Influencing factors of mild cognitive impairment in patients with type 2 diabetes: a meta-analysis_Chinese Journal of Evidence-Based Medicine

Authors：

XUE Chenghao ¹ ,  GUO Haijian ² , LI Mingma ¹ , YAN Tao ¹ ,  WANG Bei ¹

1. Department of Epidemiology and Health Statistics, School of Public Health, Southeast University, Nanjing 210009, P. R. China;
2. Jiangsu Provincial Center for Disease Control and Prevention, Nanjing 210009, P. R. China;

Corresponding?author：

GUO Haijian, Email: guohjcdc@163.com; WANG Bei, Email: wangbeilxb@163.com

Keywords：

Type 2 diabetes; Mild cognitive impairment; Influencing factor; Meta-analysis; Systematic review

DOI：

10.7507/1672-2531.202111062

Video：

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Objective To systematically review the influencing factors of mild cognitive impairment in type 2 diabetic patients. Methods PubMed, Web of Science, EMbase, The Cochrane Library, CNKI, WanFang Data, VIP, and CBM databases were electronically searched to collect studies on the influencing factors of mild cognitive impairment in patients with type 2 diabetes from inception to December 31, 2021. Two reviewers independently screened the literature, extracted data, and assessed the risk of bias of included studies; then, meta-analysis was performed by using RevMan 5.4 software and Stata 12.0 software. Results A total of 32 studies involving 7 519 subjects were included. The results of the meta-analysis showed that the main influencing factors of mild cognitive impairment in type 2 diabetic patients were age, duration of type 2 diabetes, educational level, cerebral infarction, hypertension, smoking, insulin resistance index, glycosylated hemoglobin, and homocysteine. Conclusion Current evidence shows that some factors such as age, duration, and educational level are the main influencing factors of mild cognitive impairment in type 2 diabetic patients. Due to the limited quality and quantity of the included studies, more high quality studies are needed to verify the above conclusions.

Citation： XUE Chenghao, GUO Haijian, LI Mingma, YAN Tao, WANG Bei. Influencing factors of mild cognitive impairment in patients with type 2 diabetes: a meta-analysis. Chinese Journal of Evidence-Based Medicine, 2022, 22(5): 568-574. doi: 10.7507/1672-2531.202111062 Copy

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2.	You Y, Liu Z, Chen Y, et al. The prevalence of mild cognitive impairment in type 2 diabetes mellitus patients: a systematic review and meta-analysis. Acta Diabetol, 2021, 58(6): 671-685.
3.	Degen C, Toro P, Sch?nknecht P, et al. Diabetes mellitus type Ⅱ and cognitive capacity in healthy aging, mild cognitive impairment and Alzheimer's disease. Psychiatry Res, 2016, 240: 42-46.
4.	Jongsiriyanyong S, Limpawattana P. Mild cognitive impairment in clinical practice: a review article. Am J Alzheimers Dis Other Demen, 2018, 33(8): 500-507.
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1. Ali MK, Pearson-Stuttard J, Selvin E, et al. Interpreting global trends in type 2 diabetes complications and mortality. Diabetologia, 2022, 65(1): 3-13.
2. You Y, Liu Z, Chen Y, et al. The prevalence of mild cognitive impairment in type 2 diabetes mellitus patients: a systematic review and meta-analysis. Acta Diabetol, 2021, 58(6): 671-685.
3. Degen C, Toro P, Sch?nknecht P, et al. Diabetes mellitus type Ⅱ and cognitive capacity in healthy aging, mild cognitive impairment and Alzheimer's disease. Psychiatry Res, 2016, 240: 42-46.
4. Jongsiriyanyong S, Limpawattana P. Mild cognitive impairment in clinical practice: a review article. Am J Alzheimers Dis Other Demen, 2018, 33(8): 500-507.
5. 朱玲玲, 朱駿, 王敏, 等. 2型糖尿病合并認知功能障礙的危險因素. 實用老年醫學, 2021, 35(6): 606-608.
6. 趙立華. 2型糖尿病認知功能障礙的特點及IDE, ADP和胰島素抵抗對認知功能的影響. 天津: 天津醫科大學, 2015.
7. 張冉騰, 康冬梅. 老年男性2型糖尿病患者骨代謝與認知功能障礙的關系. 慢性病學雜志, 2021, 22(5): 655-658.
8. 張玲, 陳政文, 陸晨, 等. 維吾爾族老年糖尿病患者輕度認知功能障礙的影響因素分析. 中華老年醫學雜志, 2017, 36(9): 951-954.
9. 張利楠, 艾比拜·玉素甫. 血清胱抑素C水平與老年2型糖尿病患者輕度認知功能障礙的關系探討. 飲食保健, 2019, 6(13): 8-9.
10. 謝小莉, 李燕, 霍敏, 等. 老年2型糖尿病患者輕度認知功能障礙與胰島素抵抗、白介素-6的相關性研究. 醫學信息, 2019, 32(15): 97-98,108.
11. 王穎. 2型糖尿病患者認知功能障礙與糖尿病血管并發癥的相關性研究. 濟南: 山東大學, 2015.
12. 王品. RAGEGly82Ser基因多態性及血清sRAGE水平與2型糖尿病相關輕度認知障礙相關性研究. 南京: 東南大學, 2015.
13. 王妮, 陳曉. 老年2型糖尿病患者輕度認知功能障礙相關危險因素研究. 現代醫藥衛生, 2021, 37(24): 4254-4257.
14. 汪璐璐, 劉安諾, 劉鴻雁, 等. 2型糖尿病患者自我管理行為與認知功能各維度的關系研究. 實用預防醫學, 2020, 27(1): 1-4.
15. 司俊霞, 談躍, 徐勉, 等. 胰島素水平與輕度認知障礙關系的臨床研究. 中國糖尿病雜志, 2008, 16(7): 418-420.
16. 毛秀英, 邱宏亮. 社區老年2型糖尿病患者合并輕度認知功能障礙危險因素分析. 實用老年醫學, 2014, 28(7): 587-590.
17. 馬麗麗. 老年2型糖尿病患者輕度認知功能障礙發生的影響因素. 中國衛生工程學, 2020, 19(3): 362-364.
18. 馬彪, 楊勇, 孟憲海, 等. 2型糖尿病伴輕度認知功能減退與載脂蛋白Eε4等位基因等因素的關系. 中國慢性病預防與控制, 2014, 22(1): 81-83.
19. 李敏, 張麗, 王敏哲. 老年2型糖尿病與輕度認知功能障礙的關系研究. 中國全科醫學, 2011, 14(14): 1537-1539.
20. 李春花, 郭昕, 豆靜, 等. 2型糖尿病患者認知功能障礙及其影響因素調查分析. 吉林大學學報(醫學版), 2018, 44(2): 431-437.
21. 李琛, 梁興倫, 周文銳, 等. 老年2型糖尿病患者輕度認知功能障礙與胰島素抵抗的關系研究. 臨床和實驗醫學雜志, 2014, 13(16): 1369-1371.
22. 坎麗比努爾·買米提民, 亞森江·買買提, 麥迪娜·阿不都熱依木, 等. 2型糖尿病患者并發輕度認知功能障礙的危險因素分析. 醫學臨床研究, 2021, 38(9): 1402-1404.
23. 黃金, 胡進, 朱熊兆, 等. 社區2型糖尿病患者認知功能現狀及其影響因素研究. 中國全科醫學, 2016, 19(2): 135-141.
24. 郝云玲, 嚴勵. 2型糖尿病合并輕度認知功能障礙相關因素分析. 中國醫藥導報, 2012, 9(35): 84-85,88.
25. 郭連雨, 劉艷, 仇海燕, 等. 2型糖尿病合并輕度認知功能障礙的危險因素分析. 天津醫藥, 2013, 41(8): 772-775.
26. 宮娟, 劉安諾, 鄭紅英, 等. 中年2型糖尿病患者認知功能損害特征及影響因素調查. 臨床護理雜志, 2020, 19(4): 26-29.
27. Cai R, Han J, Sun J, et al. Plasma clusterin and the CLU gene rs11136000 variant are associated with mild cognitive impairment in type 2 diabetic patients. Front Aging Neurosci, 2016, 8: 179.
28. Zheng M, Zhang M, Yang J, et al. Relationship between blood levels of methyl donor and folate and mild cognitive impairment in Chinese patients with type 2 diabetes: a case-control study. J Clin Biochem Nutr, 2014, 54(2): 122-128.
29. Damanik J, Mayza A, Rachman A, et al. Association between serum homocysteine level and cognitive function in middle-aged type 2 diabetes mellitus patients. PLoS One, 2019, 14(11): e0224611.
30. Guo D, Yuan Y, Huang R, et al. Association between plasma adipsin level and mild cognitive impairment in Chinese patients with type 2 diabetes: a cross-sectional study. BMC Endocr Disord, 2019, 19(1): 108.
31. Gorska-Ciebiada M, Saryusz-Wolska M, Borkowska A, et al. Adiponectin, leptin and IL-1 β in elderly diabetic patients with mild cognitive impairment. Metab Brain Dis, 2016, 31(2): 257-266.
32. Gorska-Ciebiada M, Saryusz-Wolska M, Borkowska A, et al. C-reactive protein, advanced glycation end products, and their receptor in type 2 diabetic, elderly patients with mild cognitive impairment. Front Aging Neurosci, 2015, 7: 209.
33. Gao Y, Xiao Y, Miao R, et al. The prevalence of mild cognitive impairment with type 2 diabetes mellitus among elderly people in China: a cross-sectional study. Arch Gerontol Geriatr, 2016, 62: 138-142.
34. Cai R, Huang R, Han J, et al. Lipoprotein-associated phospholipase A2 is associated with risk of mild cognitive impairment in Chinese patients with type 2 diabetes. Sci Rep, 2017, 7(1): 12311.
35. Blanquisco L, Abejero JE, Buno Ii B, et al. Factors associated with mild cognitive impairment among elderly filipinos with type 2 diabetes mellitus. J ASEAN Fed Endocr Soc, 2017, 32(2): 145-150.
36. Aljohani A, Salem KA, Aljohani A, et al. Factors related to mild cognitive impairment among type 2 diabetic patients attending diabetes center in Al-Madinah, Saudi Arabia 2019-2020. Med Sci, 2020, 24(106): 4080-4090.
37. Chen RH, Jiang XZ, Zhao XH, et al. Risk factors of mild cognitive impairment in middle aged patients with type 2 diabetes: a cross-section study. Ann Endocrinol (Paris), 2012, 73(3): 208-212.
38. Korf ES, White LR, Scheltens P, et al. Brain aging in very old men with type 2 diabetes: the Honolulu-Asia Aging Study. Diabetes Care, 2006, 29(10): 2268-2274.
39. 鄒小燕. 社區老年糖尿病患者認知功能障礙原因及危險因素調查. 實用預防醫學, 2014, 21(5): 632-634.
40. Espeland MA, Bryan RN, Goveas JS, et al. Influence of type 2 diabetes on brain volumes and changes in brain volumes: results from the women's health initiative magnetic resonance imaging studies. Diabetes Care, 2013, 36(1): 90-97.
41. Parikh NM, Morgan RO, Kunik ME, et al. Risk factors for dementia in patients over 65 with diabetes. Int J Geriatr Psychiatry, 2011, 26(7): 749-757.
42. Biessels GJ, Deary IJ, Ryan CM. Cognition and diabetes: a lifespan perspective. Lancet Neurol, 2008, 7(2): 184-190.
43. 劉風蘭. 認知干預對輕度認知障礙患者認知功能和生活質量的影響研究. 長沙: 中南大學, 2012.
44. Tu J, Wang LX, Wen HF, et al. The association of different types of cerebral infarction with post-stroke depression and cognitive impairment. Medicine (Baltimore), 2018, 97(23): e10919.
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Chinese Journal of Evidence-Based Medicine

Influencing factors of mild cognitive impairment in patients with type 2 diabetes: a meta-analysis

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