Analysis of hotspots and frontiers of frailty research: a visualization analysis based on CiteSpace_Chinese Journal of Evidence-Based Medicine

Authors：

ZHANG Weiyi ^1,2 , CAO Liujiao ^1,2 , LI Yanfei ^1,2 ,  MA Bin ^2,3 ,  YANG Kehu ^1,2,3,4

1. Evidence-based Social Science Research Center of Lanzhou University, Lanzhou 730000, P.R.China;
2. Key Laboratory of Evidence-based Medicine and Clinical Transformation in Gansu Province, Lanzhou 730000, P.R.China;
3. Evidence-based Medicine Center of Lanzhou University, Lanzhou 730000, P.R.China;
4. Evidence-based Rehabilitation Medicine Research Center in Gansu Province, Lanzhou 730000, P.R.China;

Corresponding?author：

MA Bin, Email: kittymb2017@163.com; YANG Kehu, Email: kehuyangebm2006@126.com

Keywords：

Frailty; Bibliometrics; Visualization; CiteSpace; Hotspots; Frontiers

DOI：

10.7507/1672-2531.202005111

Video：

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Abstract Full text Figures/Tables Video References Cited by

Objectives To analyze and track the hotspots and frontiers of the field of frailty by analyzing the related research published by SCI-journals in recent decade.Methods Data of publications from 2010 to 2019 were retrieved from the Web of Science Core Collection database. CiteSpace was used to analyze the hotspots and frontiers of frailty research from high-impact countries/regions, institutions, authors, high-frequency keywords and burst terms.Results A total of 12 768 publications were identified. The United States was the leading country for publications. Research hotspots focused on adverse health outcomes associated with frailty, interventions, and frailty in elderly patients and females. Besides, frailty assessment and screening, cohort study, meta-analysis and cognitive impairment were the frontier fields.Conclusions Adverse health outcomes associated with frailty, interventions, and frailty in elderly patients and females are the hotspots and frontiers of frailty research.

Citation： ZHANG Weiyi, CAO Liujiao, LI Yanfei, MA Bin, YANG Kehu. Analysis of hotspots and frontiers of frailty research: a visualization analysis based on CiteSpace. Chinese Journal of Evidence-Based Medicine, 2020, 20(11): 1308-1315. doi: 10.7507/1672-2531.202005111 Copy

1.	Fried LP, Tangen CM, Walston J, et al. Frailty in older adults: evidence for a phenotype. J Gerontol A Biol Sci Med Sci, 2001, 56(3): M146-156.
2.	Sieber CC. Frailty - From concept to clinical practice. Exp Gerontol, 2017, 87(Pt B): 160-167.
3.	董碧蓉. 老年衰弱綜合征的研究進展. 中華保健醫學雜志, 2014, 16(6): 417-420.
4.	郝秋奎, 董碧蓉. 老年人衰弱綜合征的國際研究現狀. 中華老年醫學雜志, 2013, 32(6): 685-688.
5.	趙國慶, 黃榮懷, 陸志堅. 知識可視化的理論與方法. 開放教育研究, 2005, 11(1): 23-27.
6.	Chen CM. CiteSpace II: Detecting and visualizing emerging trends and transient patterns in scientific literature. J Am Soc Inf Sci Tec. 2006, 57(3): 359-377.
7.	Cobo MJ, Lopez-Herrera AG, Herrera-Viedma E, et al. Science mapping software tools: review, analysis, and cooperative study among tools. J Am Soc Inf Sci Tec, 2011, 62(7): 1382-1402.
8.	陳悅, 陳超美, 劉則淵, 等. CiteSpace 知識圖譜的方法論功能. 科學學研究, 2015, 33(2): 242-253.
9.	Johnson NE, Climo JJ. Aging and eldercare in more developed countries - The United States, South Korea, and Puerto Rico. J Fam Issues, 2000, 21(5): 531-540.
10.	Smrcka L, Arltova M. Economic aspects of population ageing in developed countries. Polit Ekon, 2012, 60(1): 113-132.
11.	邱均平, 馬瑞敏. 基于 CSSCI 的圖書館、情報與檔案管理一級學科文獻計量評價研究. 中國圖書館學報, 2006, 32(1): 24-29.
12.	Rockwood K. Response to the Letter From Xue and Varadhan: “What Is Missing in the Validation of Frailty Instruments?”. J Am Med Dir Assoc, 2014, 15(2): 144-145.
13.	Searle SD, Rockwood K. What proportion of older adults in hospital are frail? Lancet, 2018, 391(10132): 1751-1752.
14.	Xiaowei Song, Arnold Mitnitski, 石婧, 等. 中國與加拿大合作開展健康與衰老研究的情況介紹. 中華老年醫學雜志, 2009, 28(10): 793-802.
15.	Callon M, Courtial JP, Laville F. Co-word analysis as a tool for describing the network of interactions between basic and technological research: The case of polymer chemsitry. Scientometrics, 1991, 22(1): 155-205.
16.	趙建保. CiteSpace 可視化流程與分析范式研究. 知識經濟, 2014, (16): 105-107.
17.	奚桓, 于普林, 劉祥. 肌少癥與衰弱綜合征的關系. 中華老年醫學雜志, 2015, 34(12): 1289-1292.
18.	Nishiguchi S, Yamada M, Fukutani N, et al. Differential association of frailty with cognitive decline and sarcopenia in community-dwelling older adults. J Am Med Dir Assoc, 2015, 16(2): 120-124.
19.	Angulo J, El Assar M, Rodriguez-Manas L. Frailty and sarcopenia as the basis for the phenotypic manifestation of chronic diseases in older adults. Mol Aspects Med, 2016, 50: 1-32.
20.	Fang X, Shi J, Song X, et al. Frailty in relation to the risk of falls, fractures, and mortality in older Chinese adults: Results from the Beijing Longitudinal Study of Aging. J Nutr Health Aging, 2012, 16(10): 903-907.
21.	Joosten E, Demuynck M, Detroyer E, et al. Prevalence of frailty and its ability to predict in hospital delirium, falls, and 6-month mortality in hospitalized older patients. BMC Geriatr, 2014, 14: 1.
22.	Kojima G. Frailty as a predictor of future falls among community-dwelling older people: a systematic review and meta-analysis. J Am Med Dir Assoc, 2015, 16(12): 1027-1033.
23.	Tom SE, Adachi JD, Anderson FA, et al. Frailty and fracture, disability, and falls: a multiple country study from the global longitudinal study of osteoporosis in women. J Am Geriatr Soc, 2013, 61(3): 327-334.
24.	周白瑜, 于冬妮, 陶永康, 等. 北京市社區老年人跌倒發生與衰弱的相關性研究. 中華流行病學雜志, 2018, 39(3): 308-312.
25.	王守琦, 石穎, 張美玲, 等. 老年人衰弱干預的研究進展. 中華護理雜志, 2017, 52(3): 365-368.
26.	宋曉月, 蘇媛媛, 孫丹, 等. 虛弱老年人運動康復的研究現狀. 中國康復理論與實踐, 2017, 23(4): 402-405.
27.	Cesari M, Vellas B, Hsu FC, et al. A physical activity intervention to treat the frailty syndrome in older persons-results from the LIFE-P study. J Gerontol A-Biol, 2015, 70(2): 216-222.
28.	Cadore EL, Rodriguez-Manas L, Sinclair A, et al. Effects of different exercise interventions on risk of falls, gait ability, and balance in physically frail older adults: a systematic review. Rejuv Res, 2013, 16(2): 105-114.
29.	Chou CH, Hwang CL, Wu YT. Effect of exercise on physical function, daily living activities, and quality of life in the frail older adults: a meta-analysis. Arch Phys Med Rehab, 2012, 93(2): 237-244.
30.	嚴雪丹, 楊永學, 陳善萍, 等. 老年人衰弱的康復營養研究進展. 中華老年多器官疾病雜志, 2020, 19(1): 66-69.
31.	Bollwein J, Diekmann R, Kaiser MJ, et al. Dietary quality is related to frailty in community-dwelling older adults. J Gerontol A-Biol, 2013, 68(4): 483-489.
32.	Talegawkar SA, Bandinelli S, Bandeen-Roche K, et al. A higher adherence to a mediterranean-style diet is inversely associated with the development of frailty in community-dwelling elderly men and women. J Nutr, 2012, 142(12): 2161-2166.
33.	Cameron ID, Fairhall N, Langron C, et al. A multifactorial interdisciplinary intervention reduces frailty in older people: randomized trial. BMC Med, 2013, 11: 65.
34.	Ng TP, Feng L, Nyunt MSZ, et al. Nutritional, physical, cognitive, and combination interventions and frailty reversal among older adults: a randomized controlled trial. Am J Med, 2015, 128(11): 1225-1236.
35.	楊帆, 王雙, 譚柯, 等. 衰弱綜合征對社區老年糖尿病患者跌倒影響的隊列研究. 中華流行病學雜志, 2018, 39(6): 776-780.
36.	中華醫學會老年醫學分會. 老年患者衰弱評估與干預中國專家共識. 中華老年醫學雜志, 2017, 36(3): 251-256.
37.	呂衛華, 王青, 趙清華, 等. 住院老年患者衰弱評估及不同衰弱評估工具的比較. 北京醫學, 2016, 38(10): 1036-1040.
38.	Makary MA, Segev DL, Pronovost PJ, et al. Frailty as a predictor of surgical outcomes in older patients. J Am Coll Surgeons, 2010, 210(6): 901-908.
39.	Martin Lesende I, Gorronogoitia Iturbe A, Gomez Pavon J, et al. The frail elderly. Detection and management in primary care. Aten Primaria, 2010, 42(7): 388-393.
40.	Williams GR, Deal AM, Sanoff HK, et al. Frailty and health-related quality of life in older women with breast cancer. Support Care Cancer, 2019, 27(7): 2693-2698.
41.	歐陽敏, 蹇在金. 老年衰弱評估研究進展. 中國實用內科雜志, 2017, 37(4): 317-321.
42.	奚興, 郭桂芳, 孫靜. 老年人衰弱評估工具及其應用研究進展. 中國老年學雜志, 2015, (20): 5993-5996.
43.	Cesari M, Gambassi G, van Kan GA, et al. The frailty phenotype and the frailty index: different instruments for different purposes. Age Ageing, 2014, 43(1): 10-12.
44.	Faller JW, Pereira DN, de Souza S, et al. Instruments for the detection of frailty syndrome in older adults: A systematic review. PloS One, 2019, 14(4): e0216166.
45.	Pan B, Ge L, Xun YQ, et al. Exercise training modalities in patients with type 2 diabetes mellitus: a systematic review and network meta-analysis. Int J Behav Nutr Phy, 2018, 15(1): 72.
46.	Huang D, Song X, Cui Q, et al. Is there an association between aircraft noise exposure and the incidence of hypertension: A meta-analysis of 16 784 participants. Noise Health, 2015, 17(75): 93-97.
47.	Siriwardhana DD, Hardoon S, Rait G, et al. Prevalence of frailty and prefrailty among community-dwelling older adults in low-income and middle income countries: a systematic review and meta-analysis. BMJ Open, 2018, 8(3): e018195.
48.	Landre B, Czernichow S, Goldberg M, et al. Association between life-course obesity and frailty in older adults: findings in the GAZEL cohort. Obesity, 2020, 28(2): 388-396.
49.	Lee KC, Streid J, Sturgeon D, et al. The impact of frailty on long-term patient-oriented outcomes after emergency general surgery: a retrospective cohort study. J Am Ger Soc, 2020, 68(5): 1037-1043.
50.	Hegendoerfer E, Vaes B, Van Pottelbergh G, et al. Predictive accuracy of frailty tools for adverse outcomes in a cohort of adults 80 years and older: a decision curve analysis. J Am Med Dir Assoc, 2020, 21(3): 400.e1-400.e8.
51.	孫晨, 施紅, 奚桓, 等. 衰弱與認知功能障礙. 中華老年醫學雜志, 2018, 37(7): 826-830.
52.	郝單單, 李放. 衰弱與認知損害相關性研究進展. 首都醫科大學學報, 2017, 38(3): 406-410.
53.	Halil M, Kizilarslanoglu MC, Kuyumcu ME, et al. Cognitive aspects of frailty: Mechanisms behind the link between frailty and cognitive impairment. J Nutr Health Aging, 2015, 19(3): 276-283.
54.	Robertson DA, Savva GM, Kenny RA. Frailty and cognitive impairment-A review of the evidence and causal mechanisms. Ageing Res Rev, 2013, 12(4): 840-851.
55.	van Kan GA, Cesari M, Gillette-Guyonnet S, et al. Sarcopenia and cognitive impairment in elderly women: results from the EPIDOS cohort. Age Ageing, 2013, 42(2): 196-202.
56.	Jha SR, Hannu MK, Gore K, et al. Cognitive impairment improves the predictive validity of physical frailty for mortality in patients with advanced heart failure referred for heart transplantation. J Heart Lung Transpl, 2016, 35(9): 1092-1100.
57.	Avila-Funes JA, Amieva H, Barberger-Gateau P, et al. Cognitive impairment improves the predictive validity of the phenotype of frailty for adverse health outcomes: the three-city study. J Am Geriatr Soc, 2009, 57(3): 453-461.

1. Fried LP, Tangen CM, Walston J, et al. Frailty in older adults: evidence for a phenotype. J Gerontol A Biol Sci Med Sci, 2001, 56(3): M146-156.
2. Sieber CC. Frailty - From concept to clinical practice. Exp Gerontol, 2017, 87(Pt B): 160-167.
3. 董碧蓉. 老年衰弱綜合征的研究進展. 中華保健醫學雜志, 2014, 16(6): 417-420.
4. 郝秋奎, 董碧蓉. 老年人衰弱綜合征的國際研究現狀. 中華老年醫學雜志, 2013, 32(6): 685-688.
5. 趙國慶, 黃榮懷, 陸志堅. 知識可視化的理論與方法. 開放教育研究, 2005, 11(1): 23-27.
6. Chen CM. CiteSpace II: Detecting and visualizing emerging trends and transient patterns in scientific literature. J Am Soc Inf Sci Tec. 2006, 57(3): 359-377.
7. Cobo MJ, Lopez-Herrera AG, Herrera-Viedma E, et al. Science mapping software tools: review, analysis, and cooperative study among tools. J Am Soc Inf Sci Tec, 2011, 62(7): 1382-1402.
8. 陳悅, 陳超美, 劉則淵, 等. CiteSpace 知識圖譜的方法論功能. 科學學研究, 2015, 33(2): 242-253.
9. Johnson NE, Climo JJ. Aging and eldercare in more developed countries - The United States, South Korea, and Puerto Rico. J Fam Issues, 2000, 21(5): 531-540.
10. Smrcka L, Arltova M. Economic aspects of population ageing in developed countries. Polit Ekon, 2012, 60(1): 113-132.
11. 邱均平, 馬瑞敏. 基于 CSSCI 的圖書館、情報與檔案管理一級學科文獻計量評價研究. 中國圖書館學報, 2006, 32(1): 24-29.
12. Rockwood K. Response to the Letter From Xue and Varadhan: “What Is Missing in the Validation of Frailty Instruments?”. J Am Med Dir Assoc, 2014, 15(2): 144-145.
13. Searle SD, Rockwood K. What proportion of older adults in hospital are frail? Lancet, 2018, 391(10132): 1751-1752.
14. Xiaowei Song, Arnold Mitnitski, 石婧, 等. 中國與加拿大合作開展健康與衰老研究的情況介紹. 中華老年醫學雜志, 2009, 28(10): 793-802.
15. Callon M, Courtial JP, Laville F. Co-word analysis as a tool for describing the network of interactions between basic and technological research: The case of polymer chemsitry. Scientometrics, 1991, 22(1): 155-205.
16. 趙建保. CiteSpace 可視化流程與分析范式研究. 知識經濟, 2014, (16): 105-107.
17. 奚桓, 于普林, 劉祥. 肌少癥與衰弱綜合征的關系. 中華老年醫學雜志, 2015, 34(12): 1289-1292.
18. Nishiguchi S, Yamada M, Fukutani N, et al. Differential association of frailty with cognitive decline and sarcopenia in community-dwelling older adults. J Am Med Dir Assoc, 2015, 16(2): 120-124.
19. Angulo J, El Assar M, Rodriguez-Manas L. Frailty and sarcopenia as the basis for the phenotypic manifestation of chronic diseases in older adults. Mol Aspects Med, 2016, 50: 1-32.
20. Fang X, Shi J, Song X, et al. Frailty in relation to the risk of falls, fractures, and mortality in older Chinese adults: Results from the Beijing Longitudinal Study of Aging. J Nutr Health Aging, 2012, 16(10): 903-907.
21. Joosten E, Demuynck M, Detroyer E, et al. Prevalence of frailty and its ability to predict in hospital delirium, falls, and 6-month mortality in hospitalized older patients. BMC Geriatr, 2014, 14: 1.
22. Kojima G. Frailty as a predictor of future falls among community-dwelling older people: a systematic review and meta-analysis. J Am Med Dir Assoc, 2015, 16(12): 1027-1033.
23. Tom SE, Adachi JD, Anderson FA, et al. Frailty and fracture, disability, and falls: a multiple country study from the global longitudinal study of osteoporosis in women. J Am Geriatr Soc, 2013, 61(3): 327-334.
24. 周白瑜, 于冬妮, 陶永康, 等. 北京市社區老年人跌倒發生與衰弱的相關性研究. 中華流行病學雜志, 2018, 39(3): 308-312.
25. 王守琦, 石穎, 張美玲, 等. 老年人衰弱干預的研究進展. 中華護理雜志, 2017, 52(3): 365-368.
26. 宋曉月, 蘇媛媛, 孫丹, 等. 虛弱老年人運動康復的研究現狀. 中國康復理論與實踐, 2017, 23(4): 402-405.
27. Cesari M, Vellas B, Hsu FC, et al. A physical activity intervention to treat the frailty syndrome in older persons-results from the LIFE-P study. J Gerontol A-Biol, 2015, 70(2): 216-222.
28. Cadore EL, Rodriguez-Manas L, Sinclair A, et al. Effects of different exercise interventions on risk of falls, gait ability, and balance in physically frail older adults: a systematic review. Rejuv Res, 2013, 16(2): 105-114.
29. Chou CH, Hwang CL, Wu YT. Effect of exercise on physical function, daily living activities, and quality of life in the frail older adults: a meta-analysis. Arch Phys Med Rehab, 2012, 93(2): 237-244.
30. 嚴雪丹, 楊永學, 陳善萍, 等. 老年人衰弱的康復營養研究進展. 中華老年多器官疾病雜志, 2020, 19(1): 66-69.
31. Bollwein J, Diekmann R, Kaiser MJ, et al. Dietary quality is related to frailty in community-dwelling older adults. J Gerontol A-Biol, 2013, 68(4): 483-489.
32. Talegawkar SA, Bandinelli S, Bandeen-Roche K, et al. A higher adherence to a mediterranean-style diet is inversely associated with the development of frailty in community-dwelling elderly men and women. J Nutr, 2012, 142(12): 2161-2166.
33. Cameron ID, Fairhall N, Langron C, et al. A multifactorial interdisciplinary intervention reduces frailty in older people: randomized trial. BMC Med, 2013, 11: 65.
34. Ng TP, Feng L, Nyunt MSZ, et al. Nutritional, physical, cognitive, and combination interventions and frailty reversal among older adults: a randomized controlled trial. Am J Med, 2015, 128(11): 1225-1236.
35. 楊帆, 王雙, 譚柯, 等. 衰弱綜合征對社區老年糖尿病患者跌倒影響的隊列研究. 中華流行病學雜志, 2018, 39(6): 776-780.
36. 中華醫學會老年醫學分會. 老年患者衰弱評估與干預中國專家共識. 中華老年醫學雜志, 2017, 36(3): 251-256.
37. 呂衛華, 王青, 趙清華, 等. 住院老年患者衰弱評估及不同衰弱評估工具的比較. 北京醫學, 2016, 38(10): 1036-1040.
38. Makary MA, Segev DL, Pronovost PJ, et al. Frailty as a predictor of surgical outcomes in older patients. J Am Coll Surgeons, 2010, 210(6): 901-908.
39. Martin Lesende I, Gorronogoitia Iturbe A, Gomez Pavon J, et al. The frail elderly. Detection and management in primary care. Aten Primaria, 2010, 42(7): 388-393.
40. Williams GR, Deal AM, Sanoff HK, et al. Frailty and health-related quality of life in older women with breast cancer. Support Care Cancer, 2019, 27(7): 2693-2698.
41. 歐陽敏, 蹇在金. 老年衰弱評估研究進展. 中國實用內科雜志, 2017, 37(4): 317-321.
42. 奚興, 郭桂芳, 孫靜. 老年人衰弱評估工具及其應用研究進展. 中國老年學雜志, 2015, (20): 5993-5996.
43. Cesari M, Gambassi G, van Kan GA, et al. The frailty phenotype and the frailty index: different instruments for different purposes. Age Ageing, 2014, 43(1): 10-12.
44. Faller JW, Pereira DN, de Souza S, et al. Instruments for the detection of frailty syndrome in older adults: A systematic review. PloS One, 2019, 14(4): e0216166.
45. Pan B, Ge L, Xun YQ, et al. Exercise training modalities in patients with type 2 diabetes mellitus: a systematic review and network meta-analysis. Int J Behav Nutr Phy, 2018, 15(1): 72.
46. Huang D, Song X, Cui Q, et al. Is there an association between aircraft noise exposure and the incidence of hypertension: A meta-analysis of 16 784 participants. Noise Health, 2015, 17(75): 93-97.
47. Siriwardhana DD, Hardoon S, Rait G, et al. Prevalence of frailty and prefrailty among community-dwelling older adults in low-income and middle income countries: a systematic review and meta-analysis. BMJ Open, 2018, 8(3): e018195.
48. Landre B, Czernichow S, Goldberg M, et al. Association between life-course obesity and frailty in older adults: findings in the GAZEL cohort. Obesity, 2020, 28(2): 388-396.
49. Lee KC, Streid J, Sturgeon D, et al. The impact of frailty on long-term patient-oriented outcomes after emergency general surgery: a retrospective cohort study. J Am Ger Soc, 2020, 68(5): 1037-1043.
50. Hegendoerfer E, Vaes B, Van Pottelbergh G, et al. Predictive accuracy of frailty tools for adverse outcomes in a cohort of adults 80 years and older: a decision curve analysis. J Am Med Dir Assoc, 2020, 21(3): 400.e1-400.e8.
51. 孫晨, 施紅, 奚桓, 等. 衰弱與認知功能障礙. 中華老年醫學雜志, 2018, 37(7): 826-830.
52. 郝單單, 李放. 衰弱與認知損害相關性研究進展. 首都醫科大學學報, 2017, 38(3): 406-410.
53. Halil M, Kizilarslanoglu MC, Kuyumcu ME, et al. Cognitive aspects of frailty: Mechanisms behind the link between frailty and cognitive impairment. J Nutr Health Aging, 2015, 19(3): 276-283.
54. Robertson DA, Savva GM, Kenny RA. Frailty and cognitive impairment-A review of the evidence and causal mechanisms. Ageing Res Rev, 2013, 12(4): 840-851.
55. van Kan GA, Cesari M, Gillette-Guyonnet S, et al. Sarcopenia and cognitive impairment in elderly women: results from the EPIDOS cohort. Age Ageing, 2013, 42(2): 196-202.
56. Jha SR, Hannu MK, Gore K, et al. Cognitive impairment improves the predictive validity of physical frailty for mortality in patients with advanced heart failure referred for heart transplantation. J Heart Lung Transpl, 2016, 35(9): 1092-1100.
57. Avila-Funes JA, Amieva H, Barberger-Gateau P, et al. Cognitive impairment improves the predictive validity of the phenotype of frailty for adverse health outcomes: the three-city study. J Am Geriatr Soc, 2009, 57(3): 453-461.

Chinese Journal of Evidence-Based Medicine

Analysis of hotspots and frontiers of frailty research: a visualization analysis based on CiteSpace

Abstract Full text Figures/Tables Video References Cited by

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