FAN Jin 1 , ZHONG Dongling 1 , LI Juan 1 , LI Yuxi 2 , ZHANG Huiling 1 , LIU Xiaobo 1 , HE Xia 3 , XIE Xiaolong 4 , JIN Rongjiang 1
  • 1. School of Health Preservation and Rehabilitation, Chengdu University of Traditional Chinese Medicine, Chengdu 610075, P.R.China;
  • 2. School of Acupuncture-Moxibustion and Tuina, Chengdu University of Traditional Chinese Medicine, Chengdu 610075, P.R.China;
  • 3. The Affiliated Rehabilitation Hospital of Chengdu University of Traditional Chinese Medicine, Sichuan Provincal Rehabilitation Hospital, Chengdu 610035, P.R.China;
  • 4. The Affiliated Meishan Hospital of Chengdu University of Traditional Chinese Medicine, Meishan 620010, P.R.China;
JIN Rongjiang, Email: cdzyydxjrj@126.com
Type 2 diabetes mellitus; Cognitive impairment; China; Detection rate; Meta-analysis
10.7507/1672-2531.202102001
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Objective To systematically review the detection rate of cognitive impairment in Chinese patients with type 2 diabetes mellitus (T2DM).Methods PubMed, EMbase, The Cochrane Library, CBM, CNKI, WanFang Data and VIP databases were searched to collect studies on the detection rate of cognitive impairment in Chinese patients with T2DM from inception to January 20th, 2021. Two reviewers independently screened literature, extracted data and evaluated the risk of bias of included studies. Meta-analysis was then performed using Stata 12.0 software.Results A total of 27 studies involving 7 920 cases were included. Meta-analysis results showed that the total detection rate of cognitive impairment in Chinese patients with T2DM was 43.2% (95%CI 36.9% to 49.6%). The results of subgroup analysis showed that in T2DM patients, the detection rate of cognitive impairment in males was 42.4% (95%CI 34.4% to 50.4%), and that in females was 48.2% (95%CI 40.9% to 55.6%). The detection rate of cognitive impairment was 25.4% (95%CI 14.7% to 36.0%) in patients under the age of 60 years, and 47.0% (95%CI 30.0% to 64.0%) in patients aged 60 years or above. The detection rate of cognitive impairment among those with primary school education level or below was 67.1% (95%CI 48.9% to 85.3%). The detection rate of cognitive impairment was 37.1% (95%CI 27.3% to 46.8%) among those with education level of junior high school or above. The detection rate of cognitive impairment in patients with disease duration less than 10 years was 28.4% (95%CI 16.0% to 40.9%) and that in patients with disease duration more than 10 years was 50.6% (95%CI 33.2% to 68.0%). The detection rate of cognitive impairment in married individuals was 45.6% (95%CI 35.8% to 55.4%) and that in singles was 68.1% (95%CI 57.5% to 78.7%). The detection rate of cognitive impairment in smokers was 38.9% (95%CI 30.7% to 47.2%) and in non-smokers was 40.9% (95%CI 32.1% to 49.6%). The detection rate of cognitive impairment in drinkers was 35.6% (95%CI 27.3% to 44.0%) and that in non-drinkers was 41.8% (95%CI 32.2% to 51.4%).Conclusions The detection rate of cognitive impairment in Chinese patients with T2DM is high. Due to the quantity and quality of included studies, more high-quality studies are needed to verify the above conclusions.

Citation： FAN Jin, ZHONG Dongling, LI Juan, LI Yuxi, ZHANG Huiling, LIU Xiaobo, HE Xia, XIE Xiaolong, JIN Rongjiang. The detection rate of cognitive impairment in Chinese patients with type 2 diabetes mellitus: a meta-analysis. Chinese Journal of Evidence-Based Medicine, 2021, 21(7): 787-795. doi: 10.7507/1672-2531.202102001 Copy

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