Efficacy of fibrin glue after thyroidectomy: a systematic review_Chinese Journal of Evidence-Based Medicine

Authors：

GUO Qiong ¹ , CHENG Rui ² , LENG Fangqun ³ , ZHANG Chenyang ³ , CHEN Xuan ² , LONG Youlin ¹ , HE Mingdong ² , ZHANG Wen ² ,  DU Liang ^1,4 ,  HUANG Jin ⁵

1. Chinese Evidence-Based Medicine Center, West China Hospital, Sichuan University, Chengdu 610041, P.R.China;
2. West China School of Medicine, Sichuan University, Chengdu 610041, P.R.China;
3. West China School of Public Health, Sichuan University, Chengdu 610041, P.R.China;
4. West China Medical Publishers, West China Hospital, Sichuan University, Chengdu 610041, P.R.China;
5. West China Hospital, Sichuan University, Chengdu 610041, P.R.China;

Corresponding?author：

DU Liang, Email: duliang0606@vip.sina.com; HUANG Jin, Email: michael.huangjin@gmail.com

Keywords：

Thyroid gland; Thyroidectomy; Fibrin tissue adhesive; Systematic review; Meta-analysis; Randomized controlled trials

DOI：

10.7507/1672-2531.201911136

Video：

Export PDF Favorites Scan Get Citation

Abstract Full text Figures/Tables Video References Cited by

Objective To systematically review efficacy application of fibrin glue (FG) after thyroidectomy.Methods PubMed, EMbase, The Cochrane Library, ClinicalTrials.gov, CBM, CNKI, WanFang Data and VIP databases were searched to collect randomized controlled trials (RCTs) regarding the use of FG after thyroidectomy from inception to October 29^th, 2019. Two reviewers independently screened literature, extracted data, and assessed the risk of bias of included studies. Then, meta-analysis was performed by using RevMan 5.3 software.Results A total of 15 RCTs involving 2 406 patients were included. The results of meta-analysis showed that compared with non-FG group, the use of FG could reduce postoperative drainage amount at the initial 24 hours (MD=?17.98, 95%CI ?28.35 to ?7.60, P=0.000 7), total amount of wound drainage (MD=?40.92, 95%CI ?46.25 to ?35.59, P<0.000 01), and postoperative discomfort (RR=0.48, 95%CI 0.35 to 0.66, P<0.000 01), as well as shorten drainage time (MD=?9.99, 95%CI ?15.74 to ?4.23, P=0.000 7) and stitches removal time (MD=?1.49, 95%CI ?2.1 to ?0.87, P<0.000 01). However, there was no statistically significant difference concerning postoperative short-term complications such as swelling (RR=0.78, 95%CI 0.48 to 1.28, P=0.32), recurrent laryngeal nerve injury (RR=0.83, 95%CI 0.21 to 3.29, P=0.79) and wound infection (RR=0.28, 95%CI 0.07 to 1.21, P=0.09) between two groups.Conclusions The current evidence shows that FG can reduce postoperative drainage amount and shorten postoperative recovery time in thyroidectomy. Due to the limited quality and quantity of included studies, more high quality studies are required to verify above conclusions.

Citation： GUO Qiong, CHENG Rui, LENG Fangqun, ZHANG Chenyang, CHEN Xuan, LONG Youlin, HE Mingdong, ZHANG Wen, DU Liang, HUANG Jin. Efficacy of fibrin glue after thyroidectomy: a systematic review. Chinese Journal of Evidence-Based Medicine, 2020, 20(7): 789-797. doi: 10.7507/1672-2531.201911136 Copy

1.	劉首記, 王湛. 醫用生物蛋白膠應用于甲狀腺次全切除術的意義. 現代生物醫學進展, 2007, 7(9): 1365-1366.
2.	S?zen S, Topuz O, Tükenmez M, et al. The use of fibrin sealant after total thyroidectomy for benign disease obviates the need for routine drainage. Results of a randomized controlled trial. Hippokratia, 2011, 15(3): 247-251.
3.	Terris DJ, Snyder S, Carneiro-Pla D, et al. American Thyroid Association statement on outpatient thyroidectomy. Thyroid, 2013, 23(10): 1193-1202.
4.	Cannizzaro MA, Lo Bianco S, Picardo MC, et al. How to avoid and to manage post-operative complications in thyroid surgery. Updates Surg, 2017, 69(2): 211-215.
5.	Materazzi G, Ambrosini CE, Fregoli L, et al. Prevention and management of bleeding in thyroid surgery. Gland Surg, 2017, 6(5): 510-515.
6.	Geraci G, D'Orazio B, Chiarenza S, et al. Efficacy of fibrin sealant in thyroid surgery. Is drainage still necessary? Ann Ital Chir, 2019, 90: 100-105.
7.	張煥君. 醫用生物蛋白膠在甲狀腺手術中的應用. 護理研究, 2008, 22(6): 562.
8.	Li L, Liu W, Tao H, et al. Efficacy and safety of negative pressure versus natural drainage after thyroid surgery: a systematic review and meta-analysis. Medicine (Baltimore), 2018, 97(31): e11576.
9.	Woods RS, Woods JF, Duignan ES, et al. Systematic review and meta-analysis of wound drains after thyroid surgery. Br J Surg, 2014, 101(5): 446-456.
10.	Smith RB, Coughlin A. Thyroidectomy hemostasis. Otolaryngol Clin North Am, 2016, 49(3): 727-748.
11.	Gao F, Ma J, Sun W, et al. Topical fibrin sealant versus intravenous tranexamic acid for reducing blood loss following total knee arthroplasty: A systematic review and meta-analysis. Int J Surg, 2016, 32: 31-37.
12.	Uwiera TC, Uwiera RR, Seikaly H, et al. Tisseel and its effects on wound drainage post-thyroidectomy: prospective, randomized, blinded, controlled study. J Otolaryngol, 2005, 34(6): 374-378.
13.	Kim TW, Choi SY, Jang MS, et al. Efficacy of fibrin sealant for drainage reduction in total thyroidectomy with bilateral central neck dissection. Otolaryngol Head Neck Surg, 2012, 147(4): 654-660.
14.	Wan X, Wang W, Liu J, et al. Estimating the sample mean and standard deviation from the sample size, median, range and/or interquartile range. BMC Med Res Methodol, 2014, 14: 135.
15.	Higgins JPT, Green S. Cochrane handbook for systematic reviews of interventions version 5.1.0. The Cochrane Collaboration, 2011. Available from: www.handbook.cochrane.org/.
16.	宋中林. 甲狀腺腺瘤摘除術不同引流方法的療效比較. 現代診斷與治療, 2017, 28(15): 2880-2881.
17.	王進超, 蔡勝華. 生物蛋白膠在頸部內鏡甲狀腺切除術中的應用及效果分析. 醫學綜述, 2016, 22(7): 1410-1411, 1414.
18.	李洪俊. 甲狀腺瘤摘除不同引流方法的療效比較. 中國醫藥指南, 2013, 11(19): 526-527.
19.	宋永蔚, 張靜潭. 醫用生物蛋白膠在甲狀腺單側腺葉及峽部切除術中的應用. 亞太傳統醫藥, 2009, 5(6): 57-58.
20.	勞衛榮, 梁國健, 林建生. 纖維蛋白封閉劑在甲狀腺手術中的應用. 中華全科醫學, 2009, 7(5): 491-492.
21.	王景麗. 醫用生物蛋白膠在甲狀腺手術中的應用觀察. 山東醫藥, 2008, 48(43): 55.
22.	王軍. 醫用生物蛋白膠在甲狀腺癌聯合根治術中的應用. 臨床外科雜志, 2006, 14(5): 317-317.
23.	何兆群, 梁偉雄. 甲狀腺次全切除術不放引流物的術式探討. 中華臨床醫學研究雜志, 2003, (14): 11965-11966.
24.	張惠, 劉治濱. 甲狀腺次全切除術兩種手術方法的療效觀察. 醫學研究雜志, 2008, 37(5): 76-78.
25.	張獻義, 劉寧青, 呂鵬飛, 等. 醫用生物蛋白膠在甲狀腺手術中的應用. 中華普通外科雜志, 2004, 19(8): 511.
26.	Nguyen SA. A trial comparing wound drainage and post-operative complications with and without the use of evicel^TM fibrin sealant in thyroidectomy. 2019. Available at: https://clinicaltrials.gov/ct2/show/results/NCT01226914.
27.	Spotnitz WD. Fibrin sealant: the only approved hemostat, sealant, and adhesive-a laboratory and clinical perspective. ISRN Surg, 2014, 2014: 203943.
28.	Carless PA, Henry DA. Systematic review and meta-analysis of the use of fibrin sealant to prevent seroma formation after breast cancer surgery. Br J Surg, 2006, 93(7): 810-819.
29.	Jain R, Wairkar S. Recent developments and clinical applications of surgical glues: an overview. Int J Biol Macromol, 2019, 137: 95-106.
30.	Pryor SG, Sykes J, Tollefson TT. Efficacy of fibrin sealant (human) (Evicel) in rhinoplasty: a prospective, randomized, single-blind trial of the use of fibrin sealant in lateral osteotomy. Arch Facial Plast Surg, 2008, 10(5): 339-344.
31.	Mankad PS, Codispoti M. The role of fibrin sealants in hemostasis. Am J Surg, 2001, 182(2 Suppl): 21S-28S.
32.	Yu MS, Kang SH, Kim BH, et al. Effect of aerosolized fibrin sealant on hemostasis and wound healing after endoscopic sinus surgery: a prospective randomized study. Am J Rhinol Allergy, 2014, 28(4): 335-340.
33.	華丹, 郭子君. 醫用生物蛋白膠在甲狀腺手術中應用的 Meta 分析. 中國組織工程研究, 2014, 18(8): 1283-1288.
34.	郭子君, 華丹. 醫用生物蛋白膠在甲狀腺手術中的應用評價. 山東醫藥, 2014, 54(27): 80-82.

1. 劉首記, 王湛. 醫用生物蛋白膠應用于甲狀腺次全切除術的意義. 現代生物醫學進展, 2007, 7(9): 1365-1366.
2. S?zen S, Topuz O, Tükenmez M, et al. The use of fibrin sealant after total thyroidectomy for benign disease obviates the need for routine drainage. Results of a randomized controlled trial. Hippokratia, 2011, 15(3): 247-251.
3. Terris DJ, Snyder S, Carneiro-Pla D, et al. American Thyroid Association statement on outpatient thyroidectomy. Thyroid, 2013, 23(10): 1193-1202.
4. Cannizzaro MA, Lo Bianco S, Picardo MC, et al. How to avoid and to manage post-operative complications in thyroid surgery. Updates Surg, 2017, 69(2): 211-215.
5. Materazzi G, Ambrosini CE, Fregoli L, et al. Prevention and management of bleeding in thyroid surgery. Gland Surg, 2017, 6(5): 510-515.
6. Geraci G, D'Orazio B, Chiarenza S, et al. Efficacy of fibrin sealant in thyroid surgery. Is drainage still necessary? Ann Ital Chir, 2019, 90: 100-105.
7. 張煥君. 醫用生物蛋白膠在甲狀腺手術中的應用. 護理研究, 2008, 22(6): 562.
8. Li L, Liu W, Tao H, et al. Efficacy and safety of negative pressure versus natural drainage after thyroid surgery: a systematic review and meta-analysis. Medicine (Baltimore), 2018, 97(31): e11576.
9. Woods RS, Woods JF, Duignan ES, et al. Systematic review and meta-analysis of wound drains after thyroid surgery. Br J Surg, 2014, 101(5): 446-456.
10. Smith RB, Coughlin A. Thyroidectomy hemostasis. Otolaryngol Clin North Am, 2016, 49(3): 727-748.
11. Gao F, Ma J, Sun W, et al. Topical fibrin sealant versus intravenous tranexamic acid for reducing blood loss following total knee arthroplasty: A systematic review and meta-analysis. Int J Surg, 2016, 32: 31-37.
12. Uwiera TC, Uwiera RR, Seikaly H, et al. Tisseel and its effects on wound drainage post-thyroidectomy: prospective, randomized, blinded, controlled study. J Otolaryngol, 2005, 34(6): 374-378.
13. Kim TW, Choi SY, Jang MS, et al. Efficacy of fibrin sealant for drainage reduction in total thyroidectomy with bilateral central neck dissection. Otolaryngol Head Neck Surg, 2012, 147(4): 654-660.
14. Wan X, Wang W, Liu J, et al. Estimating the sample mean and standard deviation from the sample size, median, range and/or interquartile range. BMC Med Res Methodol, 2014, 14: 135.
15. Higgins JPT, Green S. Cochrane handbook for systematic reviews of interventions version 5.1.0. The Cochrane Collaboration, 2011. Available from: www.handbook.cochrane.org/.
16. 宋中林. 甲狀腺腺瘤摘除術不同引流方法的療效比較. 現代診斷與治療, 2017, 28(15): 2880-2881.
17. 王進超, 蔡勝華. 生物蛋白膠在頸部內鏡甲狀腺切除術中的應用及效果分析. 醫學綜述, 2016, 22(7): 1410-1411, 1414.
18. 李洪俊. 甲狀腺瘤摘除不同引流方法的療效比較. 中國醫藥指南, 2013, 11(19): 526-527.
19. 宋永蔚, 張靜潭. 醫用生物蛋白膠在甲狀腺單側腺葉及峽部切除術中的應用. 亞太傳統醫藥, 2009, 5(6): 57-58.
20. 勞衛榮, 梁國健, 林建生. 纖維蛋白封閉劑在甲狀腺手術中的應用. 中華全科醫學, 2009, 7(5): 491-492.
21. 王景麗. 醫用生物蛋白膠在甲狀腺手術中的應用觀察. 山東醫藥, 2008, 48(43): 55.
22. 王軍. 醫用生物蛋白膠在甲狀腺癌聯合根治術中的應用. 臨床外科雜志, 2006, 14(5): 317-317.
23. 何兆群, 梁偉雄. 甲狀腺次全切除術不放引流物的術式探討. 中華臨床醫學研究雜志, 2003, (14): 11965-11966.
24. 張惠, 劉治濱. 甲狀腺次全切除術兩種手術方法的療效觀察. 醫學研究雜志, 2008, 37(5): 76-78.
25. 張獻義, 劉寧青, 呂鵬飛, 等. 醫用生物蛋白膠在甲狀腺手術中的應用. 中華普通外科雜志, 2004, 19(8): 511.
26. Nguyen SA. A trial comparing wound drainage and post-operative complications with and without the use of evicel^TM fibrin sealant in thyroidectomy. 2019. Available at: https://clinicaltrials.gov/ct2/show/results/NCT01226914.
27. Spotnitz WD. Fibrin sealant: the only approved hemostat, sealant, and adhesive-a laboratory and clinical perspective. ISRN Surg, 2014, 2014: 203943.
28. Carless PA, Henry DA. Systematic review and meta-analysis of the use of fibrin sealant to prevent seroma formation after breast cancer surgery. Br J Surg, 2006, 93(7): 810-819.
29. Jain R, Wairkar S. Recent developments and clinical applications of surgical glues: an overview. Int J Biol Macromol, 2019, 137: 95-106.
30. Pryor SG, Sykes J, Tollefson TT. Efficacy of fibrin sealant (human) (Evicel) in rhinoplasty: a prospective, randomized, single-blind trial of the use of fibrin sealant in lateral osteotomy. Arch Facial Plast Surg, 2008, 10(5): 339-344.
31. Mankad PS, Codispoti M. The role of fibrin sealants in hemostasis. Am J Surg, 2001, 182(2 Suppl): 21S-28S.
32. Yu MS, Kang SH, Kim BH, et al. Effect of aerosolized fibrin sealant on hemostasis and wound healing after endoscopic sinus surgery: a prospective randomized study. Am J Rhinol Allergy, 2014, 28(4): 335-340.
33. 華丹, 郭子君. 醫用生物蛋白膠在甲狀腺手術中應用的 Meta 分析. 中國組織工程研究, 2014, 18(8): 1283-1288.
34. 郭子君, 華丹. 醫用生物蛋白膠在甲狀腺手術中的應用評價. 山東醫藥, 2014, 54(27): 80-82.

Chinese Journal of Evidence-Based Medicine

Efficacy of fibrin glue after thyroidectomy: a systematic review

View correction

Abstract Full text Figures/Tables Video References Cited by

Previous Article

Next Article

Format

Content