Systematic evaluation and meta-analysis of repeated transcranial magnetic stimulation for epilepsy_Journal of Epilepsy

Authors：

TONG Jingyi ¹ , LI Changxuan ¹ , LIU Yonghong ² , LIU Hui ¹ , MA Lin ¹ ,  LI Qifu ¹

1. Department of Neurology, second ward, the First Affiliated Hospital of Hainan Medical College, Haikou 570100, China;
2. Department of Neurology, Leshan Geriatric Hospital, Leshan 614900, China;

Corresponding?author：

LI Qifu, Email: lee-chief@163.com

Keywords：

repetitive Transcranial magnetic stimulation; Epilepsy; Anxiety depression comorbidity; Epilepsy with cerebral palsy merger; Adjuvant therapy; Randomized controlled trials

DOI：

10.7507/2096-0247.20190055

Video：

Export PDF Favorites Scan Get Citation

Abstract Full text Figures/Tables Video References Cited by

Objective To systematically evaluate the effect of repeated transcranial magnetic stimulation (rTMS) in treating epilepsy.Methods The randomized controlled trials (RCTs) of rTMS for epilepsy and related diseases were collected from PubMed, EMbase, Cochrane Library, CBM, CNKI, VIP, and Wanfang databases by computer. The retrieval time was from establishment to June 2019. Two researchers independently screened the literature, extracted the data and evaluated the deviation risks of the included studies. RevMan5.3 software was used for Meta analysis.Results A total of 21 RCTs were included, including 1 587 patients. The results showed that rTMS assisted antiepileptics drugs (AEDs) could improve the effective rate of epilepsy treatment [RR=1.28, 95% CI (1.19, 1.37)], significantly reduced HAMA, HAMD and NFDS scores in the treatment of patients with epilepsy combined with anxiety and depression [MD=?3.94, 95% CI (?4.25, ?3.63)], and improve DQ and GMFM-88 scores in children with cerebral palsy combined with epilepsy [MD=7.95, 95% CI (7.00, 8.90)]. In addition, using rTMS will not cause additional adverse reaction [peto OR=0.52, 95% CI (0.31, 0.84)].Conclusions The current evidence showed that rTMS combined AEDs can improve the efficient of AEDs therapy. When treat anxiety depression comorbidity, it can significantly reduce the anxiety depression score. In addition in children with cerebral palsy merger, it can improve muscle strength and development. And rTMS will not cause additional adverse reactions. Limited by the quantity and quality of the selected studies, the conclusions need to be verified by more high-quality studies.

Citation： TONG Jingyi, LI Changxuan, LIU Yonghong, LIU Hui, MA Lin, LI Qifu. Systematic evaluation and meta-analysis of repeated transcranial magnetic stimulation for epilepsy. Journal of Epilepsy, 2019, 5(5): 338-350. doi: 10.7507/2096-0247.20190055 Copy

1.	李艷. 癲癇發病機制及治療的研究進展. 醫學食療與健康, 2018, 10(11): 166-168.
2.	Rybka S, Obniska J, Rapacz A, et al. Synthesis, Physicochemical, and anticonvulsant properties of new N-mannich bases derived from pyrrolidine-2, 5-dione and Its 3-methyl analog. Arch Pharm (Weinheim), 2014, 347(10): 768-776.
3.	楊敏玲, 肖農. 小兒腦性癱瘓共患癲癇研究進展. 中華實用兒科臨床雜志, 2017, 32(11): 878-880.
4.	Gersner R, Dhamne SC, Zangen A, et al. Bursts of high-frequency repetitive transcranial magnetic stimulation (rTMS), together with lorazepam, suppress seizures in a rat kainate status epilepticus model. Epilepsy Behav, 2016, 9(62): 136-139.
5.	Guse B, Falkai P, Wobrock T. Cognitive effects of high-frequency repetitive transcranial magnetic stimulation: a systematic review. Journal of Neural Transmission, 2010, 117(1): 105-122.
6.	馬改霞, 盧瑞峰. 經顱磁刺激用于口服卡馬西平癲癇患者的療效及安全性評價. 臨床研究, 2019, 27(5): 72-74.
7.	黃鶯鶯. 經顱磁刺激療法治療癲癇的效果探究. 當代醫藥論叢, 2018, 16(3): 99-101.
8.	趙征. 經顱磁刺激治療配合抗癲癇藥物治療癲癇患兒 60 例臨床效果觀察. 醫藥論壇雜志, 2018, 39(4): 150-152.
9.	臧軻君. 雙側小腦高頻重復經顱磁刺激治療難治性癲癇的隨機雙盲對照研究. 山東大學(碩士學位論文), 2018: 13-22.
10.	賴明君, 李澤, 鄧慧琨, 等. 重復經顱磁刺激(rTMS)治療難治性癲癇的療效及對認知功能的影響. 齊齊哈爾醫學院學報, 2018, 39(16): 1897-1898.
11.	趙紅艷, 鄭文權, 馬建功. 左乙拉西坦與醒腦靜聯合重復經顱磁刺激治療癲癇臨床觀察. 中國實用神經疾病雜志, 2018, 21(05): 491-495.
12.	袁婕, 崔小麗, 李紅, 等. 經顱磁刺激聯合丙戊酸鈉注射液治療癲癇持續狀態的效果分析. 現代生物醫學進展, 2018, 18(20): 3913-3916.
13.	安影丹, 李令娟. 重復經顱磁刺激對腦卒中后癲癇合并焦慮抑郁共病病人去甲腎上腺素及 5-羥色胺的調節作用. 中西醫結合心腦血管病雜志, 2018, 16(19): 2889-2891.
14.	張塬坤, 李楠, 董萬亮, 等. 重復經顱磁刺激治療冠心病合并腦梗死遲發性癲癇患者焦慮抑郁共病. 中國實用神經疾病雜志, 2018, 21(22): 2482-2486.
15.	魏抗洪. rTMS 聯合康復訓練治療腦癱并發癲癇的效果觀察. 中國民康醫學, 2018, 30(13): 82-84.
16.	張風林, 柳惠青, 姚瑋, 等. 經顱磁刺激聯合醫癇丸輔助治療顱腦外傷繼發性癲癇效果觀察. 山東醫藥, 2017, 57(20): 52-54.
17.	張桂玲. 重復經顱磁刺激治療腦卒中后遲發性癲癇患者的不良效果觀察. 世界最新醫學信息文摘, 2017, 17(22): 130.
18.	王桂賢. 康復訓練配合重復經顱磁刺激對腦癱并發癲癇患兒運動功能的影響. 現代診斷與治療, 2017, 28(18): 3354-3355.
19.	田繼剛. 應用經顱磁刺激治療癲癇的臨床療效及安全性分析. 中國社區醫師, 2016, 32(31): 59-60.
20.	李慶全. 重復經顱磁刺激治療腦卒中后遲發性癲癇患者焦慮抑郁共病的療效. 中國實用神經疾病雜志, 2016, 19(15): 114-115.
21.	楊霄鵬, 楊顏滋, 楊瑞玲. 重復經顱磁刺激治療癲癇的臨床療效及安全性分析. 中國實用神經疾病雜志, 2016, 19(12): 85-86.
22.	符惠芳. 重復經顱磁刺激治療腦卒中后遲發性癲癇患者焦慮抑郁共病的療效觀察. 中國實用神經疾病雜志, 2015, 21(1): 90-92.
23.	王迎紅, 馬丙祥. 重復經顱磁刺激對腦性癱瘓并發癲癇患兒智力發育的影響. 中國康復理論與實踐, 2014, (12): 1153-1155.
24.	單嶠, 王世勛, 王新軍. 重復經顱磁刺激治療腦卒中后遲發性癲癇患者焦慮抑郁共病的療效. 實用醫學雜志, 2013, 29(24): 4000-4003.
25.	Cantello R, Rossi S, Varrasi C. Slow repetitive TMS for drug-resistant epilepsy: clinical and EEG findings of a placebo-controlled trial. Epilepsia, 2007, 48(2): 366-374.
26.	Theodore WH, Hunter K, Chen R, et al. Transcranial magnetic stimulation for the treatment of seizures: a controlled study. Neurology, 2002, 59(4): 560-562.
27.	王夢, 潘小平. 經顱磁刺激在癲癇研究與治療中的應用. 實用醫院臨床雜志志, 2014, 12(3): 210-214.
28.	Palanisamy A, Rajendran NN, Narmadha MP, et al. Association of apolipoprotein Eε4 allele with cognitive impairment in patients with epilepsy and interaction with phenytoin monotherapy. Epilepsy Behav, 2013, 26(2): 165-169.
29.	Hammoud MZ, Milad MR. Symptom changes in posttraumatic stress disorder and major depressive disorder after transcranial magnetic stimulation: mechanisms of where and how in the brain. Biol Psychiatry, 2018, 83(3): 200-202.

1. 李艷. 癲癇發病機制及治療的研究進展. 醫學食療與健康, 2018, 10(11): 166-168.
2. Rybka S, Obniska J, Rapacz A, et al. Synthesis, Physicochemical, and anticonvulsant properties of new N-mannich bases derived from pyrrolidine-2, 5-dione and Its 3-methyl analog. Arch Pharm (Weinheim), 2014, 347(10): 768-776.
3. 楊敏玲, 肖農. 小兒腦性癱瘓共患癲癇研究進展. 中華實用兒科臨床雜志, 2017, 32(11): 878-880.
4. Gersner R, Dhamne SC, Zangen A, et al. Bursts of high-frequency repetitive transcranial magnetic stimulation (rTMS), together with lorazepam, suppress seizures in a rat kainate status epilepticus model. Epilepsy Behav, 2016, 9(62): 136-139.
5. Guse B, Falkai P, Wobrock T. Cognitive effects of high-frequency repetitive transcranial magnetic stimulation: a systematic review. Journal of Neural Transmission, 2010, 117(1): 105-122.
6. 馬改霞, 盧瑞峰. 經顱磁刺激用于口服卡馬西平癲癇患者的療效及安全性評價. 臨床研究, 2019, 27(5): 72-74.
7. 黃鶯鶯. 經顱磁刺激療法治療癲癇的效果探究. 當代醫藥論叢, 2018, 16(3): 99-101.
8. 趙征. 經顱磁刺激治療配合抗癲癇藥物治療癲癇患兒 60 例臨床效果觀察. 醫藥論壇雜志, 2018, 39(4): 150-152.
9. 臧軻君. 雙側小腦高頻重復經顱磁刺激治療難治性癲癇的隨機雙盲對照研究. 山東大學(碩士學位論文), 2018: 13-22.
10. 賴明君, 李澤, 鄧慧琨, 等. 重復經顱磁刺激(rTMS)治療難治性癲癇的療效及對認知功能的影響. 齊齊哈爾醫學院學報, 2018, 39(16): 1897-1898.
11. 趙紅艷, 鄭文權, 馬建功. 左乙拉西坦與醒腦靜聯合重復經顱磁刺激治療癲癇臨床觀察. 中國實用神經疾病雜志, 2018, 21(05): 491-495.
12. 袁婕, 崔小麗, 李紅, 等. 經顱磁刺激聯合丙戊酸鈉注射液治療癲癇持續狀態的效果分析. 現代生物醫學進展, 2018, 18(20): 3913-3916.
13. 安影丹, 李令娟. 重復經顱磁刺激對腦卒中后癲癇合并焦慮抑郁共病病人去甲腎上腺素及 5-羥色胺的調節作用. 中西醫結合心腦血管病雜志, 2018, 16(19): 2889-2891.
14. 張塬坤, 李楠, 董萬亮, 等. 重復經顱磁刺激治療冠心病合并腦梗死遲發性癲癇患者焦慮抑郁共病. 中國實用神經疾病雜志, 2018, 21(22): 2482-2486.
15. 魏抗洪. rTMS 聯合康復訓練治療腦癱并發癲癇的效果觀察. 中國民康醫學, 2018, 30(13): 82-84.
16. 張風林, 柳惠青, 姚瑋, 等. 經顱磁刺激聯合醫癇丸輔助治療顱腦外傷繼發性癲癇效果觀察. 山東醫藥, 2017, 57(20): 52-54.
17. 張桂玲. 重復經顱磁刺激治療腦卒中后遲發性癲癇患者的不良效果觀察. 世界最新醫學信息文摘, 2017, 17(22): 130.
18. 王桂賢. 康復訓練配合重復經顱磁刺激對腦癱并發癲癇患兒運動功能的影響. 現代診斷與治療, 2017, 28(18): 3354-3355.
19. 田繼剛. 應用經顱磁刺激治療癲癇的臨床療效及安全性分析. 中國社區醫師, 2016, 32(31): 59-60.
20. 李慶全. 重復經顱磁刺激治療腦卒中后遲發性癲癇患者焦慮抑郁共病的療效. 中國實用神經疾病雜志, 2016, 19(15): 114-115.
21. 楊霄鵬, 楊顏滋, 楊瑞玲. 重復經顱磁刺激治療癲癇的臨床療效及安全性分析. 中國實用神經疾病雜志, 2016, 19(12): 85-86.
22. 符惠芳. 重復經顱磁刺激治療腦卒中后遲發性癲癇患者焦慮抑郁共病的療效觀察. 中國實用神經疾病雜志, 2015, 21(1): 90-92.
23. 王迎紅, 馬丙祥. 重復經顱磁刺激對腦性癱瘓并發癲癇患兒智力發育的影響. 中國康復理論與實踐, 2014, (12): 1153-1155.
24. 單嶠, 王世勛, 王新軍. 重復經顱磁刺激治療腦卒中后遲發性癲癇患者焦慮抑郁共病的療效. 實用醫學雜志, 2013, 29(24): 4000-4003.
25. Cantello R, Rossi S, Varrasi C. Slow repetitive TMS for drug-resistant epilepsy: clinical and EEG findings of a placebo-controlled trial. Epilepsia, 2007, 48(2): 366-374.
26. Theodore WH, Hunter K, Chen R, et al. Transcranial magnetic stimulation for the treatment of seizures: a controlled study. Neurology, 2002, 59(4): 560-562.
27. 王夢, 潘小平. 經顱磁刺激在癲癇研究與治療中的應用. 實用醫院臨床雜志志, 2014, 12(3): 210-214.
28. Palanisamy A, Rajendran NN, Narmadha MP, et al. Association of apolipoprotein Eε4 allele with cognitive impairment in patients with epilepsy and interaction with phenytoin monotherapy. Epilepsy Behav, 2013, 26(2): 165-169.
29. Hammoud MZ, Milad MR. Symptom changes in posttraumatic stress disorder and major depressive disorder after transcranial magnetic stimulation: mechanisms of where and how in the brain. Biol Psychiatry, 2018, 83(3): 200-202.

Previous Article
癲癇共患偏頭痛診斷治療的中國專家共識
Next Article
Analysis of rural epilepsy management program tracking investigation and analysis in Hailin City Heilongjiang Province

Journal of Epilepsy

Systematic evaluation and meta-analysis of repeated transcranial magnetic stimulation for epilepsy

Abstract Full text Figures/Tables Video References Cited by

Previous Article

Next Article

Format

Content