Interpretation of Comprehensive intervention for sarcopenia among older adults: an evidence-based clinical practice guideline_Chinese Journal of Evidence-Based Medicine

Authors：

LI Daiping ¹ , SHEN Yanjiao ² , HAO Qiukui ¹ , ZHANG Meng ¹ , XIAN Hong ¹ , DONG Birong ¹ ,  YUE Jirong ¹

1. Department of Geriatrics, National Clinical Research Center for Geriatrics, West China Hospital, Sichuan University, Chengdu 610041, P. R. China;
2. Innovation Institute for Integration of Medicine and Engineering, Chinese Evidence-Based Medicine Center, West China Hospital, Sichuan University, Chengdu 610041, P. R. China;

Corresponding?author：

YUE Jirong, Email: yuejirong11@hotmail.com

Keywords：

Sarcopenia; Intervention; Nutrition; Exercise; Interpretation

DOI：

10.7507/1672-2531.202405112

Video：

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Sarcopenia, a skeletal muscle degenerative condition, is inextricably linked to the physiological processes of aging. Sarcopenia is characterized by a reduction in muscle mass, a decline in muscle strength, and/or deterioration of physical function. Comprehensive interventions are essential for the management of sarcopenia. The team from the National Clinical Research Center for Geriatrics has authored the "Comprehensive intervention for sarcopenia among older adults: an evidence-based clinical practice guideline" which discuss the specific contents of exercise, nutrition, and drug interventions for sarcopenia. This article provides a comprehensive interpretation of the guideline to facilitate their dissemination, promotion, and application.

Citation： LI Daiping, SHEN Yanjiao, HAO Qiukui, ZHANG Meng, XIAN Hong, DONG Birong, YUE Jirong. Interpretation of Comprehensive intervention for sarcopenia among older adults: an evidence-based clinical practice guideline. Chinese Journal of Evidence-Based Medicine, 2025, 25(4): 475-478. doi: 10.7507/1672-2531.202405112 Copy

1.	Dent E, Morley JE, Cruz-Jentoft AJ, et al. International clinical practice guidelines for sarcopenia (ICFSR): screening, diagnosis and management. J Nutr Health Aging, 2018, 22(10): 1148-1161.
2.	Cruz-Jentoft AJ, Sayer AA. Sarcopenia. Lancet, 2019, 393(10191): 2636-2646.
3.	劉娟, 丁清清, 周白瑜, 等. 中國老年人肌少癥診療專家共識(2021). 中華老年醫學雜志, 2021, 40(8): 943-952.
4.	甄志龍, 趙建民, 孫遜, 等. 肌少癥的診療共識解讀與研究進展. 生物骨科材料與臨床研究, 2023, 20(1): 71-75.
5.	Cruz-Jentoft AJ, Bahat G, Bauer J, et al. Sarcopenia: revised European consensus on definition and diagnosis. Age Ageing, 2019, 48(1): 16-31.
6.	沈妍交, 郝秋奎, 張蒙, 等. 老年肌少癥綜合干預循證臨床實踐指南. 中國循證醫學雜志, 2024, 24(4): 378-384.
7.	楊玲, 杜娟, 劉榮雁, 等. 肌肉減少癥病因學研究現狀與展望. 中國骨質疏松雜志, 2020, 26(11): 1689-1693.
8.	Fragala MS, Cadore EL, Dorgo S, et al. Resistance training for older adults: position statement from the National Strength and Conditioning Association. J Strength Cond Res, 2019, 33(8): 2019-2052.
9.	de Mello RGB, Dalla Corte RR, Gioscia J, et al. Effects of physical exercise programs on sarcopenia management, dynapenia, and physical performance in the elderly: a systematic review of randomized clinical trials. J Aging Res, 2019, 2019: 1959486.
10.	Lopes KG, Bottino DA, Farinatti P, et al. Strength training with blood flow restriction - a novel therapeutic approach for older adults with sarcopenia. A case report. Clin Interv Aging, 2019, 14: 1461-1469.
11.	中華醫學會老年醫學分會老年康復學組, 肌肉衰減綜合征專家共識撰寫組. 肌肉衰減綜合征中國專家共識(草案). 中華老年醫學雜志, 2017, 36(7): 711-718.
12.	Ossowski ZM, Skrobot W, Aschenbrenner P, et al. Effects of short-term Nordic walking training on sarcopenia-related parameters in women with low bone mass: a preliminary study. Clin Interv Aging, 2016, 11: 1763-1771.
13.	Yang LJ, Wu GH, Yang YL, et al. Nutrition, physical exercise, and the prevalence of sarcopenia in elderly residents in nursing homes in China. Med Sci Monit, 2019, 25: 4390-4399.
14.	Shen Y, Shi Q, Nong K, et al. Exercise for sarcopenia in older people: a systematic review and network meta-analysis. J Cachexia Sarcopenia Muscle, 2023, 14(3): 1199-1211.
15.	閔文珺, 陳亞梅, 盧群, 等. 老年肌少癥患者運動干預的最佳證據總結. 解放軍護理雜志, 2022, 39(3): 75-78.
16.	Liu X, Xia X, Hu F, et al. Nutrition status mediates the association between cognitive decline and sarcopenia. Aging (Albany NY), 2021, 13(6): 8599-8610.
17.	Beaudart C, Sanchez-Rodriguez D, Locquet M, et al. Malnutrition as a strong predictor of the onset of sarcopenia. Nutrients, 2019, 11(12): 2883.
18.	Sieber CC. Malnutrition and sarcopenia. Aging Clin Exp Res, 2019, 31(6): 793-798.
19.	崔華, 王朝暉, 吳劍卿, 等. 老年人肌少癥防控干預中國專家共識(2023). 中華老年醫學雜志, 2023, 42(2): 144-153.
20.	周曉寧, 許金海, 王國棟, 等. 肌少癥治療. 中華骨質疏松和骨礦鹽疾病雜志, 2020, 13(3): 272-279.
21.	Brioche T, Kireev RA, Cuesta S, et al. Growth hormone replacement therapy prevents sarcopenia by a dual mechanism: improvement of protein balance and of antioxidant defenses. J Gerontol A Biol Sci Med Sci, 2014, 69(10): 1186-1198.
22.	Giannoulis MG, Martin FC, Nair KS, et al. Hormone replacement therapy and physical function in healthy older men. Time to talk hormones? Endocr Rev, 2012, 33(3): 314-377.
23.	Morley JE. Pharmacologic options for the treatment of sarcopenia. Calcif Tissue Int, 2016, 98(4): 319-333.
24.	Nieschlag E. Current topics in testosterone replacement of hypogonadal men. Best Pract Res Clin Endocrinol Metab, 2015, 29(1): 77-90.
25.	Papanicolaou DA, Ather SN, Zhu H, et al. A phase ⅡA randomized, placebo-controlled clinical trial to study the efficacy and safety of the selective androgen receptor modulator (SARM), MK-0773 in female participants with sarcopenia. J Nutr Health Aging, 2013, 17(6): 533-543.
26.	Dobs AS, Boccia RV, Croot CC, et al. Effects of enobosarm on muscle wasting and physical function in patients with cancer: a double-blind, randomised controlled phase 2 trial. Lancet Oncol, 2013, 14(4): 335-345.
27.	White HK, Petrie CD, Landschulz W, et al. Effects of an oral growth hormone secretagogue in older adults. J Clin Endocrinol Metab, 2009, 94(4): 1198-1206.
28.	楊惠, 額爾敦木圖, 姜建強, 等. 肌肉生長抑制素對骨骼肌作用研究進展. 動物醫學進展, 2016, 37(5): 77-81, 82.
29.	Padhi D, Higano CS, Shore ND, et al. Pharmacological inhibition of myostatin and changes in lean body mass and lower extremity muscle size in patients receiving androgen deprivation therapy for prostate cancer. J Clin Endocrinol Metab, 2014, 99(10): E1967-E1975.
30.	梁清月, 王仲, 劉戎, 等. 加減八珍湯聯合營養支持治療老年骨骼肌減少癥療效觀察. 中國中西醫結合雜志, 2019, 39(7): 821-825.
31.	陳歡, 張莉, 崔強, 等. 電針阿是穴對骨骼肌損傷大鼠肌肉再生及堿性成纖維細胞生長因子表達的影響. 中國康復理論與實踐, 2013, 19(4): 334-340.

1. Dent E, Morley JE, Cruz-Jentoft AJ, et al. International clinical practice guidelines for sarcopenia (ICFSR): screening, diagnosis and management. J Nutr Health Aging, 2018, 22(10): 1148-1161.
2. Cruz-Jentoft AJ, Sayer AA. Sarcopenia. Lancet, 2019, 393(10191): 2636-2646.
3. 劉娟, 丁清清, 周白瑜, 等. 中國老年人肌少癥診療專家共識(2021). 中華老年醫學雜志, 2021, 40(8): 943-952.
4. 甄志龍, 趙建民, 孫遜, 等. 肌少癥的診療共識解讀與研究進展. 生物骨科材料與臨床研究, 2023, 20(1): 71-75.
5. Cruz-Jentoft AJ, Bahat G, Bauer J, et al. Sarcopenia: revised European consensus on definition and diagnosis. Age Ageing, 2019, 48(1): 16-31.
6. 沈妍交, 郝秋奎, 張蒙, 等. 老年肌少癥綜合干預循證臨床實踐指南. 中國循證醫學雜志, 2024, 24(4): 378-384.
7. 楊玲, 杜娟, 劉榮雁, 等. 肌肉減少癥病因學研究現狀與展望. 中國骨質疏松雜志, 2020, 26(11): 1689-1693.
8. Fragala MS, Cadore EL, Dorgo S, et al. Resistance training for older adults: position statement from the National Strength and Conditioning Association. J Strength Cond Res, 2019, 33(8): 2019-2052.
9. de Mello RGB, Dalla Corte RR, Gioscia J, et al. Effects of physical exercise programs on sarcopenia management, dynapenia, and physical performance in the elderly: a systematic review of randomized clinical trials. J Aging Res, 2019, 2019: 1959486.
10. Lopes KG, Bottino DA, Farinatti P, et al. Strength training with blood flow restriction - a novel therapeutic approach for older adults with sarcopenia. A case report. Clin Interv Aging, 2019, 14: 1461-1469.
11. 中華醫學會老年醫學分會老年康復學組, 肌肉衰減綜合征專家共識撰寫組. 肌肉衰減綜合征中國專家共識(草案). 中華老年醫學雜志, 2017, 36(7): 711-718.
12. Ossowski ZM, Skrobot W, Aschenbrenner P, et al. Effects of short-term Nordic walking training on sarcopenia-related parameters in women with low bone mass: a preliminary study. Clin Interv Aging, 2016, 11: 1763-1771.
13. Yang LJ, Wu GH, Yang YL, et al. Nutrition, physical exercise, and the prevalence of sarcopenia in elderly residents in nursing homes in China. Med Sci Monit, 2019, 25: 4390-4399.
14. Shen Y, Shi Q, Nong K, et al. Exercise for sarcopenia in older people: a systematic review and network meta-analysis. J Cachexia Sarcopenia Muscle, 2023, 14(3): 1199-1211.
15. 閔文珺, 陳亞梅, 盧群, 等. 老年肌少癥患者運動干預的最佳證據總結. 解放軍護理雜志, 2022, 39(3): 75-78.
16. Liu X, Xia X, Hu F, et al. Nutrition status mediates the association between cognitive decline and sarcopenia. Aging (Albany NY), 2021, 13(6): 8599-8610.
17. Beaudart C, Sanchez-Rodriguez D, Locquet M, et al. Malnutrition as a strong predictor of the onset of sarcopenia. Nutrients, 2019, 11(12): 2883.
18. Sieber CC. Malnutrition and sarcopenia. Aging Clin Exp Res, 2019, 31(6): 793-798.
19. 崔華, 王朝暉, 吳劍卿, 等. 老年人肌少癥防控干預中國專家共識(2023). 中華老年醫學雜志, 2023, 42(2): 144-153.
20. 周曉寧, 許金海, 王國棟, 等. 肌少癥治療. 中華骨質疏松和骨礦鹽疾病雜志, 2020, 13(3): 272-279.
21. Brioche T, Kireev RA, Cuesta S, et al. Growth hormone replacement therapy prevents sarcopenia by a dual mechanism: improvement of protein balance and of antioxidant defenses. J Gerontol A Biol Sci Med Sci, 2014, 69(10): 1186-1198.
22. Giannoulis MG, Martin FC, Nair KS, et al. Hormone replacement therapy and physical function in healthy older men. Time to talk hormones? Endocr Rev, 2012, 33(3): 314-377.
23. Morley JE. Pharmacologic options for the treatment of sarcopenia. Calcif Tissue Int, 2016, 98(4): 319-333.
24. Nieschlag E. Current topics in testosterone replacement of hypogonadal men. Best Pract Res Clin Endocrinol Metab, 2015, 29(1): 77-90.
25. Papanicolaou DA, Ather SN, Zhu H, et al. A phase ⅡA randomized, placebo-controlled clinical trial to study the efficacy and safety of the selective androgen receptor modulator (SARM), MK-0773 in female participants with sarcopenia. J Nutr Health Aging, 2013, 17(6): 533-543.
26. Dobs AS, Boccia RV, Croot CC, et al. Effects of enobosarm on muscle wasting and physical function in patients with cancer: a double-blind, randomised controlled phase 2 trial. Lancet Oncol, 2013, 14(4): 335-345.
27. White HK, Petrie CD, Landschulz W, et al. Effects of an oral growth hormone secretagogue in older adults. J Clin Endocrinol Metab, 2009, 94(4): 1198-1206.
28. 楊惠, 額爾敦木圖, 姜建強, 等. 肌肉生長抑制素對骨骼肌作用研究進展. 動物醫學進展, 2016, 37(5): 77-81, 82.
29. Padhi D, Higano CS, Shore ND, et al. Pharmacological inhibition of myostatin and changes in lean body mass and lower extremity muscle size in patients receiving androgen deprivation therapy for prostate cancer. J Clin Endocrinol Metab, 2014, 99(10): E1967-E1975.
30. 梁清月, 王仲, 劉戎, 等. 加減八珍湯聯合營養支持治療老年骨骼肌減少癥療效觀察. 中國中西醫結合雜志, 2019, 39(7): 821-825.
31. 陳歡, 張莉, 崔強, 等. 電針阿是穴對骨骼肌損傷大鼠肌肉再生及堿性成纖維細胞生長因子表達的影響. 中國康復理論與實踐, 2013, 19(4): 334-340.

Chinese Journal of Evidence-Based Medicine

Interpretation of Comprehensive intervention for sarcopenia among older adults: an evidence-based clinical practice guideline

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