The seizure and cognitive outcome of 499 patients with childhood intractable epilepsy after different treatment_Journal of Epilepsy

Authors：

LIU Changqing ^1,2,3 ,  LUAN Guoming ^1,2,3 , GUAN Yuguang ^1,2,3 , CHENG Qian ^1,2,3 , CHEN Sichang ⁴

1. Department of Neurosurgery, Sanbo Brain Hospital, Capital Medical University, Beijing 100093, China;
2. Beijing Key Laboratory of Epilepsy, Beijing 100093, China;
3. Center of Epilepsy, Beijing Institute for Brain Disorders, Beijing 100093, China;
4. Department of Neurosurgery, Xuanwu Hospital Capital Medical University, Beijing 100053, China;

Corresponding?author：

LUAN Guoming, Email: luangm3@163.com

Keywords：

Children; Intractable epilepsy; Medication; Operation; Cognitive function

DOI：

10.7507/2096-0247.20170075

Video：

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Objective Analyzing the seizure and cognitive outcome after different treatment by observation of a large group of intractable child epilepsy patients under 15 years old. Methods Collecting data of children with Intractable epilepsy from Apirl 2008 to December 2013 in Sanbo Brain Hospital, Capital Medical University. Three historical cohorts of intractable child epilepsy defined by the final treatment including medication, curative operation and palliative operation depending on the surgical assessment and the families intension was retrospectively observed. 1 year and 3 years follow-up postoperatively were conducted including seizure outcome and cognitive outcome. Results The curative operation group had significant better seizure free rate, and cognitive statement than medication group. And, the seizure free and cognitive outcome were better in palliative operation group than the medication group. Conclusions Early surgical intervention is highly recommended for intractable epilepsy chilelren in order to improve both the seizure and cognitive prognosis.

Citation： LIU Changqing, LUAN Guoming, GUAN Yuguang, CHENG Qian, CHEN Sichang. The seizure and cognitive outcome of 499 patients with childhood intractable epilepsy after different treatment. Journal of Epilepsy, 2017, 3(6): 474-478. doi: 10.7507/2096-0247.20170075 Copy

1.	洪震.癲癇流行病學研究.中國現代神經疾病雜志, 2014, 14(11): 919-923.
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5.	Son EI, KimJE. Spectrum of neurosurgeon's role in epilepsy surgery. Biomed J, 2016, 39(3): 177-182.
6.	Vogt VL, iki M, Del Barrio A, et al. Current standards of neuropsychological assessment in epilepsy surgery centers across Europe. Epilepsia, 2017, 58(3): 343-355.
7.	Pham T, Sauro KM, Patten SB, et al. The prevalence of anxiety and associated factors in persons with epilepsy. Epilepsia, 2017, 58(8): e107-e110.
8.	鄭婉君.癲癇持續狀態腦損傷防治方法的研究進展.中醫研究, 2017, 30(1): 73-75.
9.	Rossini L, Garbelli R, Gnatkovsky V, et al. Seizure activity per se does not induce tissue damage markers in human neocortical focal epilepsy. Ann Neurol, 2017, 82(3): 331-341.
10.	Oguni H, Otsuki T, Kobayashi K, et al. Clinical analysis of catastrophic epilepsy in infancy and early childhood: results of the Far-East Asia Catastrophic Epilepsy (FACE) study group. Brain Dev, 2013, 35(8): 786-792.
11.	Harvey AS, Cross JH, Shinnar S, et al. Defining the spectrum of international practice in pediatric epilepsy surgery patients. Epilepsia, 2008, 49(1): 146-155.
12.	Steinbok P, Gan PY, Connolly MB, et al. Epilepsy surgery in the first 3 years of life: a Canadian survey. Epilepsia, 2009, 50(6): 142-149.
13.	Oka E, Ohtsuka Y, Yoshinaga H, et al. Prevalence of childhood epilepsy and distribution of epileptic syndromes: a population-based survey in Okayama, Japan. Epilepsia, 2006, 47(3): 626-630.
14.	Giulioni M, Marucci G, Pelliccia V, et al. Epilepsy surgery of "low grade epilepsy associated neuroepithelial tumors": a retrospective nationwide Italian study. Epilepsia, 2017. [Epub ahead of print].
15.	Chugani HT, Shields WD, Shewmon DA, et al. Infantile spasms: Ⅰ. PET identifies focal cortical dysgenesis in cryptogenic cases for surgical treatment. Ann Neurol, 1990, 27(4): 406-413.
16.	Ono T, Baba H, Toda K, et al. Callosotomy and subsequent surgery for children with refractory epilepsy. Epilepsy Res, 2011, 93(2-3): 185-191.
17.	Guan Y, Chen S, Liu C, et al. Timing and type of hemispherectomy for Rasmussen's encephalitis: analysis of 45 patients. Epilepsy Res, 2017, 132: 109-115.

1. 洪震.癲癇流行病學研究.中國現代神經疾病雜志, 2014, 14(11): 919-923.
2. Rizvi S, Ladino LD, Hernandez-Ronquillo L, et al. Epidemiology of early stages of epilepsy: risk of seizure recurrence after a first seizure. Seizure, 2017, 49: 46-53.
3. 蔣偉, 雷霆, 李齡. 嬰幼兒期災難性癲癇的術前評估. 2011中華醫學會神經外科學學術會議, 2011: 1.
4. Shankar R, Donner EJ, McLean B, et al. Sudden unexpected death in epilepsy (SUDEP): what every neurologist should know. Epileptic Disord, 2017, 19(1): 1-9.
5. Son EI, KimJE. Spectrum of neurosurgeon's role in epilepsy surgery. Biomed J, 2016, 39(3): 177-182.
6. Vogt VL, iki M, Del Barrio A, et al. Current standards of neuropsychological assessment in epilepsy surgery centers across Europe. Epilepsia, 2017, 58(3): 343-355.
7. Pham T, Sauro KM, Patten SB, et al. The prevalence of anxiety and associated factors in persons with epilepsy. Epilepsia, 2017, 58(8): e107-e110.
8. 鄭婉君.癲癇持續狀態腦損傷防治方法的研究進展.中醫研究, 2017, 30(1): 73-75.
9. Rossini L, Garbelli R, Gnatkovsky V, et al. Seizure activity per se does not induce tissue damage markers in human neocortical focal epilepsy. Ann Neurol, 2017, 82(3): 331-341.
10. Oguni H, Otsuki T, Kobayashi K, et al. Clinical analysis of catastrophic epilepsy in infancy and early childhood: results of the Far-East Asia Catastrophic Epilepsy (FACE) study group. Brain Dev, 2013, 35(8): 786-792.
11. Harvey AS, Cross JH, Shinnar S, et al. Defining the spectrum of international practice in pediatric epilepsy surgery patients. Epilepsia, 2008, 49(1): 146-155.
12. Steinbok P, Gan PY, Connolly MB, et al. Epilepsy surgery in the first 3 years of life: a Canadian survey. Epilepsia, 2009, 50(6): 142-149.
13. Oka E, Ohtsuka Y, Yoshinaga H, et al. Prevalence of childhood epilepsy and distribution of epileptic syndromes: a population-based survey in Okayama, Japan. Epilepsia, 2006, 47(3): 626-630.
14. Giulioni M, Marucci G, Pelliccia V, et al. Epilepsy surgery of "low grade epilepsy associated neuroepithelial tumors": a retrospective nationwide Italian study. Epilepsia, 2017. [Epub ahead of print].
15. Chugani HT, Shields WD, Shewmon DA, et al. Infantile spasms: Ⅰ. PET identifies focal cortical dysgenesis in cryptogenic cases for surgical treatment. Ann Neurol, 1990, 27(4): 406-413.
16. Ono T, Baba H, Toda K, et al. Callosotomy and subsequent surgery for children with refractory epilepsy. Epilepsy Res, 2011, 93(2-3): 185-191.
17. Guan Y, Chen S, Liu C, et al. Timing and type of hemispherectomy for Rasmussen's encephalitis: analysis of 45 patients. Epilepsy Res, 2017, 132: 109-115.

Journal of Epilepsy

The seizure and cognitive outcome of 499 patients with childhood intractable epilepsy after different treatment

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