307 (45.61%), abnormal in platelet hematocrit in 311 (46.21%); the mean volume of RBC was decreased in319 (47.39%) tests. The content of was reduced in 20/55 cases (36.36%). 25-hydroxy vitamin D was 33 (44.5%) decreased in 74 cases. The blood glucose was measured in 146 cases, 60 (41.09%) increased, total cholesterol was 31 (40.78%) increased in 76 cases, serum C peptide was 12 (29.26%) increased in 41 cases.Conclusion Adenoid hypertrophy in children with epilepsy may be related to infection, inflammation or immune disorder, which may cause nutritional, metabolic or internal environment disorders. Therefore, there is need of nursing and health education, transferring to specialized centers for diagnosis and treatment.

Citation： JIANG Yumei, LING Zhijuan, SU Ying, YE Jinghua, PAN Hongguang, LI Lan, YE Yuanzhen, HU Zhanqi, CAO Dezhi, LIAO Jianxiang. A preliminary investigation of adenoid hypertrophy in children with epilepsy. Journal of Epilepsy, 2021, 7(5): 397-401. doi: 10.7507/2096-0247.20210064 Copy

1.	Camfield P. Incidence, prevalence and aetiology of seizures and epilepsy in children. Epileptic Disord, 2015, 17(2): 117-123.
2.	李桃利. 癲癇兒童神經精神共患病的研究進展. 復旦學報(醫學版), 2018, 45(4): 578-584, 597.
3.	Joosten KF, Larramona H, Miano S, et al. How do we recognize the child with OSAS?. PediatrPulmonol, 2017, 52(2): 260-271.
4.	元芳芳, 康天, 陳惠軍, 等. 兒童注意缺陷多動障礙及其共患病臨床分析. 新鄉醫學院學報, 2019, 36(12): 1152-1154, 1158.
5.	楊一海, 劉丕松, 劉英. 兒童腺樣體肥大與EB病毒感染的相關性分析. 山西大同大學學報(自然科學版), 2018, 34(4): 58-59, 65.
6.	韓婷. 兒童慢性扁桃體炎和腺樣體肥大EB病毒感染特點的研究. 山東: 青島大學, 2019, 碩士論文.
7.	呂夢穎, 盧大松, 馮勇軍, 等. 腺樣體肥大患者圍手術期醫院感染病原學特點及影響因素分析. 中華醫院感染學雜志, 2018, 28(1): 81-83.
8.	翟長文, 王紓宜. EB病毒在原發性扁桃體彌漫大B細胞淋巴瘤(PT腺樣體肥大并發分泌性中耳炎兒童的淋巴細胞亞群分布[DLBCL)中的表達及其臨床意義. 復旦學報(醫學版), 2014, 41(2): 210-215.
9.	張迎俊, 袁菲, 劉穎慧, 等. 腺樣體肥大兒童的變應原檢測及病因探討. 臨床耳鼻咽喉頭頸外科雜志, 2017, 031(007): 549-551.
10.	Uludag I F, Duksal T, Tiftikcioglu B I, et al. IL-1β, IL-6 and IL1Ra levels in temporal lobe epilepsy. Seizure, 2015, 26: 22-25.
11.	Singh Tanveer, Kaur Taranjot, Goel Rajesh Kumar. Ferulic acid supplementation for management of depression in epilepsy. Neurochemical research, 2017, 42(10): 2940-2948.
12.	操金金, 崔凡, 劉福榮, 等. 降鈣素原、C-反應蛋白、紅細胞沉降率與白細胞計數聯合檢測在呼吸道感染診斷中的應用價值. 中國醫藥導報, 2020, 17(10): 161-164.
13.	柳蔭, 楊娜. 腺樣體肥大并發分泌性中耳炎兒童的淋巴細胞亞群分布. 實用醫學雜志, 2017, 033(14): 2376-2379.
14.	Zahorec R. Ratio of neutrophil to lymphocyte counts—rapid and simpleparameter of systemic inflammation and stress in critically ill. Bratisl LekListy, 2001, 102(1): 5-14.
15.	劉紅釗, 張保朝, 張小林, 等. 血小板體積指數、腦灌注壓對動脈瘤性蛛網膜下腔出血后患者遲發性腦缺血的預測價值. 實用醫學雜志, 2019, 35(19): 3018-3021.
16.	Jeppesen Jesper, Beniczky Sándor, Johansen Peter, et al. Exploring the capability of wireless near infrared spectroscopy as a portable seizure detection device for epilepsy patients. Seizure, 2015, 26: 43-88.
17.	劉釗, 韓俊霞, 朱曉涵, 等. 應用功能近紅外腦成像對伴中央顳區棘波的良性癲癇患兒數學計算認知功能的研究. 北京醫學, 2019, 41(11): 980-983.
18.	劉巍巍, 馬建榮, 鄒麗穎. 經皮氧氣二氧化碳分壓監測在呼吸支持新生兒的應用. 北京醫學, 2020, 42(3): 193-196.
19.	閆中峰, 夏文菁, 李紅, 等. 血氣分析對發作性意識障礙的鑒別診斷意義. 中國實驗診斷學, 2020, 24(2): 208-211.
20.	汪義勝, 陳開蘭. MCV、MCH及RDW檢測在小兒缺鐵性貧血臨床診斷價值的研究. 當代醫學, 2019, 25(12): 38-40.
21.	楊瑞祥. 血清C肽、皮質醇、胰島素與早產兒血糖代謝紊亂的臨床研究. 中國實驗診斷學, 2018, 22(8): 1410-1412.
22.	S?ylemez E, ?ztürk O, Baslo SA, et al. Metabolic syndrome andobstructive sleep apnea syndrome among patients with epilepsy on monotherapy. Epilepsy Behav. 2020 Oct;111: 107296. doi: 10.1016/j.yebeh.2020.107296. Epub 2020Aug 6.
23.	傅蓉, 李鳴, 楊紫茜, 等. 癲癇伴發抑郁的研究進展. 中風與神經疾病雜志, 2019, 36(10): 955-957.
24.	Al-Abri M, Al-Asmi A, Al-Shukairi A, et al. Frequency of obstructive sleep apnea syndrome among patients with epilepsy attending a tertiary neurology clinic. Oman Med J, 2015, 30(1): 31-35.
25.	Miano S, Paolino MC, Peraita-Adrados R, et al. Prevalence of EEG paroxysmal activity ina population of children withobstructive sleep apnea syndrome. Sleep, 2009, 32(4): 522-529.
26.	Miano S, Bachiller C, Gutiérrez M, et al. Paroxysmal activity and seizures associated with sleep breathing disorder inchildren: a possible overlap between diurnal and nocturnal symptoms. Seizure, 2010, 19(9): 547-552.
27.	Oliveira AJ, Zamagni M, Dolso P, et al. Respiratory disorders during sleep in patients with epilepsy: effect of ventilatory therapy on EEG interictal epileptiform discharges. Clin Neurophysiol, 2000, 111 Suppl2: S141-145.
28.	姜濤. 兒童腺樣體肥大的MR表現在癲癇診療中的應用價值初探. 醫學理論與實踐, 2016, 29(12): 1631-1632.

1. Camfield P. Incidence, prevalence and aetiology of seizures and epilepsy in children. Epileptic Disord, 2015, 17(2): 117-123.
2. 李桃利. 癲癇兒童神經精神共患病的研究進展. 復旦學報(醫學版), 2018, 45(4): 578-584, 597.
3. Joosten KF, Larramona H, Miano S, et al. How do we recognize the child with OSAS?. PediatrPulmonol, 2017, 52(2): 260-271.
4. 元芳芳, 康天, 陳惠軍, 等. 兒童注意缺陷多動障礙及其共患病臨床分析. 新鄉醫學院學報, 2019, 36(12): 1152-1154, 1158.
5. 楊一海, 劉丕松, 劉英. 兒童腺樣體肥大與EB病毒感染的相關性分析. 山西大同大學學報(自然科學版), 2018, 34(4): 58-59, 65.
6. 韓婷. 兒童慢性扁桃體炎和腺樣體肥大EB病毒感染特點的研究. 山東: 青島大學, 2019, 碩士論文.
7. 呂夢穎, 盧大松, 馮勇軍, 等. 腺樣體肥大患者圍手術期醫院感染病原學特點及影響因素分析. 中華醫院感染學雜志, 2018, 28(1): 81-83.
8. 翟長文, 王紓宜. EB病毒在原發性扁桃體彌漫大B細胞淋巴瘤(PT腺樣體肥大并發分泌性中耳炎兒童的淋巴細胞亞群分布[DLBCL)中的表達及其臨床意義. 復旦學報(醫學版), 2014, 41(2): 210-215.
9. 張迎俊, 袁菲, 劉穎慧, 等. 腺樣體肥大兒童的變應原檢測及病因探討. 臨床耳鼻咽喉頭頸外科雜志, 2017, 031(007): 549-551.
10. Uludag I F, Duksal T, Tiftikcioglu B I, et al. IL-1β, IL-6 and IL1Ra levels in temporal lobe epilepsy. Seizure, 2015, 26: 22-25.
11. Singh Tanveer, Kaur Taranjot, Goel Rajesh Kumar. Ferulic acid supplementation for management of depression in epilepsy. Neurochemical research, 2017, 42(10): 2940-2948.
12. 操金金, 崔凡, 劉福榮, 等. 降鈣素原、C-反應蛋白、紅細胞沉降率與白細胞計數聯合檢測在呼吸道感染診斷中的應用價值. 中國醫藥導報, 2020, 17(10): 161-164.
13. 柳蔭, 楊娜. 腺樣體肥大并發分泌性中耳炎兒童的淋巴細胞亞群分布. 實用醫學雜志, 2017, 033(14): 2376-2379.
14. Zahorec R. Ratio of neutrophil to lymphocyte counts—rapid and simpleparameter of systemic inflammation and stress in critically ill. Bratisl LekListy, 2001, 102(1): 5-14.
15. 劉紅釗, 張保朝, 張小林, 等. 血小板體積指數、腦灌注壓對動脈瘤性蛛網膜下腔出血后患者遲發性腦缺血的預測價值. 實用醫學雜志, 2019, 35(19): 3018-3021.
16. Jeppesen Jesper, Beniczky Sándor, Johansen Peter, et al. Exploring the capability of wireless near infrared spectroscopy as a portable seizure detection device for epilepsy patients. Seizure, 2015, 26: 43-88.
17. 劉釗, 韓俊霞, 朱曉涵, 等. 應用功能近紅外腦成像對伴中央顳區棘波的良性癲癇患兒數學計算認知功能的研究. 北京醫學, 2019, 41(11): 980-983.
18. 劉巍巍, 馬建榮, 鄒麗穎. 經皮氧氣二氧化碳分壓監測在呼吸支持新生兒的應用. 北京醫學, 2020, 42(3): 193-196.
19. 閆中峰, 夏文菁, 李紅, 等. 血氣分析對發作性意識障礙的鑒別診斷意義. 中國實驗診斷學, 2020, 24(2): 208-211.
20. 汪義勝, 陳開蘭. MCV、MCH及RDW檢測在小兒缺鐵性貧血臨床診斷價值的研究. 當代醫學, 2019, 25(12): 38-40.
21. 楊瑞祥. 血清C肽、皮質醇、胰島素與早產兒血糖代謝紊亂的臨床研究. 中國實驗診斷學, 2018, 22(8): 1410-1412.
22. S?ylemez E, ?ztürk O, Baslo SA, et al. Metabolic syndrome andobstructive sleep apnea syndrome among patients with epilepsy on monotherapy. Epilepsy Behav. 2020 Oct;111: 107296. doi: 10.1016/j.yebeh.2020.107296. Epub 2020Aug 6.
23. 傅蓉, 李鳴, 楊紫茜, 等. 癲癇伴發抑郁的研究進展. 中風與神經疾病雜志, 2019, 36(10): 955-957.
24. Al-Abri M, Al-Asmi A, Al-Shukairi A, et al. Frequency of obstructive sleep apnea syndrome among patients with epilepsy attending a tertiary neurology clinic. Oman Med J, 2015, 30(1): 31-35.
25. Miano S, Paolino MC, Peraita-Adrados R, et al. Prevalence of EEG paroxysmal activity ina population of children withobstructive sleep apnea syndrome. Sleep, 2009, 32(4): 522-529.
26. Miano S, Bachiller C, Gutiérrez M, et al. Paroxysmal activity and seizures associated with sleep breathing disorder inchildren: a possible overlap between diurnal and nocturnal symptoms. Seizure, 2010, 19(9): 547-552.
27. Oliveira AJ, Zamagni M, Dolso P, et al. Respiratory disorders during sleep in patients with epilepsy: effect of ventilatory therapy on EEG interictal epileptiform discharges. Clin Neurophysiol, 2000, 111 Suppl2: S141-145.
28. 姜濤. 兒童腺樣體肥大的MR表現在癲癇診療中的應用價值初探. 醫學理論與實踐, 2016, 29(12): 1631-1632.

Journal of Epilepsy

A preliminary investigation of adenoid hypertrophy in children with epilepsy

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