良性內側顳葉癲癇的研究進展_Journal of Epilepsy

Authors：

黃小冬 ,  任惠

昆明醫科大學第一附屬醫院老年神經內科（昆明 650032）;

Corresponding?author：

任惠, Email: HuiRen2006@163.com

Keywords：

良性內側顳葉癲癇; 海馬硬化; 遺傳學; 核磁共振成像

DOI：

10.7507/2096-0247.20190008

Video：

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Abstract Full text Figures/Tables Video References Cited by

顳葉癲癇（TLE）是指異常過度放電起源于一側或雙側顳葉結構的癲癇，是最常見的成人局灶性癲癇，也是最常見的藥物難治性癲癇。內側（Mesial）TLE 是 TLE 的主要類型，手術切除致癇灶是有效治療方法。然而，部分患者的癥狀則較輕，并且能夠在服用或未服用抗癲癇藥物治療的情況下達到無限期的緩解期，被認為是良性（benign）MTLE，此類患者經常有發熱發作和癲癇的家族史。目前研究者認為 MTLE 可能與海馬硬化和遺傳因素有關，文章就 bMTLE 的研究進展進行總結，以提高臨床對其認識。

Citation： 黃小冬, 任惠. 良性內側顳葉癲癇的研究進展. Journal of Epilepsy, 2019, 5(1): 38-40. doi: 10.7507/2096-0247.20190008 Copy

1.	Tatum WO 4th. Mesial temporal lobe epilepsy. J Clin Neurophysiol, 2012, 29(5): 356-365.
2.	于云莉, 蔣莎莎, 史夢婷, 等. 磁共振波譜聯合視頻腦電圖對伴海馬硬化的內側顳葉癲癇的診斷價值. 貴州醫科大學學報, 2017, 42(8): 946-951.
3.	Hosomi K, Kishima H, Oshino S, et al. Altered extrafocal iomazenil activity in mesial temporal lobe epilepsy. Epilepsy Res, 2013, 103(2-3): 195-204.
4.	幸小亮, 沙龍澤, 張丹, 等. β-catenin 在內側顳葉癲癇發病機制中的作用. 中國醫學科學院學報, 2011, 33(6): 659-662.
5.	王麗琨, 洪震. 耐藥性顳葉癲癇的研究進展. 癲癇與神經電生理學雜志, 2016, 25(2): 100-108.
6.	AlQassmi A, Burneo JG, McLachlan RS, et al. Benign mesial temporal lobe epilepsy: A clinical cohort and literature review. Epilepsy Behav, 2016, 65: 60-64.
7.	Labate A, Gambardella A, Andermann E, et al. Benign mesial temporal lobe epilepsy. Nat Rev Neurol, 2011, 7(4): 237-240.
8.	陳聰, 汪珊, 王爽. 良性顳葉癲癇研究進展. 中華神經科雜志, 2017, 50(12): 953-955.
9.	Spooner CG, Berkovic SF, Mitchell LA, et al. New-onset temporal lobe epilepsy in children: lesion on MRI predicts poor seizure outcome. Neurology, 2006, 67(12): 2147-2153.
10.	Hernandez-Ronquillo L, Buckley S, Ladino LD, et al. How many adults with temporal epilepsy have a mild course and do not require epilepsy surgery? Epileptic Disord, 2016, 18(2): 137-147.
11.	Yang K, Su J, Hu Z, et al. Triple pathology in patients with temporal lobe epilepsy: a case report and review of the literature. Exp Ther Med, 2013, 6(4): 925-928.
12.	Sequeira KM, Tabesh A, Sainju RK, et al. Perfusion network shift during seizures in medial temporal lobe epilepsy. PLoS One, 2013, 8(1): e53204.
13.	Abou-Khalil B. The relationship between febrile seizures and epilepsy. Epilepsia, 2010, 51(Suppl 1): 40-42.
14.	Liu C, Russin J, Heck C, et al. Dysregulation of PINCH signaling in mesial temporal epilepsy. J Clin Neurosci, 2017, 36: 43-52.
15.	Lewis DV, Shinnar S, Hesdorffer DC, et al. Hippocampal sclerosis after febrile status epilepticus: the FEBSTAT study. Ann Neurol, 2014, 75(2): 178-185.
16.	Sokol DK, Demyer WE, Edwards-Brown M, et al. From swelling to sclerosis: acute change in mesial hippocampus after prolonged febrile seizure. Seizure, 2003, 12(4): 237-240.
17.	黃誠衙, 梁春妍, 鐘建東, 等. 顱腦損傷患者繼發外傷性癲癇的危險因素分析. 臨床神經外科雜志, 2017, 14(3): 182-185.
18.	Cohen I, Navarro V, Le Duigou C, et al. Mesial temporal lobe epilepsy: a pathological replay of developmental mechanisms? Biol Cell, 2003, 95(6): 329-333.
19.	Berkovic SF, McIntosh A, Howell RA, et al. familial temporal lobe epilepsy: a common disorder identified in twins. Ann Neurol, 1996, 40(2): 227-235.
20.	Gambardella A, Labate A, Giallonardo A, et al. Familial mesial temporal lobe epilepsies: clinical and genetic features. Epilepsia, 2009, 50(Suppl 5): 55-57.
21.	Crompton DE, Scheffer IE, Taylor I, et al. Familial mesial temporal lobe epilepsy: a benign epilepsy syndrome showing complex inheritance. Brain, 2010, 133(11): 3221-3231.
22.	Hedera P, Blair MA, Andermann E, et al. familial mesial temporal lobe epilepsy maps to chromosome 4q13.2-q21.3. Neurology, 2007, 68(24): 2107-2112.
23.	Fanciulli M, Di Bonaventura C, Egeo G, et al. Suggestive linkage of familial mesial temporal lobe epilepsy to chromosome 3q26. Epilepsy Res, 2014, 108(2): 232-240.
24.	陳薇, 岳建蘭, 林志春. 顳葉癲癇大腦網絡研究進展. 中華神經醫學雜志, 2016, 15(9): 965-968.
25.	Kinjo ER, Rodriguez PXR, Dos Santos BA, et al. New insights on temporal lobe epilepsy based on plasticity-related network changes and high-order statistics. Mol Neurobiol, 2017, 55(5): 3990-3998.
26.	張麗云, 羅國剛. 顳葉癲癇患者的臨床癥狀及腦電圖分析. 吉林醫學, 2014, 35(5): 975-976.
27.	Michelucci R, Pasini E, Nobile C. Lateral temporal lobe epilepsies: clinical and genetic features. Epilepsia, 2009, 50(Suppl 5): 52-54.
28.	Pittau F, Bisulli F, Mai R, et al. Prognostic factors in patients with mesial temporal lobe epilepsy. Epilepsia, 2009, 50(Suppl 1): 41-44.
29.	Labate A, Ventura P, Gambardella A, et al. MRI evidence of mesial temporal sclerosis in sporadic "benign" temporal lobe epilepsy. Neurology, 2006, 66(4): 562-565.
30.	Coan AC, Kobayashi E, Lopes-Cendes I, et al. Abnormalities of hippocampal signal intensity in patients with familial mesial temporal lobe epilepsy. Braz J Med Biol Res, 2004, 37(6): 827-832.
31.	裴家生, 楊朋范. 高分辨率磁共振成像海馬內部結構顯影對內側型顳葉癲癇的診斷價值. 癲癇與神經電生理學雜志, 2014, 23(6): 353-356, 373.
32.	Labate A, Aguglia U, Tripepi G, et al. Long-term outcome of mild mesial temporal lobe epilepsy: A prospective longitudinal cohort study. Neurology, 2016, 86(20): 1904-1910.

1. Tatum WO 4th. Mesial temporal lobe epilepsy. J Clin Neurophysiol, 2012, 29(5): 356-365.
2. 于云莉, 蔣莎莎, 史夢婷, 等. 磁共振波譜聯合視頻腦電圖對伴海馬硬化的內側顳葉癲癇的診斷價值. 貴州醫科大學學報, 2017, 42(8): 946-951.
3. Hosomi K, Kishima H, Oshino S, et al. Altered extrafocal iomazenil activity in mesial temporal lobe epilepsy. Epilepsy Res, 2013, 103(2-3): 195-204.
4. 幸小亮, 沙龍澤, 張丹, 等. β-catenin 在內側顳葉癲癇發病機制中的作用. 中國醫學科學院學報, 2011, 33(6): 659-662.
5. 王麗琨, 洪震. 耐藥性顳葉癲癇的研究進展. 癲癇與神經電生理學雜志, 2016, 25(2): 100-108.
6. AlQassmi A, Burneo JG, McLachlan RS, et al. Benign mesial temporal lobe epilepsy: A clinical cohort and literature review. Epilepsy Behav, 2016, 65: 60-64.
7. Labate A, Gambardella A, Andermann E, et al. Benign mesial temporal lobe epilepsy. Nat Rev Neurol, 2011, 7(4): 237-240.
8. 陳聰, 汪珊, 王爽. 良性顳葉癲癇研究進展. 中華神經科雜志, 2017, 50(12): 953-955.
9. Spooner CG, Berkovic SF, Mitchell LA, et al. New-onset temporal lobe epilepsy in children: lesion on MRI predicts poor seizure outcome. Neurology, 2006, 67(12): 2147-2153.
10. Hernandez-Ronquillo L, Buckley S, Ladino LD, et al. How many adults with temporal epilepsy have a mild course and do not require epilepsy surgery? Epileptic Disord, 2016, 18(2): 137-147.
11. Yang K, Su J, Hu Z, et al. Triple pathology in patients with temporal lobe epilepsy: a case report and review of the literature. Exp Ther Med, 2013, 6(4): 925-928.
12. Sequeira KM, Tabesh A, Sainju RK, et al. Perfusion network shift during seizures in medial temporal lobe epilepsy. PLoS One, 2013, 8(1): e53204.
13. Abou-Khalil B. The relationship between febrile seizures and epilepsy. Epilepsia, 2010, 51(Suppl 1): 40-42.
14. Liu C, Russin J, Heck C, et al. Dysregulation of PINCH signaling in mesial temporal epilepsy. J Clin Neurosci, 2017, 36: 43-52.
15. Lewis DV, Shinnar S, Hesdorffer DC, et al. Hippocampal sclerosis after febrile status epilepticus: the FEBSTAT study. Ann Neurol, 2014, 75(2): 178-185.
16. Sokol DK, Demyer WE, Edwards-Brown M, et al. From swelling to sclerosis: acute change in mesial hippocampus after prolonged febrile seizure. Seizure, 2003, 12(4): 237-240.
17. 黃誠衙, 梁春妍, 鐘建東, 等. 顱腦損傷患者繼發外傷性癲癇的危險因素分析. 臨床神經外科雜志, 2017, 14(3): 182-185.
18. Cohen I, Navarro V, Le Duigou C, et al. Mesial temporal lobe epilepsy: a pathological replay of developmental mechanisms? Biol Cell, 2003, 95(6): 329-333.
19. Berkovic SF, McIntosh A, Howell RA, et al. familial temporal lobe epilepsy: a common disorder identified in twins. Ann Neurol, 1996, 40(2): 227-235.
20. Gambardella A, Labate A, Giallonardo A, et al. Familial mesial temporal lobe epilepsies: clinical and genetic features. Epilepsia, 2009, 50(Suppl 5): 55-57.
21. Crompton DE, Scheffer IE, Taylor I, et al. Familial mesial temporal lobe epilepsy: a benign epilepsy syndrome showing complex inheritance. Brain, 2010, 133(11): 3221-3231.
22. Hedera P, Blair MA, Andermann E, et al. familial mesial temporal lobe epilepsy maps to chromosome 4q13.2-q21.3. Neurology, 2007, 68(24): 2107-2112.
23. Fanciulli M, Di Bonaventura C, Egeo G, et al. Suggestive linkage of familial mesial temporal lobe epilepsy to chromosome 3q26. Epilepsy Res, 2014, 108(2): 232-240.
24. 陳薇, 岳建蘭, 林志春. 顳葉癲癇大腦網絡研究進展. 中華神經醫學雜志, 2016, 15(9): 965-968.
25. Kinjo ER, Rodriguez PXR, Dos Santos BA, et al. New insights on temporal lobe epilepsy based on plasticity-related network changes and high-order statistics. Mol Neurobiol, 2017, 55(5): 3990-3998.
26. 張麗云, 羅國剛. 顳葉癲癇患者的臨床癥狀及腦電圖分析. 吉林醫學, 2014, 35(5): 975-976.
27. Michelucci R, Pasini E, Nobile C. Lateral temporal lobe epilepsies: clinical and genetic features. Epilepsia, 2009, 50(Suppl 5): 52-54.
28. Pittau F, Bisulli F, Mai R, et al. Prognostic factors in patients with mesial temporal lobe epilepsy. Epilepsia, 2009, 50(Suppl 1): 41-44.
29. Labate A, Ventura P, Gambardella A, et al. MRI evidence of mesial temporal sclerosis in sporadic "benign" temporal lobe epilepsy. Neurology, 2006, 66(4): 562-565.
30. Coan AC, Kobayashi E, Lopes-Cendes I, et al. Abnormalities of hippocampal signal intensity in patients with familial mesial temporal lobe epilepsy. Braz J Med Biol Res, 2004, 37(6): 827-832.
31. 裴家生, 楊朋范. 高分辨率磁共振成像海馬內部結構顯影對內側型顳葉癲癇的診斷價值. 癲癇與神經電生理學雜志, 2014, 23(6): 353-356, 373.
32. Labate A, Aguglia U, Tripepi G, et al. Long-term outcome of mild mesial temporal lobe epilepsy: A prospective longitudinal cohort study. Neurology, 2016, 86(20): 1904-1910.

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