Association of micronucleus and polycystic ovary syndrome: a meta-analysis_Chinese Journal of Evidence-Based Medicine

Authors：

LI Xiaozhen ¹ , SONG Zeli ² , WANG Yefeng ³ , CAO Wenting ¹ ,  HUANG Hairong ¹

1. Department of Epidemiology, School of Public Health, Hainan Medical University, Haikou, 571199, P.R.China;
2. Department of Toxicology, College of Public Health, China Medical University, Shenyang, 110001, P.R.China;
3. School of Public Health and Management, NingXia Medical University, Yinchuan, 750004, P.R.China;

Corresponding?author：

HUANG Hairong, Email: jialidog1@163.com

Keywords：

PCOS; Micronucleus; Oxidative stress; Meta-analysis; Systematic review; Case-control study

DOI：

10.7507/1672-2531.201906131

Video：

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Objective To systematically review the association of micronucleus and polycystic ovary syndrome (PCOS).Methods PubMed, OVID, Elsevier, CNKI, WanFang Data and CBM databases were electronically searched to collect case-control studies on the association of micronucleus and PCOS. Two reviewers independently screened literature, extracted data and assessed the risk of bias of included studies, then, meta-analysis was performed by using RevMan 5.3 software.Results A total of 5 case-control studies were included, in which 170 patients were in the case group and 148 in the control group. The results of meta-analysis showed: there were significant differences between the two groups for micronucleus frequency (MD=2.02%, 95%CI 1.63% to 2.41%, P<0.000 01) in peripheral blood lymphocytes and micro nucleated cells frequency (MD=2.43%, 95%CI 0.10% to 4.76%, P=0.04) in oral epithelial cells.Conclusion The current evidence shows that micronucleus is associated with PCOS. Due to limited quality and quantity of the included studies, more high quality studies are needed to verify above conclusion.

Citation： LI Xiaozhen, SONG Zeli, WANG Yefeng, CAO Wenting, HUANG Hairong. Association of micronucleus and polycystic ovary syndrome: a meta-analysis. Chinese Journal of Evidence-Based Medicine, 2020, 20(2): 181-185. doi: 10.7507/1672-2531.201906131 Copy

1.	Azziz R, Carmina E, Chen Z, et al. Polycystic ovary syndrome. Nat Rev Dis Primers, 2016, 2: 16057.
2.	張鳶, 蔣惠愈. 胰島素抵抗與體質量指數對 PCOS 婦女脂代謝及性激素的影響. 中國婦幼健康研究, 2017, 28(11): 1412-1414.
3.	Azziz R. Polycystic ovary syndrome. Obstet Gynecol, 2018, 132(2): 321-336.
4.	Karatayl? R, Gül Zamani A, Gezgin? K, et al. Micronuclei frequencies in lymphocytes and cervical cells of women with polycystic ovarian syndrome. Turk J Obstet Gynecol, 2017, 14(3): 151-155.
5.	Rotterdam ESHRE/ASRM-Sponsored PCOS Consensus Workshop Group. Revised 2003 consensus on diagnostic criteria and long-term health risks related to polycystic ovary syndrome. Fertil Steril, 2004, 81(1): 19-25.
6.	周月琴, 凌迎春, 沈群弟, 等. 中國女性血清瘦素與多囊卵巢綜合征關系的 Meta 分析. 中國婦幼健康研究, 2019, 30(3): 385-388.
7.	陳詠, 于月新, 蘆冬梅, 等. 維生素 D 受體基因多態性與多囊卵巢綜合征 Meta 分析. 中國實用婦科與產科雜志, 2018, 34(1): 94-99.
8.	Deepika ML, Nalini S, Maruthi G, et al. Analysis of oxidative stress status through MN test and serum MDA levels in PCOS women. Pak J Biol Sci, 2014, 17(4): 574-577.
9.	Hamurcu Z, Bayram F, Kahriman G, et al. Micronucleus frequency in lymphocytes and 8-hydroxydeoxyguanosine level in plasma of women with polycystic ovary syndrome. Gynecol Endocrinol, 2010, 26(8): 590-595.
10.	Moran LJ, Noakes M, Clifton PM, et al. Genome instability is increased in lymphocytes of women with polycystic ovary syndrome and is correlated with insulin resistance. Mutat Res, 2008, 639(1-2): 55-63.
11.	Nersesyan A, Chobanyan N. Micronuclei and other nuclear anomalies levels in exfoliated buccal cells and DNA damage in leukocytes of patients with polycystic ovary syndrome. J BUON, 2010, 15(2): 337-339.
12.	Rocha AL, Oliveira FR, Azevedo RC, et al. Recent advances in the understanding and management of polycystic ovary syndrome. F1000Res, 2019, 8: 1000-1565.
13.	Ortiz-Flores AE, Luque-Ramírez M, Escobar-Morreale HF. Polycystic ovary syndrome in adult women. Med Clin (Barc), 2019, 152(11): 450-457.
14.	熊冬梅, 谷霞, 許良智, 等. 多囊卵巢綜合征患者高雄激素的相關性研究. 實用醫院臨床雜志, 2013, 10(4): 56-58.
15.	朱茜, 倪郝, 全松. 多囊卵巢綜合征高雄激素特征及管理. 中國實用婦科與產科雜志, 2019, 35(3): 274-278.
16.	曹嬌嬌. 中國人群 CYP17 基因多態性與多囊卵巢綜合征關系的薈萃分析. 哈爾濱: 黑龍江中醫藥大學, 2011.
17.	董文嬌, 王玉霞, 楊海婷. 雄激素受體基因(CAG)n 多態性對多囊卵巢綜合征形成的影響. 國際生殖健康/計劃生育雜志, 2017, 36(1): 70-73.
18.	左莉, 傅亞均. 多囊卵巢綜合征病因及治療進展. 重慶醫學, 2018, 47(9): 1247-1250.
19.	?zer A, Bakacak M, K?ran H, et al. Increased oxidative stress is associated with insulin resistance and infertility in polycystic ovary syndrome. Ginekol Pol, 2016, 87(11): 733-738.
20.	Papalou O, Victor VM, Diamanti-Kandarakis E. Oxidative stress in polycystic ovary syndrome. Curr Pharm Des, 2016, 22(18): 2709-2722.
21.	Hintzsche H, Hemmann U, Poth A, et al. Fate of micronuclei and micronucleated cells. Mutat Res, 2017, 771: 85-98.
22.	Hyderali BN, Mala K. Oxidative stress and cardiovascular complications in polycystic ovarian syndrome. Eur J Obstet Gynecol Reprod Biol, 2015, 191: 15-22.
23.	高貴花, 曹云霞, 易龍, 等. 膽固醇側鏈裂解酶 CYP11 A1 基因多態性與多囊卵巢綜合征發病的相關性. 中華婦產科雜志, 2010, 45(3): 191-196.
24.	楊柳, 張磊, 李春輝, 等. 膽固醇側鏈裂解酶基因微衛星多態性與多囊卵巢綜合征發病風險的關聯. 山東大學學報(醫學版), 2013, 51(10): 85-89.
25.	Zuo T, Zhu M, Xu W. Roles of oxidative stress in polycystic ovary syndrome and cancers. Oxid Med Cell Longev, 2016, 2016: 8589318.

1. Azziz R, Carmina E, Chen Z, et al. Polycystic ovary syndrome. Nat Rev Dis Primers, 2016, 2: 16057.
2. 張鳶, 蔣惠愈. 胰島素抵抗與體質量指數對 PCOS 婦女脂代謝及性激素的影響. 中國婦幼健康研究, 2017, 28(11): 1412-1414.
3. Azziz R. Polycystic ovary syndrome. Obstet Gynecol, 2018, 132(2): 321-336.
4. Karatayl? R, Gül Zamani A, Gezgin? K, et al. Micronuclei frequencies in lymphocytes and cervical cells of women with polycystic ovarian syndrome. Turk J Obstet Gynecol, 2017, 14(3): 151-155.
5. Rotterdam ESHRE/ASRM-Sponsored PCOS Consensus Workshop Group. Revised 2003 consensus on diagnostic criteria and long-term health risks related to polycystic ovary syndrome. Fertil Steril, 2004, 81(1): 19-25.
6. 周月琴, 凌迎春, 沈群弟, 等. 中國女性血清瘦素與多囊卵巢綜合征關系的 Meta 分析. 中國婦幼健康研究, 2019, 30(3): 385-388.
7. 陳詠, 于月新, 蘆冬梅, 等. 維生素 D 受體基因多態性與多囊卵巢綜合征 Meta 分析. 中國實用婦科與產科雜志, 2018, 34(1): 94-99.
8. Deepika ML, Nalini S, Maruthi G, et al. Analysis of oxidative stress status through MN test and serum MDA levels in PCOS women. Pak J Biol Sci, 2014, 17(4): 574-577.
9. Hamurcu Z, Bayram F, Kahriman G, et al. Micronucleus frequency in lymphocytes and 8-hydroxydeoxyguanosine level in plasma of women with polycystic ovary syndrome. Gynecol Endocrinol, 2010, 26(8): 590-595.
10. Moran LJ, Noakes M, Clifton PM, et al. Genome instability is increased in lymphocytes of women with polycystic ovary syndrome and is correlated with insulin resistance. Mutat Res, 2008, 639(1-2): 55-63.
11. Nersesyan A, Chobanyan N. Micronuclei and other nuclear anomalies levels in exfoliated buccal cells and DNA damage in leukocytes of patients with polycystic ovary syndrome. J BUON, 2010, 15(2): 337-339.
12. Rocha AL, Oliveira FR, Azevedo RC, et al. Recent advances in the understanding and management of polycystic ovary syndrome. F1000Res, 2019, 8: 1000-1565.
13. Ortiz-Flores AE, Luque-Ramírez M, Escobar-Morreale HF. Polycystic ovary syndrome in adult women. Med Clin (Barc), 2019, 152(11): 450-457.
14. 熊冬梅, 谷霞, 許良智, 等. 多囊卵巢綜合征患者高雄激素的相關性研究. 實用醫院臨床雜志, 2013, 10(4): 56-58.
15. 朱茜, 倪郝, 全松. 多囊卵巢綜合征高雄激素特征及管理. 中國實用婦科與產科雜志, 2019, 35(3): 274-278.
16. 曹嬌嬌. 中國人群 CYP17 基因多態性與多囊卵巢綜合征關系的薈萃分析. 哈爾濱: 黑龍江中醫藥大學, 2011.
17. 董文嬌, 王玉霞, 楊海婷. 雄激素受體基因(CAG)n 多態性對多囊卵巢綜合征形成的影響. 國際生殖健康/計劃生育雜志, 2017, 36(1): 70-73.
18. 左莉, 傅亞均. 多囊卵巢綜合征病因及治療進展. 重慶醫學, 2018, 47(9): 1247-1250.
19. ?zer A, Bakacak M, K?ran H, et al. Increased oxidative stress is associated with insulin resistance and infertility in polycystic ovary syndrome. Ginekol Pol, 2016, 87(11): 733-738.
20. Papalou O, Victor VM, Diamanti-Kandarakis E. Oxidative stress in polycystic ovary syndrome. Curr Pharm Des, 2016, 22(18): 2709-2722.
21. Hintzsche H, Hemmann U, Poth A, et al. Fate of micronuclei and micronucleated cells. Mutat Res, 2017, 771: 85-98.
22. Hyderali BN, Mala K. Oxidative stress and cardiovascular complications in polycystic ovarian syndrome. Eur J Obstet Gynecol Reprod Biol, 2015, 191: 15-22.
23. 高貴花, 曹云霞, 易龍, 等. 膽固醇側鏈裂解酶 CYP11 A1 基因多態性與多囊卵巢綜合征發病的相關性. 中華婦產科雜志, 2010, 45(3): 191-196.
24. 楊柳, 張磊, 李春輝, 等. 膽固醇側鏈裂解酶基因微衛星多態性與多囊卵巢綜合征發病風險的關聯. 山東大學學報(醫學版), 2013, 51(10): 85-89.
25. Zuo T, Zhu M, Xu W. Roles of oxidative stress in polycystic ovary syndrome and cancers. Oxid Med Cell Longev, 2016, 2016: 8589318.

Chinese Journal of Evidence-Based Medicine

Association of micronucleus and polycystic ovary syndrome: a meta-analysis

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