特發性全面性癲癇的神經影像研究進展_Journal of Epilepsy

Authors：

 羅程 , 堯德中

電子科技大學信息醫學研究中心神經信息教育部重點實驗室高場磁共振腦成像四川省重點實驗室, 成都, 610054;

Corresponding?author：

羅程, Email: chengluo@uestc.edu.cn

Keywords：

特發性全面發作性癲癇; 神經檢查; 腦電圖; 磁共振; 彌散張量成像

DOI：

10.7507/2096-0247.20160011

Video：

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特發性全面發作性癲癇(Idiopathic generalized epilepsy, IGE)是一類沒有明顯病因和大腦病灶的癲癇, 主要腦電圖(EEG)表現為突出背景的雙側對稱的癲癇放電。現在新興的無創的神經成像技術改變了以前對IGE的腦結構和功能網絡的研究模式。當前的研究者已經迅速地采用這些新技術研究IGE的腦特征性改變, 包括EEG、功能磁共振、同步腦電和功能磁共振、結構磁共振、彌散張量成像以及結構功能腦網絡技術。這些發現表明IGE中皮層-丘腦網絡中存在著結構和功能指標的異常, 且越來越多的多模態神經成像結果也評估了癲癇活動對大量腦功能網絡的影響。將來的研究將集中在多學科的融合和發展多模態神經成像技術, 更深入地研究IGE的腦網絡機制

Citation： 羅程, 堯德中. 特發性全面性癲癇的神經影像研究進展. Journal of Epilepsy, 2016, 2(1): 55-63. doi: 10.7507/2096-0247.20160011 Copy

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17. Rugg-Gunn FJ, Eriksson SH, Symms MR, et al. Diffusion tensor imaging of cryptogenic and acquired partial epilepsies. Brain, 2001, 124 (3): 627.
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19. Concha L, Gross DW, Beaulieu C. Diffusion tensor tractography of the limbic system. American Journal Neuroradiology, 2005, 26 (9): 2267-2274.
20. Powell HW, Parker GJ, Alexander DC, et al. Abnormalities of language networks in temporal lobe epilepsy. Neuroimage, 2007, 36 (1): 209-221.
21. Chahboune H, Mishra AM, DeSalvo MN, et al. DTI abnormalities in anterior corpus callosum of rats with spike-wave epilepsy. NeuroImage, 2009, 47 (2): 459-466.
22. Ogawa S, Lee TM, Kay AR, et al. Brain magnetic resonance imaging with contrast dependent on blood oxygenation. Proc Natl Acad Sci USA, 1990, 87 (24): 9868-9872.
23. Lui S, Ouyang L, Chen Q, et al. Differential interictal activity of the precuneus/posterior cingulate cortex revealed by resting state functional MRI at 3T in generalized vs. partial seizure. J Magn Reson Imaging, 2008, 27 (6): 1214-1220.
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27. Wang P, Luo C, Dong L, et al. Altered intrinsic brain activity in patients with familial cortical myoclonic tremor and epilepsy: an amplitude of low-frequency fluctuation study. J Neurol Sci, 2015, 351 (1-2): 133-139.
28. Zhong Y, Lu G, Zhang Z, et al. Altered regional synchronization in epileptic patients with generalized tonic-clonic seizures. Epilepsy Res, 2011, 97 (1-2): 83-91.
29. Ding J, An D, Liao W, et al. Abnormal functional connectivity density in psychogenic non-epileptic seizures. Epilepsy Res, 2014, 108 (7): 1184-1194.
30. Dong L, Luo C, Cao W, et al. Spatiotemporal consistency of local neural activities: A new imaging measure for functional MRI data. J Magn Reson Imaging, 2015, 42 (3): 729-736.
31. Ives JR, Warach S, Schmitt F, et al. Monitoring the patient's EEG during echo planar MRI. Electroencephalogr Clin Neurophysiol, 1993, 87 (6): 417-420.
32. Mantini D, Perrucci MG, Gratta C Del, et al. Electrophysiological signatures of resting state networks in the human brain. Proc Natl Acad Sci USA, 2007, 104 (32): 13170-13175.
33. Gotman J, Kobayashi E, Bagshaw AP, et al. Combining EEG and fMRI: a multimodal tool for epilepsy research. J Magn Reson Imaging, 2006, 23 (6): 906-920.
34. Luo C, Yao Z, Li Q, et al. Imaging foci of epileptic discharges from simultaneous EEG and fMRI using the canonical HRF. Epilepsy Res, 2010, 91 (2-3): 133-142.
35. Dong L, Zhang Y, Zhang R, et al. Characterizing nonlinear relationships in functional imaging data using eigenspace maximal information canonical correlation analysis (emiCCA). Neuroimage, 2015, 10(9): 388-401.
36. Lei X, Xu P, Luo C, et al. fMRI functional networks for EEG source imaging. Hum Brain Mapp, 2011, 32 (7): 1141-1160.
37. Lei X, Hu J, Yao D. Incorporating FMRI functional networks in EEG source imaging: a Bayesian model comparison approach. Brain Topogr, 2012, 25 (1): 27-38.
38. Lei X, Qiu C, Xu P, et al. A parallel framework for simultaneous EEG/fMRI analysis: methodology and simulation. Neuroimage, 2010, 52 (3): 1123-1134.
39. Dong L, Gong D, Valdes-Sosa PA, et al. Simultaneous EEG-fMRI: trial level spatio-temporal fusion for hierarchically reliable information discovery. Neuroimage, 2014, 99: 28-41.
40. Tyvaert L, Hawco C, Kobayashi E, et al. Different structures involved during ictal and interictal epileptic activity in malformations of cortical development: an EEG-fMRI study. Brain, 2008, 131 (Pt 8): 2042-2060.
41. Kobayashi E, Bagshaw AP, Benar CG, et al. Temporal and extratemporal BOLD responses to temporal lobe interictal spikes. Epilepsia, 2006, 47 (2): 343-354.
42. Aghakhani Y, Kobayashi E, Bagshaw AP, et al. Cortical and thalamic fMRI responses in partial epilepsy with focal and bilateral synchronous spikes. Clin Neurophysiol, 2006, 117 (1): 177-191.
43. An D, Fahoum F, Hall J, et al. Electroencephalography/functional magnetic resonance imaging responses help predict surgical outcome in focal epilepsy. Epilepsia, 2013, 54 (12): 2184-2194.
44. Gotman J, Grova C, Bagshaw A, et al. Generalized epileptic discharges show thalamocortical activation and suspension of the default state of the brain. Proc Natl Acad Sci USA, 2005, 102 (42): 15236-15240.
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