癲癇共患偏頭痛的研究進展_Journal of Epilepsy

Authors：

 陳蕾 , 邱湘苗 , 朱曦 , 何時旭 , 周東

四川大學華西醫院神經內科(成都，610041);

Corresponding?author：

陳蕾, Email: leilei_25@126.com

Keywords：

癲癇; 偏頭痛; 癇性發作; 頭痛

DOI：

10.7507/2096-0247.20160024

Video：

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癲癇和偏頭痛有很多相同的臨床表現，偏頭痛可出現在癲癇發作間期、發作前、發作時和發作后，使癲癇和偏頭痛在有時難以鑒別。部分抗癲癇藥物可應用于偏頭痛治療。這些均表明癲癇和偏頭痛之間的共病關系。癲癇和偏頭痛的基礎研究也表明皮質擴散抑制可能是兩者之間共病的基礎。目前關于癲癇伴偏頭痛有不同的國際分類，由于偏頭痛可以是癲癇的唯一癥狀，有學者建議設立一種新的分類，命名為發作性癲癇性頭痛。現將從流行病學、發病機制、臨床特征、國際分類，以及治療等方面對癲癇共患偏頭痛作一綜述。

Citation： 陳蕾, 邱湘苗, 朱曦, 何時旭, 周東. 癲癇共患偏頭痛的研究進展. Journal of Epilepsy, 2016, 2(2): 128-132. doi: 10.7507/2096-0247.20160024 Copy

1.	鄢波, 周東. 神經系統慢性疾病的綜合管理. 華西醫學, 2015, 30(4): 601-603.
2.	于生元, 李舜偉, 李焰生. 中國偏頭痛診斷治療指南. 中國疼痛醫學雜志, 2011, 17(2): 65-86.
3.	Nakano H, Inoue Y. Epidemiology and cause of epilepsy. Nihon rinsho Japanese Journal of Clinical Medicine, 2014, 72(5): 785-789.
4.	Yu S, Liu R, Zhao G, et al. The Prevalence and Burden of Primary Headaches in China:A Population-Based Door-to-Door Survey. Headache, 2012, 52(4): 582-591.
5.	Keezer MR, Bauer PR, Ferrari MD, et al. The comorbid relationship between migraine and epilepsy: a systematic review and meta-analysis. European Journal of Neurology, 2015, 22(7): 1038-1047.
6.	Wang XQ, Lang SY, Zhang X, et al. Comidity between headache and epilepsy in a Chinese epileptic center. Epilepsy Research, 2014, 108(3): 535-541.
7.	Grafstein B. Mechanism of spreading cortical depression. Journal of Neurophysiology, 1956, 19(2): 154-171.
8.	Herreras O. Electrical prodromals of spreading depression void Grafstein’s potassium hypothesis. Journal of Neurophysiology, 2005, 94(5): 3656; author reply 3656-3657.
9.	Bolay H, Reuter U, Dunn AK, et al. Intrinsic brain activity triggers trigeminal meningeal afferents in a migraine model. Nature Medicine, 2002, 8(2): 136-142.
10.	Ghaemi A, Sajadian A, Khodaie B, et al. The immunological and neuroimmunological response to spreading depression in Wistar rats. International Journal of Developmental Neuroscience, 2015, 47(Pt A): 6-7.
11.	Parisi P. Why is migraine rarely, and not usually, the sole ictal epileptic manifestation?. Seizure, 2009, 18(5): 309-312.
12.	Parisi P, Kasteleijn-Nolst Trenite DG, Piccioli M, et al.A case with atypical childhood occipital epilepsy “Gastaut type”: an ictal migraine manifestation with a good response to intravenous diazepam. Epilepsia, 2007, 48(11): 2181-2186.
13.	Parisi P, Piccioli M, de Sneeuw S, et al. Redefining headache diagnostic criteria as epileptic manifestation? Cephalalgia, 2008, 28(4): 408-409; author reply 409.
14.	Parisi P, Piccioli M, Villa MP, et al. Hypothesis on neurophysiopathological mechanisms linking epilepsy and headache. Medical Hypotheses, 2008, 70(6): 1150-1154.
15.	Pedersen M, Curwood EK, Vaughan DN, et al. Abnormal brain areas common to the focal epilepsies: Multivariate pattern analysis of fMRI. Brain Connectivity, 2015, Epub ahead of print.
16.	Zhao L, Liu J, Dong X, et al. Alterations in regional homogeneity assessed by fMRI in patients with migraine without aura stratified by disease duration. The Journal of Headache and Pain, 2013, 14(2): 85.
17.	Haglund MM, Schwartzkroin PA. Role of Na-K pump potassium regulation and IPSPs in seizures and spreading depression in immature rabbit hippocampal slices. Journal of Neurophysiology, 1990, 63(2): 225-239.
18.	Silberstein SD, Dodick DW. Migraine genetics: Part II. Headache, 2013, 53(8): 1218-1229.
19.	Vanmolkot KR, Kors EE, Hottenga JJ, et al. Novel mutations in the Na⁺, K⁺-ATPase pump gene ATP1A2 associated with familial hemiplegic migraine and benign familial infantile convulsions. Annals of Neurology, 2003, 54(3): 360-366.
20.	Costa C, Prontera P, Sarchielli P, et al.A novel ATP1A2 gene mutation in familial hemiplegic migraine and epilepsy. Cephalalgia, 2014, 34(1): 68-72.
21.	Cestele S, Labate A, Rusconi R, et al. Divergent effects of the T1174S SCN1A mutation associated with seizures and hemiplegic migraine. Epilepsia, 2013, 54(5): 927-935.
22.	Winawer MR, Connors R, Investigators E. Evidence for a shared genetic susceptibility to migraine and epilepsy. Epilepsia, 2013, 54(2): 288-295.
23.	Raggi A, Leonardi M, D’Amico D, et al.A Step Forward on Similarities Between Migraine and Epilepsy: Psychosocial Difficulties. Headache, 2015, 55(9): 1272-1273.
24.	Hughes J, Devinsky O, Feldmann E, et al. Premonitory symptoms in epilepsy. Seizure, 1993, 2(3): 201-203.
25.	Giffin NJ, Ruggiero L, Lipton RB, et al. Premonitory symptoms in migraine: an electronic diary study. Neurology, 2003, 60(6): 935-940.
26.	Crompton DE, Berkovic SF. The borderland of epilepsy: clinical and molecular features of phenomena that mimic epileptic seizures. The Lancet Neurology, 2009, 8(4): 370-381.
27.	Wild E. Deja vu in neurology. Journal of Neurology, 2005, 252(1): 1-7.
28.	Russell MB, Olesen J.A nosographic analysis of the migraine aura in a general population. Brain, 1996, 119 ( Pt 2): 355-361.
29.	Mainieri G, Cevoli S, Giannini G, et al. Headache in epilepsy: prevalence and clinical features. The Journal of Headache and Pain, 2015, 16(10): 556.
30.	Haut SR, Bigal ME, Lipton RB. Chronic disorders with episodic manifestations: focus on epilepsy and migraine. The Lancet Neurology, 2006, 5(2): 148-157.
31.	Duchaczek B, Ghaeni L, Matzen J, et al. Interictal and periictal headache in patients with epilepsy. European Journal of Neurology, 2013, 20(10): 1360-1366.
32.	Vollono C, Mariotti P, Losurdo A, et al. Headache Following Occipital Brain Lesion:A Case of Migraine Triggered by Occipital Spikes?. Clinical EEG and Neuroscience, 2015, 46(4): 364-369.
33.	Berg AT, Berkovic SF, Brodie MJ, et al. Revised terminology and concepts for organization of seizures and epilepsies: report of the ILAE Commission on Classification and Terminology, 2005-2009. Epilepsia, 2010, 51(4): 676-685.
34.	Parisi P. Who’s still afraid of the link between headache and epilepsy? Some reactions to and reflections on the article by Marte Helene Bjork and co-workers. The Journal of Headache and Pain, 2009, 10(5): 327-329.
35.	Koutroumanidis M. Panayiotopoulos syndrome: an important electroclinical example of benign childhood system epilepsy. Epilepsia, 2007, 48(6): 1044-1053.
36.	Panayiotopoulos CP. Visual phenomena and headache in occipital epilepsy: a review, a systematic study and differentiation from migraine. Epileptic Disorders, 1999, 1(4): 205-216.
37.	Sances G, Guaschino E, Perucca P, et al. Migralepsy: a call for a revision of the definition. Epilepsia, 2009, 50(11): 2487-2496.
38.	Isler H, Wieser H, Egli M. Hemicrania epileptica: synchronous ipsilateral ictal headache with migraine features// In: Andermann F, LugaresiE(eds) Migraine and epilepsy. Butterworth, Boston, 1987: 249-263.
39.	Cianchetti C, Ledda MG, Pruna D. Headache, migraine and epileptic seizures.A comment on the types of association and on terminology. Cephalalgia, 2012, 32(16): 1225-1226.
40.	Parisi P, Striano P, Negro A, et al. Ictal epileptic headache: an old story with courses and appeals. The Journal of Headache and Pain, 2012, 13(8): 607-613.
41.	Hofstra WA, Hageman G, de Weerd AW. Periictal and interictal headache including migraine in Dutch patients with epilepsy: a cross-sectional study. Epilepsy & Behavior, 2015, 44(8): 155-158.
42.	Jacob J, Goadsby PJ, Duncan JS. Use of sumatriptan in post-ictal migraine headache. Neurology, 1996, 47(4): 1104.
43.	Evans RW, Gladstein J. Postictal headache and migraine. Headache, 2006, 46(5): 810-812.
44.	Hofstra WA, Hageman G, de Weerd AW. Headache in epilepsy patients: the (un)awareness of this phenomenon among Dutch neurologists. Seizure, 2015, 25(7): 37-39.
45.	Kossoff EH, Andermann F. Migraine and epilepsy. Seminars in Pediatric Neurology, 2010, 17(2): 117-122.
46.	Piccioli M, Parisi P, Tisei P, et al. Ictal headache and visual sensitivity. Cephalalgia, 2009, 29(2): 194-203.
47.	Gronseth GS, Greenberg MK. The utility of the electroencephalogram in the evaluation of patients presenting with headache: a review of the literature. Neurology, 1995, 45(7): 1263-1267.
48.	Salazar AM, Grafman J. Post-traumatic epilepsy: clinical clues to pathogenesis and paths to prevention. Handbook of Clinical Neurology, 2015, 128(20): 525-538.
49.	Silberstein SD. Topiramate in migraine prevention: evidence-based medicine from clinical trials. Neurological Sciences, 2004, 25(Suppl 3): 244-245.
50.	Felton EA, Cervenka MC. Dietary therapy is the best option for refractory nonsurgical epilepsy. Epilepsia, 2015, 56(9): 1325-1329.
51.	Strahlman RS. Can ketosis help migraine sufferers?.A Case Report. Headache, 2006, 46(1): 182.
52.	Diener H-C, Charles A, Goadsby PJ, et al. New therapeutic approaches for the prevention and treatment of migraine. The Lancet Neurology, 2015, 14(10): 1010-1022.
53.	Bhola R, Kinsella E, Giffin N, et al. Single-pulse transcranial magnetic stimulation (sTMS) for the acute treatment of migraine: evaluation of outcome data for the UK post market pilot program. The Journal of Headache and Pain, 2015, 16(7): 535.
54.	魏強. 經顱磁刺激治療神經系統疾病的研究進展. 國際神經病學神經外科學雜志, 2011, 38(5): 492-496.
55.	Pakalnis A, Greenberg G, Drake ME, et al. Pediatric migraine prophylaxis with divalproex. Journal of Child Neurology, 2001, 16(10): 731-734.
56.	Gaitatzis A, Sander JW. The mortality of epilepsy revisited. Epileptic Disorders, 2004, 6(1): 3-13.
57.	Velioglu SK, Boz C, Ozmenoglu M. The impact of migraine on epilepsy: a prospective prognosis study. Cephalalgia, 2005, 25(7): 528-535.
58.	Headache Classification Committee of the International Headache S. The International Classification of Headache Disorders, 3rd edition (beta version). Cephalalgia, 2013, 33(9): 629-808.
59.	Bianchin MM, Londero RG, Lima JE, et al. Migraine and epilepsy: a focus on overlapping clinical, pathophysiological, molecular, and therapeutic aspects. Current Pain and Headache Reports, 2010, 14(4): 276-283.

1. 鄢波, 周東. 神經系統慢性疾病的綜合管理. 華西醫學, 2015, 30(4): 601-603.
2. 于生元, 李舜偉, 李焰生. 中國偏頭痛診斷治療指南. 中國疼痛醫學雜志, 2011, 17(2): 65-86.
3. Nakano H, Inoue Y. Epidemiology and cause of epilepsy. Nihon rinsho Japanese Journal of Clinical Medicine, 2014, 72(5): 785-789.
4. Yu S, Liu R, Zhao G, et al. The Prevalence and Burden of Primary Headaches in China:A Population-Based Door-to-Door Survey. Headache, 2012, 52(4): 582-591.
5. Keezer MR, Bauer PR, Ferrari MD, et al. The comorbid relationship between migraine and epilepsy: a systematic review and meta-analysis. European Journal of Neurology, 2015, 22(7): 1038-1047.
6. Wang XQ, Lang SY, Zhang X, et al. Comidity between headache and epilepsy in a Chinese epileptic center. Epilepsy Research, 2014, 108(3): 535-541.
7. Grafstein B. Mechanism of spreading cortical depression. Journal of Neurophysiology, 1956, 19(2): 154-171.
8. Herreras O. Electrical prodromals of spreading depression void Grafstein’s potassium hypothesis. Journal of Neurophysiology, 2005, 94(5): 3656; author reply 3656-3657.
9. Bolay H, Reuter U, Dunn AK, et al. Intrinsic brain activity triggers trigeminal meningeal afferents in a migraine model. Nature Medicine, 2002, 8(2): 136-142.
10. Ghaemi A, Sajadian A, Khodaie B, et al. The immunological and neuroimmunological response to spreading depression in Wistar rats. International Journal of Developmental Neuroscience, 2015, 47(Pt A): 6-7.
11. Parisi P. Why is migraine rarely, and not usually, the sole ictal epileptic manifestation?. Seizure, 2009, 18(5): 309-312.
12. Parisi P, Kasteleijn-Nolst Trenite DG, Piccioli M, et al.A case with atypical childhood occipital epilepsy “Gastaut type”: an ictal migraine manifestation with a good response to intravenous diazepam. Epilepsia, 2007, 48(11): 2181-2186.
13. Parisi P, Piccioli M, de Sneeuw S, et al. Redefining headache diagnostic criteria as epileptic manifestation? Cephalalgia, 2008, 28(4): 408-409; author reply 409.
14. Parisi P, Piccioli M, Villa MP, et al. Hypothesis on neurophysiopathological mechanisms linking epilepsy and headache. Medical Hypotheses, 2008, 70(6): 1150-1154.
15. Pedersen M, Curwood EK, Vaughan DN, et al. Abnormal brain areas common to the focal epilepsies: Multivariate pattern analysis of fMRI. Brain Connectivity, 2015, Epub ahead of print.
16. Zhao L, Liu J, Dong X, et al. Alterations in regional homogeneity assessed by fMRI in patients with migraine without aura stratified by disease duration. The Journal of Headache and Pain, 2013, 14(2): 85.
17. Haglund MM, Schwartzkroin PA. Role of Na-K pump potassium regulation and IPSPs in seizures and spreading depression in immature rabbit hippocampal slices. Journal of Neurophysiology, 1990, 63(2): 225-239.
18. Silberstein SD, Dodick DW. Migraine genetics: Part II. Headache, 2013, 53(8): 1218-1229.
19. Vanmolkot KR, Kors EE, Hottenga JJ, et al. Novel mutations in the Na⁺, K⁺-ATPase pump gene ATP1A2 associated with familial hemiplegic migraine and benign familial infantile convulsions. Annals of Neurology, 2003, 54(3): 360-366.
20. Costa C, Prontera P, Sarchielli P, et al.A novel ATP1A2 gene mutation in familial hemiplegic migraine and epilepsy. Cephalalgia, 2014, 34(1): 68-72.
21. Cestele S, Labate A, Rusconi R, et al. Divergent effects of the T1174S SCN1A mutation associated with seizures and hemiplegic migraine. Epilepsia, 2013, 54(5): 927-935.
22. Winawer MR, Connors R, Investigators E. Evidence for a shared genetic susceptibility to migraine and epilepsy. Epilepsia, 2013, 54(2): 288-295.
23. Raggi A, Leonardi M, D’Amico D, et al.A Step Forward on Similarities Between Migraine and Epilepsy: Psychosocial Difficulties. Headache, 2015, 55(9): 1272-1273.
24. Hughes J, Devinsky O, Feldmann E, et al. Premonitory symptoms in epilepsy. Seizure, 1993, 2(3): 201-203.
25. Giffin NJ, Ruggiero L, Lipton RB, et al. Premonitory symptoms in migraine: an electronic diary study. Neurology, 2003, 60(6): 935-940.
26. Crompton DE, Berkovic SF. The borderland of epilepsy: clinical and molecular features of phenomena that mimic epileptic seizures. The Lancet Neurology, 2009, 8(4): 370-381.
27. Wild E. Deja vu in neurology. Journal of Neurology, 2005, 252(1): 1-7.
28. Russell MB, Olesen J.A nosographic analysis of the migraine aura in a general population. Brain, 1996, 119 ( Pt 2): 355-361.
29. Mainieri G, Cevoli S, Giannini G, et al. Headache in epilepsy: prevalence and clinical features. The Journal of Headache and Pain, 2015, 16(10): 556.
30. Haut SR, Bigal ME, Lipton RB. Chronic disorders with episodic manifestations: focus on epilepsy and migraine. The Lancet Neurology, 2006, 5(2): 148-157.
31. Duchaczek B, Ghaeni L, Matzen J, et al. Interictal and periictal headache in patients with epilepsy. European Journal of Neurology, 2013, 20(10): 1360-1366.
32. Vollono C, Mariotti P, Losurdo A, et al. Headache Following Occipital Brain Lesion:A Case of Migraine Triggered by Occipital Spikes?. Clinical EEG and Neuroscience, 2015, 46(4): 364-369.
33. Berg AT, Berkovic SF, Brodie MJ, et al. Revised terminology and concepts for organization of seizures and epilepsies: report of the ILAE Commission on Classification and Terminology, 2005-2009. Epilepsia, 2010, 51(4): 676-685.
34. Parisi P. Who’s still afraid of the link between headache and epilepsy? Some reactions to and reflections on the article by Marte Helene Bjork and co-workers. The Journal of Headache and Pain, 2009, 10(5): 327-329.
35. Koutroumanidis M. Panayiotopoulos syndrome: an important electroclinical example of benign childhood system epilepsy. Epilepsia, 2007, 48(6): 1044-1053.
36. Panayiotopoulos CP. Visual phenomena and headache in occipital epilepsy: a review, a systematic study and differentiation from migraine. Epileptic Disorders, 1999, 1(4): 205-216.
37. Sances G, Guaschino E, Perucca P, et al. Migralepsy: a call for a revision of the definition. Epilepsia, 2009, 50(11): 2487-2496.
38. Isler H, Wieser H, Egli M. Hemicrania epileptica: synchronous ipsilateral ictal headache with migraine features// In: Andermann F, LugaresiE(eds) Migraine and epilepsy. Butterworth, Boston, 1987: 249-263.
39. Cianchetti C, Ledda MG, Pruna D. Headache, migraine and epileptic seizures.A comment on the types of association and on terminology. Cephalalgia, 2012, 32(16): 1225-1226.
40. Parisi P, Striano P, Negro A, et al. Ictal epileptic headache: an old story with courses and appeals. The Journal of Headache and Pain, 2012, 13(8): 607-613.
41. Hofstra WA, Hageman G, de Weerd AW. Periictal and interictal headache including migraine in Dutch patients with epilepsy: a cross-sectional study. Epilepsy & Behavior, 2015, 44(8): 155-158.
42. Jacob J, Goadsby PJ, Duncan JS. Use of sumatriptan in post-ictal migraine headache. Neurology, 1996, 47(4): 1104.
43. Evans RW, Gladstein J. Postictal headache and migraine. Headache, 2006, 46(5): 810-812.
44. Hofstra WA, Hageman G, de Weerd AW. Headache in epilepsy patients: the (un)awareness of this phenomenon among Dutch neurologists. Seizure, 2015, 25(7): 37-39.
45. Kossoff EH, Andermann F. Migraine and epilepsy. Seminars in Pediatric Neurology, 2010, 17(2): 117-122.
46. Piccioli M, Parisi P, Tisei P, et al. Ictal headache and visual sensitivity. Cephalalgia, 2009, 29(2): 194-203.
47. Gronseth GS, Greenberg MK. The utility of the electroencephalogram in the evaluation of patients presenting with headache: a review of the literature. Neurology, 1995, 45(7): 1263-1267.
48. Salazar AM, Grafman J. Post-traumatic epilepsy: clinical clues to pathogenesis and paths to prevention. Handbook of Clinical Neurology, 2015, 128(20): 525-538.
49. Silberstein SD. Topiramate in migraine prevention: evidence-based medicine from clinical trials. Neurological Sciences, 2004, 25(Suppl 3): 244-245.
50. Felton EA, Cervenka MC. Dietary therapy is the best option for refractory nonsurgical epilepsy. Epilepsia, 2015, 56(9): 1325-1329.
51. Strahlman RS. Can ketosis help migraine sufferers?.A Case Report. Headache, 2006, 46(1): 182.
52. Diener H-C, Charles A, Goadsby PJ, et al. New therapeutic approaches for the prevention and treatment of migraine. The Lancet Neurology, 2015, 14(10): 1010-1022.
53. Bhola R, Kinsella E, Giffin N, et al. Single-pulse transcranial magnetic stimulation (sTMS) for the acute treatment of migraine: evaluation of outcome data for the UK post market pilot program. The Journal of Headache and Pain, 2015, 16(7): 535.
54. 魏強. 經顱磁刺激治療神經系統疾病的研究進展. 國際神經病學神經外科學雜志, 2011, 38(5): 492-496.
55. Pakalnis A, Greenberg G, Drake ME, et al. Pediatric migraine prophylaxis with divalproex. Journal of Child Neurology, 2001, 16(10): 731-734.
56. Gaitatzis A, Sander JW. The mortality of epilepsy revisited. Epileptic Disorders, 2004, 6(1): 3-13.
57. Velioglu SK, Boz C, Ozmenoglu M. The impact of migraine on epilepsy: a prospective prognosis study. Cephalalgia, 2005, 25(7): 528-535.
58. Headache Classification Committee of the International Headache S. The International Classification of Headache Disorders, 3rd edition (beta version). Cephalalgia, 2013, 33(9): 629-808.
59. Bianchin MM, Londero RG, Lima JE, et al. Migraine and epilepsy: a focus on overlapping clinical, pathophysiological, molecular, and therapeutic aspects. Current Pain and Headache Reports, 2010, 14(4): 276-283.

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