顳葉癲癇術后癲癇無發作不能使已改變的功能連接正常化_Journal of Epilepsy

Authors：

LuigiMaccotta ,  Mayra A.Lopez , BabatundeAdeyemo , 江欣玥　譯 , 熊維希 , 慕潔　審

Corresponding?author：

Mayra A.Lopez, Email: l.maccotta@wustl.edu

Keywords：

顳葉癲癇; 癲癇手術; 功能核磁共振; 功能網絡; 縱向研究

DOI：

10.7507/2096-0247.20180045

Video：

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癲癇患者大腦網絡的功能連接存在特異性改變。然而這種改變是疾病本身或是癲癇發作產生的結果尚不明確。研究為縱向研究，找對難治性顳葉癲癇患者（Temporal lobe epilepsy，TLE）手術前及術后發作得到控制后的標準認知功能網絡連接。該研究納入 17 例手術預后達到 Engel I 級的難治性 TLE 患者作為試驗組，同時納入 17 例匹配的正常受試者作為對照組。在手術前后使用經典認知任務以評估認知網絡的功能連接（含對照組），并使用嚴格的方法消除偽影。TLE 患者在術前與健康對照組相比，功能連接存在顯著差異，這種差異是廣泛而非唯一的，包括默認網絡以及顳葉/聽覺子網絡。然而，接受癲癇手術并且發作得到控制后患者的網絡連接并未得到明顯改善，術后功能網絡的異常與術前幾乎一致。研究結果提示，癲癇對大腦功能連接存在長期而持續的影響，當難治性 TLE 患者進行手術時（一般發生在首次診斷的數年后）此種改變已經不可逆轉。此結果對于頑固性癲癇的治療具有潛在的意義，提示延遲的手術治療可能控制癲癇發作，但不能逆轉疾病所導致的功能性大腦網絡改變。

Citation： LuigiMaccotta, Mayra A.Lopez, BabatundeAdeyemo, 江欣玥　譯, 熊維希, 慕潔　審. 顳葉癲癇術后癲癇無發作不能使已改變的功能連接正常化. Journal of Epilepsy, 2018, 4(3): 257-272. doi: 10.7507/2096-0247.20180045 Copy

1.	Cataldi M, Avoli M, de Villers-Sidani E. Resting state networks in temporal lobe epilepsy. Epilepsia, 2013, 54(12): 2048-2059.
2.	Liao W, Zhang Z, Pan Z, et al. Default mode network abnormalities in mesial temporal lobe epilepsy: a study combining fMRI and DTI. Hum Brain Mapp, 2011, 32(6): 883-895.
3.	Maccotta L, He BJ, Snyder AZ, et al. Impaired and facilitated functional networks in temporal lobe epilepsy. Neuroimage Clin, 2013, 2: 862-872.
4.	Douw L, DeSalvo MN, Tanaka N, et al. Dissociated multimodal hubs and seizures in temporal lobe epilepsy. Ann Clin Transl Neurol, 2015, 2(4): 338-352.
5.	Tellez-Zenteno JF, Dhar R, Wiebe S. Long-term seizure outcomes following epilepsy surgery: a systematic review and meta-analysis. Brain, 2005, 128(Pt 5): 1188-1198.
6.	McIntosh AM, Averill CA, Kalnins RM, et al. Long-term seizure outcome and risk factors for recurrence after extratemporal epilepsy surgery. Epilepsia, 2012, 53(6): 970-978.
7.	Osipowicz K, Sperling MR, Sharan AD, et al. Functional MRI, resting state fMRI, and DTI for predicting verbal fluency outcome following resective surgery for temporal lobe epilepsy. J Neurosurg, 2016, 124(4): 929-937.
8.	Doucet GE, Rider R, Taylor N, et al. Presurgery resting-state local graph-theory measures predict neurocognitive outcomes after brain surgery in temporal lobe epilepsy. Epilepsia, 2015, 56(4): 517-526.
9.	Negishi M, Martuzzi R, Novotny EJ, et al. Functional MRI connectivity as a predictor of the surgical outcome of epilepsy. Epilepsia, 2011, 52(9): 1733-1740.
10.	Weaver KE, Chaovalitwongse WA, Novotny EJ, et al. Local functional connectivity as a pre-surgical tool for seizure focus identification in non-lesion, focal epilepsy. Front Neurol, 2013, 4: 43.
11.	Morgan VL, Sonmezturk HH, Gore JC, et al. Lateralization of temporal lobe epilepsy using resting functional magnetic resonance imaging connectivity of hippocampal networks. Epilepsia, 2012, 53(9): 1628-1635.
12.	Ibrahim GM, Morgan BR, Smith ML, et al. Thalamocortical connectivity is enhanced following functional hemispherotomy for intractable lateralized epilepsy. Epilepsy Behav, 2015, 51: 281-285.
13.	McCormick C, Quraan M, Cohn M, et al. Default mode network connectivity indicates episodic memory capacity in mesial temporal lobe epilepsy. Epilepsia, 2013, 54(5): 809-818.
14.	Pizoli CE, Shah MN, Snyder AZ, et al. Resting-state activity in development and maintenance of normal brain function. Proc Natl Acad Sci USA, 2011, 108(28): 11638-11643.
15.	Johnston JM, Vaishnavi SN, Smyth MD, et al. Loss of resting interhemispheric functional connectivity after complete section of the corpus callosum. J Neurosci, 2008, 28(25): 6453-6458.
16.	Engel J Jr, Van Ness PC, Rasmussen TB, et al. Outcome with respect to epileptic seizures. In: Engel J Jr (Ed)//Surgical treatment of the epilepsies. New York: Raven Press, 1993: 609-621.
17.	Power JD, Cohen AL, Nelson SM, et al. Functional network organization of the human brain. Neuron, 2011, 72(4): 665-678.
18.	Power JD, Mitra A, Laumann TO, et al. Methods to detect, characterize, and remove motion artifact in resting state fMRI. Neuroimage, 2014, 84: 320-341.
19.	Wieser HG. Ictal manifestations of temporal lobe seizures. Adv Neurol, 1991, 55: 301-315.
20.	Talairach J, Tournoux P. Co-planar stereotaxic atlas of the human brain. New York: Thieme Medical, 1988.
21.	Briellmann RS, Wellard RM, Jackson GD. Seizure-associated abnormalities in epilepsy: evidence from MR imaging. Epilepsia, 2005, 46(5): 760-766.
22.	Bernhardt BC, Worsley KJ, Kim H, et al. Longitudinal and cross-sectional analysis of atrophy in pharmacoresistant temporal lobe epilepsy. Neurology, 2009, 72(20): 1747-1754.
23.	Song M, Du H, Wu N, et al. Impaired resting-state functional integrations within default mode network of generalized tonic-clonic seizures epilepsy. PLoS One, 2011, 6(2): e17294.
24.	Voets NL, Beckmann CF, Cole DM, et al. Structural substrates for resting network disruption in temporal lobe epilepsy. Brain, 2012, 135(Pt 8): 2350-2357.
25.	Hogan RE, Kaiboriboon K, Bertrand ME, et al. Composite SISCOM perfusion patterns in right and left temporal seizures. Arch Neurol, 2006, 63(10): 1419-1426.
26.	Tae WS, Joo EY, Kim JH, et al. Cerebral perfusion changes in mesial temporal lobe epilepsy: SPM analysis of ictal and interictal SPECT. Neuroimage, 2005, 24(1): 101-110.
27.	Van Paesschen W, Dupont P, Van Driel G, et al. SPECT perfusion changes during complex partial seizures in patients with hippocampal sclerosis. Brain, 2003, 126(Pt 5): 1103-1111.
28.	Bernhardt BC, Bernasconi N, Concha L, et al. Cortical thickness analysis in temporal lobe epilepsy: reproducibility and relation to outcome. Neurology, 2010, 74(22): 1776-1784.
29.	Xiao F, An D, Lei D, et al. Real-time effects of centrotemporal spikes on cognition in rolandic epilepsy: an EEG-fMRI study. Neurology, 2016, 86(6): 544-551.
30.	Vogt VL, Aikia M, Del Barrio A, et al. Current standards of neuropsychological assessment in epilepsy surgery centers across Europe. Epilepsia, 2017, 58(3): 343-355.
31.	Baxendale S, Thompson P. Beyond localization: the role of traditional neuropsychological tests in an age of imaging. Epilepsia, 2010, 51(11): 2225-2230.
32.	Sherman EM, Wiebe S, Fay-McClymont TB, et al. Neuropsychological outcomes after epilepsy surgery: systematic review and pooled estimates. Epilepsia, 2011, 52(5): 857-869.
33.	Detre JA, Maccotta L, King D, et al. Functional MRI lateralization of memory in temporal lobe epilepsy. Neurology, 1998, 50(4): 926-932.
34.	Jokeit H, Okujava M, Woermann FG. Memory fMRI lateralizes temporal lobe epilepsy. Neurology, 2001, 57(10): 1786-1793.
35.	Voets NL, Zamboni G, Stokes MG, et al. Aberrant functional connectivity in dissociable hippocampal networks is associated with deficits in memory. J Neurosci, 2014, 34(14): 4920-4928.
36.	Baldassarre A, Ramsey L, Hacker CL, et al. Large-scale changes in network interactions as a physiological signature of spatial neglect. Brain, 2014, 137(Pt 12): 3267-3283.
37.	Makin TR, Filippini N, Duff EP, et al. Network-level reorganisation of functional connectivity following arm amputation. Neuroimage, 2015, 114: 217-225.
38.	Glasser MF, Coalson TS, Robinson EC, et al. A multi-modal parcellation of human cerebral cortex. Nature, 2016, 536(7615): 171-178.
39.	Van Essen DC, Smith SM, Barch DM, et al. The wu-minn human connectome project: an overview. Neuroimage, 2013, 80: 62-79.
40.	Van Essen DC, Glasser MF, Dierker DL, et al. Parcellations and hemispheric asymmetries of human cerebral cortex analyzed on surfacebased atlases. Cereb Cortex, 2012, 22(10): 2241-2262.

1. Cataldi M, Avoli M, de Villers-Sidani E. Resting state networks in temporal lobe epilepsy. Epilepsia, 2013, 54(12): 2048-2059.
2. Liao W, Zhang Z, Pan Z, et al. Default mode network abnormalities in mesial temporal lobe epilepsy: a study combining fMRI and DTI. Hum Brain Mapp, 2011, 32(6): 883-895.
3. Maccotta L, He BJ, Snyder AZ, et al. Impaired and facilitated functional networks in temporal lobe epilepsy. Neuroimage Clin, 2013, 2: 862-872.
4. Douw L, DeSalvo MN, Tanaka N, et al. Dissociated multimodal hubs and seizures in temporal lobe epilepsy. Ann Clin Transl Neurol, 2015, 2(4): 338-352.
5. Tellez-Zenteno JF, Dhar R, Wiebe S. Long-term seizure outcomes following epilepsy surgery: a systematic review and meta-analysis. Brain, 2005, 128(Pt 5): 1188-1198.
6. McIntosh AM, Averill CA, Kalnins RM, et al. Long-term seizure outcome and risk factors for recurrence after extratemporal epilepsy surgery. Epilepsia, 2012, 53(6): 970-978.
7. Osipowicz K, Sperling MR, Sharan AD, et al. Functional MRI, resting state fMRI, and DTI for predicting verbal fluency outcome following resective surgery for temporal lobe epilepsy. J Neurosurg, 2016, 124(4): 929-937.
8. Doucet GE, Rider R, Taylor N, et al. Presurgery resting-state local graph-theory measures predict neurocognitive outcomes after brain surgery in temporal lobe epilepsy. Epilepsia, 2015, 56(4): 517-526.
9. Negishi M, Martuzzi R, Novotny EJ, et al. Functional MRI connectivity as a predictor of the surgical outcome of epilepsy. Epilepsia, 2011, 52(9): 1733-1740.
10. Weaver KE, Chaovalitwongse WA, Novotny EJ, et al. Local functional connectivity as a pre-surgical tool for seizure focus identification in non-lesion, focal epilepsy. Front Neurol, 2013, 4: 43.
11. Morgan VL, Sonmezturk HH, Gore JC, et al. Lateralization of temporal lobe epilepsy using resting functional magnetic resonance imaging connectivity of hippocampal networks. Epilepsia, 2012, 53(9): 1628-1635.
12. Ibrahim GM, Morgan BR, Smith ML, et al. Thalamocortical connectivity is enhanced following functional hemispherotomy for intractable lateralized epilepsy. Epilepsy Behav, 2015, 51: 281-285.
13. McCormick C, Quraan M, Cohn M, et al. Default mode network connectivity indicates episodic memory capacity in mesial temporal lobe epilepsy. Epilepsia, 2013, 54(5): 809-818.
14. Pizoli CE, Shah MN, Snyder AZ, et al. Resting-state activity in development and maintenance of normal brain function. Proc Natl Acad Sci USA, 2011, 108(28): 11638-11643.
15. Johnston JM, Vaishnavi SN, Smyth MD, et al. Loss of resting interhemispheric functional connectivity after complete section of the corpus callosum. J Neurosci, 2008, 28(25): 6453-6458.
16. Engel J Jr, Van Ness PC, Rasmussen TB, et al. Outcome with respect to epileptic seizures. In: Engel J Jr (Ed)//Surgical treatment of the epilepsies. New York: Raven Press, 1993: 609-621.
17. Power JD, Cohen AL, Nelson SM, et al. Functional network organization of the human brain. Neuron, 2011, 72(4): 665-678.
18. Power JD, Mitra A, Laumann TO, et al. Methods to detect, characterize, and remove motion artifact in resting state fMRI. Neuroimage, 2014, 84: 320-341.
19. Wieser HG. Ictal manifestations of temporal lobe seizures. Adv Neurol, 1991, 55: 301-315.
20. Talairach J, Tournoux P. Co-planar stereotaxic atlas of the human brain. New York: Thieme Medical, 1988.
21. Briellmann RS, Wellard RM, Jackson GD. Seizure-associated abnormalities in epilepsy: evidence from MR imaging. Epilepsia, 2005, 46(5): 760-766.
22. Bernhardt BC, Worsley KJ, Kim H, et al. Longitudinal and cross-sectional analysis of atrophy in pharmacoresistant temporal lobe epilepsy. Neurology, 2009, 72(20): 1747-1754.
23. Song M, Du H, Wu N, et al. Impaired resting-state functional integrations within default mode network of generalized tonic-clonic seizures epilepsy. PLoS One, 2011, 6(2): e17294.
24. Voets NL, Beckmann CF, Cole DM, et al. Structural substrates for resting network disruption in temporal lobe epilepsy. Brain, 2012, 135(Pt 8): 2350-2357.
25. Hogan RE, Kaiboriboon K, Bertrand ME, et al. Composite SISCOM perfusion patterns in right and left temporal seizures. Arch Neurol, 2006, 63(10): 1419-1426.
26. Tae WS, Joo EY, Kim JH, et al. Cerebral perfusion changes in mesial temporal lobe epilepsy: SPM analysis of ictal and interictal SPECT. Neuroimage, 2005, 24(1): 101-110.
27. Van Paesschen W, Dupont P, Van Driel G, et al. SPECT perfusion changes during complex partial seizures in patients with hippocampal sclerosis. Brain, 2003, 126(Pt 5): 1103-1111.
28. Bernhardt BC, Bernasconi N, Concha L, et al. Cortical thickness analysis in temporal lobe epilepsy: reproducibility and relation to outcome. Neurology, 2010, 74(22): 1776-1784.
29. Xiao F, An D, Lei D, et al. Real-time effects of centrotemporal spikes on cognition in rolandic epilepsy: an EEG-fMRI study. Neurology, 2016, 86(6): 544-551.
30. Vogt VL, Aikia M, Del Barrio A, et al. Current standards of neuropsychological assessment in epilepsy surgery centers across Europe. Epilepsia, 2017, 58(3): 343-355.
31. Baxendale S, Thompson P. Beyond localization: the role of traditional neuropsychological tests in an age of imaging. Epilepsia, 2010, 51(11): 2225-2230.
32. Sherman EM, Wiebe S, Fay-McClymont TB, et al. Neuropsychological outcomes after epilepsy surgery: systematic review and pooled estimates. Epilepsia, 2011, 52(5): 857-869.
33. Detre JA, Maccotta L, King D, et al. Functional MRI lateralization of memory in temporal lobe epilepsy. Neurology, 1998, 50(4): 926-932.
34. Jokeit H, Okujava M, Woermann FG. Memory fMRI lateralizes temporal lobe epilepsy. Neurology, 2001, 57(10): 1786-1793.
35. Voets NL, Zamboni G, Stokes MG, et al. Aberrant functional connectivity in dissociable hippocampal networks is associated with deficits in memory. J Neurosci, 2014, 34(14): 4920-4928.
36. Baldassarre A, Ramsey L, Hacker CL, et al. Large-scale changes in network interactions as a physiological signature of spatial neglect. Brain, 2014, 137(Pt 12): 3267-3283.
37. Makin TR, Filippini N, Duff EP, et al. Network-level reorganisation of functional connectivity following arm amputation. Neuroimage, 2015, 114: 217-225.
38. Glasser MF, Coalson TS, Robinson EC, et al. A multi-modal parcellation of human cerebral cortex. Nature, 2016, 536(7615): 171-178.
39. Van Essen DC, Smith SM, Barch DM, et al. The wu-minn human connectome project: an overview. Neuroimage, 2013, 80: 62-79.
40. Van Essen DC, Glasser MF, Dierker DL, et al. Parcellations and hemispheric asymmetries of human cerebral cortex analyzed on surfacebased atlases. Cereb Cortex, 2012, 22(10): 2241-2262.

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顳葉癲癇術后癲癇無發作不能使已改變的功能連接正常化

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