Electroclinical features of the atypical of benign childhood epilepsy with central temporal spikes_Journal of Epilepsy

Authors：

 JIAGuijuan ,  LIBaomin , SUNRuopeng

Department of Neurology, Pediatric Medical Center, Qilu Hospital of Shandong University, Jinan 250012, China;

Corresponding?author：

LIBaomin, Email: lbmsqf@163.com

Keywords：

Epilepsy; Central temporal spikes; Children

DOI：

10.7507/2096-0247.20160017

Video：

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Objective To identify clinical and electroencephalographic features of the variants of benign childhood epilespy with centrotemporal spikes (BECTs). Methods A total of 51 children with BECTs were restrospectively reviewed from July 2008 to December 2015 in the study, including the clinical data, electrophysiologic characteristics and effects of antiepileptic drugs. Results Age of the patients ranged from 2.5 to 11 years old, which were averged 7.03 years old. The duration of disease varied from 4 days to 6 years, and 2.36 years in average. Nearly continuous electric discharge were detected in slow sleeping, during which, the busting index was 90% in 19 patients’, 78% in 26, 52% in 6. the average busting index was 82.44%.47 patients (92.1%) had synptom of hand shaking; 8 patients(15.6%) had oropharyngeal automatism; 7 patients (13.7%) had language barrier; sample absence seizures or tumble occurred in 11 patients (21.5%); cognitive declined in 17 patients (33.3%). VPA monotherapy had good effect on 12 patients, 33 patients need combination of VPA and CBZ. However, there’s still 6 patients need adrenocortical hormone to control seizures. Conclusion The variants of BECT are companied with obvious deterioration of EEG. Lack of standard AED therapy may cause aggravations, so we need to monitor EEG closely. We use AED not merely in orde to control seizure but also inhibit abnormal EEG discharge.

Citation： JIAGuijuan, LIBaomin, SUNRuopeng. Electroclinical features of the atypical of benign childhood epilepsy with central temporal spikes. Journal of Epilepsy, 2016, 2(2): 97-100. doi: 10.7507/2096-0247.20160017 Copy

1.	Roulet E,Deonna T,Despland PA.Prolonged intermittent drooling and oronqotor dyspraxia in benign childhood epilepsy with centrotemporal spikes.Epilepsia, 1989, 30(5): 564-568.
2.	Fejeman N, Caraballo R, Tenembaum SN. Atypical evolutions of benign localization-related epilepsies in children:are they predictable?. Epilepisa, 2009, 41(4): 380-390.
3.	楊志仙,劉曉燕,秦炯, 等. 不典型兒童良性部分性癲癇中癲癇性負性肌陣攣的臨床及電生理研究. 中華兒科雜志,2008, 46(12): 885-890.
4.	Aicard J. Atypical benign partial epilepsy of childhood. Develop Med Child Neurol, 1982, 24(3): 281-292.
5.	Patry G, Lyagoubi S, Tassinari CA. Subclinical “electrical status epilepticus” induced by sleep in children:a clinical and electroencephalographic study of six cases. Arch Neural, 1971, 24(3): 242-252.
6.	Tassinari CA, Bureau M, Dravet CH, et al. Epilepsy with continuous spikes and weaves during slow sleep (otherwise described as ESES-epilepsy with electrical status epilepus during slow sleep). Epileptic syndromes in infancy, childhood and adolescence. 2nd ed. Londo: Libbey-Eurotext, 1992: 245.
7.	Haha A, Pistohl J, Neubauer BA, et al. Atypial“benign” partical epilepsy or pseudo-Lennox syndrome:symptomatology and long-term prognosis. Neuropediatrics, 2006, 32(1): 1-8.
8.	劉曉燕,張月華,包新華,等. 兒童良性癲癇伴中央顳區棘波的變異型. 中華循證兒科雜志, 2007, 1(1): 33-39.
9.	Alper Dai, Seniz Demiryurek. The clinical implications of todd paralysis in children with benign rolandic epilepsy. Journal of Child Neurology.J Child Neurol, 2015, Jun 9. pii: 0883073815589760. [Epub ahead of print].
10.	Hideaki,Kanemura, Fumikazu Sano, et al. Sequential EEG characteristics may predict seizure recurrence in rolandic epilepsy. Seizure, 2014, 23 (8): 646-650.
11.	Kramer U. Atypical presentations of benign childhood epilepsywith centrotemporal spikes:a review.J Child Neurol, 2008, 23(5) : 785-790.
12.	Cerminara C, Montanaro ML, Curetolo P, et al. Lamotrigine induced seizure aggravation and negative myoclonus in idiopathic rolandic epilepsy.Neurology, 2004, 63(2): 373-375.
13.	Hamann S, Mochizuki M,Morikawa T. Phenobarbital induced atypical absence seizures in benign chiM hood epilepsy with centrotemporal spikes.Seizure, 2002, 11(3): 201-204.
14.	Corda D, Gelisse P, Genton P, et al. Incidence of drug-induced aggravation in benign epilepsy with centrotemporal spikes. Acta Neurol Scandal, 2003, 107(8): 302-303.
15.	Nanba Y, Maegaki Y. Epileptic negative myoclonus induced by carbamazepine inachild with benign childhood epilepsy with centrotemporal spikes. Pediatr Neurol, 1999, 21(3): 664-667.
16.	Fenglai Xiao, Dongmei An, Dong Zhou. Real-time effects of centrotemporal spikes on cognition in rolandic epilepsy: an EEG-fMRI study. Neurology, 2016 Jan 8. pii: 10.1212/WNL.0000000000002358. [Epub ahead of print].

1. Roulet E,Deonna T,Despland PA.Prolonged intermittent drooling and oronqotor dyspraxia in benign childhood epilepsy with centrotemporal spikes.Epilepsia, 1989, 30(5): 564-568.
2. Fejeman N, Caraballo R, Tenembaum SN. Atypical evolutions of benign localization-related epilepsies in children:are they predictable?. Epilepisa, 2009, 41(4): 380-390.
3. 楊志仙,劉曉燕,秦炯, 等. 不典型兒童良性部分性癲癇中癲癇性負性肌陣攣的臨床及電生理研究. 中華兒科雜志,2008, 46(12): 885-890.
4. Aicard J. Atypical benign partial epilepsy of childhood. Develop Med Child Neurol, 1982, 24(3): 281-292.
5. Patry G, Lyagoubi S, Tassinari CA. Subclinical “electrical status epilepticus” induced by sleep in children:a clinical and electroencephalographic study of six cases. Arch Neural, 1971, 24(3): 242-252.
6. Tassinari CA, Bureau M, Dravet CH, et al. Epilepsy with continuous spikes and weaves during slow sleep (otherwise described as ESES-epilepsy with electrical status epilepus during slow sleep). Epileptic syndromes in infancy, childhood and adolescence. 2nd ed. Londo: Libbey-Eurotext, 1992: 245.
7. Haha A, Pistohl J, Neubauer BA, et al. Atypial“benign” partical epilepsy or pseudo-Lennox syndrome:symptomatology and long-term prognosis. Neuropediatrics, 2006, 32(1): 1-8.
8. 劉曉燕,張月華,包新華,等. 兒童良性癲癇伴中央顳區棘波的變異型. 中華循證兒科雜志, 2007, 1(1): 33-39.
9. Alper Dai, Seniz Demiryurek. The clinical implications of todd paralysis in children with benign rolandic epilepsy. Journal of Child Neurology.J Child Neurol, 2015, Jun 9. pii: 0883073815589760. [Epub ahead of print].
10. Hideaki,Kanemura, Fumikazu Sano, et al. Sequential EEG characteristics may predict seizure recurrence in rolandic epilepsy. Seizure, 2014, 23 (8): 646-650.
11. Kramer U. Atypical presentations of benign childhood epilepsywith centrotemporal spikes:a review.J Child Neurol, 2008, 23(5) : 785-790.
12. Cerminara C, Montanaro ML, Curetolo P, et al. Lamotrigine induced seizure aggravation and negative myoclonus in idiopathic rolandic epilepsy.Neurology, 2004, 63(2): 373-375.
13. Hamann S, Mochizuki M,Morikawa T. Phenobarbital induced atypical absence seizures in benign chiM hood epilepsy with centrotemporal spikes.Seizure, 2002, 11(3): 201-204.
14. Corda D, Gelisse P, Genton P, et al. Incidence of drug-induced aggravation in benign epilepsy with centrotemporal spikes. Acta Neurol Scandal, 2003, 107(8): 302-303.
15. Nanba Y, Maegaki Y. Epileptic negative myoclonus induced by carbamazepine inachild with benign childhood epilepsy with centrotemporal spikes. Pediatr Neurol, 1999, 21(3): 664-667.
16. Fenglai Xiao, Dongmei An, Dong Zhou. Real-time effects of centrotemporal spikes on cognition in rolandic epilepsy: an EEG-fMRI study. Neurology, 2016 Jan 8. pii: 10.1212/WNL.0000000000002358. [Epub ahead of print].

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