拉科酰胺在癲癇持續狀態中的應用　　—針對現有證據的系統評價_Journal of Epilepsy

Authors：

 AdamStrzelczyk , JohannPhilipp Zollner , LaurentM Willems , 肖英鳳　譯 , 童馨　慕潔　審

Corresponding?author：

AdamStrzelczyk, Email: strzelczyk@med.uni-frankfurt.de

Keywords：

拉科酰胺; 癲癇持續狀態; 癇性發作; 癲癇; 電壓門控鈉通道

DOI：

10.7507/2096-0247.20180073

Video：

Export PDF Favorites Scan Get Citation

Abstract Full text Figures/Tables Video References Cited by

拉科酰胺（Lacosamide，LCM）的靜脈制劑具有良好的耐受性和安全性，促使其在癲癇持續狀態（Status Epilepticus，SE）中得到應用。本項系統評價的目的是確定和評估 LCM 在 SE 中的使用情況。在電子數據庫中用聯合檢索方式對 2008 年—2016 年 10 月的文獻進行了系統檢索，并使用標準化的評估表格從各項研究中將有關研究設計、方法框架、數據源、有效性和 LCM 引起的不良反應的信息進行提取并系統地報告。研究共評估了 522 次 SE 發作，其中包括 486 例成人和 36 例兒童及青少年發作，女性占 51.7%。LCM 的總體效力為 57%。LCM 對非驚厥性（57%，82/145）和全面痙攣性（61%，30/49，P=0.68）SE 的效力相似，但對局灶運動性 SE 的總體有效率更高（92%，34/39，P<0.001）。而 LCM 在用藥次序靠后時其療效從 100%下降到 20%。治療期間的主要不良反應是眩暈，視力異常，復視和共濟失調。總體而言，LCM 具有良好的耐受性，并且沒有具臨床意義的藥物相互作用。現有數據表明 LCM 在 SE 中的使用是有前景的，有效率為 57%。LCM 的優勢在于沒有潛在的藥物相互作用，并且在緊急情況需迅速增加劑量時可靜脈使用。

Citation： AdamStrzelczyk, JohannPhilipp Zollner, LaurentM Willems, 肖英鳳　譯, 童馨　慕潔　審. 拉科酰胺在癲癇持續狀態中的應用　　—針對現有證據的系統評價. Journal of Epilepsy, 2018, 4(5): 446-460. doi: 10.7507/2096-0247.20180073 Copy

1.	Kortland LM, Alfter A, Bahr O, et al. Costs and cost-driving factors for acute treatment of adults with status epilepticus: A multicenter cohort study from Germany. Epilepsia, 2016, 57(12): 2056-2066.
2.	Kortland LM, Knake S, Rosenow F, et al. Cost of status epilepticus: A systematic review. Seizure, 2015, 24: 17-20.
3.	Ferlisi M, Shorvon S. The outcome of therapies in refractory and super-refractory convulsive status epilepticus and recommendations for therapy. Brain, 2012, 135(Pt 8): 2314-2328.
4.	Shorvon S, Ferlisi M. The treatment of super-refractory status epilepticus: a critical review of available therapies and a clinical treatment protocol. Brain, 2011, 134(Pt 10): 2802-2818.
5.	Perucca E. What is the promise of new antiepileptic drugs in status epilepticus? Focus on brivaracetam, carisbamate, lacosamide, NS-1209, and topiramate. Epilepsia, 2009, 50(Suppl 12): 49-50.
6.	Glauser T, Ben-Menachem E, Bourgeois B, et al. Updated ILAE evidence review of antiepileptic drug efficacy and effectiveness as initial monotherapy for epileptic seizures and syndromes. Epilepsia, 2013, 54(3): 551-563.
7.	Wechsler RT, Li G, French J, et al. Conversion to lacosamide monotherapy in the treatment of focal epilepsy: Results from a historical-controlled, multicenter, double-blind study. Epilepsia, 2014, 55(7): 1088-1098.
8.	Baulac M, Rosenow F, Toledo M, et al. Efficacy, safety, and tolerability of lacosamide monotherapy versus controlled-release carbamazepine in patients with newly diagnosed epilepsy: a phase 3, randomised, double-blind, non-inferiority trial. Lancet Neurol, 2017, 16(1): 43-54.
9.	Doty P, Hebert D, Mathy FX, et al. Development of lacosamide for the treatment of partial-onset seizures. Ann N Y Acad Sci, 2013, 1291: 56-68.
10.	Doty P, Rudd GD, Stoehr T, et al. Lacosamide. Neurotherapeutics, 2007, 4(1): 145-148.
11.	Cawello W, Stockis A, Andreas JO, et al. Advances in epilepsy treatment: Lacosamide pharmacokinetic profile. Ann N Y Acad Sci, 2014, 1329: 18-32.
12.	Cawello W, Boekens H, Bonn R. Absorption, disposition, metabolic fate and elimination of the anti-epileptic drug lacosamide in humans: mass balance following intravenous and oral administration. Eur J Drug Metab Pharmacokinet, 2012, 37(4): 241-248.
13.	Ben-Menachem E, Biton V, Jatuzis D, et al. Efficacy and safety of oral lacosamide as adjunctive therapy in adults with partial-onset seizures. Epilepsia, 2007, 48(7): 1308-1317.
14.	Chung S, Sperling MR, Biton V, et al. Lacosamide as adjunctive therapy for partial-onset seizures: A randomized controlled trial. Epilepsia, 2010, 51(6): 958-967.
15.	Halasz P, Kalviainen R, Mazurkiewicz-Beldzinska M, et al. Adjunctive lacosamide for partial-onset seizures: efficacy and safety results from a randomized controlled trial. Epilepsia, 2009, 50(3): 443-453.
16.	Baulac M, Rosenow F, Toledo M, et al. Efficacy and tolerability of lacosamide monotherapy in patients with newly diagnosed epilepsy: a randomized double-blind trial versus controlled release carbamazepine. Eur J Neurol, 2016, 23: 52.
17.	Rosenfeld W, Fountain NB, Kaubrys G, et al. Safety and efficacy of adjunctive lacosamide among patients with partial-onset seizures in a long-term open-label extension trial of up to 8 years. Epilepsy Behav, 2014, 41: 164-170.
18.	Husain A, Chung S, Faught E, et al. Long-term safety and efficacy in patients with uncontrolled partial-onset seizures treated with adjunctive lacosamide: results from a Phase III open-label extension trial. Epilepsia, 2012, 53(3): 521-528.
19.	Rosenow F, Kelemen A, Ben-Menachem E, et al. Long-term adjunctive lacosamide treatment in patients with partial-onset seizures. Acta Neurol Scand, 2016, 133: 136-144.
20.	Steinhoff BJ, Eckhardt K, Doty P, et al. A long-term noninterventional safety study of adjunctive lacosamide therapy in patients with epilepsy and uncontrolled partial-onset seizures. Epilepsy Behav, 2016, 58: 35-43.
21.	Wehner T, Bauer S, Hamer HM, et al. Six months of postmarketing experience with adjunctive lacosamide in patients with pharmacoresistant focal epilepsy at a tertiary epilepsy center in germany. Epilepsy Behav, 2009, 16(3): 423-425.
22.	Biton V, Rosenfeld WE, Whitesides J, et al. Intravenous lacosamide as replacement for oral lacosamide in patients with partial-onset seizures. Epilepsia, 2008, 49(3): 418-424.
23.	Cawello W, Bonn R, Boekens H. Bioequivalence of intravenous and oral formulations of the antiepileptic drug lacosamide. Pharmacology, 2012, 90(1-2): 40-46.
24.	Fountain NB, Krauss G, Isojarvi J, et al. Safety and tolerability of adjunctive lacosamide intravenous loading dose in lacosamide-na?ve patients with partial-onset seizures. Epilepsia, 2013, 54(1): 58-65.
25.	H?fler J, Trinka E. Lacosamide as a new treatment option in status epilepticus. Epilepsia, 2013, 54(3): 393-404.
26.	Bauer S, Willems LM, Paule E, et al. The efficacy of lacosamide as monotherapy and adjunctive therapy in focal epilepsy and its use in status epilepticus: clinical trial evidence and experience. Ther Adv Neurol Disord, 2017, 10(2): 103-126.
27.	Albers JM, Moddel G, Dittrich R, et al. Intravenous lacosamide-an effective add-on treatment of refractory status epilepticus. Seizure, 2011, 20(5): 428-430.
28.	Cherry S, Judd L, Muniz JC, et al. Safety and efficacy of lacosamide in the intensive care unit. Neurocrit Care, 2012, 16(2): 294-298.
29.	Goodwin H, Hinson HE, Shermock KM, et al. The use of lacosamide in refractory status epilepticus. Neurocrit Care, 2011, 14(3): 348-353.
30.	Jain V, Harvey AS. Treatment of refractory tonic status epilepticus with intravenous lacosamide. Epilepsia, 2012, 53(4): 761-762.
31.	Koubeissi MZ, Mayor CL, Estephan B, et al. Efficacy and safety of intravenous lacosamide in refractory nonconvulsive status epilepticus. Acta Neurol Scand, 2011, 123(2): 142-146.
32.	Rantsch K, Walter U, Wittstock M, et al. Efficacy of intravenous lacosamide in refractory nonconvulsive status epilepticus and simple partial status epilepticus. Seizure, 2011, 20(7): 529-532.
33.	Mnatsakanyan L, Chung JM, Tsimerinov EI, et al. Intravenous lacosamide in refractory nonconvulsive status epilepticus. Seizure, 2012, 21(3): 198-201.
34.	H?fler J, Unterberger I, Dobesberger J, et al. Intravenous lacosamide in status epilepticus and seizure clusters. Epilepsia, 2011, 52(10): e148-e152.
35.	Kellinghaus C, Berning S, Immisch I, et al. Intravenous lacosamide for treatment of status epilepticus. Acta Neurol Scand, 2011, 123(2): 137-141.
36.	Granda-Mendez J, Toledo M, Flores-Flores A, et al. Intravenous lacosamide in monotherapy in a case of complex partial epileptic status. Rev Neurol, 2011, 53(1): 61-63, authors reply 64.
37.	Kellinghaus C, Berning S, Besselmann M. Intravenous lacosamide as successful treatment for nonconvulsive status epilepticus after failure of first-line therapy. Epilepsy Behav, 2009, 14(2): 429-431.
38.	Tilz C, Resch R, Hofer T, et al. Successful treatment for refractory convulsive status epilepticus by non-parenteral lacosamide. Epilepsia, 2010, 51(2): 316-317.
39.	Turpin-Fenoll L, Millan-Pascual J, Navarro-Munoz S, et al. The use of oral lacosamide in a patient with refractory partial epileptic status. Rev Neurol, 2010, 50(10): 603-606.
40.	Chen LL, Haneef Z, Dorsch A, et al. Successful treatment of refractory simple motor status epilepticus with lacosamide and levetiracetam. Seizure, 2011, 20(3): 263-265.
41.	Krause LU, Brodowski KO, Kellinghaus C. Atrioventricular block following lacosamide intoxication. Epilepsy Behav, 2011, 20(4): 725-727.
42.	Parkerson KA, Reinsberger C, Chou SH, et al. Lacosamide in the treatment of acute recurrent seizures and periodic epileptiform patterns in critically ill patients. Epilepsy Behav, 2011, 20(1): 48-51.
43.	Torres-Cano N, Giner Bayarri P, Chilet-Chilet MR, et al. Refractory nonconvulsive status epilepticus. Rev Neurol, 2011, 53(4): 255-256.
44.	LaRoche SM, Shivdat-Nanhoe R. Subacute encephalopathy and seizures in alcoholics (SESA) presenting with non-convulsive status epilepticus. Seizure, 2011, 20(6): 505-508.
45.	Shiloh-Malawsky Y, Fan Z, Greenwood R, et al. Successful treatment of childhood prolonged refractory status epilepticus with lacosamide. Seizure, 2011, 20(7): 586-588.
46.	Belcastro V, Vidale S, Pierguidi L, et al. Intravenous lacosamide as treatment option in post-stroke non convulsive status epilepticus in the elderly: a proof-of-concept, observational study. Seizure, 2013, 22(10): 905-907.
47.	Kaplan PW. EEG criteria for nonconvulsive status epilepticus. Epilepsia, 2007, 48(Suppl 8): 39-41.
48.	Miro J, Toledo M, Santamarina E, et al. Efficacy of intravenous lacosamide as an add-on treatment in refractory status epilepticus: a multicentric prospective study. Seizure, 2013, 22(1): 77-79.
49.	Santamarina E, Toledo M, Sueiras M, et al. Usefulness of intravenous lacosamide in status epilepticus. J Neurol, 2013, 260(12): 3122-3128.
50.	Kellinghaus C, Berning S, Stogbauer F. Intravenous lacosamide or phenytoin for treatment of refractory status epilepticus. Acta Neurol Scand, 2014, 129: 294-299.
51.	Moreno Morales EY, Fernandez Peleteiro M, Bondy Pena EC, et al. Observational study of intravenous lacosamide in patients with convulsive versus non-convulsive status epilepticus. Clin Drug Investig, 2015, 35(7): 463-469.
52.	Sutter R, Marsch S, Ruegg S. Safety and efficacy of intravenous lacosamide for adjunctive treatment of refractory status epilepticus: a comparative cohort study. Cns Drugs, 2013, 27(4): 321-329.
53.	Garces M, Villanueva V, Mauri JA, et al. Factors influencing response to intravenous lacosamide in emergency situations: LACO-IV study. Epilepsy Behav, 2014, 36: 144-152.
54.	Legros B, Depondt C, Levy-Nogueira M, et al. Intravenous lacosamide in refractory seizure clusters and status epilepticus: comparison of 200 and 400 mg loading doses. Neurocrit Care, 2014, 20(3): 484-488.
55.	Brophy GM, Bell R, Claassen J, et al. Guidelines for the evaluation and management of status epilepticus. Neurocrit Care, 2012, 17(1): 3-23.
56.	Bachhuber A, Lasrich M, Halmer R, et al. Comparison of antiepileptic approaches in treatment of benzodiazepine nonresponsive status epilepticus. CNS Neurosci Ther, 2016, 22(3): 178-183.
57.	d’Orsi G, Pascarella MG, Martino T, et al. Intravenous lacosamide in seizure emergencies: observations from a hospitalized in-patient adult population. Seizure, 2016, 42: 20-28.
58.	d’Orsi G, Pacillo F, Trivisano M, et al. Lacosamide in absence status epilepticus. Seizure, 2014, 23(5): 397-398.
59.	Lang N, Lange M, Schmitt FC, et al. Intravenous lacosamide in clinical practice-results from an independent registry. Seizure, 2016, 39: 5-9.
60.	Hawkes MA, Fernandez Suarez M, Ugarnes G, et al. Single-dose oral lacosamide in refractory simple partial status epilepticus: case report and review. Clin Neuropharmacol, 2013, 36(4): 138-140.
61.	Spalletti M, Comanducci A, Vagaggini A, et al. Efficacy of lacosamide on seizures and myoclonus in a patient with epilepsia partialis continua. Epileptic Disord, 2013, 15(2): 193-196.
62.	Illan-Gala I, D?az de Teran FJ, Alonso P, et al. Nonconvulsive status epilepticus secondary to paclitaxel administration. Epilepsy Behav Case Rep, 2015, 4: 20-22.
63.	Fernandez-Torre JL, Burgueno P, Ballesteros MA, et al. Super-refractory nonconvulsive status epilepticus secondary to fat embolism: a clinical, electrophysiological, and pathological study. Epilepsy Behav, 2015, 49: 184-188.
64.	Sodemann U, Moller HS, Blaabjerg M, et al. Successful treatment of refractory absence status epilepticus with lacosamide. J Neurol, 2014, 261(10): 2025-2027.
65.	d’Orsi G, Pascarella MG, Martino T, et al. Lacosamide in absence status epilepticus: Effective or ineffective? Seizure, 2015, 25: 32.
66.	Hadjigeorgiou GF, Petsanas A, Anagnostopoulos C, et al. Treatment of refractory simple partial status epilepticus by the addition of oral lacosamide in neurosurgical patients. Report of 3 cases. Epilepsy Behav Case Rep, 2013, 1: 69-70.
67.	Husain AM. Lacosamide in status epilepticus: update on the TRENdS study. Epilepsy Behav, 2015, 49: 337-339.
68.	Husain AM. Treatment of recurrent electrographic nonconvulsive seizures (TRENdS) study. Epilepsia, 2013, 54(Suppl 6): 84-88.
69.	Arkilo D, Gustafson M, Ritter FJ. Clinical experience of intravenous lacosamide in infants and young children. Eur J Paediatr Neurol, 2016, 20(2): 212-217.
70.	Poddar K, Sharma R, Ng YT. Intravenous lacosamide in pediatric status epilepticus: an open-label efficacy and safety study. Pediatr Neurol, 2016, 61: 83-86.
71.	Grosso S, Zamponi N, Bartocci A, et al. Lacosamide in children with refractory status epilepticus. A multicenter italian experience. Eur J Paediatr Neurol, 2014, 18(5): 604-608.
72.	Trinka E, Cock H, Hesdorffer D, et al. A definition and classification of status epilepticus- Report of the ILAE Task Force on Classification of Status Epilepticus. Epilepsia, 2015, 56(10): 1515-1523.
73.	Sutter R, Marsch S, Fuhr P, et al. Anesthetic drugs in status epilepticus: risk or rescue? A 6-year cohort study. Neurology, 2014, 82(8): 656-664.
74.	Chen JW, Wasterlain CG. Status epilepticus: Pathophysiology and management in adults. Lancet Neurol, 2006, 5(3): 246-256.
75.	Sake JK, Hebert D, Isojarvi J, et al. A pooled analysis of lacosamide clinical trial data grouped by mechanism of action of concomitant antiepileptic drugs. Cns Drugs, 2010, 24(12): 1055-1068.
76.	Ramsay RE, Sabharwal V, Khan F, et al. Safety & pK of IV loading dose of lacosamide in the ICU. Epilepsy Behav, 2015, 49: 340-342.
77.	Trinka E, H?fler J, Leitinger M, et al. Pharmacotherapy for status epilepticus. Drugs, 2015, 75(13): 1499-1521.
78.	Rudd GD, Haverkamp W, Mason JW, et al. Lacosamide cardiac safety: clinical trials in patients with partial-onset seizures. Acta Neurol Scand, 2015, 132(5): 355-363.

1. Kortland LM, Alfter A, Bahr O, et al. Costs and cost-driving factors for acute treatment of adults with status epilepticus: A multicenter cohort study from Germany. Epilepsia, 2016, 57(12): 2056-2066.
2. Kortland LM, Knake S, Rosenow F, et al. Cost of status epilepticus: A systematic review. Seizure, 2015, 24: 17-20.
3. Ferlisi M, Shorvon S. The outcome of therapies in refractory and super-refractory convulsive status epilepticus and recommendations for therapy. Brain, 2012, 135(Pt 8): 2314-2328.
4. Shorvon S, Ferlisi M. The treatment of super-refractory status epilepticus: a critical review of available therapies and a clinical treatment protocol. Brain, 2011, 134(Pt 10): 2802-2818.
5. Perucca E. What is the promise of new antiepileptic drugs in status epilepticus? Focus on brivaracetam, carisbamate, lacosamide, NS-1209, and topiramate. Epilepsia, 2009, 50(Suppl 12): 49-50.
6. Glauser T, Ben-Menachem E, Bourgeois B, et al. Updated ILAE evidence review of antiepileptic drug efficacy and effectiveness as initial monotherapy for epileptic seizures and syndromes. Epilepsia, 2013, 54(3): 551-563.
7. Wechsler RT, Li G, French J, et al. Conversion to lacosamide monotherapy in the treatment of focal epilepsy: Results from a historical-controlled, multicenter, double-blind study. Epilepsia, 2014, 55(7): 1088-1098.
8. Baulac M, Rosenow F, Toledo M, et al. Efficacy, safety, and tolerability of lacosamide monotherapy versus controlled-release carbamazepine in patients with newly diagnosed epilepsy: a phase 3, randomised, double-blind, non-inferiority trial. Lancet Neurol, 2017, 16(1): 43-54.
9. Doty P, Hebert D, Mathy FX, et al. Development of lacosamide for the treatment of partial-onset seizures. Ann N Y Acad Sci, 2013, 1291: 56-68.
10. Doty P, Rudd GD, Stoehr T, et al. Lacosamide. Neurotherapeutics, 2007, 4(1): 145-148.
11. Cawello W, Stockis A, Andreas JO, et al. Advances in epilepsy treatment: Lacosamide pharmacokinetic profile. Ann N Y Acad Sci, 2014, 1329: 18-32.
12. Cawello W, Boekens H, Bonn R. Absorption, disposition, metabolic fate and elimination of the anti-epileptic drug lacosamide in humans: mass balance following intravenous and oral administration. Eur J Drug Metab Pharmacokinet, 2012, 37(4): 241-248.
13. Ben-Menachem E, Biton V, Jatuzis D, et al. Efficacy and safety of oral lacosamide as adjunctive therapy in adults with partial-onset seizures. Epilepsia, 2007, 48(7): 1308-1317.
14. Chung S, Sperling MR, Biton V, et al. Lacosamide as adjunctive therapy for partial-onset seizures: A randomized controlled trial. Epilepsia, 2010, 51(6): 958-967.
15. Halasz P, Kalviainen R, Mazurkiewicz-Beldzinska M, et al. Adjunctive lacosamide for partial-onset seizures: efficacy and safety results from a randomized controlled trial. Epilepsia, 2009, 50(3): 443-453.
16. Baulac M, Rosenow F, Toledo M, et al. Efficacy and tolerability of lacosamide monotherapy in patients with newly diagnosed epilepsy: a randomized double-blind trial versus controlled release carbamazepine. Eur J Neurol, 2016, 23: 52.
17. Rosenfeld W, Fountain NB, Kaubrys G, et al. Safety and efficacy of adjunctive lacosamide among patients with partial-onset seizures in a long-term open-label extension trial of up to 8 years. Epilepsy Behav, 2014, 41: 164-170.
18. Husain A, Chung S, Faught E, et al. Long-term safety and efficacy in patients with uncontrolled partial-onset seizures treated with adjunctive lacosamide: results from a Phase III open-label extension trial. Epilepsia, 2012, 53(3): 521-528.
19. Rosenow F, Kelemen A, Ben-Menachem E, et al. Long-term adjunctive lacosamide treatment in patients with partial-onset seizures. Acta Neurol Scand, 2016, 133: 136-144.
20. Steinhoff BJ, Eckhardt K, Doty P, et al. A long-term noninterventional safety study of adjunctive lacosamide therapy in patients with epilepsy and uncontrolled partial-onset seizures. Epilepsy Behav, 2016, 58: 35-43.
21. Wehner T, Bauer S, Hamer HM, et al. Six months of postmarketing experience with adjunctive lacosamide in patients with pharmacoresistant focal epilepsy at a tertiary epilepsy center in germany. Epilepsy Behav, 2009, 16(3): 423-425.
22. Biton V, Rosenfeld WE, Whitesides J, et al. Intravenous lacosamide as replacement for oral lacosamide in patients with partial-onset seizures. Epilepsia, 2008, 49(3): 418-424.
23. Cawello W, Bonn R, Boekens H. Bioequivalence of intravenous and oral formulations of the antiepileptic drug lacosamide. Pharmacology, 2012, 90(1-2): 40-46.
24. Fountain NB, Krauss G, Isojarvi J, et al. Safety and tolerability of adjunctive lacosamide intravenous loading dose in lacosamide-na?ve patients with partial-onset seizures. Epilepsia, 2013, 54(1): 58-65.
25. H?fler J, Trinka E. Lacosamide as a new treatment option in status epilepticus. Epilepsia, 2013, 54(3): 393-404.
26. Bauer S, Willems LM, Paule E, et al. The efficacy of lacosamide as monotherapy and adjunctive therapy in focal epilepsy and its use in status epilepticus: clinical trial evidence and experience. Ther Adv Neurol Disord, 2017, 10(2): 103-126.
27. Albers JM, Moddel G, Dittrich R, et al. Intravenous lacosamide-an effective add-on treatment of refractory status epilepticus. Seizure, 2011, 20(5): 428-430.
28. Cherry S, Judd L, Muniz JC, et al. Safety and efficacy of lacosamide in the intensive care unit. Neurocrit Care, 2012, 16(2): 294-298.
29. Goodwin H, Hinson HE, Shermock KM, et al. The use of lacosamide in refractory status epilepticus. Neurocrit Care, 2011, 14(3): 348-353.
30. Jain V, Harvey AS. Treatment of refractory tonic status epilepticus with intravenous lacosamide. Epilepsia, 2012, 53(4): 761-762.
31. Koubeissi MZ, Mayor CL, Estephan B, et al. Efficacy and safety of intravenous lacosamide in refractory nonconvulsive status epilepticus. Acta Neurol Scand, 2011, 123(2): 142-146.
32. Rantsch K, Walter U, Wittstock M, et al. Efficacy of intravenous lacosamide in refractory nonconvulsive status epilepticus and simple partial status epilepticus. Seizure, 2011, 20(7): 529-532.
33. Mnatsakanyan L, Chung JM, Tsimerinov EI, et al. Intravenous lacosamide in refractory nonconvulsive status epilepticus. Seizure, 2012, 21(3): 198-201.
34. H?fler J, Unterberger I, Dobesberger J, et al. Intravenous lacosamide in status epilepticus and seizure clusters. Epilepsia, 2011, 52(10): e148-e152.
35. Kellinghaus C, Berning S, Immisch I, et al. Intravenous lacosamide for treatment of status epilepticus. Acta Neurol Scand, 2011, 123(2): 137-141.
36. Granda-Mendez J, Toledo M, Flores-Flores A, et al. Intravenous lacosamide in monotherapy in a case of complex partial epileptic status. Rev Neurol, 2011, 53(1): 61-63, authors reply 64.
37. Kellinghaus C, Berning S, Besselmann M. Intravenous lacosamide as successful treatment for nonconvulsive status epilepticus after failure of first-line therapy. Epilepsy Behav, 2009, 14(2): 429-431.
38. Tilz C, Resch R, Hofer T, et al. Successful treatment for refractory convulsive status epilepticus by non-parenteral lacosamide. Epilepsia, 2010, 51(2): 316-317.
39. Turpin-Fenoll L, Millan-Pascual J, Navarro-Munoz S, et al. The use of oral lacosamide in a patient with refractory partial epileptic status. Rev Neurol, 2010, 50(10): 603-606.
40. Chen LL, Haneef Z, Dorsch A, et al. Successful treatment of refractory simple motor status epilepticus with lacosamide and levetiracetam. Seizure, 2011, 20(3): 263-265.
41. Krause LU, Brodowski KO, Kellinghaus C. Atrioventricular block following lacosamide intoxication. Epilepsy Behav, 2011, 20(4): 725-727.
42. Parkerson KA, Reinsberger C, Chou SH, et al. Lacosamide in the treatment of acute recurrent seizures and periodic epileptiform patterns in critically ill patients. Epilepsy Behav, 2011, 20(1): 48-51.
43. Torres-Cano N, Giner Bayarri P, Chilet-Chilet MR, et al. Refractory nonconvulsive status epilepticus. Rev Neurol, 2011, 53(4): 255-256.
44. LaRoche SM, Shivdat-Nanhoe R. Subacute encephalopathy and seizures in alcoholics (SESA) presenting with non-convulsive status epilepticus. Seizure, 2011, 20(6): 505-508.
45. Shiloh-Malawsky Y, Fan Z, Greenwood R, et al. Successful treatment of childhood prolonged refractory status epilepticus with lacosamide. Seizure, 2011, 20(7): 586-588.
46. Belcastro V, Vidale S, Pierguidi L, et al. Intravenous lacosamide as treatment option in post-stroke non convulsive status epilepticus in the elderly: a proof-of-concept, observational study. Seizure, 2013, 22(10): 905-907.
47. Kaplan PW. EEG criteria for nonconvulsive status epilepticus. Epilepsia, 2007, 48(Suppl 8): 39-41.
48. Miro J, Toledo M, Santamarina E, et al. Efficacy of intravenous lacosamide as an add-on treatment in refractory status epilepticus: a multicentric prospective study. Seizure, 2013, 22(1): 77-79.
49. Santamarina E, Toledo M, Sueiras M, et al. Usefulness of intravenous lacosamide in status epilepticus. J Neurol, 2013, 260(12): 3122-3128.
50. Kellinghaus C, Berning S, Stogbauer F. Intravenous lacosamide or phenytoin for treatment of refractory status epilepticus. Acta Neurol Scand, 2014, 129: 294-299.
51. Moreno Morales EY, Fernandez Peleteiro M, Bondy Pena EC, et al. Observational study of intravenous lacosamide in patients with convulsive versus non-convulsive status epilepticus. Clin Drug Investig, 2015, 35(7): 463-469.
52. Sutter R, Marsch S, Ruegg S. Safety and efficacy of intravenous lacosamide for adjunctive treatment of refractory status epilepticus: a comparative cohort study. Cns Drugs, 2013, 27(4): 321-329.
53. Garces M, Villanueva V, Mauri JA, et al. Factors influencing response to intravenous lacosamide in emergency situations: LACO-IV study. Epilepsy Behav, 2014, 36: 144-152.
54. Legros B, Depondt C, Levy-Nogueira M, et al. Intravenous lacosamide in refractory seizure clusters and status epilepticus: comparison of 200 and 400 mg loading doses. Neurocrit Care, 2014, 20(3): 484-488.
55. Brophy GM, Bell R, Claassen J, et al. Guidelines for the evaluation and management of status epilepticus. Neurocrit Care, 2012, 17(1): 3-23.
56. Bachhuber A, Lasrich M, Halmer R, et al. Comparison of antiepileptic approaches in treatment of benzodiazepine nonresponsive status epilepticus. CNS Neurosci Ther, 2016, 22(3): 178-183.
57. d’Orsi G, Pascarella MG, Martino T, et al. Intravenous lacosamide in seizure emergencies: observations from a hospitalized in-patient adult population. Seizure, 2016, 42: 20-28.
58. d’Orsi G, Pacillo F, Trivisano M, et al. Lacosamide in absence status epilepticus. Seizure, 2014, 23(5): 397-398.
59. Lang N, Lange M, Schmitt FC, et al. Intravenous lacosamide in clinical practice-results from an independent registry. Seizure, 2016, 39: 5-9.
60. Hawkes MA, Fernandez Suarez M, Ugarnes G, et al. Single-dose oral lacosamide in refractory simple partial status epilepticus: case report and review. Clin Neuropharmacol, 2013, 36(4): 138-140.
61. Spalletti M, Comanducci A, Vagaggini A, et al. Efficacy of lacosamide on seizures and myoclonus in a patient with epilepsia partialis continua. Epileptic Disord, 2013, 15(2): 193-196.
62. Illan-Gala I, D?az de Teran FJ, Alonso P, et al. Nonconvulsive status epilepticus secondary to paclitaxel administration. Epilepsy Behav Case Rep, 2015, 4: 20-22.
63. Fernandez-Torre JL, Burgueno P, Ballesteros MA, et al. Super-refractory nonconvulsive status epilepticus secondary to fat embolism: a clinical, electrophysiological, and pathological study. Epilepsy Behav, 2015, 49: 184-188.
64. Sodemann U, Moller HS, Blaabjerg M, et al. Successful treatment of refractory absence status epilepticus with lacosamide. J Neurol, 2014, 261(10): 2025-2027.
65. d’Orsi G, Pascarella MG, Martino T, et al. Lacosamide in absence status epilepticus: Effective or ineffective? Seizure, 2015, 25: 32.
66. Hadjigeorgiou GF, Petsanas A, Anagnostopoulos C, et al. Treatment of refractory simple partial status epilepticus by the addition of oral lacosamide in neurosurgical patients. Report of 3 cases. Epilepsy Behav Case Rep, 2013, 1: 69-70.
67. Husain AM. Lacosamide in status epilepticus: update on the TRENdS study. Epilepsy Behav, 2015, 49: 337-339.
68. Husain AM. Treatment of recurrent electrographic nonconvulsive seizures (TRENdS) study. Epilepsia, 2013, 54(Suppl 6): 84-88.
69. Arkilo D, Gustafson M, Ritter FJ. Clinical experience of intravenous lacosamide in infants and young children. Eur J Paediatr Neurol, 2016, 20(2): 212-217.
70. Poddar K, Sharma R, Ng YT. Intravenous lacosamide in pediatric status epilepticus: an open-label efficacy and safety study. Pediatr Neurol, 2016, 61: 83-86.
71. Grosso S, Zamponi N, Bartocci A, et al. Lacosamide in children with refractory status epilepticus. A multicenter italian experience. Eur J Paediatr Neurol, 2014, 18(5): 604-608.
72. Trinka E, Cock H, Hesdorffer D, et al. A definition and classification of status epilepticus- Report of the ILAE Task Force on Classification of Status Epilepticus. Epilepsia, 2015, 56(10): 1515-1523.
73. Sutter R, Marsch S, Fuhr P, et al. Anesthetic drugs in status epilepticus: risk or rescue? A 6-year cohort study. Neurology, 2014, 82(8): 656-664.
74. Chen JW, Wasterlain CG. Status epilepticus: Pathophysiology and management in adults. Lancet Neurol, 2006, 5(3): 246-256.
75. Sake JK, Hebert D, Isojarvi J, et al. A pooled analysis of lacosamide clinical trial data grouped by mechanism of action of concomitant antiepileptic drugs. Cns Drugs, 2010, 24(12): 1055-1068.
76. Ramsay RE, Sabharwal V, Khan F, et al. Safety & pK of IV loading dose of lacosamide in the ICU. Epilepsy Behav, 2015, 49: 340-342.
77. Trinka E, H?fler J, Leitinger M, et al. Pharmacotherapy for status epilepticus. Drugs, 2015, 75(13): 1499-1521.
78. Rudd GD, Haverkamp W, Mason JW, et al. Lacosamide cardiac safety: clinical trials in patients with partial-onset seizures. Acta Neurol Scand, 2015, 132(5): 355-363.

Journal of Epilepsy

拉科酰胺在癲癇持續狀態中的應用　　—針對現有證據的系統評價

Abstract Full text Figures/Tables Video References Cited by

Previous Article

Next Article

Format

Content

Journal of Epilepsy

拉科酰胺在癲癇持續狀態中的應用 —針對現有證據的系統評價

Abstract Full text Figures/Tables Video References Cited by

Previous Article

Next Article

Format

Content

拉科酰胺在癲癇持續狀態中的應用　　—針對現有證據的系統評價