Efficacy and aging comparative study of different doses and sources of lamotrigine on cortex convulsive threshold in electrical stimulated rats_Journal of Epilepsy

Authors：

 SUYu ¹ , HAOWeicheng ¹ , LIUCongxi ¹ , ZHAOYongxiong ¹ ,  LIUYuxi ²

1. West courtyard of the Second Hospital of Shanxi Medical University, Taiyuan 030024, China;
2. Institute of Epilepsy of Shanxi Medical University, Taiyuan 030053, China;

Corresponding?author：

LIUYuxi, Email: liuyuxi2003@163.com

Keywords：

Epilepsy; Lamotrigine; Different sources; Convulsions threshold; Rats

DOI：

10.7507/2096-0247.20160022

Video：

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Abstract Full text Figures/Tables Video References Cited by

Objective Using cortex convulsions threshold detector and electrical stimulation in rats cortex convulsions threshold model, compare the efficacy and aging of domestic lamotrigine (LTG) and imported LTG. Methods Electrical stimulation convulsions threshold model in rats after stability, 40 rats were randomly divided into A、B、C、D groups,AandBgroup were divided into three different dose groups: domestic LTG low dose (12.5 mg/kg/d), middle dose (25 mg/kg·d), high dose group (37.5 mg/kg·d); imported LTG low doses (12.5 mg/kg·d), middle dose (25 mg/kg·d), high dose group (37.5 mg/kg·d); Carbamazepine middle dose group (72 mg/kg·d); the control group (normal saline 2 ml/time). Recording electrical stimulation in rats cortex convulsions threshold model after administration, compare the differences before and after the administration. Results Three different dose groups of domestic LTG and imported LTG all hadahigher level of electrical stimulation cortex convulsions threshold, and showedadose-response relationship. Onset time of LTG after administration was 1 to 2 hours, peak time was 3 to 4 hours, maintaining time was 8 to 10 hours. Conclusion LTG can improve cortex convulsions threshold in the electrical stimulated rats, there was no significant difference with carbamazepine, and showedadose-response relationship; Repeat dosing for 4 days, both domestic and imported LIG can maintain effective anticonvulsive effect, the efficacy and the aging of two groups of LTG have no significant difference (P＞0.05).

Citation： SUYu, HAOWeicheng, LIUCongxi, ZHAOYongxiong, LIUYuxi. Efficacy and aging comparative study of different doses and sources of lamotrigine on cortex convulsive threshold in electrical stimulated rats. Journal of Epilepsy, 2016, 2(2): 118-122. doi: 10.7507/2096-0247.20160022 Copy

1.	Liu Yuxi, Geng Leiyu. Experimental research on physiological and pathological electric convulsion thresholds in rats. Neural Regeneration Research, 2008, 3(3): 250-257.
2.	郝衛成, 蘇彧, 劉玉璽. 伊來西胺與卡馬西平在抗癲癇治療中的時效與藥效比較研究.中國藥物與臨床, 2012, 16(6): 739-741.
3.	Voskuyl RA, Dingemanse J, Danhof M. Determination of the threshold for convulsions by direct cortical stimulation. Epelepsy Res, 1989, 13(3): 120-129.
4.	Voskuyl RA,Hoogerkamp A, Danhof M. Properties of the convulsive threshold determined by direct cortical stimulation in rats. Epilepsy Res,1992, 12(6): 111-120.
5.	郝衛成, 劉玉璽. 拉莫三嗪對電刺激大鼠運動皮層驚厥模型干預的病理生理學研究. 中國藥物與臨床, 2008, 12(8): 963-966.
6.	蘇彧,劉玉璽.迷走神經、軀體神經與運動皮質電刺激對戊四氮點燃大鼠驚厥行為影響的實驗研究.中華神經科雜志,2010,43(7): 267-271.
7.	落成壽,康宏春,劉玉璽.拉莫三嗪消化道給藥對大鼠驚厥閾值的影響,實用醫技雜志, 2013, 20(7): 721-722.
8.	劉春, 任惠. 新型抗癲癇藥物拉莫三嗪研究進展. 實用臨床醫學, 2015, 16(2): 104-107.
9.	鄧洪, 廖齊. 林原斌.拉莫三嗪的合成. 中國醫藥工業雜志, 2006, 37(10): 657-658.
10.	王學峰, 晏勇, 沈鼎烈. 拉莫三嗪對難治性癲癇的治療作用. 新藥與臨床, 1997, 16 (5): 260-263.
11.	Adachi M, Kawasaki Y. The effects of lamotrigine on refractory epilepsies in persons with severe motor and intellectual disabilities. Brain and Development, 2012, 44(6): 445-449.
12.	Saetre E, Abdelnoor M, Perucca E, et al. Aatiepileptic drugs and quality of life in the elderly:results fromarandomized double-blind trail of carbamazepine and lamotrigine in patients with onset of epilepsy in old age. Epilepsy & Behavior, 2001,17(3): 395-401.
13.	Tomson T, Hirsch LJ, Friedman D, et al. Sudden unexpected death in epilepey in lamotrigine tandomized-controlled trials. Epilepsia, 2013, 54(1): 135-140.
14.	郝衛成,蘇彧,劉聰喜,等.利用電刺激大鼠皮層驚厥閾值模型測定不同劑量國產和進口左乙拉西坦的藥效與時效.中國藥物與臨床,2015,(9):1261-1264.

1. Liu Yuxi, Geng Leiyu. Experimental research on physiological and pathological electric convulsion thresholds in rats. Neural Regeneration Research, 2008, 3(3): 250-257.
2. 郝衛成, 蘇彧, 劉玉璽. 伊來西胺與卡馬西平在抗癲癇治療中的時效與藥效比較研究.中國藥物與臨床, 2012, 16(6): 739-741.
3. Voskuyl RA, Dingemanse J, Danhof M. Determination of the threshold for convulsions by direct cortical stimulation. Epelepsy Res, 1989, 13(3): 120-129.
4. Voskuyl RA,Hoogerkamp A, Danhof M. Properties of the convulsive threshold determined by direct cortical stimulation in rats. Epilepsy Res,1992, 12(6): 111-120.
5. 郝衛成, 劉玉璽. 拉莫三嗪對電刺激大鼠運動皮層驚厥模型干預的病理生理學研究. 中國藥物與臨床, 2008, 12(8): 963-966.
6. 蘇彧,劉玉璽.迷走神經、軀體神經與運動皮質電刺激對戊四氮點燃大鼠驚厥行為影響的實驗研究.中華神經科雜志,2010,43(7): 267-271.
7. 落成壽,康宏春,劉玉璽.拉莫三嗪消化道給藥對大鼠驚厥閾值的影響,實用醫技雜志, 2013, 20(7): 721-722.
8. 劉春, 任惠. 新型抗癲癇藥物拉莫三嗪研究進展. 實用臨床醫學, 2015, 16(2): 104-107.
9. 鄧洪, 廖齊. 林原斌.拉莫三嗪的合成. 中國醫藥工業雜志, 2006, 37(10): 657-658.
10. 王學峰, 晏勇, 沈鼎烈. 拉莫三嗪對難治性癲癇的治療作用. 新藥與臨床, 1997, 16 (5): 260-263.
11. Adachi M, Kawasaki Y. The effects of lamotrigine on refractory epilepsies in persons with severe motor and intellectual disabilities. Brain and Development, 2012, 44(6): 445-449.
12. Saetre E, Abdelnoor M, Perucca E, et al. Aatiepileptic drugs and quality of life in the elderly:results fromarandomized double-blind trail of carbamazepine and lamotrigine in patients with onset of epilepsy in old age. Epilepsy & Behavior, 2001,17(3): 395-401.
13. Tomson T, Hirsch LJ, Friedman D, et al. Sudden unexpected death in epilepey in lamotrigine tandomized-controlled trials. Epilepsia, 2013, 54(1): 135-140.
14. 郝衛成,蘇彧,劉聰喜,等.利用電刺激大鼠皮層驚厥閾值模型測定不同劑量國產和進口左乙拉西坦的藥效與時效.中國藥物與臨床,2015,(9):1261-1264.

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Efficacy and aging comparative study of different doses and sources of lamotrigine on cortex convulsive threshold in electrical stimulated rats

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