The surgical treatment of Alzheimer's disease: a rapid health technology assessment_Chinese Journal of Evidence-Based Medicine

Authors：

ZHU Ye ^1,2,3,4 , WANG Hanbin ^1,3,4 , LIANG Cui ^1,3,4 , HUANG Jiayi ^1,3,4 , LI Yafang ^1,3,4 , ZHANG Faqiang ^1,3,4 , TAO Junliang ^1,3,4 ,  BAI Fei ⁵ ,  LI Xiuxia ^1,4,6

1. Lanzhou University Center for Health Technology Assessment/Evidence-Based Social Sciences Research Center, School of Public Health, Lanzhou University, Lanzhou 730000, P. R. China;
2. Hulunbuir Center for Disease Control and Prevention, Hulunbuir 021000, P. R. China;
3. Lanzhou University Center for Evidence-Based Medicine, School of Basic Medical Sciences, Lanzhou University, Lanzhou 730000, P. R. China;
4. Gansu Provincial Key Laboratory of Evidence-Based Medicine, Lanzhou 730000, P. R. China;
5. National Center for Medical Service Administration, National Health Commission of the People’s Republic of China, Beijing 100086, P. R. China;
6. Lanzhou University Center for Medical Device Regulation and Research, Lanzhou 730000, P. R. China;

Corresponding?author：

BAI Fei, Email: gsyzbf@163.com; LI Xiuxia, Email: lixiuxia@lzu.edu.cn

Keywords：

Alzheimer's disease; Surgical treatment; Neurosurgery; Rapid health technology assessment

DOI：

10.7507/1672-2531.202503076

Video：

Export PDF Favorites Scan Get Citation

Abstract Full text Figures/Tables Video References Cited by

Objective To systematically review the efficacy, safety, cost-effectiveness, indications, contraindications, and ethical issues for surgical treatment of Alzheimer's disease (AD). Methods The CNKI, WanFang Data, VIP, PubMed, Web of Science, Embase and Cochrane Library databases were electronically searched to collect for relevant studies on surgical treatment of AD from inception to November 26, 2024. Two reviewers independently screened literature, extracted data, and assessed the risk of bias of the included studies. Meta-analysis was performed by using Stata 17 software. Results A total of 59 studies were included. The results revealed that surgical treatment for AD had higher safety (OR=0.44, 95%CI 0.17 to 0.72, P<0.05), and patients had better ADAS-cog scores (SMD=0.54, 95%CI 0.18 to 0.90, P<0.05), with statistically significant differences. The economic burden of surgical treatment for AD increased with the severity of the disease. Deep brain stimulation may offer high economic benefits in the treatment of mild AD. The surgical indications can be summarized as: short disease duration, mild to moderate severity, and insufficient response to pharmacological interventions. Regarding contraindications, analysis of the included literature identified four core aspects: physiological and pathological contraindications, medical comorbidities and surgical risk contraindications, cognitive and psychological factor contraindications, and other contraindications. Ethical issues can be categorized into: informed consent and autonomy, ethical review and approval of research, and assessment of risks and benefits. Conclusion Current evidence suggests that surgical treatment for AD has certain benefits, but the surgical approaches for treating AD are still in the exploratory stage. Limited by the number and quality of the included studies, the above conclusion still requires more high-quality research to be verified.

Citation： ZHU Ye, WANG Hanbin, LIANG Cui, HUANG Jiayi, LI Yafang, ZHANG Faqiang, TAO Junliang, BAI Fei, LI Xiuxia. The surgical treatment of Alzheimer's disease: a rapid health technology assessment. Chinese Journal of Evidence-Based Medicine, 2025, 25(9): 1055-1063. doi: 10.7507/1672-2531.202503076 Copy

1.	高洋, 秦合偉, 李彥杰. NLRP3炎癥小體在阿爾茲海默癥中的作用及潛在治療靶點. 中國生物化學與分子生物學報, 2024, 40(1): 18-27.
2.	Ayodele T, Rogaeva E, Kurup JT, et al. Early-onset Alzheimer's disease: what is missing in research. Curr Neurol Neurosci Rep, 2021, 21(2): 4.
3.	Ballard C, Gauthier S, Corbett A, et al. Alzheimer's disease. Lancet, 2011, 377(9770): 1019-1031.
4.	Meng X, Su J, Li H, et al. Effectiveness of caregiver non-pharmacological interventions for behavioural and psychological symptoms of dementia: an updated meta-analysis. Ageing Res Rev, 2021, 71: 101448.
5.	Sperling RA, Aisen PS, Beckett LA, et al. Toward defining the preclinical stages of Alzheimer's disease: recommendations from the National Institute on Aging-Alzheimer's Association workgroups on diagnostic guidelines for Alzheimer's disease. Alzheimers Dement, 2011, 7(3): 280-292.
6.	Chen Y, Lai M, Tao M. Evaluating the efficacy and safety of Alzheimer's disease drugs: a meta-analysis and systematic review. Medicine (Baltimore), 2024, 103(16): e37799.
7.	Livingston G, Huntley J, Sommerlad A, et al. Dementia prevention, intervention, and care: 2020 report of the Lancet Commission. Lancet, 2020, 396(10248): 413-446.
8.	Yiannopoulou KG, Papageorgiou SG. Current and future treatments in Alzheimer disease: an update. J Cent Nerv Syst Dis, 2020, 12: 1179573520907397.
9.	Pereira JL, Downes A, Gorgulho A, et al. Alzheimer's disease: the role for neurosurgery. Surg Neurol Int, 2014, 5(Suppl 8): S385-S390.
10.	劉夢鴿, 劉欣欣, 鄭霞, 等. 高頻重復經顱磁刺激聯合卡巴拉汀治療老年癡呆認知障礙的臨床效果觀察. 實用中西醫結合臨床, 2024, 24(12): 1-4, 22.
11.	夏青春, 那萬秋, 薛鳳玲. 不同腦區高頻重復經顱磁刺激對輕、中度阿爾茨海默病患者認知功能的影響. 臨床精神醫學雜志, 2023, 33(6): 439-443.
12.	賈建平, 邢怡, 武力勇, 等. 阿爾茨海默病診療指南. 浙江醫學, 2014, (13): 1127-1128.
13.	Leoutsakos JS, Yan H, Anderson WS, et al. Deep brain stimulation targeting the fornix for mild Alzheimer dementia (the ADvance trial): a two year follow-up including results of delayed activation. J Alzheimers Dis, 2018, 64(2): 597-606.
14.	Ríos AS, Oxenford S, Neudorfer C, et al. Optimal deep brain stimulation sites and networks for stimulation of the fornix in Alzheimer's disease. Nat Commun, 2022, 13(1): 7707.
15.	Sankar T, Chakravarty MM, Bescos A, et al. Deep brain stimulation influences brain structure in Alzheimer's disease. Brain Stimul, 2015, 8(3): 645-654.
16.	Jiang Y, Yuan TS, Chen YC, et al. Deep brain stimulation of the nucleus basalis of Meynert modulates hippocampal–frontoparietal networks in patients with advanced Alzheimer’s disease. Transl Neurodegener, 2022, 11(1): 51.
17.	Kuhn J, Hardenacke K, Lenartz D, et al. Deep brain stimulation of the nucleus basalis of Meynert in Alzheimer's dementia. Mol Psychiatry, 2015, 20(3): 353-360.
18.	Jakobs M, Lee DJ, Lozano AM. Modifying the progression of Alzheimer's and Parkinson's disease with deep brain stimulation. Neuropharmacology, 2020, 171: 107860.
19.	Ponce FA, Asaad WF, Foote KD, et al. Bilateral deep brain stimulation of the fornix for Alzheimer's disease: surgical safety in the advance trial. J Neurosurg, 2016, 125(1): 75-84.
20.	Holroyd KB, Fosdick L, Smith GS, et al. Deep brain stimulation targeting the fornix for mild Alzheimer dementia: design of the advance randomized controlled trial. Open Access J Clin T, 2015, 7: 63-76.
21.	Noreik M, Kuhn J, Hardenacke K, et al. Changes in nutritional status after deep brain stimulation of the nucleus basalis of Meynert in Alzheimer's disease--results of a phase I study. J Nutr Health Aging, 2015, 19(8): 812-818.
22.	Maksimovich, IV. An example of Alzheimer's disease in endovascular treatment application. Interac Cardiov Th, 2011, 12: S160.
23.	Martin M. Deep brain stimulation with LIFUP for mild cognitive impairment and mild Alzheimer's disease. Cochrane Central Register of Controlled Trials, 2017.
24.	蘇寧, 胡衛紅. 深部腦刺激治療阿爾茨海默病的研究進展. 神經疾病與精神衛生, 2019, 19(8): 839-842.
25.	孫璐, 潘隆盛. 阿爾茲海默病外科治療進展. 立體定向和功能性神經外科雜志, 2014, 27(6): 377-378.
26.	余新光, 張艷陽. 腦深部電刺激術在阿爾茲海默病中的應用進展. 山東大學學報(醫學版), 2020, 58(8): 22-27, 33.
27.	許軍鵬, 余新光, 張艷陽, 等. 低頻Meynert基底核腦深部電刺激對早發型重度阿爾茨海默病患者的長期改善作用研究. 中華神經醫學雜志, 2024, 23(2): 152-158.
28.	Fontaine D, Santucci S. Deep brain stimulation in Alzheimer's disease. Int Rev Neurobiol, 2021, 159: 69-87.
29.	Laxton AW, Tang-Wai DF, McAndrews MP, et al. A phase I trial of deep brain stimulation of memory circuits in Alzheimer's disease. Ann Neurol, 2010, 68(4): 521-534.
30.	Baldermann JC, Hardenacke K, Hu X, et al. Neuroanatomical characteristics associated with response to deep brain stimulation of the nucleus basalis of Meynert for Alzheimer's disease. Neuromodulation, 2018, 21(2): 184-190.
31.	Barcia JA, Viloria MA, Yubero R, et al. Directional DBS of the fornix in Alzheimer's disease achieves long-term benefits: a case report. Front Aging Neurosci, 2022, 14: 809972.
32.	Silverberg GD, Levinthal E, Sullivan EV, et al. Assessment of low-flow CSF drainage as a treatment for AD: results of a randomized pilot study. Neurology, 2002, 59(8): 1139-1145.
33.	Davidson B, Vetkas A, Germann J, et al. Deep brain stimulation for Alzheimer's disease - current status and next steps. Expert Rev Med Devices, 2024, 21(4): 285-292.
34.	盧天喜, 鐘立行, 雷鑒潮. V-P分流術治療老年性癡呆的臨床研究. 世界最新醫學信息文摘(連續型電子期刊), 2019, 19(8): 214.
35.	Jafari Z, Kolb BE, Mohajerani MH. Neural oscillations and brain stimulation in Alzheimer's disease. Prog Neurobiol, 2020, 194: 101878.
36.	Lam J, Lee J, Liu CY, et al. Deep brain stimulation for Alzheimer's disease: tackling circuit dysfunction. Neuromodulation, 2021, 24(2): 171-186.
37.	Laxton AW, Lozano AM. Deep brain stimulation for the treatment of Alzheimer disease and dementias. World Neurosurg, 2013, 80(3-4): S28.
38.	Suell, C. Cholinergic deep brain stimulation for Alzheimer's disease. Cochrane Central Register of Controlled Trials, 2023.
39.	王寅旭, 肖軍, 王曉明. 阿爾茨海默病的神經調控. 阿爾茨海默病及相關病, 2021, 4(4): 333-336.
40.	Silverberg GD, Mayo M, Saul T, et al. Continuous CSF drainage in AD: results of a double-blind, randomized, placebo-controlled study. Neurology, 2008, 71(3): 202-209.
41.	Huang P, Lin L, Zhang J, et al. Efficacy analysis of three brain stimulation techniques for Alzheimer's disease: a meta-analysis of repeated transcranial magnetic stimulation, transcranial direct current stimulation, and deep brain stimulation. Expert Rev Neurother, 2024, 24(1): 117-127.
42.	武衛周, 王朕, 高宇霞, 等. 阿爾茨海默病非藥物治療研究進展. 臨床合理用藥, 2024, 17(15): 178-181.
43.	雷亞靜, 劉雨薇, 尚進林. 阿爾茨海默病的非藥物治療研究進展. 世界最新醫學信息文摘(連續型電子期刊), 2020, 20(A2): 59-60.
44.	Mao ZQ, Wang X, Xu X, et al. Partial improvement in performance of patients with severe Alzheimer's disease at an early stage of fornix deep brain stimulation. Neural Regen Res, 2018, 13(12): 2164-2172.
45.	Smith GS, Laxton AW, Tang-Wai DF, et al. Increased cerebral metabolism after 1 year of deep brain stimulation in Alzheimer disease. Arch Neurol, 2012, 69(9): 1141-1148.
46.	Targum SD, Fosdick L, Drake KE, et al. Effect of age on clinical trial outcome in participants with probable Alzheimer's disease. J Alzheimers Dis, 2021, 82(3): 1243-1257.
47.	Lozano AM, Fosdick L, Chakravarty MM, et al. A Phase II study of fornix deep brain stimulation in mild Alzheimer's disease. J Alzheimers Dis, 2016, 54(2): 777-787.
48.	Goldsmith HS. Omental transposition for Alzheimer 's disease. Neurol Res, 1996, 18(2): 103-108.
49.	Zibly Z, Shaw A, Harnof S, et al. Modulation of mind: therapeutic neuromodulation for cognitive disability. J Clin Neurosci, 2014, 21(9): 1473-1477.
50.	Via?a JNM, Bittlinger M, Gilbert F. Ethical considerations for deep brain stimulation trials in patients with early-onset Alzheimer's disease. J Alzheimers Dis, 2017, 58(2): 289-301.
51.	張建國. 腦深部電刺激治療阿爾茨海默病的現狀和進展. 中華神經創傷外科電子雜志, 2018, 4(6): 379-381.
52.	Lyketsos C, Smith GS, Fosdick L. Deep brain stimulation targeting the fornix for mild Alzheimer's disease: initial results of the advance randomized controlled trial. Alzhe Dement, 2015, 11(7): P332-P333.
53.	Agrawal S, Chowdhury T, Venkatraghavan L, et al. Deep brain stimulation for Alzheimer disease: physiological considerations and anesthetic challenges. J Neurosurg Anesthesiol, 2024, 36(1): 90-91.
54.	Fontaine D, Deudon A, Lemaire JJ, et al. Symptomatic treatment of memory decline in Alzheimer's disease by deep brain stimulation: a feasibility study. J Alzheimers Dis, 2013, 34(1): 315-323.
55.	Gilbert F, Via?a JNM, Bittlinger M, et al. Invasive experimental brain surgery for dementia: ethical shifts in clinical research practices. Bioethics, 2022, 36(1): 25-41.
56.	Via?a JNM. Deep brain stimulation for preclinical and prodromal Alzheimer's disease: integrating beneficence, non-maleficence, and autonomy considerations through responsible innovation. AJOB Neurosci, 2021, 12(4): 236-239.
57.	Yang X, Zhang R, Sun Z, et al. Controlling Alzheimer's disease through the deep brain stimulation to thalamic relay cells. Front Comput Neurosci, 2021, 15: 636770.
58.	Bittlinger M, Müller S. Opening the debate on deep brain stimulation for Alzheimer disease - a critical evaluation of rationale, shortcomings, and ethical justification. BMC Med Ethics, 2018, 19(1): 41.
59.	Hardenacke K, Kuhn J, Lenartz D, et al. Stimulate or degenerate: deep brain stimulation of the nucleus basalis Meynert in Alzheimer dementia. World Neurosurg, 2013, 80(3-4): S27.
60.	Siegel AM, Barrett MS, Bhati MT. Deep brain stimulation for Alzheimer's disease: ethical challenges for clinical research. J Alzheimers Dis, 2017, 56(2): 429-439.
61.	Via?a JNM, Gilbert F. Deep brain stimulation for people with Alzheimer's disease: anticipating potential effects on the tripartite self. Dementia (London), 2019, 18(7-8): 2836-2855.
62.	Zhang W, Liu W, Patel B, et al. Case report: deep brain stimulation of the nucleus basalis of Meynert for advanced Alzheimer's disease. Front Hum Neurosci, 2021, 15: 645584.
63.	張安琪, 王玲, 王寧, 等. 神經調控技術在阿爾茨海默病認知障礙研究中的應用. 生物化學與生物物理進展, 2023, 50(10): 2276-2286.
64.	祁婧, 郭建雄, 朱潤秀. 腦深部刺激在阿爾茨海默病中的應用前景. 中風與神經疾病雜志, 2019, 36(1): 82-85.
65.	Chang CH, Lane HY, Lin CH. Brain stimulation in Alzheimer's disease. Front Psychiatry, 2018, 9: 201.
66.	Lin W, Bao WQ, Ge JJ, et al. Forniceal deep brain stimulation in severe Alzheimer's disease: a case report. World J Clin Cases, 2020, 8(20): 4938-4945.
67.	Deeb W, Salvato B, Almeida L, et al. Fornix-region deep brain stimulation-induced memory flashbacks in Alzheimer's disease. N Engl J Med, 2019, 381(8): 783-785.
68.	Senevirathne DKL, Mahboob A, Zhai K, et al. Deep brain stimulation beyond the clinic: navigating the future of Parkinson's and Alzheimer's disease therapy. Cells, 2023, 12(11): 1478.
69.	Ovadia D, Bottini G. Neuroethical implications of deep brain stimulation in degenerative disorders. Curr Opin Neurol, 2015, 28(6): 598-603.
70.	McMullen DP, Rosenberg P, Cheng J, et al. Bilateral cortical encephalomalacia in a patient implanted with bilateral deep brain stimulation for Alzheimer's disease: a case report. Alzheimer Dis Assoc Disord, 2016, 30(1): 70-72.
71.	毛之奇, 王鑫, 徐欣, 等. 穹窿腦深部電刺激術治療重度阿爾茨海默病. 中華神經外科雜志, 2019, 35(4): 378-381.
72.	Benussi A, Borroni B. Brain stimulation in Alzheimer's disease trials. J Alzheimers Dis, 2024, 101(S1): S545-S565.
73.	湯韞鈺, 劉如恩. 阿爾茲海默病的診斷與綜合治療進展. 中國實用神經疾病雜志, 2022, 25(8): 996-1000.
74.	Bouwens van der Vlis TAM, van de Veerdonk MMGH, Ackermans L, et al. Surgical and hardware-related adverse events of deep brain stimulation: a ten-year single-center experience. Neuromodulation, 2022, 25(2): 296-304.
75.	馬雨, 趙霞. 精準醫療的起始與范疇. 實用婦產科雜志, 2017, 33(6): 400-401.
76.	Luo Y, Sun Y, Tian X, et al. Deep brain stimulation for Alzheimer's disease: stimulation parameters and potential mechanisms of action. Front Aging Neurosci, 2021, 13: 619543.
77.	王婧, Lily, Dongxia, 等. 老年癡呆患者家庭照護者負擔及其應對策略. 中國老年學雜志, 2014, 34(8): 2295-2298.
78.	中國醫師協會精神科醫師分會, 精神疾病外科治療聯盟, 中國醫師協會神經調控專業委員會. 中國精神疾病外科治療專家共識. 中國神經精神疾病雜志, 2024, 50(7): 385-402.
79.	本刊特約評論員. 凝聚共識, 協同推進醫保支付方式改革. 中國農村衛生事業管理, 2022, 42(4): 229.

1. 高洋, 秦合偉, 李彥杰. NLRP3炎癥小體在阿爾茲海默癥中的作用及潛在治療靶點. 中國生物化學與分子生物學報, 2024, 40(1): 18-27.
2. Ayodele T, Rogaeva E, Kurup JT, et al. Early-onset Alzheimer's disease: what is missing in research. Curr Neurol Neurosci Rep, 2021, 21(2): 4.
3. Ballard C, Gauthier S, Corbett A, et al. Alzheimer's disease. Lancet, 2011, 377(9770): 1019-1031.
4. Meng X, Su J, Li H, et al. Effectiveness of caregiver non-pharmacological interventions for behavioural and psychological symptoms of dementia: an updated meta-analysis. Ageing Res Rev, 2021, 71: 101448.
5. Sperling RA, Aisen PS, Beckett LA, et al. Toward defining the preclinical stages of Alzheimer's disease: recommendations from the National Institute on Aging-Alzheimer's Association workgroups on diagnostic guidelines for Alzheimer's disease. Alzheimers Dement, 2011, 7(3): 280-292.
6. Chen Y, Lai M, Tao M. Evaluating the efficacy and safety of Alzheimer's disease drugs: a meta-analysis and systematic review. Medicine (Baltimore), 2024, 103(16): e37799.
7. Livingston G, Huntley J, Sommerlad A, et al. Dementia prevention, intervention, and care: 2020 report of the Lancet Commission. Lancet, 2020, 396(10248): 413-446.
8. Yiannopoulou KG, Papageorgiou SG. Current and future treatments in Alzheimer disease: an update. J Cent Nerv Syst Dis, 2020, 12: 1179573520907397.
9. Pereira JL, Downes A, Gorgulho A, et al. Alzheimer's disease: the role for neurosurgery. Surg Neurol Int, 2014, 5(Suppl 8): S385-S390.
10. 劉夢鴿, 劉欣欣, 鄭霞, 等. 高頻重復經顱磁刺激聯合卡巴拉汀治療老年癡呆認知障礙的臨床效果觀察. 實用中西醫結合臨床, 2024, 24(12): 1-4, 22.
11. 夏青春, 那萬秋, 薛鳳玲. 不同腦區高頻重復經顱磁刺激對輕、中度阿爾茨海默病患者認知功能的影響. 臨床精神醫學雜志, 2023, 33(6): 439-443.
12. 賈建平, 邢怡, 武力勇, 等. 阿爾茨海默病診療指南. 浙江醫學, 2014, (13): 1127-1128.
13. Leoutsakos JS, Yan H, Anderson WS, et al. Deep brain stimulation targeting the fornix for mild Alzheimer dementia (the ADvance trial): a two year follow-up including results of delayed activation. J Alzheimers Dis, 2018, 64(2): 597-606.
14. Ríos AS, Oxenford S, Neudorfer C, et al. Optimal deep brain stimulation sites and networks for stimulation of the fornix in Alzheimer's disease. Nat Commun, 2022, 13(1): 7707.
15. Sankar T, Chakravarty MM, Bescos A, et al. Deep brain stimulation influences brain structure in Alzheimer's disease. Brain Stimul, 2015, 8(3): 645-654.
16. Jiang Y, Yuan TS, Chen YC, et al. Deep brain stimulation of the nucleus basalis of Meynert modulates hippocampal–frontoparietal networks in patients with advanced Alzheimer’s disease. Transl Neurodegener, 2022, 11(1): 51.
17. Kuhn J, Hardenacke K, Lenartz D, et al. Deep brain stimulation of the nucleus basalis of Meynert in Alzheimer's dementia. Mol Psychiatry, 2015, 20(3): 353-360.
18. Jakobs M, Lee DJ, Lozano AM. Modifying the progression of Alzheimer's and Parkinson's disease with deep brain stimulation. Neuropharmacology, 2020, 171: 107860.
19. Ponce FA, Asaad WF, Foote KD, et al. Bilateral deep brain stimulation of the fornix for Alzheimer's disease: surgical safety in the advance trial. J Neurosurg, 2016, 125(1): 75-84.
20. Holroyd KB, Fosdick L, Smith GS, et al. Deep brain stimulation targeting the fornix for mild Alzheimer dementia: design of the advance randomized controlled trial. Open Access J Clin T, 2015, 7: 63-76.
21. Noreik M, Kuhn J, Hardenacke K, et al. Changes in nutritional status after deep brain stimulation of the nucleus basalis of Meynert in Alzheimer's disease--results of a phase I study. J Nutr Health Aging, 2015, 19(8): 812-818.
22. Maksimovich, IV. An example of Alzheimer's disease in endovascular treatment application. Interac Cardiov Th, 2011, 12: S160.
23. Martin M. Deep brain stimulation with LIFUP for mild cognitive impairment and mild Alzheimer's disease. Cochrane Central Register of Controlled Trials, 2017.
24. 蘇寧, 胡衛紅. 深部腦刺激治療阿爾茨海默病的研究進展. 神經疾病與精神衛生, 2019, 19(8): 839-842.
25. 孫璐, 潘隆盛. 阿爾茲海默病外科治療進展. 立體定向和功能性神經外科雜志, 2014, 27(6): 377-378.
26. 余新光, 張艷陽. 腦深部電刺激術在阿爾茲海默病中的應用進展. 山東大學學報(醫學版), 2020, 58(8): 22-27, 33.
27. 許軍鵬, 余新光, 張艷陽, 等. 低頻Meynert基底核腦深部電刺激對早發型重度阿爾茨海默病患者的長期改善作用研究. 中華神經醫學雜志, 2024, 23(2): 152-158.
28. Fontaine D, Santucci S. Deep brain stimulation in Alzheimer's disease. Int Rev Neurobiol, 2021, 159: 69-87.
29. Laxton AW, Tang-Wai DF, McAndrews MP, et al. A phase I trial of deep brain stimulation of memory circuits in Alzheimer's disease. Ann Neurol, 2010, 68(4): 521-534.
30. Baldermann JC, Hardenacke K, Hu X, et al. Neuroanatomical characteristics associated with response to deep brain stimulation of the nucleus basalis of Meynert for Alzheimer's disease. Neuromodulation, 2018, 21(2): 184-190.
31. Barcia JA, Viloria MA, Yubero R, et al. Directional DBS of the fornix in Alzheimer's disease achieves long-term benefits: a case report. Front Aging Neurosci, 2022, 14: 809972.
32. Silverberg GD, Levinthal E, Sullivan EV, et al. Assessment of low-flow CSF drainage as a treatment for AD: results of a randomized pilot study. Neurology, 2002, 59(8): 1139-1145.
33. Davidson B, Vetkas A, Germann J, et al. Deep brain stimulation for Alzheimer's disease - current status and next steps. Expert Rev Med Devices, 2024, 21(4): 285-292.
34. 盧天喜, 鐘立行, 雷鑒潮. V-P分流術治療老年性癡呆的臨床研究. 世界最新醫學信息文摘(連續型電子期刊), 2019, 19(8): 214.
35. Jafari Z, Kolb BE, Mohajerani MH. Neural oscillations and brain stimulation in Alzheimer's disease. Prog Neurobiol, 2020, 194: 101878.
36. Lam J, Lee J, Liu CY, et al. Deep brain stimulation for Alzheimer's disease: tackling circuit dysfunction. Neuromodulation, 2021, 24(2): 171-186.
37. Laxton AW, Lozano AM. Deep brain stimulation for the treatment of Alzheimer disease and dementias. World Neurosurg, 2013, 80(3-4): S28.
38. Suell, C. Cholinergic deep brain stimulation for Alzheimer's disease. Cochrane Central Register of Controlled Trials, 2023.
39. 王寅旭, 肖軍, 王曉明. 阿爾茨海默病的神經調控. 阿爾茨海默病及相關病, 2021, 4(4): 333-336.
40. Silverberg GD, Mayo M, Saul T, et al. Continuous CSF drainage in AD: results of a double-blind, randomized, placebo-controlled study. Neurology, 2008, 71(3): 202-209.
41. Huang P, Lin L, Zhang J, et al. Efficacy analysis of three brain stimulation techniques for Alzheimer's disease: a meta-analysis of repeated transcranial magnetic stimulation, transcranial direct current stimulation, and deep brain stimulation. Expert Rev Neurother, 2024, 24(1): 117-127.
42. 武衛周, 王朕, 高宇霞, 等. 阿爾茨海默病非藥物治療研究進展. 臨床合理用藥, 2024, 17(15): 178-181.
43. 雷亞靜, 劉雨薇, 尚進林. 阿爾茨海默病的非藥物治療研究進展. 世界最新醫學信息文摘(連續型電子期刊), 2020, 20(A2): 59-60.
44. Mao ZQ, Wang X, Xu X, et al. Partial improvement in performance of patients with severe Alzheimer's disease at an early stage of fornix deep brain stimulation. Neural Regen Res, 2018, 13(12): 2164-2172.
45. Smith GS, Laxton AW, Tang-Wai DF, et al. Increased cerebral metabolism after 1 year of deep brain stimulation in Alzheimer disease. Arch Neurol, 2012, 69(9): 1141-1148.
46. Targum SD, Fosdick L, Drake KE, et al. Effect of age on clinical trial outcome in participants with probable Alzheimer's disease. J Alzheimers Dis, 2021, 82(3): 1243-1257.
47. Lozano AM, Fosdick L, Chakravarty MM, et al. A Phase II study of fornix deep brain stimulation in mild Alzheimer's disease. J Alzheimers Dis, 2016, 54(2): 777-787.
48. Goldsmith HS. Omental transposition for Alzheimer 's disease. Neurol Res, 1996, 18(2): 103-108.
49. Zibly Z, Shaw A, Harnof S, et al. Modulation of mind: therapeutic neuromodulation for cognitive disability. J Clin Neurosci, 2014, 21(9): 1473-1477.
50. Via?a JNM, Bittlinger M, Gilbert F. Ethical considerations for deep brain stimulation trials in patients with early-onset Alzheimer's disease. J Alzheimers Dis, 2017, 58(2): 289-301.
51. 張建國. 腦深部電刺激治療阿爾茨海默病的現狀和進展. 中華神經創傷外科電子雜志, 2018, 4(6): 379-381.
52. Lyketsos C, Smith GS, Fosdick L. Deep brain stimulation targeting the fornix for mild Alzheimer's disease: initial results of the advance randomized controlled trial. Alzhe Dement, 2015, 11(7): P332-P333.
53. Agrawal S, Chowdhury T, Venkatraghavan L, et al. Deep brain stimulation for Alzheimer disease: physiological considerations and anesthetic challenges. J Neurosurg Anesthesiol, 2024, 36(1): 90-91.
54. Fontaine D, Deudon A, Lemaire JJ, et al. Symptomatic treatment of memory decline in Alzheimer's disease by deep brain stimulation: a feasibility study. J Alzheimers Dis, 2013, 34(1): 315-323.
55. Gilbert F, Via?a JNM, Bittlinger M, et al. Invasive experimental brain surgery for dementia: ethical shifts in clinical research practices. Bioethics, 2022, 36(1): 25-41.
56. Via?a JNM. Deep brain stimulation for preclinical and prodromal Alzheimer's disease: integrating beneficence, non-maleficence, and autonomy considerations through responsible innovation. AJOB Neurosci, 2021, 12(4): 236-239.
57. Yang X, Zhang R, Sun Z, et al. Controlling Alzheimer's disease through the deep brain stimulation to thalamic relay cells. Front Comput Neurosci, 2021, 15: 636770.
58. Bittlinger M, Müller S. Opening the debate on deep brain stimulation for Alzheimer disease - a critical evaluation of rationale, shortcomings, and ethical justification. BMC Med Ethics, 2018, 19(1): 41.
59. Hardenacke K, Kuhn J, Lenartz D, et al. Stimulate or degenerate: deep brain stimulation of the nucleus basalis Meynert in Alzheimer dementia. World Neurosurg, 2013, 80(3-4): S27.
60. Siegel AM, Barrett MS, Bhati MT. Deep brain stimulation for Alzheimer's disease: ethical challenges for clinical research. J Alzheimers Dis, 2017, 56(2): 429-439.
61. Via?a JNM, Gilbert F. Deep brain stimulation for people with Alzheimer's disease: anticipating potential effects on the tripartite self. Dementia (London), 2019, 18(7-8): 2836-2855.
62. Zhang W, Liu W, Patel B, et al. Case report: deep brain stimulation of the nucleus basalis of Meynert for advanced Alzheimer's disease. Front Hum Neurosci, 2021, 15: 645584.
63. 張安琪, 王玲, 王寧, 等. 神經調控技術在阿爾茨海默病認知障礙研究中的應用. 生物化學與生物物理進展, 2023, 50(10): 2276-2286.
64. 祁婧, 郭建雄, 朱潤秀. 腦深部刺激在阿爾茨海默病中的應用前景. 中風與神經疾病雜志, 2019, 36(1): 82-85.
65. Chang CH, Lane HY, Lin CH. Brain stimulation in Alzheimer's disease. Front Psychiatry, 2018, 9: 201.
66. Lin W, Bao WQ, Ge JJ, et al. Forniceal deep brain stimulation in severe Alzheimer's disease: a case report. World J Clin Cases, 2020, 8(20): 4938-4945.
67. Deeb W, Salvato B, Almeida L, et al. Fornix-region deep brain stimulation-induced memory flashbacks in Alzheimer's disease. N Engl J Med, 2019, 381(8): 783-785.
68. Senevirathne DKL, Mahboob A, Zhai K, et al. Deep brain stimulation beyond the clinic: navigating the future of Parkinson's and Alzheimer's disease therapy. Cells, 2023, 12(11): 1478.
69. Ovadia D, Bottini G. Neuroethical implications of deep brain stimulation in degenerative disorders. Curr Opin Neurol, 2015, 28(6): 598-603.
70. McMullen DP, Rosenberg P, Cheng J, et al. Bilateral cortical encephalomalacia in a patient implanted with bilateral deep brain stimulation for Alzheimer's disease: a case report. Alzheimer Dis Assoc Disord, 2016, 30(1): 70-72.
71. 毛之奇, 王鑫, 徐欣, 等. 穹窿腦深部電刺激術治療重度阿爾茨海默病. 中華神經外科雜志, 2019, 35(4): 378-381.
72. Benussi A, Borroni B. Brain stimulation in Alzheimer's disease trials. J Alzheimers Dis, 2024, 101(S1): S545-S565.
73. 湯韞鈺, 劉如恩. 阿爾茲海默病的診斷與綜合治療進展. 中國實用神經疾病雜志, 2022, 25(8): 996-1000.
74. Bouwens van der Vlis TAM, van de Veerdonk MMGH, Ackermans L, et al. Surgical and hardware-related adverse events of deep brain stimulation: a ten-year single-center experience. Neuromodulation, 2022, 25(2): 296-304.
75. 馬雨, 趙霞. 精準醫療的起始與范疇. 實用婦產科雜志, 2017, 33(6): 400-401.
76. Luo Y, Sun Y, Tian X, et al. Deep brain stimulation for Alzheimer's disease: stimulation parameters and potential mechanisms of action. Front Aging Neurosci, 2021, 13: 619543.
77. 王婧, Lily, Dongxia, 等. 老年癡呆患者家庭照護者負擔及其應對策略. 中國老年學雜志, 2014, 34(8): 2295-2298.
78. 中國醫師協會精神科醫師分會, 精神疾病外科治療聯盟, 中國醫師協會神經調控專業委員會. 中國精神疾病外科治療專家共識. 中國神經精神疾病雜志, 2024, 50(7): 385-402.
79. 本刊特約評論員. 凝聚共識, 協同推進醫保支付方式改革. 中國農村衛生事業管理, 2022, 42(4): 229.

Chinese Journal of Evidence-Based Medicine

The surgical treatment of Alzheimer's disease: a rapid health technology assessment

Abstract Full text Figures/Tables Video References Cited by

Previous Article

Next Article

Format

Content