Analysis of 24 cases of intractable temporal lobe epilepsy surgery_Journal of Epilepsy

Authors：

ZHANG Haozheng ^1,2 , LI Kun ³ , YU Huafeng ⁴ , WANG Guangxin ⁵ , MENG Jiao ⁶ ,  CHEN Jie ¹

1. Department of Maternal and Child Health, School of Public Health, Shandong University, Jinan 250012, China;
2. Pediatric Research Institute, Jinan Children's Hospital,Jinan, Shandong 250022, China;
3. Department of Neurology, Changguo Hospital, Zibo, Shandong 250022, China;
4. Pediatric Internal Medicine Department, Jinan Children's Hospital,Jinan, Shandong 250022, China;
5. Institute of Translational Medicine, Jinan Central Hospital Affiliated to Shandong University, Jinan, Shandong 250022, China;
6. Pathology Department, Jinan Children's Hospital,Jinan, Shandong 250022, China;

Corresponding?author：

CHEN Jie, Email: 77chenjie@sdu.edu.cn

Keywords：

Intractable epilepsy; Hippocampal sclerosis; Surgery

DOI：

10.7507/2096-0247.20210005

Video：

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Objective To investigate the status and prognosis effect of surgical operation for Temporal lobe epilepsy.Methods Retrospective analyses were performed on 24 patients with intractable temporal lobe epilepsy who were treated by surgery in Zibo Changguo Hospital and had complete clinical and follow-up data, during the period from April 2011 to June 2014. Among them, 14 were male and 10 were female, 16 to 44 years old, the average age was (24.40±6.26) years old, and the average course of disease was (12.50±8.42) years old. The clinical characteristics and prognosis of the patients were analyzed.Results All 24 patients had hippocampal sclerosis and underwent "anterior temporal lobe and medial temporal structural resection". Patients were followed up for 5~7 years, the postoperative epileptic seizure of the patient reached grade Engel Ⅰ in 20 cases (83.3%), grade Engel Ⅱ in 2 cases (8.3%) and grade Engel Ⅳ in 2 cases (8.3%).Conclusion Hippocampal sclerosis and cortical dysplasia were common in 24 patients, and the operation controlling intractable epilepsy was better. In order to improve the prognosis of patients, surgical treatment should be carried out as soon as possible.

Citation： ZHANG Haozheng, LI Kun, YU Huafeng, WANG Guangxin, MENG Jiao, CHEN Jie. Analysis of 24 cases of intractable temporal lobe epilepsy surgery. Journal of Epilepsy, 2021, 7(1): 34-38. doi: 10.7507/2096-0247.20210005 Copy

1.	葉林妹, 陳聰, 丁芳, 等. 磁共振成像陰性顳葉癲癇的臨床特點分析. 中華神經科雜志, 2020, 53(2): 103-109.
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3.	霍俊杰. 難治性顳葉癲癇的手術預后及相關影響因素分析. 南京醫科大學, 2019, 碩士學位論文: 4-17.
4.	K Kamada, C Kapeller, F Takeuchi, et al. Tailor-made surgery based on functional networks for intractable epilepsy. Front Neurol, 2020, 11(1): 73.
5.	Guang-Xin Wang, Da-Wei Wang, Yong Liu, et al. Intractable epilepsy and the P-glycoprotein hypothesis. Int J Neurosci, 2016, 26(5): 385-392.
6.	Taoyun Ji, Zhao Yang, Qingzhu Liu, et al. Vagus nerve stimulation for pediatric patients with intractable epilepsy between 3 and 6 years of age: study protocol for a double-blind, randomized control trial. Trials, 2019, 20(1): 44.
7.	孔德燕, 羅杰峰, 石勝良, 等. 藥物難治性癲癇患者認知功能損害影響因素的研究. 腦與神經疾病雜志, 2020, 28(4): 251-254.
8.	喻韜, 羅蓉, 周東, 等. 西南地區40例兒童癲癇手術病例分析. 四川大學學報(醫學版), 2019, 50(2): 272-275.
9.	華剛, 譚紅平, 姜楠, 等. 結節性硬化的診斷及相關藥物難治性癲癇的手術治療. 臨床神經外科雜志, 2019, 16(4): 304-308, 314.
10.	范吉康, 尹紹雅. 迷走神經刺激治療癲癇新進展. 中國實用神經疾病雜志, 2019, 22(8): 910-916.
11.	張祎鳴, 錢若兵, 傅先明, 等. 迷走神經刺激術治療藥物難治性癲癇的療效分析(附110例報道). 中華神經外科雜志, 2019, 35(10): 1059-1063.
12.	Nitin Tandon, Brian A Tong, Elliott R Friedman, et al. Analysis of morbidity and outcomes associated with use of subdural grids vs stereoelectroencephalography in patients with intractable epilepsy. JAMA Neurol, 2019, 76(6): 672-681.
13.	Foit NA, Bernasconi A, Ladbon-Bernasconi N. Contributions of imaging to neuromodulatory treatment of drug-refractory epilepsy. Brain Sci, 2020, 10(10): 700.
14.	Philipp S Reif, Adam Strzelczyk, Felix Rosenow, et al. The history of invasive EEG evaluation in epilepsy patients. Seizure, 2016, 41(10): 191-195.
15.	Nitesh Shrestha. 磁共振成像在顳葉癲癇中的應用. 實用放射學雜志, 2020, 36(5): 838-841.
16.	Azab SF, Sherief LM, Saleh SH, et al. Childhood temporal lobe epilepsy: correlation between electroencephalography and magnetic resonance spectroscopy: a case-control study. Ital J Pediatr, 2015, 41(1): 32.

1. 葉林妹, 陳聰, 丁芳, 等. 磁共振成像陰性顳葉癲癇的臨床特點分析. 中華神經科雜志, 2020, 53(2): 103-109.
2. CY Lee, T Wu, CW Chang, et al. Electrical cortical stimulation for treatment of intractable epilepsy originating from eloquent cortex: surgical accuracy and clinical efficacy. Acta Neurochir (Wien), 2020, 162(2): 261-269.
3. 霍俊杰. 難治性顳葉癲癇的手術預后及相關影響因素分析. 南京醫科大學, 2019, 碩士學位論文: 4-17.
4. K Kamada, C Kapeller, F Takeuchi, et al. Tailor-made surgery based on functional networks for intractable epilepsy. Front Neurol, 2020, 11(1): 73.
5. Guang-Xin Wang, Da-Wei Wang, Yong Liu, et al. Intractable epilepsy and the P-glycoprotein hypothesis. Int J Neurosci, 2016, 26(5): 385-392.
6. Taoyun Ji, Zhao Yang, Qingzhu Liu, et al. Vagus nerve stimulation for pediatric patients with intractable epilepsy between 3 and 6 years of age: study protocol for a double-blind, randomized control trial. Trials, 2019, 20(1): 44.
7. 孔德燕, 羅杰峰, 石勝良, 等. 藥物難治性癲癇患者認知功能損害影響因素的研究. 腦與神經疾病雜志, 2020, 28(4): 251-254.
8. 喻韜, 羅蓉, 周東, 等. 西南地區40例兒童癲癇手術病例分析. 四川大學學報(醫學版), 2019, 50(2): 272-275.
9. 華剛, 譚紅平, 姜楠, 等. 結節性硬化的診斷及相關藥物難治性癲癇的手術治療. 臨床神經外科雜志, 2019, 16(4): 304-308, 314.
10. 范吉康, 尹紹雅. 迷走神經刺激治療癲癇新進展. 中國實用神經疾病雜志, 2019, 22(8): 910-916.
11. 張祎鳴, 錢若兵, 傅先明, 等. 迷走神經刺激術治療藥物難治性癲癇的療效分析(附110例報道). 中華神經外科雜志, 2019, 35(10): 1059-1063.
12. Nitin Tandon, Brian A Tong, Elliott R Friedman, et al. Analysis of morbidity and outcomes associated with use of subdural grids vs stereoelectroencephalography in patients with intractable epilepsy. JAMA Neurol, 2019, 76(6): 672-681.
13. Foit NA, Bernasconi A, Ladbon-Bernasconi N. Contributions of imaging to neuromodulatory treatment of drug-refractory epilepsy. Brain Sci, 2020, 10(10): 700.
14. Philipp S Reif, Adam Strzelczyk, Felix Rosenow, et al. The history of invasive EEG evaluation in epilepsy patients. Seizure, 2016, 41(10): 191-195.
15. Nitesh Shrestha. 磁共振成像在顳葉癲癇中的應用. 實用放射學雜志, 2020, 36(5): 838-841.
16. Azab SF, Sherief LM, Saleh SH, et al. Childhood temporal lobe epilepsy: correlation between electroencephalography and magnetic resonance spectroscopy: a case-control study. Ital J Pediatr, 2015, 41(1): 32.

Journal of Epilepsy

Analysis of 24 cases of intractable temporal lobe epilepsy surgery

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