Retrospective study of seventy patients with periventricular nodular heterotrophic and epilepsy in west China_Journal of Epilepsy

Authors：

LIU Wenyu , AN Dongmei ,  ZHOU Dong

Department of Neurology, West China Hospital, Sichuan University, Chengdu, 610041, China;

Corresponding?author：

ZHOU Dong, Email: zhoudong66@yahoo.de

Keywords：

Periventricular nodular heterotopia; Epilepsy; MRI

DOI：

10.7507/2096-0247.20170072

Video：

Export PDF Favorites Scan Get Citation

Abstract Full text Figures/Tables Video References Cited by

Objective The purpose of this study was to better delineate the clinical spectrum of periventricular nodular heterotopia (PNH) in a large patient population to better understand social support in people with PNH and epilepsy in west China. Specifically, this study aimed to relate PNH subtypes to clinical or epileptic outcomes and epileptic discharges by analyzing anatomical features. Methods The study included 70 patients with radiologically confirmed nodular heterotopias and epilepsy. We also recruited healthy controls from nearby urban and rural areas. People with PNH and epilepsy and healthy controls were gender-and age-matched. Two-sided Chi-square test and Fisher's exact t-test were used to assess associations between the distribution of PNHs and specific clinical features. Results Based on imaging data, patients were subdivided into three groups: (a) classical (bilateral frontal and body, n=25), (b) bilateral asymmetrical or posterior (n=9) and (c) unilateral heterotopia (n=36). Most patients with classical heterotopia were females, but were mostly seizure-free. Patients with unilateral heterotopia were prone to develop refractory epilepsy. Conclusions Each group's distinctive genetic mutations, epileptic discharge patterns and overall clinical outcomes confirm that the proposed classification system is reliable. These findings could not only be an indicator of a more severe morphological and clinical phenotype, but could also have clinical implications with respect to the epilepsy management and optimization of therapeutic options.

Citation： LIU Wenyu, AN Dongmei, ZHOU Dong. Retrospective study of seventy patients with periventricular nodular heterotrophic and epilepsy in west China. Journal of Epilepsy, 2017, 3(6): 459-464. doi: 10.7507/2096-0247.20170072 Copy

1.	齊旭紅, 郭惠平, 溫智勇, 等.腦灰質異位癥的MRI診斷.腦與神經疾病雜志, 2011, 19(5): 355-358.
2.	劉文鈺, 安冬梅, 郝南亞, 等. 150例癲癇伴皮質發育不良患者的回顧性研究.癲癇雜志, 2016, 2(1): 14-17.
3.	Sisodiya SM. Malformations of cortical development: burdens and insights from important causes of human epilepsy. Lancet Neurol, 2004, 3(1): 29-38.
4.	Desikan RS, Barkovich AJ. Malformations of cortical development. Annneurol. 2016, 80(6): 797-810.
5.	Pisano T, Barkovich AJ, Leventer RJ, et al.Peritrigonal and temporo-occipital heterotopia with corpus callosum and cerebellar dysgenesis. Neurology, 2012, 79(12): 1244-1251.
6.	林紹鵬, 常好會, 劉曉蓉, 等.灰質異位癥所致癲癇的臨床表現與視頻腦電圖特征分析.中國全科醫學, 2009, 12(24): 2204-2206.
7.	Parrini E, Ramazzotti A, Dobyns WB, et al. Periventricular heterotopia: phenotypic heterogeneity and correlation with FilaminA mutations. Brain, 2006, 129(Pt 7): 1892-1906.
8.	鄭奎宏, 胡向紅, 王克勤, 等.腦灰質異位癥的MRI診斷(附18例分析).海軍總醫院學報, 2000, 13(1): 32-34.
9.	孫紅霞, 陶尋明.腦灰質異位癥致難治性癲癇一例.中國社區醫師, 2014, 30(19):132-133.
10.	郝秀芹, 司傳越, 張國先, 等.灰質異位癥合并腦裂畸形一例.貴州醫藥, 2001, 25(10): 956.
11.	張蕾莉, 崔世民, 劉梅麗, 等.腦灰質異位癥的影像學診斷.中國醫學影像技術, 2001, 17(03): 229-230.
12.	祁俐, 李蕾, 趙奕楠, 等.灰質異位癥的臨床表現及影像學特點.中國實用醫藥, 2011, 6(10): 126.
13.	Barkovich AJ, Guerrini R, Kuzniecky RI, et al.A developmental and genetic classification for malformations of cortical development: update 2012. Brain, 2012, 135(Pt 5): 1348-1369.
14.	Srour M, Rioux MF, Varga C, et al. The clinical spectrum of nodular heterotopias in children: report of 31 patients. Epilepsia, 2011, 52(4): 728-737.
15.	黃力, 王彤歌.大腦灰質異位癥的MRI診斷(附2例家族性病例報告).現代醫用影像學, 1996, 5(4): 157-159.
16.	Lange M, Kasper B, Bohring A, et al. 47 patients with FLNA associated periventricular nodular heterotopia.Orphanet JRare Dis, 2015, 10:134-144.
17.	Battaglia G, Chiapparini L, Franceschetti S, et al. Periventricular nodular heterotopia: classification, epileptic history, and genesis of epileptic discharges. Epilepsia, 2006, 47(1): 86-97.
18.	范振, 魏祥品, 錢若兵, 等.電生理監測結合神經導航手術治療灰質異位癥所致癲癇.立體定向和功能性神經外科雜志, 2010, 23(2): 90-93.
19.	薛漢忠, 張麗娟, 寧安.腦立體定向術治療腦灰質異位癥一例.武警醫學, 2002, 13(10): 635.
20.	Christodoulou JA, Walker LM, Del Tufo SN, et al. Abnormal structural and functional brain connectivity in gray matter heterotopia. Epilepsia, 2012, 53(6): 1024-1032.
21.	Filippi CG, Maxwell AW, Watts R. Magnetic resonance diffusion tensor imaging metrics in perilesional white matter among children with periventricular nodular gray matter heterotopia. Pediatric radiology, 2013, 43(9): 1196-1203.
22.	Tassi L, Colombo N, Cossu M, et al. Electroclinical, MRI and neuropathological study of 10 patients with nodular heterotopia, with surgical outcomes. Brain, 2005, 128(Pt 2): 321-337.
23.	姚慶和, 張華, 高國棟.灰質異位癥診療進展.立體定向和功能性神經外科雜志, 2008, 21(4): 247-249.

1. 齊旭紅, 郭惠平, 溫智勇, 等.腦灰質異位癥的MRI診斷.腦與神經疾病雜志, 2011, 19(5): 355-358.
2. 劉文鈺, 安冬梅, 郝南亞, 等. 150例癲癇伴皮質發育不良患者的回顧性研究.癲癇雜志, 2016, 2(1): 14-17.
3. Sisodiya SM. Malformations of cortical development: burdens and insights from important causes of human epilepsy. Lancet Neurol, 2004, 3(1): 29-38.
4. Desikan RS, Barkovich AJ. Malformations of cortical development. Annneurol. 2016, 80(6): 797-810.
5. Pisano T, Barkovich AJ, Leventer RJ, et al.Peritrigonal and temporo-occipital heterotopia with corpus callosum and cerebellar dysgenesis. Neurology, 2012, 79(12): 1244-1251.
6. 林紹鵬, 常好會, 劉曉蓉, 等.灰質異位癥所致癲癇的臨床表現與視頻腦電圖特征分析.中國全科醫學, 2009, 12(24): 2204-2206.
7. Parrini E, Ramazzotti A, Dobyns WB, et al. Periventricular heterotopia: phenotypic heterogeneity and correlation with FilaminA mutations. Brain, 2006, 129(Pt 7): 1892-1906.
8. 鄭奎宏, 胡向紅, 王克勤, 等.腦灰質異位癥的MRI診斷(附18例分析).海軍總醫院學報, 2000, 13(1): 32-34.
9. 孫紅霞, 陶尋明.腦灰質異位癥致難治性癲癇一例.中國社區醫師, 2014, 30(19):132-133.
10. 郝秀芹, 司傳越, 張國先, 等.灰質異位癥合并腦裂畸形一例.貴州醫藥, 2001, 25(10): 956.
11. 張蕾莉, 崔世民, 劉梅麗, 等.腦灰質異位癥的影像學診斷.中國醫學影像技術, 2001, 17(03): 229-230.
12. 祁俐, 李蕾, 趙奕楠, 等.灰質異位癥的臨床表現及影像學特點.中國實用醫藥, 2011, 6(10): 126.
13. Barkovich AJ, Guerrini R, Kuzniecky RI, et al.A developmental and genetic classification for malformations of cortical development: update 2012. Brain, 2012, 135(Pt 5): 1348-1369.
14. Srour M, Rioux MF, Varga C, et al. The clinical spectrum of nodular heterotopias in children: report of 31 patients. Epilepsia, 2011, 52(4): 728-737.
15. 黃力, 王彤歌.大腦灰質異位癥的MRI診斷(附2例家族性病例報告).現代醫用影像學, 1996, 5(4): 157-159.
16. Lange M, Kasper B, Bohring A, et al. 47 patients with FLNA associated periventricular nodular heterotopia.Orphanet JRare Dis, 2015, 10:134-144.
17. Battaglia G, Chiapparini L, Franceschetti S, et al. Periventricular nodular heterotopia: classification, epileptic history, and genesis of epileptic discharges. Epilepsia, 2006, 47(1): 86-97.
18. 范振, 魏祥品, 錢若兵, 等.電生理監測結合神經導航手術治療灰質異位癥所致癲癇.立體定向和功能性神經外科雜志, 2010, 23(2): 90-93.
19. 薛漢忠, 張麗娟, 寧安.腦立體定向術治療腦灰質異位癥一例.武警醫學, 2002, 13(10): 635.
20. Christodoulou JA, Walker LM, Del Tufo SN, et al. Abnormal structural and functional brain connectivity in gray matter heterotopia. Epilepsia, 2012, 53(6): 1024-1032.
21. Filippi CG, Maxwell AW, Watts R. Magnetic resonance diffusion tensor imaging metrics in perilesional white matter among children with periventricular nodular gray matter heterotopia. Pediatric radiology, 2013, 43(9): 1196-1203.
22. Tassi L, Colombo N, Cossu M, et al. Electroclinical, MRI and neuropathological study of 10 patients with nodular heterotopia, with surgical outcomes. Brain, 2005, 128(Pt 2): 321-337.
23. 姚慶和, 張華, 高國棟.灰質異位癥診療進展.立體定向和功能性神經外科雜志, 2008, 21(4): 247-249.

Next Article
Analysis of risk factors for seizure recurrence in patients with post-stroke epilepsy

Journal of Epilepsy

Retrospective study of seventy patients with periventricular nodular heterotrophic and epilepsy in west China

Abstract Full text Figures/Tables Video References Cited by

Next Article

Format

Content