外科手術與藥物治療對于難治性癲癇患者發作控制外的結局指標的比較_Journal of Epilepsy

Authors：

 鄒雪梅 ¹ ,  慕潔 ²

1. ;
2. ;

Corresponding?author：

慕潔, Email: mujie2010@foxmail.com

Keywords：

生活質量; 認知; 社會心理功能; 死亡率; 費用; 難治性癲癇

DOI：

10.7507/2096-0247.20160014

Video：

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約有1/3的癲癇患者發展為耐藥性癲癇, 控制達無發作的可能性隨著添加藥物而降低。經適當篩選的患者, 癲癇手術增加了其達到無發作并徹底停藥的可能性。癲癇手術和藥物治療一樣, 并非沒有副作用。為了給病人提供明智、全面的建議, 醫療人員需要了解這兩種治療的優勢和劣勢。隨機對照試驗結果顯示對于顳葉癲癇, 手術比持續藥物治療效果更好。雖然所有治療的最終目標都是無發作, 但它只代表了各種影響患者生活質量的其中一個預后指標。了解影響預后指標的變量以及預后指標間如何相互影響是有必要的。關于比較手術治療與藥物治療難治性癲癇的研究數據有限, 對治療結局相關指標的數據進行了回顧。這些結局指標除無發作以外, 還包括生活質量、認知、社會心理功能、死亡率及經濟成本等

Citation： 鄒雪梅, 慕潔. 外科手術與藥物治療對于難治性癲癇患者發作控制外的結局指標的比較. Journal of Epilepsy, 2016, 2(1): 72-80. doi: 10.7507/2096-0247.20160014 Copy

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9.	Benifla M, Rutka JT, Otsubo H, et al. Long-term seizure and social outcomes following temporal lobesurgery for intractable epilepsy during childhood. Epilepsy Res, 2008, 82(10):133-138.
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1. Alexandre L Jr, Walz R, Bianchin MM, et al.Seizure outcomeafter surgery for epilepsy due to focal cortical dysplastic lesions.Seizure, 2006, 15(6): 420-427.
2. Baca CB, Vickrey BG, Vassar S, et al.Time to pediatricepilepsy surgery is related to disease severity and nonclinical factors.Neurology, 2013, 80(12):1231-1239.
3. Baker GA, Taylor J, Aldenkamp AP. Newly diagnosed epilepsy:cognitive outcome after 12 months. Epilepsia, 2013, 52(8):1084-1091.
4. Baxendale S, Heaney D, Thompson PJ, et al. Cognitive consequences of childhood-onset temporal lobe epilepsy across theadult lifespan.Neurology, 2010, 75(6):705-711.
5. Begley CE, Beghi E. The economic cost of epilepsy: a review of theliterature. Epilepsia, 2002, 43(10):3-9.
6. Begley CE, Annegers JF, Lairson DR, et al. Cost of epilepsy in the United States: a model based onincidence and prognosis. Epilepsia, 1994, 35(3):1230-1243.
7. Begley CE, Famulair M, Annegers JF, et al. The cost of epilepsy in the United States: an estimate from population-basedclinical and survey data. Epilepsia, 2000, 41(8):342-351.
8. Bell GS, Sinha S, de Tsi JD, et al. Premature mortality in refractory partial epilepsy: does surgical treatment make a difference?. J Neurol Neurosurg Psychiatry, 2010, 81(13):716-718.
9. Benifla M, Rutka JT, Otsubo H, et al. Long-term seizure and social outcomes following temporal lobesurgery for intractable epilepsy during childhood. Epilepsy Res, 2008, 82(10):133-138.
10. Berg AT, Zelko FA, Levi SR, et al.Age at onset of epilepsy, pharmacoresistance and cognitive outcomes: a prospective cohortstudy. Neurology, 2008, 79(9):1384-1391.
11. Bernasconi N, Natsume J, Bernasconi A. Progression in temporallobe epilepsy: differential atrophy is mesial temporal structures.Neurology, 2005, 65(11):223-228.
12. Bilginer B, Yalnizoglu D, Soylemezoglu F, et al.Surgery for epilepsy in children withdysembryoplastic neuroepithelial tumor: clinical spectrum, seizureoutcome, neuroradiology and pathology. Childs Nerv Syst, 2009, 25(7): 485-491.
13. Chang EF, Wang DD, Barkovich AJ, et al.Predictors of seizure freedom aftersurgery for malformations of cortical development. Ann Neurol, 2011, 70(9):151-162.
14. Chen LS, Wang N, Mei-Ing L. Seizure outcome of intractablepartial epilepsy in children. Pediatr Neurol, 2002, 26(5): 282-287.
15. Choi H, Sell RL, Lenert L, et al. Epilepsy surgery for pharmacoresistant temporal lobeepilepsy: a decision analysis. JAMA, 2008, 300(25):2497-2505.
16. Coan AC, Appenzeller S, Bonilha LM, et al. Seizure frequency and lateralization affect progression of atrophy in temporal lobeepilepsy. Neurology, 2009, 73(12):834-842.
17. Cockerell OC, Johnson AL, Sander JWAS, et al. Prognosis of epilepsy: a review and further analysis of the first nine years of theBritish national general practice study of epilepsy, a prospective population-based study. Epilepsia, 1997, 38(11):31-46.
18. Cossu M, Lo Russo G, Francione S, et al. Epilepsy surgery in children: results and predictors of outcomeon seizures. Epilepsia, 2008, 49(20):65-72.
19. Dupont S, Tanguy ML, Clemenceau S, et al.Long-term prognosis and psychosocial outcomes after surgery for MTLE. Epilepsia, 2006, 47(12):2115-2124.
20. Elsharkawy AE, Thorbecke R, Ebner A, et al. Determinants of quality of life in patients with refractory focal epilepsy who were not eligible for surgery or who rejected surgery. Epilepsy Behav, 2012, 24(8):249-255.
21. Engel J Jr, McDermott MP, Wiebe S, et al.Early surgical therapy for drug-resistant temporal lobe epilepsy. JAMA, 2012, 307(25):922-930.
22. Freitag H, Tuxhorn I. Cognitive function in preschool children after epilepsy surgery: rationale for early intervention. Epilepsia, 2005, 46(12):561-567.
23. Gilliam F. Optimizing health outcomes in active epilepsy.Neurology, 2002, 58(Suppl 1):9-20.
24. Gilliam F. The impact of epilepsy of subjective health status. Curr Neurol Neurosci Rep, 2003, 3(7):357-362.
25. Gilliam F, Kuzniecky R, Meador K, et al.Patient-oriented outcome assessment after temporal lobectomy for refractory epilepsy. Neurology, 2006, 53(11):687-694.
26. Gilman J, Duchowny M, Jayakar P, et al. Medical intract ability in children evaluated for epilepsy surgery. Neurology, 1994, 44(16):1341-1343.
27. Griffiths SY, Sherman EM, Slick DJ, et al. Postsurgical health-related quality of life (HRQOL) in children following hemispherectomy for intractable epilepsy. Epilepsia, 2007, 48(22):564-570.
28. Guarnieri R, Walz R, Hallak JE, et al.Do psychiatric comorbidities predict postoperative seizure outcome in temporal lobe epilepsy? EpilepsyBehav, 2009, 14(8):529-534.
29. Guilioni M, Rubboli G, Marucci G, et al.Seizure outcome of epilepsy surgery in focal epilepsiesassociated with temporomesial glioneuronal tumors: lesione ctomycompared with tailored resection. J Neurosurg, 2009, 111(24):1275-1282.
30. Guldvog B, Loyning Y, Hauglie-Hanssen E, et al.Surgical versus medical treatment for epilepsy: outcome related tosurvival, seizures, and neurologic deficit. Epilepsia, 1991, 32(8a):375-388.
31. Guldvog B, Loyning Y, Hauglie-Hanssen E, et al.Surgical versus medical treatment for epilepsy: outcome related tosocial areas. Epilepsia, 1991, 32(8b):477-486.
32. Helmstaedter C, Kurthen M, Lux S, et al.Chronic epilepsy and cognition: a longitudinal study in temporal lobe epilepsy.Ann Neurol, 2003, 54(10):425-432.
33. Hermann BP, Seidenberg M, Bell B, et al.The neurodevelopmental impact ofchildhood-onset temporal lobe epilepsy on brain structure and function.Epilepsia, 2002, 43(15):1062-1071.
34. Hermann BP, Seidenberg M, Dow C, et al.Cognitive prognosis in chronic temporal lobe epilepsy.Ann Neurol, 2006, 60(15):80-87.
35. Jonas R, Nguyen S, Hu B, et al.Cerebral hemispherectomy: hospital course, seizure, developmental, language and motor outcomes. Neurology, 2004, 62(17):1712-1721.
36. Kanner AM, Byrne R, Chicarro A, et al. A life time psychiatric history predicts a worse seizure outcome followingtemporal lobectomy. Neurology, 2009, 72(16):793-799.
37. Keene D, Ventureya ECG. Epilepsy surgery for 5-to 18-year old patients with refractory epilepsy-is it cost efficient? Childs Nerv Syst, 1999, 15(9):52-54.
38. Kemmotsu N, Girard HM, Bernhardt BC, et al.Comparison of white matter tracts and cortical volume in RTLE vs LTLE. Epilepsia, 2001, 52(7):2257-2266.
39. Korman B, Bernal B, Duchowny M, et al. Atpical propositional language organization in prenatal and early-acquired lesions. J Child Neurol, 2001, 25(6):985-993.
40. Krsek P, Maton B, Jayakar P, et al. Incomplete resection of focal cortical dysplasia isthe main predictor of poor surgical outcome. Neurology, 2009, 72(30):217-223.
41. Kwan P, Brodie MJ. Early identification of refractory epilepsy. NEngl J Med, 2000, 342(5):314-319.
42. Langfitt JT, Holloway RG, McDermott MP, et al.Health care costs decline after successful epilepsy surgery.Neurology, 2007, 68(7a):1290-1298.
43. Langfitt JT, Westerveld M, Hamberger MJ, et al.Worsening of quality of life after epilepsy surgery: effect of seizures and memory decline. Neurology, 2007, 68(7b):1988-1994.
44. Lettori D, Battaglia D, Sacco A, et al. Early hemispherectomy in catastrophic epilepsy: a cognitive and epileptic long-term follow-up. Seizure, 2008, 17(3):49-63.
45. Luciano AL, Shorvon SD. Results of treatment changes in patientswith apparently drug-resistant chronic epilepsy. Ann Neurol, 2007, 62(15):375-381.
46. Macrodimitris S, Sherman EMS, Forde S, et al. Psychiatric outcomes of epilepsy surgery: a systemic review. Epilepsia, 2011, 52(10):880-890.
47. Malmgren K, Olsson I, Engman E, et al.Seizure outcome after resective surgery in patients with low IQ. Brain, 2008, 131(29):535-542.
48. McClelland S, Guo H, Okuyemi KS. Population-based analysis of morbidity and mortality following surgery for intractable temporal lobe epilepsy in the United States. Arch Neurol, 2011, 68(20):725-729.
49. Mikati MA, Ataya N, Ferzil J, et al.Quality of life after surgery for intractable partial epilepsy in children: a cohort study with controls.Epilepsy Res, 2010, 90(32):207-213.
50. Murray MI, Halpern MT, Leppik IE. Cost of refractory epilepsy inadults in the USA. Epilepsy Res, 1996, 23(5):139-148.
51. Neligan A, Bell GS, Sander JW, et al. How refractory is refractory epilepsy? Patterns of relapse and remission in people with refractory epilepsy. Epilepsy Res, 2011, 96(30):225-230.
52. Nickels KC, Grossardt BR, Wirrell EC. Epilepsy-related mortalityis low in children: a 30-year population-based study in Olmsted County, MN. Epilepsia, 2012, 53(17):2164-2171.
53. Nilsson L, Tomson T, Farahmand BY, et al.Cause-specific mortality in epilepsy: a cohort study of more than 9000 patients once hospitalized for epilepsy. Epilepsia, 1997, 38(8):1062-1068.
54. Paolicchi JM, Jayakar J, Dean P, et al.Predictors of outcome in pediatric epilepsy surgery. Neurology, 2000, 54(7):642-647.
55. Perrine K, Hermann BP, Meador KJ, et al.The relationship of neuropsychological functioning to quality of life in epilepsy. Arch Neurol, 1995, 52(16):997-1003.
56. Perry MS, Dunoyer C, Dean P, et al. Predictors of seizure freedom after incomplete resection in children. Neurology, 2010, 75(23):1448-1453.
57. Platt M, Sperling MR. A comparison of surgical and medical costsfor refractory epilepsy. Epilepsia, 2002, 43(14):25-31.
58. Rowland NC, Englot DJ, Cage TA, et al. A meta-analysis of predictors of seizure freedom in the surgical management of focal cortical dysplasia. J Neurosurg, 2012, 116(45):1035-1041.
59. Sabaz M, Lawson JL, Cairns DR, et al.The impact of epilepsy surgery on quality of life in children. Neurology, 2006, 66(20):557-561.
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Journal of Epilepsy

外科手術與藥物治療對于難治性癲癇患者發作控制外的結局指標的比較

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